Large-Scale Investigation into Dumping Syndrome after Gastrectomy for Gastric Cancer
Open accessAbstract
BACKGROUND: The aim of this study was to investigate early and late dumping syndromes in a large number of patients after gastrectomy for gastric cancer. STUDY DESIGN: Responses to questions on a visual analogue scale survey completed by 1,153 gastrectomy patients were analyzed for associations between clinical factors and occurrence of dumping syndrome. Types of gastrectomy included distal gastrectomy with Billroth I or with Roux-Y reconstruction, pylorus preserving gastrectomy, proximal gastrectomy, and total gastrectomy. RESULTS: Based on the visual analogue scale rating of symptomatic discomfort, patients were categorized into 1 of 2 groups: symptom-free or symptomatic. Incidences of early or late dumping syndrome in all patients were 67.6% and 38.4%, respectively. Patients in whom early dumping syndrome developed were significantly more likely to experience late dumping syndrome than those in whom it did not develop (p < 0.001). According to multivariate analyses, factors that decreased the risk for developing early dumping syndrome were reduced weight loss (p < 0.01), old age (p < 0.01), pylorus preserving gastrectomy (p < 0.01), distal gastrectomy with Roux-Y reconstruction (p < 0.01), and distal gastrectomy with Billroth I (p = 0.019). In addition, factors that decreased the risk of developing late dumping syndrome were reduced weight loss (p = 0.03), being male (p < 0.01), pylorus preserving gastrectomy (p < 0.01), and distal gastrectomy with Roux-Y reconstruction (p < 0.01). No other clinical factors (lymph node dissection, vagal nerve preservation, and postoperative period) showed a substantial association with the occurrence of dumping syndrome in multivariate analyses. CONCLUSIONS: Substantially more patients suffered from early dumping syndrome than late dumping syndrome after gastrectomy. Two clinical factors, surgical procedures and amount of body weight loss, associated significantly with the occurrence of both early and late dumping syndrome.
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A relatively recent report describes the use of a visual analogue scale (VAS) survey to evaluate early and late dumping syndromes in more than 1,000 patients after gastrectomy for gastric cancer.
“A relatively recent report also describes the use of a visual analogue scale (VAS) survey to evaluate early and late dumping syndromes in more than 1,000 patients after gastrectomy for gastric cancer (32).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [32]
This survey used a very low cutoff for dumping complaints (VAS score >10 mm), and a single item on the questionnaire was sufficient to label patients as symptomatic for late dumping.
“This survey used a very low cutoff for dumping complaints (VAS score >10 mm), and a single item on the questionnaire was sufficient to label patients as symptomatic for late dumping (32).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [32]
The available Abstract passage says patients were classified as symptomatic or symptom-free using visual analogue scale ratings, but it gives neither a >10 mm cutoff nor the number of questionnaire items required for a late-dumping classification. Searches for “10 mm” and for a single late-dumping symptom found no passage addressing those details in our copy. (LLM, conf=0.69)
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Cites
Clinical applications of visual analogue scales: a critical review
McCormack, H. M., Horne, D. J. D. L., & Sheather, S. J. (1988) · Psychological Medicine · doi:10.1017/s0033291700009934 · Cited by 2,108 · see citing works
Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice
Townsend, C. M. (2007) · Andalas University Repository (Andalas University) · Cited by 807 · see citing works
Tacke, W., & Hausmann, L. (1990) · PubMed · Cited by 338 · see citing works
Postprandial GLP-1, Norepinephrine, and Reactive Hypoglycemia in Dumping Syndrome
