CSF biomarkers of Alzheimer's disease concord with amyloid‐β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts
Hansson, Oskar, Seibyl, John, Stomrud, Erik, Zetterberg, Henrik, Trojanowski, John Q., Bittner, Tobias, Lifke, Valeria, Corradini, Veronika +9 more·2018·Alzheimer's & Dementia
Cited by (809)
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- Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves CognitionTanja Blume, Maximilian Deußing, Gloria Biechele, Finn Peters, Benedikt Zott, Claudio Schmidt, Nicolai Franzmeier, Karin Wind-Mark, Florian Eckenweber, Christian Sacher et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genes ATP8B4, FCGR1A , and LILRB1 that associate with Alzheimer’s diseaseJoseph S. Reddy, Xue Wang, Mariet Allen, Minerva M. Carrasquillo, Joanna M. Biernacka, Gregory D. Jenkins, Brandon J. Coombes, Olivia Belbin, Todd Eliot Golde, Nilüfer Ertekin‐Taner et al. · 2022 · medRxiv
- CSF tau phosphorylation at T217 and T205 are improved biomarkers of amyloid and tau pathology in Alzheimer diseaseNicolas R. Barthélemy, Benjamin A. Saef, Yan Li, Brian Andrew Gordon, Yingxin He, Kanta Horie, Erik Stomrud, Gemma Salvadó, Shorena Janelidze, Chihiro Sato et al. · 2022 · Research Square
- Risk of Alzheimer’s Disease is Associated with Longitudinal Changes in Plasma Biomarkers in the Multiethnic Washington Heights, Inwood Columbia Aging Project CohortYian Gu, Lawrence S. Honig, Min Suk Kang, Aanya Bahl, Danurys L. Sanchez, Dolly Reyes‐Dumeyer, Jennifer Jaie Manly, Rafael Lantigua, Jeffrey L. Dage, Adam M. Brickman et al. · 2023 · medRxiv
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- Medial temporal lobe atrophy patterns in early- versus late-onset amnestic Alzheimer’s diseaseAnika Wuestefeld, Alexa Pichet Binette, Danielle van Westen, Olof T. Strandberg, Erik Stomrud, Niklas Mattsson, Shorena Janelidze, Ruben A Smith, Sebastian Palmqvist, Hannah Baumeister et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- A seven-year longitudinal study of the Alzheimer’s disease blood metabolomeBharadwaj Marella, Patrick Weinisch, Josef J. Bless, Shannon L. Risacher, Colette Blach, Naama Karu, Karel Kalecký, Tingting Wang, Kevin Huynh, Alexandra Kueider‐Paisley et al. · 2025 · medRxiv
- The fluid biomarkers of Alzheimer’s diseaseQinyu Peng, Zhentao Zhang · 2021 · Brain Science Advances
- Optimized Pre-analytical Handling Protocol for Blood-Based Biomarkers of Alzheimer’s DiseaseAlexander Jethwa, Laura Stöckl · 2024 · Methods in molecular biology
- Cortical Thickness Correlates of Go/No-go and Motor Sequencing in Mild Cognitive Impairment and Suspected Alzheimer Disease DementiaCierra M. Keith, Katharine E. Lindberg, Kirk C. Wilhelmsen, Rashi I. Mehta, Camila Vieira Ligo Teixeira, Mark D. Miller, Melanie Ward, Ramiro Osvaldo Navia, William Travis McCuddy, Liv E. Miller et al. · 2024 · Cognitive and Behavioral Neurology
- Diffusion MRI Allows Capturing the Amyloid-β and τ Proteins Status in Alzheimer’s Disease ContinuumGiorgio Dolci, Federica Cruciani, Lorenza Brusini, Lorenzo Pini, Ilaria Boscolo Galazzo, Vince D. Calhoun, Gloria Menegaz · 2024 · IEEE International Symposium on Biomedical Imaging (ISBI)
