Cited by 224Alzheimer's disease research and treatmentsMetabolomics and Mass Spectrometry StudiesDementia and Cognitive Impairment Research

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Dysregulation of lipids in Alzheimer’s disease and their role as potential biomarkers

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Wong, Matthew W., Braidy, Nady, Poljak, Anne, Pickford, Russell, Thambisetty, Madhav, Sachdev, Perminder S.·2017·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2017.01.008

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Abstract

The brain is highly enriched in lipids, and an intensive study of these lipids may be informative, not only of normal brain function but also of changes with age and in disease. In recent years, the development of highly sensitive mass spectrometry platforms and other high-throughput technologies has enabled the discovery of complex changes in the entire lipidome. This lipidomics approach promises to be a particularly useful tool for identifying diagnostic biomarkers for early detection of age-related neurodegenerative disease, such as Alzheimer's disease (AD), which has till recently been limited to protein- and gene-centric approaches. This review highlights known lipid changes affecting the AD brain and presents an update on the progress of lipid biomarker research in AD. Important considerations for designing large-scale lipidomics experiments are discussed to help standardize findings across different laboratories, as well as challenges associated with moving toward clinical application.

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Authors: Wong, M. W., Braidy, N., Poljak, A., Pickford, R., Thambisetty, M., & Sachdev, P. S.
Affiliations: UNSW Sydney (AU)
National Institutes of Health (US)
Corresponding author: Sachdev, Perminder S.
ORCID: Wong, Matthew W.
Braidy, Nady
Poljak, Anne
Pickford, Russell
Thambisetty, Madhav
Sachdev, Perminder S.
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2017-02-24
Volume: 13
Issue: 7
Pages: 810-827
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2017.01.008
OpenAlex: W2589881680
Cited by: 223
References: 120
Citations by year: 2026: 19 · 2025: 18 · 2024: 31 · 2023: 29 · 2022: 26 · 2021: 38 · 2020: 33 · 2019: 18 · 2018: 8 · 2017: 3
FWCI: 2.08
Type: journal article
Language: en
Open access: green
handle.unsw.edu.au
Licence: cc-by-nc-nd
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
Funders: UNSW Faculty of Medicine Research Grant
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, lipid dysregulation
MeSH terms: Alzheimer Disease, Humans, Lipids, Mass Spectrometry, Biomarkers, Lipid Metabolism

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Dysregulation of lipids in Alzheimer’s disease and their role as potential biomarkers

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