Gebhard, B., Holst, J. J., Biegelmayer, C., & Miholic, J. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1010635131228 · Cited by 92 · see citing works
THE SO-CALLED “DUMPING SYNDROME” AFTER SUBTOTAL GASTRECTOMY
Custer, M. D., Butt, H. R., & Waugh, J. M. (1946) · Annals of Surgery · doi:10.1097/00000658-194603000-00007 · Cited by 81 · see citing works
Improved quality of life with jejunal pouch reconstruction after total gastrectomy
Kono, K., Iizuka, H., Sekikawa, T., Sugai, H., Takahashi, A., Fujii, H., & Matsumoto, Y. (2003) · The American Journal of Surgery · doi:10.1016/s0002-9610(02)01211-4 · Cited by 80 · see citing works
Shibata, C., Shiiba, K., Funayama, Y., Ishii, S., Fukushima, K., Mizoi, T., Koyama, K., Miura, K., Matsuno, S., Naito, H., et al. (2004) · World Journal of Surgery · doi:10.1007/s00268-004-7369-5 · Cited by 71 · see citing works
Surgical Treatment of Advanced Gastric Cancer: Japanese Perspective
Sasako, M., Saka, M., Fukagawa, T., Katai, H., & Sano, T. (2007) · Digestive Surgery · doi:10.1159/000101896 · Cited by 68 · see citing works
Self-citationLength of the antral segment in pylorus-preserving gastrectomy
Nakane, Y., Michiura, T., Inoue, K., Sato, M., Nakai, K., & Yamamichi, K. (2002) · British journal of surgery · doi:10.1046/j.1365-2168.2002.01984.x · Cited by 64 · see citing works
Tomita, R., Fujisaki, S., & Tanjoh, K. (2003) · World Journal of Surgery · doi:10.1007/s00268-003-6906-y · Cited by 55 · see citing works
Hotta, T., Taniguchi, K., Kobayashi, Y., Johata, K., Sahara, M., Naka, T., Terashita, S., Yokoyama, S., & Matsuyama, K. (2001) · Surgery Today · doi:10.1007/s005950170046 · Cited by 43 · see citing works
Tomita, R., Fujisaki, S., Tanjoh, K., & Fukuzawa, M. (2003) · The American Journal of Surgery · doi:10.1016/s0002-9610(02)01423-x · Cited by 36 · see citing works
Webber, B. M., Bender, M. A., & Moore, G. E. (1957) · New England Journal of Medicine · doi:10.1056/nejm195702142560702 · Cited by 29 · see citing works
Postoperative clinical evaluation following pylorus-preserving gastrectomy.
Yamaguchi, T., Ichikawa, D., KURIOKA, H., Ikoma, H., Koike, H., Otsuji, E., Ueshima, Y., Shioaki, Y., Lee, C. J., HAMASHIMA, T., et al. (2004) · PubMed · Cited by 25 · see citing works
Tomita, R., Tanjoh, K., & Fujisaki, S. (2004) · World Journal of Surgery · doi:10.1007/s00268-004-6987-2 · Cited by 23 · see citing works
Abbott, W. E., Krieger, H., Levey, S., & Bradshaw, J. (1960) · Gastroenterology · doi:10.1016/s0016-5085(19)35311-9 · Cited by 17 · see citing works
Gastrointestinal hormone in dumping syndrome and reflux esophagitis after gastric surgery.
Yamashita, Y., Toge, T., & Adrian, T. (1997) · Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · doi:10.1540/jsmr.33.37 · Cited by 16 · see citing works
Everson, T. C., & Abrams, B. (1958) · Annals of Surgery · doi:10.1097/00000658-195807000-00011 · Cited by 14 · see citing works
EARLY POSTOPERATIVE AND POSTGASTRECTOMY SYNDROMES
Donahue, P. E. (1994) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(21)00129-1 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
van der Post, R. S., Vogelaar, I. P., Carneiro, F., Guilford, P., Huntsman, D. D., Hoogerbrugge, N., Caldas, C., Schreiber, K. E. C., Hardwick, R. H., Ausems, M. G. E. M., et al. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103094 · Cited by 567 · see citing works
International consensus on the diagnosis and management of dumping syndrome
Scarpellini, E., Arts, J., Karamanolis, G., Laurenius, A., Siquini, W., Suzuki, H., Ukleja, A., van Beek, A. V., Vanuytsel, T., Bor, S., et al. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0357-5 · Cited by 247 · see citing works
van Beek, A. P., Emous, M., Laville, M., & Tack, J. (2017) · Obesity Reviews · doi:10.1111/obr.12467 · Cited by 288 · see citing works
“This survey used a very low cutoff for dumping complaints (VAS score >10mm), and a single item on the questionnaire was sufficient to label patients as symptomatic for late dumping (32).”
