The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Surgical Strategies for Synchronous Colorectal Liver Metastases in 156 Consecutive Patients: Classic, Combined or Reverse Strategy?
Abstract
BACKGROUND: An increasing number of patients with synchronous colorectal liver metastases (CLM) are candidates for resection. The optimal treatment sequence in these patients has not been defined. STUDY DESIGN: Data on 156 consecutive patients with synchronous resectable CLM and intact primary were reviewed. Surgical strategies were defined as combined (combined resection of primary and liver), classic (primary before liver), and reverse (liver before primary) after preoperative chemotherapy. Postoperative morbidity and mortality rates and overall survival were analyzed. RESULTS: One hundred forty-two patients (83%) had resection of all disease. Seventy-two patients underwent classic, 43 combined, and 27 reverse strategies. Median numbers of CLMs per patient were 1 in the combined, 3 in the classic, and 4 in the reverse strategy group (p = 0.01 classic vs reverse; p < 0.001 reverse vs combined). Postoperative mortality rates in the combined, classic, and reverse strategies were 5%, 3%, and 0%, respectively (p = NS), and postoperative cumulative morbidity rates were 47%, 51%, and 31%, respectively (p = NS). Three-year and 5-year overall survival rates were, respectively, 65% and 55% in the combined, 58% and 48% in the classic, and 79% and 39% in the reverse strategy (NS). On multivariate analysis, liver tumor size >3 cm (hazard ratio [HR] 2.72, 95% CI 1.52 to 4.88) and cumulative postoperative morbidity (HR 1.8, 95% CI 1.03 to 3.19) were independently associated with overall survival after surgery. CONCLUSIONS: The classic, combined, or reverse surgical strategies in patients with synchronous presentation of CLM are associated with similar outcomes. The reverse strategy can be considered as an alternative option in patients with advanced CLM and an asymptomatic primary.
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Cites
Dindo, D., Demartines, N., & Clavien, P.-A. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000133083.54934.ae · Cited by 31,378
Chemotherapy with Preoperative Radiotherapy in Rectal Cancer
Bosset, J.-F., Collette, L., Calais, G., Mineur, L., Maingon, P., Radosevic-Jelic, L., Daban, A., Bardet, E., Beny, A., & Ollier, J.-C. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060829 · Cited by 2,688
Nordlinger, B., Sorbye, H., Glimelius, B., Poston, G. J., Schlag, P. M., Rougier, P., Bechstein, W. O., Primrose, J. N., Walpole, E. T., Finch-Jones, M., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60455-9 · Cited by 1,937
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Hepatic insufficiency and mortality in 1,059 noncirrhotic patients undergoing major hepatectomy
Mullen, J. T., Ribero, D., Reddy, S. K., Donadon, M., Zorzi, D., Gautam, S., Abdalla, E. K., Curley, S. A., Capussotti, L., Clary, B. M., et al. (2007) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2006.12.032 · Cited by 660
Self-citationBlazer, D. G., Kishi, Y., Maru, D. M., Kopetz, S., Chun, Y. S., Overman, M. J., Fogelman, D., Eng, C., Chang, D. Z., Wang, H., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.17.5299 · Cited by 604
Self-citationImproving Resectability of Hepatic Colorectal Metastases: Expert Consensus Statement
Abdalla, E. K., Adam, R., Bilchik, A. J., Jaeck, D., Vauthey, J.-N., & Mahvi, D. (2006) · Annals of Surgical Oncology · doi:10.1245/s10434-006-9045-5 · Cited by 557
Self-citationKishi, Y., Abdalla, E. K., Chun, Y. S., Zorzi, D., Madoff, D. C., Wallace, M. J., Curley, S. A., & Vauthey, J.-N. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181b674df · Cited by 516
Self-citationSolitary Colorectal Liver Metastasis: Resection Determines Outcome
Aloia, T. A. (2006) · Archives of Surgery · doi:10.1001/archsurg.141.5.460 · Cited by 432
Cited by
Brouquet, A., Abdalla, E. K., Kopetz, S., Garrett, C. R., Overman, M. J., Eng, C., Andreou, A., Loyer, E. M., Madoff, D. C., Curley, S. A., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.6132 · Cited by 396
Self-citationShindoh, J., Truty, M. J., Aloia, T. A., Curley, S. A., Zimmitti, G., Huang, S. Y., Mahvash, A., Gupta, S., Wallace, M. J., & Vauthey, J.-N. (2013) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2012.10.018 · Cited by 329
Self-citationCurrent Surgical Management Strategies for Colorectal Cancer Liver Metastases
Ivey, G. D., Johnston, F. M., Azad, N. S., Christenson, E. S., Lafaro, K. J., & Shubert, C. R. (2022) · Cancers · doi:10.3390/cancers14041063 · Cited by 70
Metadata
- Authors
- Brouquet, A., Mortenson, M. M., Vauthey, J.-N., Rodriguez-Bigas, M. A., Overman, M. J., Chang, G. J., Kopetz, S., Garrett, C., Curley, S. A., & Abdalla, E. K.
- Venue
- Journal of the American College of Surgeons
- Published
- 2010-06
- Volume
- 210
- Issue
- 6
- Pages
- 934-941
- ISSN
- 1072-7515 (ISSN-L)
- OpenAlex
- W1974494579
- Cited by
- 273
- References
- 21
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brouquet, A., Mortenson, M. M., Vauthey, J.-N., Rodriguez-Bigas, M. A., Overman, M. J., Chang, G. J., Kopetz, S., Garrett, C., Curley, S. A., & Abdalla, E. K. (2010). Surgical Strategies for Synchronous Colorectal Liver Metastases in 156 Consecutive Patients: Classic, Combined or Reverse Strategy? Journal of the American College of Surgeons. https://doi.org/10.1016/j.jamcollsurg.2010.02.039
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