The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Dysregulation of lipids in Alzheimer’s disease and their role as potential biomarkers
Open accessAbstract
The brain is highly enriched in lipids, and an intensive study of these lipids may be informative, not only of normal brain function but also of changes with age and in disease. In recent years, the development of highly sensitive mass spectrometry platforms and other high-throughput technologies has enabled the discovery of complex changes in the entire lipidome. This lipidomics approach promises to be a particularly useful tool for identifying diagnostic biomarkers for early detection of age-related neurodegenerative disease, such as Alzheimer's disease (AD), which has till recently been limited to protein- and gene-centric approaches. This review highlights known lipid changes affecting the AD brain and presents an update on the progress of lipid biomarker research in AD. Important considerations for designing large-scale lipidomics experiments are discussed to help standardize findings across different laboratories, as well as challenges associated with moving toward clinical application.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Lipids provide a further advantage in that dietary intervention represents a fairly straightforward manner to achieve proper lipid homeostasis [111,112,113].”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [113]
In the citing paper
“their dysregulation has been linked to neurodegenerative disorders, including AD24”
From Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease (2025) · cites this paper as [24]
Citations
Cites
1 retracted
Rao, J. S., Rapoport, S. I., & Kim, H. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.27 · Cited by 86
RetractedA SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Metabolite profiles and the risk of developing diabetes
Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S., Rhee, E. P., McCabe, E., Lewis, G. D., Fox, C. S., Jacques, P. F., Fernandez, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2307 · Cited by 3,143
Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics
Matyash, V., Liebisch, G., Kurzchalia, T. V., Shevchenko, A., & Schwudke, D. (2008) · Journal of Lipid Research · doi:10.1194/jlr.d700041-jlr200 · Cited by 2,633
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,269
Update of the LIPID MAPS comprehensive classification system for lipids
Fahy, E., Subramaniam, S., Murphy, R. C., Nishijima, M., Raetz, C. R. H., Shimizu, T., Spener, F., van Meer, G., Wakelam, M. J. O., & Dennis, E. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800095-jlr200 · Cited by 1,628
Ion Suppression in Mass Spectrometry
Annesley, T. M. (2003) · Clinical Chemistry · doi:10.1373/49.7.1041 · Cited by 1,598
Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance
Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,242
Han, X., & Gross, R. W. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20023 · Cited by 1,126
Plasma phospholipids identify antecedent memory impairment in older adults
Mapstone, M. E., Cheema, A. K., Fiandaca, M. S., Zhong, X., Mhyre, T. R., MacArthur, L. H., Hall, W. J., Fisher, S. G., Peterson, D. R., Haley, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3466 · Cited by 1,060
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
Ehehalt, R., Keller, P., Haass, C., Thiele, C., & Simons, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207113 · Cited by 932
Lipidomics: coming to grips with lipid diversity
Shevchenko, A., & Simons, K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2934 · Cited by 838
Kivipelto, M., Helkala, E., Laakso, M. P., Hänninen, T., Hallikainen, M., Alhainen, K., Iivonen, S., Mannermaa, A., Tuomilehto, J., Nissinen, A. M., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-3-200208060-00006 · Cited by 642