BackgroundMethodPostgastrectomy Syndromes and Nutritional Considerations Following Gastric Surgery.
Davis, J. L., & Ripley, R. T. (2017) · Surgical Clinics of North America · doi:10.1016/j.suc.2016.11.005 · Cited by 110 · see citing works
Abrahamsson, N., Engström, B. E., Sundbom, M., & Karlsson, F. A. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0504 · Cited by 99 · see citing works
Fujita, J., Takahashi, M., Urushihara, T., Tanabe, K., Kodera, Y., Yumiba, T., Matsumoto, H., Takagane, A., Kunisaki, C., & Nakada, K. (2015) · Gastric Cancer · doi:10.1007/s10120-015-0460-9 · Cited by 85 · see citing works
Bolton, J. S., & Conway, W. C. (2011) · Surgical Clinics of North America · doi:10.1016/j.suc.2011.07.001 · Cited by 77 · see citing works
Pylorus-Preserving Gastrectomy for Gastric Cancer
Oh, S., Lee, H., & Yang, H. (2016) · Journal of the Korean Gastric Cancer Association · doi:10.5230/jgc.2016.16.2.63 · Cited by 70 · see citing works
“A large scale retrospective study on dumping syndrome after gastrectomy involving 1,153 patients found that PPG was a preventive factor for early and late dumping syndromes.(47) In another questionnaire-based study on QOL after gastrectomy, PPG was found to have significantly lower scores in terms of diarrhea as well…”
ResultKosuga, T., Hiki, N., Nunobe, S., Noma, H., Honda, M., Tanimura, S., Sano, T., & Yamaguchi, T. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3520-1 · Cited by 64 · see citing works
Self-citationPark, D. J., Kim, Y., Yang, H., Ryu, K. W., Han, S., Kim, H., Hyung, W. J., Park, J., Suh, Y., Kwon, O. K., et al. (2021) · British journal of surgery · doi:10.1093/bjs/znab295 · Cited by 59 · see citing works
Diagnostic tools for post‐gastric bypass hypoglycaemia
Emous, M., Ubels, F. L., & van Beek, A. P. (2015) · Obesity Reviews · doi:10.1111/obr.12307 · Cited by 58 · see citing works
“used a questionnaire in patients after different gastric operations for ulcers and cancer (32).”
MethodRonellenfitsch, U., Najmeh, S., Andalib, A., Perera, R. M., Rousseau, M., Mulder, D. S., & Ferri, L. E. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-4078-7 · Cited by 54 · see citing works
“In our study, the proportion of patients reporting typical symptoms was lower than in total gastrectomies even though the majority of patients received a pyloric drainage procedure to prevent gastric remnant emptying disorders.(38) Likewise, we observed no cases of duodenal reflux into the stomach, which is feared by…”
ResultImpact of gastric cancer treatment on quality of life of patients.
Schütte, K., Schulz, C., & Middelberg-Bisping, K. (2021) · Best practice & research. Clinical gastroenterology · doi:10.1016/j.bpg.2021.101727 · Cited by 44 · see citing works
Outcomes after prophylactic gastrectomy for hereditary diffuse gastric cancer
van der Kaaij, R. T., Kessel, J., van Dieren, J. M., Snæbjörnsson, P., Balagué, O., van Coevorden, F., van der Kolk, L. E., Sikorska, K., Cats, A., & van Sandick, J. W. (2018) · British journal of surgery · doi:10.1002/bjs.10754 · Cited by 47 · see citing works
Nutritional Considerations After Gastrectomy and Esophagectomy for Malignancy
Baker, A., Wooten, L.-A., & Malloy, M. (2011) · Current Treatment Options in Oncology · doi:10.1007/s11864-010-0134-0 · Cited by 44 · see citing works
“Incidences of early or late dumping syndrome were seen in 67.6% and 38.4%, respectively [ 33 ].”