- Interval-specific likelihood ratios and probability-based models for interpreting combined CSF biomarkers for Alzheimer’s diseaseJonas Dubin, Rik R. Vandenberghe, Koen Poesen · 2024 · Clinica Chimica Acta
- Biomarkers for Alzheimer's DiseaseDeepak Panwar, Parul Sharma, Shweta Sharma, Manoj Malik, Jaspreet Kaur · 2024 · Advances in bioinformatics and biomedical engineering book series
- sTREM2 in discordant CSF Aβ42 and p‐tau181Danni Li, William G. Mantyh, Lu Men, Ishika Jain, Matthew Glittenberg, Binchong An, Lin Zhang, Ling Li, Alzheimer’s Disease Neuroimaging Initiative · 2025 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Evaluation of preanalytical factors on quantification of amyloid-β (1-42), phosphorylated tau 181, and total tau in cerebrospinal fluidTiffany R Allison, Sonia L. La’ulu, Kelly J. Doyle, Heather A. Nelson · 2025 · Laboratory Medicine
- Comparison of diagnostic accuracy of Alzheimer's disease cerebrospinal fluid core biomarkers using INNOTEST, Lumipulse G, and Elecsys assays: Insights from the PUMCH dementia cohort studyChenhui Mao, Yutong Zou, Tianyi Wang, Longze Sha, Meiqi Wu, Shanshan Chu, Wei Jin, Bo Li, Yixuan Huang, Yuyue Qiu et al. · 2025 · Journal of Alzheimer s Disease
- Molecular pathways and biomarkers associated with age-related cognitive declineShreyasi Mitra, Sampoorn Pandey, Aman Gill, Anannya Roy, Shibam Dutta, Amit Kumar, Majid Ali, Geetanjali Chawla · 2025 · Academia Biology
- Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological changeYuexuan Xu, Min Qiao, Tamil Iniyan Gunasekaran, Yian Gu, Dolly Reyes‐Dumeyer, Angel L. Piriz, Danurys L. Sanchez, Belisa Soriano, Yahaira Franco, Zoraida Dominguez Coronado et al. · 2025 · Alzheimer s & Dementia
- The Utility of CSF Biomarkers in Diagnosing Alzheimer’s Disease: A Thai Cohort StudyWitsarut Nanthasi, Chatchawan Rattanabannakit, Natthamon Wongkom, Pathitta Dujada, Atthapon Raksthaput, Sunisa Chaichanettee, Paphawadee Phoyoo, Leatchai Wachirutmanggur, Seong Soo A. An, Vorapun Senanarong · 2025 · Dementia and Geriatric Cognitive Disorders Extra
- Clinical validation of new alzheimer disease diagnosis tools based on plasma p-Tau217Aleix Martí Navia, Lourdes Álvarez‐Sánchez, Laura Ferré‐González, Alejandro López, Carmen Peña‐Bautista, Ángel Balaguer, N. Risueño Pedrosa, Helena Vico, Miguel Baquero, Consuelo Cháfer‐Pericás · 2025 · Scientific Reports
- In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer’s disease continuumDouglas Teixeira Leffa, Guilherme Povala, Pâmela C.L. Ferreira, João Pedro Ferrari‐Souza, Guilherme Bauer‐Negrini, Matheus Scarpatto Rodrigues, Lívia Amaral, Firoza Zubeida Lussier, Marina Scop Medeiros, Carolina Soares et al. · 2025 · Molecular Psychiatry
- The biomarker and clinical changes across the Alzheimer’s continuum study (BCAS): rationale, design, and baseline characteristics of the first 1,013 participantsHui Chen, Hong Dai, L D Zhang, Yongjian Deng, Kan Zhang, Jie Yu, Guoping Peng, Zexin Guo, Jing Zhang, Changzheng Yuan et al. · 2025 · Alzheimer s Research & Therapy
- The capacity for Alzheimer's disease confirmatory testing in the United States: The current situation and simulations for future increaseSophie Roth, Jessie T. Yan, Maria-Magdalena Patru, Soeren Mattke, Anders Gustavsson, Gustaf Ortsäter · 2026 · Journal of Alzheimer s Disease
- Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive ImpairmentHu Xu, Yang Li, Chensi Li, Fenglin Xu, Yun Liu, Kehan Yan, Shiyi Chen, Wenxiu Song, Yifeng Luo, Yuefeng Li · 2026 · Human Brain Mapping
- Associations of plasma sphingomyelin SM (d18:1/24:0) with Alzheimer's disease pathology and cognition in non-demented adultsFan Guo, Ze-Hu Sheng, Tao Li, Liang-Yu Huang, Bingyu Li, Xi-Jin Wang, Alzheimer’s Disease Neuroimaging Initiative · 2026 · Journal of Alzheimer s Disease
- Longitudinal Associations Between Neurodegenerative Biomarkers and Cognitive Decline in Older Adults: Insights From the LASI ‐ DAD StudyAbhijith R. Rao, Rashmita Pradhan, Masroor Anwar, Abhishek Gupta, Manjusha Bhagwasia, Emma L. Nichols, Alden L. Gross, Bharat Thyagarajan, Peifeng Hu, Eileen M. Crimmins et al. · 2026 · Journal of the American Geriatrics Society
- Multivariate patterns of plasma biomarkers predict region‐specific Alzheimer's pathology and cognitive decline across independent cohortsJafar Zamani, Amirali Vahid, Edward N. Wilson, S. M. Hadi Hosseini, the Frontotemporal Lobar Degeneration Neuroimaging Initiative · 2026 · Alzheimer s & Dementia
- Ultrasensitive chemiluminescent detection of plasma Aβ1-40 based on soluble macromolecular signal amplification carrierChao Guo, Meng Liu, Zhanfei An, Shuaipeng Li, Menglin Cui, Jianqi Nie, Yang Sun, Zhonghu Bai · 2026 · Talanta
- Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter StudyMiquel Massons, Núria Guillén, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller, Magda Castellvı́, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell et al. · 2026 · Annals of Clinical and Translational Neurology
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- Hypertension acts together with Aβ pathology in late-life to promote memory lossLucas Uglione Da Ros, João Pedro Ferrari‐Souza, Marco Antônio De Bastiani, Lucas Augusto Hauschild, Bruna Bellaver, Pâmela C.L. Ferreira, Douglas Teixeira Leffa, Guilherme Povala, Firoza Zubeida Lussier, Mira Chamoun et al. · 2026 · The Journal of Prevention of Alzheimer s Disease
- The Multiple Functions of Amyloid Beta in the Gut Epithelium and the Role of the Microbiota: A Study in the APP/PS1 Animal Model Subjected to Chronic Synbiotic TreatmentGiorgia Sarti, Giorgio Tognozzi, Giada Magni, Daniele Lana, Francesca Rossi, Chiara Traini, Maria Giuliana Vannucchi · 2026 · Nutrients
- Plasmonic nanoplatforms for Alzheimer’s disease biomarker detection: LSPR and SERS strategies toward clinical translationHyejin Chang, Homan Kang, Seung-Ki Lee, Jaehong Lim, Ksenia V. Kastanenka, Satoshi Kashiwagi, Bong‐Hyun Jun · 2026 · Materials Today
- Plasma neurofilament light chain and regional brain atrophy mediate the association of neuropsychiatric symptoms with cognition in Alzheimer’s disease: evidence from two population-based studiesYayu Wang, Huai-Yuan Zhu, Wei Miao, Zi Wang, Jia-Jia Qin, Xiao-Han Song, Yue-Hua Wang, Zhong-wu Sun, Xia Zhou, Xian-Feng Yu et al. · 2026 · Psychological Medicine
- Circulating lipids are related to longitudinal changes of ATN biomarkers for Alzheimer’s diseaseJun Pyo Kim, Kwangsik T. Nho, Tingting Wang, Kevin Huynh, Matthias Arnold, Shannon L. Risacher, Paula J. Bice, Xianlin Han, Bruce S. Kristal, Colette Blach et al. · 2026 · Molecular Psychiatry