Han, X., Holtzman, D. M., & McKeel, D. W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00332.x · Cited by 571
Identification of type 2 diabetes subgroups through topological analysis of patient similarity
Li, L., Cheng, W., Glicksberg, B. S., Gottesman, O., Tamler, R., Chen, R., Böttinger, E. P., & Dudley, J. T. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa9364 · Cited by 554
Differences between Human Plasma and Serum Metabolite Profiles
Yu, Z., Kastenmüller, G., He, Y., Belcredi, P., Möller, G., Prehn, C. P., Mendes, J., Wahl, S., Roemisch‐Margl, W., Ceglarek, U., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021230 · Cited by 523
Deregulation of sphingolipid metabolism in Alzheimer’s disease
He, X., Huang, Y., Li, B., Gong, C.-X., & Schuchman, E. H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.010 · Cited by 516
Trushina, E., Dutta, T., Persson, X.-M. T., Mielke, M. M., & Petersen, R. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063644 · Cited by 438
Han, X., Rozen, S., Boyle, S. H., Hellegers, C., Cheng, H., Burke, J. R., Welsh-Bohmer, K. A., Doraiswamy, P. M., & Kaddurah-Daouk, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021643 · Cited by 429
Translation of proteomic biomarkers into FDA approved cancer diagnostics: issues and challenges
Füzéry, A. K., Levin, J. D., Chan, M. M., & Chan, D. W. (2013) · Clinical Proteomics · doi:10.1186/1559-0275-10-13 · Cited by 428
Dieterle, F., Sistare, F. D., Goodsaid, F. M., Papaluca, M., Ozer, J. S., Webb, C. P., Baer, W., Senagore, A. J., Schipper, M. J., Vonderscher, J., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1625 · Cited by 410
Drucker, E., & Krapfenbauer, K. (2013) · The EPMA Journal · doi:10.1186/1878-5085-4-7 · Cited by 360
Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease
Whiley, L., Sen, A., Heaton, J. C., Proitsi, P., García‐Gómez, D., Leung, R., Smith, N. W., Thambisetty, M., Kłoszewska, I., Mecocci, P., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.08.001 · Cited by 334
Self-citationPonnusamy, S., Meyers‐Needham, M., Senkal, C. E., Saddoughi, S. A., Sentelle, D., Selvam, S. P., Salas, A., & Öğretmen, B. (2010) · Future Oncology · doi:10.2217/fon.10.116 · Cited by 319
Efficacy of Souvenaid in Mild Alzheimer's Disease: Results from a Randomized, Controlled Trial
Scheltens, P., Twisk, J. W. R., Blesa, R., Scarpini, E. A., Arnim, C. A. F. V., Bongers, A., Harrison, J., Willemsen‐Swinkels, S. H. N., Stam, C. J., de Waal, H., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121189 · Cited by 314
O’Bryant, S. E., Gupta, V. B., Henriksen, K., Edwards, M., Jeromin, A., Lista, S., Bazenet, C. E., Soares, H. D., Lovestone, S., Hampel, H. J., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.08.099 · Cited by 294
Xiong, H., Callaghan, D., Jones, A., Walker, D. G., Lue, L., Beach, T. G., Sue, L. I., Woulfe, J., Xu, H., Stanimirovic, D. B., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.10.005 · Cited by 293
Surma, M. A., Herzog, R., Vasilj, A., Klose, C. D., Christinat, N., Morin‐Rivron, D., Simons, K., Masoodi, M., & Sampaio, J. L. (2015) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201500145 · Cited by 285
Barri, T., & Dragsted, L. O. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.01.015 · Cited by 278
SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function
Dart, C. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.191585 · Cited by 273
Brügger, B. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035324 · Cited by 265
A comparison of five lipid extraction solvent systems for lipidomic studies of human LDL