BackgroundInfluentialLidoriki, I., Schizas, D., Mylonas, K. S., Frountzas, M., Mastoraki, A. T., Pikoulis, E. A., Liakakos, T., & Karavokyros, I. (2020) · Journal of the American College of Nutrition · doi:10.1080/07315724.2020.1723453 · Cited by 44 · see citing works
Enteral Nutrition in Operated-On Gastric Cancer Patients: An Update
Triantafillidis, J. K., Papakontantinou, J., Antonakis, P. T., Konstadoulakis, M. M., & Papalois, A. E. (2024) · Nutrients · doi:10.3390/nu16111639 · Cited by 43 · see citing works
“Mine et al. studied the prevalence of dumping syndrome in 1153 patients operated on for GC [38].”
BackgroundNakada, K., Takahashi, M., Ikeda, M., Kinami, S., Yoshida, M., Uenosono, Y., Kawashima, Y., Nakao, S., Oshio, A., Suzukamo, Y., et al. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i40.8978 · Cited by 43 · see citing works
Common and Co-Occurring Symptoms Experienced by Patients With Gastric Cancer
Lin, Y., Docherty, S. L., Porter, L. S., & Bailey, D. E. (2020) · Oncology nursing forum · doi:10.1188/20.onf.187-202 · Cited by 43 · see citing works
Bouras, G., Markar, S. R., Burns, E. M., Huddy, J., Bottle, A., Athanasiou, T., Darzi, A. W., & Hanna, G. B. (2016) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2016.10.010 · Cited by 39 · see citing works
Tanizawa, Y., Tanabe, K., Kawahira, H., Fujita, J., Takiguchi, N., Takahashi, M., Ito, Y., Mitsumori, N. N. M., Namikawa, T., Oshio, A., et al. (2015) · Digestive Surgery · doi:10.1159/000442217 · Cited by 39 · see citing works
Intermittent Use of Continuous Glucose Monitoring: Expanding the Clinical Value of CGM
Ziegler, R., Heinemann, L., Freckmann, G., Schnell, O., Hinzmann, R., & Kulzer, B. (2020) · Journal of Diabetes Science and Technology · doi:10.1177/1932296820905577 · Cited by 40 · see citing works
Hazlehurst, J., Khoo, B. C. E., Lobato, C. B., Ilesanmi, I., Abbott, S., Chan, T. L., Pillai, S., Maslin, K., Purkayastha, S., McGowan, B. M., et al. (2024) · Endocrine Connections · doi:10.1530/ec-23-0285 · Cited by 43 · see citing works
“This phenomenon was first described in people after upper gastrointestinal surgery such as oesophagectomy, Nissen fundoplication (17 ), and gastrectomy for cancer (18 ).”
Gastric Motility Physiology and Surgical Intervention
Rostas, J. W., Mai, T. T., & Richards, W. O. (2011) · Surgical Clinics of North America · doi:10.1016/j.suc.2011.06.012 · Cited by 37 · see citing works
“has been shown to result in a reduced incidence of dumping syndrome as compared with Billroth I reconstruction.(49) Anatomic alterations imposed by bariatric surgery constitute an increasing propor-”
BackgroundMethodInfluentialGastroparesis and Dumping Syndrome: Current Concepts and Management
Vavricka, S. R., & Greuter, T. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081127 · Cited by 37 · see citing works
“A simple visual analogue scale might also be used [61].”
MethodLin, Y., Docherty, S. L., Porter, L. S., & Bailey, D. E. (2020) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2020.101860 · Cited by 34 · see citing works
Nutritional management of gastric cancer
Lozano, E. C., Zárate, V. O., & del Portillo, R. C. (2021) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2020.09.005 · Cited by 33 · see citing works
Shibata, C., Saijo, F., Kakyo, M., Kinouchi, M., Tanaka, N., Sasaki, I., Aikou, T., & The Society for the Study of Postoperative Morbidity After Gastrectomy (2012) · World Journal of Surgery · doi:10.1007/s00268-012-1491-6 · Cited by 30 · see citing works
Masclee, G. M. C., & Masclee, A. (2023) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s392265 · Cited by 32 · see citing works
“29 With regard to post-bariatric surgery, presence of dumping symptoms differs per type of surgery performed.”