- Head-to-head comparison of neurodegeneration biomarkers across two analytical platforms in Alzheimer’s diseaseCarolin Kurz, Daniela Hattenkofer, Maximilian Pihale-Haug, Anna Hufnagel, Selim Guersel, Matthias Brendel, Boris‐Stephan Rauchmann, Johannes Levin, Günter U. Höglinger, Robert Perneczky · 2026 · Aging Clinical and Experimental Research
- Valine modulates Alzheimer’s disease risk in APOE ε4 carriers: evidence from two cohortsZe-Lin Yang, Can Zhang, Shi Tang, Xin-Yu Zhang, Liang-Yu Huang, Lan Tan, Wei Xu · 2026 · Journal of Advanced Research
- Role of Machine Learning Algorithms on Alzheimer Disease PredictionV. Krishna Kumar, M.S. Geetha Devasena, G. Gopu, N. Sivakumaran · 2022 · Lecture notes in networks and systems
- An Experimental Study on Evaluating Alzheimer’s Disease Features using Data Mining TechniquesHadeel Albalawi · 2022 · Journal of Information & Knowledge Management
- Alzheimer’s disease biomarkers in cerebrospinal fluid are stable with the Elecsys immunoassay to most pre-analytical influencing factors except freezing at -80 °CFranz Felix Konen, Hannah Benedictine Maier, Alexandra Neyazi, Stefan Bleich, Konstantin Neumann, Thomas Skripuletz · 2023 · Neurological Research and Practice
- A rat model established by simulating genetic–environmental interactions recapitulates human Alzheimer's disease pathologyXiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao · 2023 · Brain Research
- Recent Advances in Understanding and Managing Alzheimer's Disease: from Pathogenesis to TreatmentRafael Leituga de Carvalho Cavalcante, Maurício Samartino, Larissa Abussafi Miranda, Jeniffer da Silva Alencar Mendes, Tatiana de Lima Tanaka, F. Silva, Lucas Monteiro Molina, Bruno Carvalho Diniz, Daniela Alves Dantas, Dhyana Ataide Ferraz Sarges et al. · 2024 · Revista de Gestão Social e Ambiental
- Real-life reliability of plasma pTau181, Aβ 42 /Aβ 40 , and pTau181/Aβ 42 measured by Lumipulse G600II in predicting cerebrospinal fluid amyloid statusDaniele Imperiale, Cristiana Atzori, Daniele Pio Angeloro, Amelia Murgioni, Alessia Bagatin, Valentina Secci, Andrea Calcagno, Marco Alfonso Narduc Capobianco, Mario Coletti Moja, Eugenia Rota et al. · 2024 · Journal of Alzheimer s Disease
- Comparison of ERlangen Score with pTau/Aβ1-42 Ratio for Predicting Cognitive Decline and Conversion to Alzheimer’s DiseaseJA Schwarz, Pauline Schulz, Janine Utz, Laura Rudtke, Johannes Jablonowski, Neele Klement, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Maler, Timo Jan Oberstein · 2025 · Brain Sciences
- Computational Risk Stratification of Preclinical Alzheimer’s in Younger AdultsOriehi Edisemi Destiny Anyaiwe, Nandini Nataraj, Bhargava Sai Gudikandula · 2025 · Diagnostics
- Mining relations between neuropsychological data to characterize Alzheimer’s diseaseGermán A. Pabón, Diana L. Giraldo, Eduardo Romero Castro · 2021 · International Symposium on Medical Information Processing and Analysis (SIPAIM)