Reis, A., Rudnitskaya, A. M., Blackburn, G. J., Fauzi, N. M., Pitt, A. R., & Spickett, C. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m034330 · Cited by 250
Targeted Metabolomics Identifies Reliable and Stable Metabolites in Human Serum and Plasma Samples
Breier, M., Wahl, S., Prehn, C. P., Fugmann, M., Ferrari, U., Weise, M., Banning, F., Seißler, J., Grallert, H., Adamski, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089728 · Cited by 240
Serum ceramides increase the risk of Alzheimer disease
Mielke, M. M., Bandaru, V. V. R., Haughey, N. J., Xia, J., Fried, L. P., Yaşar, S., Albert, M., Varma, V. R., Harris, G., Schneider, E. B., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318264e380 · Cited by 227
Dhingra, R., & Vasan, R. S. (2016) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2016.07.005 · Cited by 221
Phospholipids and Alzheimer’s Disease: Alterations, Mechanisms and Potential Biomarkers
Košiček, M., & Hecimovic, S. K. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011310 · Cited by 220
An Efficient Single Phase Method for the Extraction of Plasma Lipids
Alshehry, Z. H., Barlow, C. K., Weir, J. M., Zhou, Y., McConville, M. J., & Meikle, P. J. (2015) · Metabolites · doi:10.3390/metabo5020389 · Cited by 219
Claxton, A., Baker, L. D., Wilkinson, C. W., Trittschuh, E. H., Chapman, D., Watson, G. S., Cholerton, B., Plymate, S. R., Arbuckle, M., & Craft, S. (2013) · Journal of Alzheimer’s Disease · doi:10.3233/jad-122308 · Cited by 215
Song, F., Poljak, A., Crawford, J., Kochan, N. A., Wen, W., Cameron, B., Lux, O., Brodaty, H., Mather, K., Smythe, G. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034078 · Cited by 214
Self-citationHong, S., Ostaszewski, B. L., Yang, T., O’Malley, T. T., Jin, M., Yanagisawa, K., Li, S., Bartels, T., & Selkoe, D. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.027 · Cited by 213
Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis
Proitsi, P., Kim, M. G., Whiley, L., Simmons, A., Sattlecker, M., Velayudhan, L., Lupton, M. K., Soininen, H., Kłoszewska, I., Mecocci, P., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.08.003 · Cited by 206
Mullen, T. D., & Obeid, L. M. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152012800228661 · Cited by 204
APOE2 enhances neuroprotection against Alzheimer’s disease through multiple molecular mechanisms
Conejero-Goldberg, C., Gomar, J. J., Bobes-Bascaran, T., Hyde, T. M., Kleinman, J. E., Herman, M. M., Chen, S., Davies, P., & Goldberg, T. E. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.194 · Cited by 199
Marquer, C., Devauges, V., Cossec, J., Liot, G., Lécart, S., Saudou, F., Duyckaerts, C. J., Lévêque‐Fort, S., & Potier, M. (2011) · The FASEB Journal · doi:10.1096/fj.10-168633 · Cited by 196
Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis
Satoi, H., Tomimoto, H., Ohtani, R., Kitano, T., Kondo, T., Watanabe, M., Oka, N., Akiguchi, I., Furuya, S., Hirabayashi, Y., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.056 · Cited by 196
Meikle, P. J., Wong, G., Barlow, C. K., & Kingwell, B. A. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.02.001 · Cited by 189
Ishikawa, M., Maekawa, K., Saito, K., Senoo, Y., Urata, M., Murayama, M., Tajima, Y., Kumagai, Y., & Saito, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091806 · Cited by 188
Mass Spectrometry Based Lipidomics: An Overview of Technological Platforms
Köfeler, H. C., Fauland, A., Rechberger, G. N., & Trötzmüller, M. (2012) · Metabolites · doi:10.3390/metabo2010019 · Cited by 187
Plasma biomarkers for mild cognitive impairment and Alzheimer's disease
Song, F., Poljak, A., Smythe, G. A., & Sachdev, P. S. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.003 · Cited by 181
Self-citationMulder, C., Wahlund, L., Teerlink, T., Blomberg, M. I., Veerhuis, R., van Kamp, G. J., Scheltens, P., & Scheffer, P. G. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0007-9 · Cited by 174