BackgroundSun, V. C.-Y., Kim, J., Kim, J. Y., Raz, D. J., Merchant, S., Chao, J., Chung, V. M., Jimenez, T., Wittenberg-Lyles, E. M., GRANT, M. M., et al. (2015) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2015.01.008 · Cited by 29 · see citing works
Inner conflict in patients receiving oral anticancer agents: a qualitative study
Yagasaki, K., Komatsu, H., & Takahashi, T. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-006699 · Cited by 23 · see citing works
Pylorus-Preserving Surgery Based on the Sentinel Node Concept in Early Gastric Cancer
Shimada, A., Takeuchi, H., Ono, T., Kamiya, S., Fukuda, K., Nakamura, R., Takahashi, T., Wada, N., Kawakubo, H., Saikawa, Y., et al. (2016) · Annals of Surgical Oncology · doi:10.1245/s10434-016-5358-1 · Cited by 22 · see citing works
“These prophylactic lymphadenectomy will result in postgastrectomy syndrome such as dumping syndrome in many patients.(3) Recently, many retrospective studies reported the usefulness of function-preserving surgery, which provides patients with a better quality of postoperative life.”
BackgroundBackground factors influencing postgastrectomy syndromes after various types of gastrectomy
Kinami, S., Takahashi, M., Urushihara, T., Ikeda, M., Yoshida, M., Uenosono, Y., Oshio, A., Suzukamo, Y., Terashima, M., Kodera, Y., et al. (2018) · World Journal of Clinical Cases · doi:10.12998/wjcc.v6.i16.1111 · Cited by 22 · see citing works
Honda, M., Wakita, T., Ônishi, Y., Nunobe, S., Hiki, N., Miura, A., Nishigori, T., Kusanagi, H., Yamamoto, T., Kobayashi, K., et al. (2014) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2014.05.017 · Cited by 22 · see citing works
“primarily related to intense reflux, a small stomach, or dumping syndrome.(3-6) These symptoms can cause a significant burden for the patients.”
BackgroundMethodLaparoscopic Pylorus-preserving Gastrectomy Versus Distal Gastrectomy for Early Gastric Cancer
Lee, H.-J., Kim, Y.-W., Park, D., Han, S.-U., Ryu, K., Kim, H.-H., Woo, J., Park, J.-H., Suh, Y., Kwon, O.-K., et al. (2024) · Annals of Surgery · doi:10.1097/sla.0000000000006503 · Cited by 17 · see citing works
Post-Gastrectomy Complications - An Overview
Ray, S., Naimish, M., & Nundy, S. (2020) · Chirurgia · doi:10.21614/chirurgia.115.4.423 · Cited by 20 · see citing works
“Billroth II have been found to havea higher risk of dumping symptoms compared to Billroth I reconstructions (11).”
BackgroundYamashita, H., Toyota, K., Kunisaki, C., Seshimo, A., Etoh, T., Ogawa, R., Baba, H., Demura, K., Kaida, S., Oshio, A., et al. (2022) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2022.11.069 · Cited by 18 · see citing works
Buscemi, S., Mattina, A., Genova, G., Genova, P., Nardi, E., & Costanzo, M. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.10.021 · Cited by 18 · see citing works
Reflux Esophagitis After Laparoscopic Pylorus-Preserving Gastrectomy for Gastric Cancer
Otake, R., Kumagai, K., Ohashi, M., Makuuchi, R., Ida, S., Sano, T., & Nunobe, S. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-12902-5 · Cited by 17 · see citing works
Self-citationAoyama, J., Kawakubo, H., Goto, O., Nakahara, T., Mayanagi, S., Fukuda, K., Suda, K., Nakamura, R., Wada, N., Takeuchi, H., et al. (2018) · Gastric Cancer · doi:10.1007/s10120-018-0865-3 · Cited by 17 · see citing works
Impact of gastric and bowel surgery on gastrointestinal drug delivery
Hua, S., & Lye, E. C. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01179-6 · Cited by 15 · see citing works
Ha, J., Lee, J.-M., Lim, Y., Kim, M. K., Kwon, H., Song, K., Jeon, H. M., Kang, M. I., & Baek, K. (2019) · Bone · doi:10.1016/j.bone.2019.115138 · Cited by 15 · see citing works
Ishii, M., Toda, T., Ikarashi, N., Kusunoki, Y., Kon, R., Ochiai, W., Machida, Y., & Sugiyama, K. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00824 · Cited by 14 · see citing works
Gastrointestinal side effects of upper gastrointestinal cancer surgery.