- Basal forebrain activity predicts functional degeneration in the entorhinal cortex and decreases with Alzheimer’s Disease progressionMarthe Mieling, Martin Göttlich, Mushfa Yousuf, Nico Bunzeck, the Alzheimer’s Disease Neuroimaging Initative · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Evaluation of ATN PD framework and biofluid markers to predict cognitive decline in early Parkinson’s diseaseKatheryn A Q Cousins, David John Irwin, Thomas Francis Tropea, Emma Rhodes, Jeffrey S. Phillips, Alice S. Chen‐Plotkin, Michael C. Brumm, Christopher S. Coffey, Ju‐Hee Kang, Tanya Simuni et al. · 2023 · medRxiv
- Genome-wide meta-analysis of CSF biomarkers in Alzheimer’s disease and Parkinson’s disease cohortsMichael Ta, Cornelis Blauwendraat, Tarek Antar, Hampton L. Leonard, Andrew Singleton, Mike A. Nalls, Hirotaka Iwaki, Alzheimer’s Disease Neuroimaging Initiative, the Fox Investigation for New Discovery of Biomarkers · 2023 · medRxiv
- Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer’s diseaseMatthew D. Howe, Karysa J. Britton, Hannah E. Joyce, William E. Menard, Sheina Emrani, Zachary J. Kunicki, Melanie A. Faust, Brittany C. Dawson, Meghan C. Riddle, Edward D. Huey et al. · 2024 · Research Square
- The Impact of Kidney Function on Alzheimer’s Disease Blood Biomarkers: Implications for Predicting Amyloid-β PositivityBurak Arslan, Wagner Scheeren Brum, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Kübra Tan, Paolo Vitali, Maxime Montembeault et al. · 2024 · Research Square
- Heterogeneous ageing of brain networks across the Alzheimer’s disease continuumYanxi Huo, Weijie Huang, Zhengzhao Liu, Tianyu Bai, Haojie Chen, Yichen Wang, Kexin Wang, Daoqiang Zhang, Jian Cheng, Yuling Sun et al. · 2025 · medRxiv
- Performance of Elecsys pTau217 plasma immunoassay to detect brain amyloid pathologyDerrek P. Hibar, Alina Bauer, Christina Rabe, Niels Borlinghaus, Alexander Jethwa, Gwendlyn Kollmorgen, Annunziata Di Domenico, Henrik Zetterberg, Kaj Blennow, Colin Louis Masters et al. · 2025 · medRxiv
- Topographical patterns of whole-brain structural alterations in association with genetic risk, cerebrospinal fluid, positron emission tomography biomarkers of Alzheimer’s disease, and neuropsychological measuresAlbert Dayor Piersson, Mazlyfarina Mohamad, Subapriya Suppiah, Nor Fadilah Rajab · 2021 · Clinical and Translational Imaging
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- CSF 14-3-3ζ is associated with tau pathology and elevated across the Alzheimer’s disease continuumQiang Qiang, Loren Skudder‐Hill, Tomoko Toyota, Zhe Huang, Wenshi Wei, Hiroaki Adachi · 2022 · Research Square
- Exploring the intricacies and pitfalls of the ATN framework: An assessment across cohorts and thresholding methodologiesYasamin Salimi, Daniel Domingo‐Fernándéz, Martin Hofmann‐Apitius, Colin J. Birkenbihl, the Alzheimer’s Disease Neuroimaging Initiative, the Japanese Alzheimer’s Disease Neuroimaging Initiative, the Alzheimer’s Disease Repository Without Borders Investigators · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- CSF 14-3-3ζ is associated with tau pathology and elevated across the Alzheimer’s disease continuumQiang Qiang, Loren Skudder‐Hill, Tomoko Toyota, Zhe Huang, Wenshi Wei, Hiroaki Adachi · 2022 · Research Square
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- The potential of extracellular vesicle lipid profiling in Alzheimer's disease.Huaqi Su, Colin Louis Masters, Ashley Ian Bush, Kevin Jeffrey Barnham, Gavin E. Reid, Laura J. Vella · 2023
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