Mielke, M. M., Haughey, N. J., Bandaru, V. V. R., Schech, S., Carrick, R., Carlson, M. C., Mori, S., Miller, M. I., Ceritoglu, C., Brown, T., et al. (2010) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.03.014 · Cited by 170
Fabelo, N., Martín, M. V., Marín, R., Moreno, D., Ferrer, I., & Díaz, M. L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.005 · Cited by 169
Zuo, H., Ueland, P. M., Ulvik, A., Eussen, S. J. P. M., Vollset, S. E., Nygard, O. K., Midttun, Ø., Theofylaktopoulou, D., Meyer, K., & Tell, G. S. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kwv242 · Cited by 169
Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients
Walter, A., Korth, U., Hilgert, M., Hartmann, J., Weichel, O., Hilgert, M., Fassbender, K. C., Schmitt, A., & Klein, J. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.016 · Cited by 165
Alshaarawy, O., Elbaz, H. A., & Andrew, M. E. (2016) · Environment International · doi:10.1016/j.envint.2016.02.006 · Cited by 162
Loss of the neuroprotective factor sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis
Couttas, T. A., Kain, N., Daniels, B., Lim, X. Y., Shepherd, C., Kril, J., Pickford, R., Li, H., Garner, B., & Don, A. S. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-9 · Cited by 161
Self-citationCasanova, R., Varma, S., Simpson, B. N., Kim, M. G., An, Y., Saldana, S. J., Riveros, C., Moscato, P., Griswold, M. E., Sonntag, D., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.12.008 · Cited by 161
Self-citationPlasma Sphingomyelins are Associated with Cognitive Progression in Alzheimer's Disease
Mielke, M. M., Haughey, N. J., Bandaru, V. V. R., Weinberg, D. D., Darby, E. J., Zaidi, N., Pavlik, V., Doody, R. S., & Lyketsos, C. G. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110405 · Cited by 158
Lipid changes in the aged brain: Effect on synaptic function and neuronal survival
Ledesma, M. D., Martín, M. G., & Dotti, C. G. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.11.004 · Cited by 154
Serum total cholesterol, statins and cognition in non-demented elderly
Solomon, A., Kåreholt, I., Ngandu, T., Wolozin, B., MacDonald, S. W. S., Winblad, B., Nissinen, A., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.09.012 · Cited by 149
Involvement of Sphingosine-1-Phosphate in Glutamate Secretion in Hippocampal Neurons
Kajimoto, T., Okada, T., Yu, H., Goparaju, S. K., Jahangeer, S. M., & Nakamura, S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01465-06 · Cited by 148
ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain
Bandaru, V. V. R., Troncoso, J. C., Wheeler, D., Pletniková, O., Wang, J., Conant, K., & Haughey, N. J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.024 · Cited by 147
González‐Domínguez, R., García‐Barrera, T., & Gómez‐Ariza, J. L. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.01.014 · Cited by 144
Lazar, A. N., Bich, C., Panchal, M., Desbenoît, N., Petit, V. W., Touboul, D., Dauphinot, L., Marquer, C., Laprévôte, O., Brunelle, A., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1041-1 · Cited by 141
Muhlestein, J. B., May, H. T., Jensen, J. R., Horne, B. D., Lanman, R. B., Lavasani, F., Wolfert, R. L., Pearson, R. R., Yannicelli, H. D., & Anderson, J. L. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.009 · Cited by 140
Karsdal, M. A., Henriksen, K., Leeming, D. J., Mitchell, P. G., Duffin, K. L., Barascuk, N., Klickstein, L. B., Aggarwal, P., Nemirovskiy, O. V., Byrjalsen, I., et al. (2009) · Biomarkers · doi:10.1080/13547500902777608 · Cited by 136
de Waal, H., Stam, C. J., Lansbergen, M. M., Wieggers, R. L., Kamphuis, P. J. G. H., Scheltens, P., Maestú, F., & van Straaten, E. C. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086558 · Cited by 120
