Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease
Abstract
Introduction: We examined whether cortical microvascular blood volume and hemodynamics in Alzheimer's disease (AD) are consistent with tissue hypoxia and whether they correlate with cognitive performance and the degree of cortical thinning. Methods: Thirty‐two AD patients underwent cognitive testing, structural magnetic resonance imaging (MRI), and perfusion MRI at baseline and after 6 months. We measured cortical thickness, microvascular cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and capillary transit time heterogeneity (CTH) and estimated tissue oxygen tension (P t O 2). Results: At baseline, poor cognitive performance and regional cortical thinning correlated with lower CBF and CBV, with higher MTT and CTH and with low P t O 2 across the cortex. Cognitive decline over time was associated with increasing whole brain relative transit time heterogeneity (RTH = CTH/MTT). Discussion: Our results confirm the importance of microvascular pathology in AD. Deteriorating microvascular hemodynamics may cause hypoxia, which is known to precipitate amyloid retention.
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Capillary dysfunction correlates with cognitive decline in Alzheimer's disease.
“Capillary dysfunction correlates with cognitive decline in AD (17).”
From Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes (2019) · cites this paper as [17]
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- Authors
- Nielsen, R. B., Egefjord, L., Angleys, H., Mouridsen, K., Gejl, M., Møller, A., Brock, B., Brændgaard, H., Gottrup, H., Rungby, J., Eskildsen, S. F., & Østergaard, L.
- Affiliations
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Bispebjerg Hospital (DK)
- Corresponding author
- Nielsen, Rune B.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2017-03-23
- Volume
- 13
- Issue
- 10
- Pages
- 1143-1153
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2598193539
- Cited by
- 119
- References
- 50
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 9 · 2023: 12 · 2022: 4 · 2021: 16 · 2020: 18 · 2019: 17 · 2018: 13 · 2017: 9
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novo Nordisk Scandinavia
- MINDLab UNIK initiative at Aarhus University
- Danish Ministry of Science, Technology and Innovation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, capillary dysfunction
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Cerebrovascular Circulation, Female, Hemodynamics, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Perfusion, Neurodegenerative Diseases, Microvessels, Cognitive Dysfunction
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