Panchal, M., Loeper, J., Cossec, J., Perruchini, C., Lazar, A. N., Pompon, D., & Duyckaerts, C. J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m001859 · Cited by 118
Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia
Han, X., Fagan, A. M., Cheng, H., Morris, J. C., Xiong, C., & Holtzman, D. M. (2003) · Annals of Neurology · doi:10.1002/ana.10618 · Cited by 113
Shah, R. C., Kamphuis, P. J., Leurgans, S., Swinkels, S. H., Sadowsky, C. H., Bongers, A., Rappaport, S. A., Quinn, J. F., Wieggers, R. L., Scheltens, P., et al. (2013) · Alzheimer's Research & Therapy · doi:10.1186/alzrt224 · Cited by 112
Klavins, K., Koal, T., Dallmann, G., Marksteiner, J., Kemmler, G., & Humpel, C. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.05.003 · Cited by 111
Biomarker Discovery and Translation in Metabolomics
Gowda, G. N., & Raftery, D. (2013) · Current Metabolomics · doi:10.2174/2213235x113019990005 · Cited by 106
Greving, J. P., Buskens, E., Koffijberg, H., & Algra, A. (2008) · Circulation · doi:10.1161/circulationaha.107.735340 · Cited by 103
Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease
Košiček, M., Zetterberg, H., Andreasen, N., Peter‐Katalinić, J., & Hecimovic, S. K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.04.019 · Cited by 102
Choi, S., Chae, A., Miller, E. R., Messig, M., Ntanios, F. Y., DeMaria, A. N., Nissen, S. E., Witztum, J. L., & Tsimikas, S. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.066 · Cited by 99
Optimizing the lipidomics workflow for clinical studies—practical considerations
Hyötyläinen, T., & Orešič, M. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8633-2 · Cited by 94
GM1 ganglioside and Alzheimer’s disease
Yanagisawa, K. (2015) · Glycoconjugate Journal · doi:10.1007/s10719-015-9579-5 · Cited by 93
Bennett, S. A. L., Valenzuela, N., Xu, H., Franko, B., Fai, S., & Figeys, D. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00168 · Cited by 89
Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons
Schneider, A., Schulz‐Schaeffer, W., Hartmann, T., Schulz, J. B., & Simons, M. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.015 · Cited by 86
Mielke, M. M., Bandaru, V. V. R., Han, D., An, Y., Resnick, S. M., Ferrucci, L., & Haughey, N. J. (2015) · Aging Cell · doi:10.1111/acel.12369 · Cited by 85
Comparison of blood plasma sample preparation methods for combined LC–MS lipidomics and metabolomics
Patterson, R. E., Ducrocq, A. J., McDougall, D. J., Garrett, T. J., & Yost, R. A. (2015) · Journal of Chromatography B · doi:10.1016/j.jchromb.2015.08.018 · Cited by 80
Mielke, M. M., Bandaru, V. V. R., Han, D., An, Y., Resnick, S. M., Ferrucci, L., & Haughey, N. J. (2014) · Aging Cell · doi:10.1111/acel.12275 · Cited by 78
Loprinzi, P. D., Branscum, A. J., Hanks, J. E., & Smit, E. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.01.009 · Cited by 76
Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease
Mielke, M. M., Haughey, N. J., Bandaru, V. V. R., Zetterberg, H., Blennow, K., Andréasson, U., Johnson, S. C., Gleason, C. E., Blazel, H. M., Puglielli, L., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.019 · Cited by 70
Yang, W. Q., Chen, Y., Xi, C., Zhang, R., Song, Y., Zhan, Q., Bi, X., & Abliz, Z. (2013) · Analytical Chemistry · doi:10.1021/ac303576b · Cited by 67
Li, D., Misialek, J. R., Boerwinkle, E., Gottesman, R. F., Sharrett, A. R., Mosley, T. H., Coresh, J., Wruck, L. M., Knopman, D. S., & Alonso, Á. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.02.008 · Cited by 67
Lipid and inflammatory biomarkers and kidney function decline in type 2 diabetes
Lin, J., Hu, F. B., Mantzoros, C. S., & Curhan, G. C. (2009) · Diabetologia · doi:10.1007/s00125-009-1597-z · Cited by 63
Blood metabolite markers of cognitive performance and brain function in aging
Simpson, B. N., Kim, M. G., Chuang, Y., Beason‐Held, L. L., Kitner‐Triolo, M. H., Kraut, M. A., Lirette, S. T., Windham, B. G., Griswold, M. E., Legido‐Quigley, C., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15611678 · Cited by 63
Self-citationSong, J., Liu, X., Wu, J., Meehan, M. J., Blevitt, J. M., Dorrestein, P. C., & Milla, M. E. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.10.022 · Cited by 61
Wood, P. L., Locke, V. A., Herling, P., Passaro, A., Vigna, G. B., Volpato, S., Valacchi, G., Cervellati, C., & Zuliani, G. (2015) · BBA Clinical · doi:10.1016/j.bbacli.2015.11.004 · Cited by 61
Discovering and validating between-subject variations in plasma lipids in healthy subjects
Begum, H., Li, B., Shui, G., Cazenave‐Gassiot, A., Soong, R. C. T., Ong, R. T., Little, P., Teo, Y., & Wenk, M. R. (2016) · Scientific Reports · doi:10.1038/srep19139 · Cited by 50
Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study
Chatterjee, P., Lim, W. L. F., Shui, G., Gupta, V. B., JAMES, I. R., Fagan, A. M., Xiong, C., Sohrabi, H. R., Taddei, K., Brown, B. M., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150948 · Cited by 49
Motoki, K., Kume, H., Oda, A., Tamaoka, A., Hosaka, A., Kametani, F., & Araki, W. (2012) · Brain and Behavior · doi:10.1002/brb3.52 · Cited by 47
Schalken, J. A. (2010) · European Urology · doi:10.1016/j.eururo.2010.02.025 · Cited by 45
Yanagisawa, K. (2005) · The Neuroscientist · doi:10.1177/1073858405275177 · Cited by 45
Miyamoto, K., Takeuchi, D., Inai, K., Shinohara, T., & Nakanishi, T. (2016) · Heart and Vessels · doi:10.1007/s00380-016-0807-0 · Cited by 44
Harmon, M. E., Campen, M. J., Miller, C. P., Shuey, C., Cajero, M., Lucas, S., Pacheco, B., Erdei, E., Ramone, S., Nez, T., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0143102 · Cited by 44
Ariga, T. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9641-0 · Cited by 43
The APOE Genotype: Modification of Therapeutic Responses in Alzheimer's Disease
Hanson, A. J., Craft, S., & Banks, W. A. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666141020164222 · Cited by 42
Li, J., Hu, C., Zhao, X., Dai, W., Chen, S., Lu, X., & Xu, G. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.10.064 · Cited by 41
Prediction of Cardiovascular Disease Risk by Cardiac Biomarkers in 2 United Kingdom Cohort Studies
Welsh, P. I., Hart, C., Papacosta, O., Preiss, D., McConnachie, A., Murray, H. M., Ramsay, S. E., Upton, M. N., Watt, G. C. M., Whincup, P. H., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.06501 · Cited by 40
Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model
Cho, S. M., Kim, H. V., Lee, S., Kim, H. Y., Kim, W., Kim, T. S., Kim, D. J., & Kim, Y. S. (2014) · Scientific Reports · doi:10.1038/srep06777 · Cited by 39
A Nutritional Approach to Ameliorate Altered Phospholipid Metabolism in Alzheimer's Disease
Hartmann, T., van Wijk, N., Wurtman, R. J., Rikkert, M. G. M. O., Sijben, J., Soininen, H. S., Vellas, B. J., & Scheltens, P. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141137 · Cited by 35
Jørgenrud, B., Jäntti, S. E., Mattila, I. M., Pöhö, P., Rnningen, K. S., Yki‐Järvinen, H., Orešič, M., & Hyötyläinen, T. (2015) · Bioanalysis · doi:10.4155/bio.15.16 · Cited by 35
Góth, L., Nagy, T., Kósa, Z., Fejes, Z., Bhattoa, H. P., Paragh, G., & Káplár, M. (2012) · Free Radical Research · doi:10.3109/10715762.2012.702899 · Cited by 35
Onakpoya, I., & Heneghan, C. J. (2015) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1110899 · Cited by 33
Commercialisation of Biomarker Tests for Mental Illnesses: Advances and Obstacles
Chan, M. K., Cooper, J. D., & Bahn, S. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.09.010 · Cited by 28
Agarwala, A., Virani, S. S., Couper, D. J., Chambless, L. E., Boerwinkle, E., Astor, B. C., Hoogeveen, R. C., Coresh, J., Sharrett, A. R., Folsom, A. R., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.028 · Cited by 21
Zhao, L., Jin, W., Rader, D. J., Packard, C. J., & Feuerstein, G. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.03.014 · Cited by 17
Sapsford, K. E., Težak, Ž., Kondratovich, M., Pacanowski, M. A., Zineh, I., & Mansfield, E. A. (2010) · Therapeutic Delivery · doi:10.4155/tde.10.62 · Cited by 16
Pharmacogenomic Biomarker Information in FDA ‐approved Paediatric Drug Labels
Kim, T., Han, N., Sohn, M., Oh, J. M., Lee, E., Ji, E., & Kim, I. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12341 · Cited by 10
Justifying reimbursement for Alzheimer's diagnostics and treatments: Seeking alignment on evidence
Foster, N. L., Hackett, J., White, G., Chenevert, S., Svarvar, P., Bain, L. J., & Carrillo, M. C. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.05.003 · Cited by 9
Cseprekál, O., Egresits, J., Tabák, Á. G., Nemcsik, J., Járai, Z., Babos, L., Fodor, E., Farkas, K., Godina, G., Kárpáthi, K. I., et al. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2015.96 · Cited by 8
Integrating Biomarkers and Imaging for Cardiovascular Disease Risk Assessment in Diabetes
Tehrani, D. M., & Wong, N. D. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0789-7 · Cited by 7
Kin, N. M. K. N. Y., Pan, L. H., Louvaris, J. H., Robitaille, Y., & Nair, N. P. V. (1995) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1857-0_8 · Cited by 4
Freidlin, B., & Korn, E. L. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv430 · Cited by 3
FDA and CLIA Oversight of Advanced Diagnostics and Biomarker Tests
Terry, S. F. (2010) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2010.1510 · Cited by 2
[Companion diagnostics and reimbursement system].
Tazawa, Y. (2013) · PubMed · Cited by 1
Laughman, K. (2014) · PubMed · Cited by 1
Cited by
Sorted by citations
Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01911-3 · Cited by 1,138
Alzheimer's Disease: Treatment Strategies and Their Limitations.
Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 689
Brain age and other bodily ‘ages’: implications for neuropsychiatry
Cole, J. H., Marioni, R. E., Harris, S. E., & Deary, I. J. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0098-1 · Cited by 450
Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies
Chew, H., Solomon, V. A., & Fonteh, A. N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00598 · Cited by 353
Brain lipidomics: From functional landscape to clinical significance
Yoon, J. H., Seo, Y., Jo, Y. S., Lee, S., Cho, E., Cazenave-Gassiot, A., Shin, Y.-S., Moon, M. H., An, H. J., Wenk, M. R., et al. (2022) · Science Advances · doi:10.1126/sciadv.adc9317 · Cited by 324
Metadata
- Authors
- Wong, M. W., Braidy, N., Poljak, A., Pickford, R., Thambisetty, M., & Sachdev, P. S.
- Affiliations
- UNSW Sydney (AU)
- National Institutes of Health (US)
- Corresponding author
- Sachdev, Perminder S.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2017-02-24
- Volume
- 13
- Issue
- 7
- Pages
- 810-827
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2589881680
- Cited by
- 223
- References
- 120
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 31 · 2023: 29 · 2022: 26 · 2021: 38 · 2020: 33 · 2019: 18 · 2018: 8 · 2017: 3
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- green
- handle.unsw.edu.au
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- Funders
- UNSW Faculty of Medicine Research Grant
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, lipid dysregulation
- MeSH terms
- Alzheimer Disease, Humans, Lipids, Mass Spectrometry, Biomarkers, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review