Antonowicz, S., Reddy, S., & Sgromo, B. (2020) · Best practice & research. Clinical gastroenterology · doi:10.1016/j.bpg.2020.101706 · Cited by 13 · see citing works
Honda, M., Hiki, N., Nunobe, S., Ohashi, M., Mine, S., Watanabe, M., Kamiya, S., Irino, T., Sano, T., & Yamaguchi, T. (2015) · Gastric Cancer · doi:10.1007/s10120-015-0553-5 · Cited by 13 · see citing works
Self-citationDing, B., Hu, Y., Yuan, L., Yan, R.-N., & Ma, J.-H. (2021) · Medicine · doi:10.1097/md.0000000000026086 · Cited by 13 · see citing works
“Dumping syndrome is a frequent and potentially severe complication after gastric surgery.([1]) Late dumping syndrome is character-”
BackgroundHonda, M., Wakita, T., Ônishi, Y., Nunobe, S., Miura, A., Nishigori, T., Kusanagi, H., Yamamoto, T., Boddy, A., & Fukuhara, S. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4696-8 · Cited by 12 · see citing works
“After upper gastrointestinal surgery, such as esophagectomy or gastrectomy, patients often suffer from several sequelae and cannot enjoy meal intake for a long time after surgery.(11,20,30) Our study team has published previously the ‘‘ES(4)’’ symptom scale to evaluate such sequelae.”
BackgroundKonishi, H., Nakada, K., Kawamura, M., Iwasaki, T., Murakami, K., Mitsumori, N. N. M., & Yanaga, K. K. (2016) · World Journal of Surgery · doi:10.1007/s00268-016-3613-z · Cited by 12 · see citing works
Ri, M., Nunobe, S., Ida, S., Ishizuka, N., Atsumi, S., Makuuchi, R., Kumagai, K., Ohashi, M., & Sano, T. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i23.3386 · Cited by 12 · see citing works
Self-citationKawamura, M., Nakada, K., Konishi, H., Iwasaki, T., Murakami, K., Mitsumori, N. N. M., Hanyu, N. N., Omura, N., & Yanaga, K. K. (2014) · World Journal of Surgery · doi:10.1007/s00268-014-2660-6 · Cited by 10 · see citing works
“Disabilities have frequently been observed following gastrectomy including reduced dietary intake, weight loss, dumping, and other gastrointestinal symptoms [12], which”
BackgroundDumon, K., & Dempsey, D. T. (2019) · Shackelford's Surgery of the Alimentary Tract, 2 Volume Set · doi:10.1016/b978-0-323-40232-3.00062-5
Function Preserving Gastrectomy and Quality of Life
Kim, J., & Lee, H. (2025) · Journal of the Korean Gastric Cancer Association · doi:10.5230/jgc.2025.25.e7 · Cited by 9 · see citing works
“Specifically, PPG has demonstrated superior outcomes in managing specific symptoms like early satiety, diarrhea, reflux, emotional functions, and taste problems [38,73,80,81].”
Herbal Medicine for Dumping Syndrome: A Systematic Review and Meta-Analysis
Hong, S., Park, B., Noh, H.-S., & Choi, D. (2019) · Integrative Cancer Therapies · doi:10.1177/1534735419873404 · Cited by 8 · see citing works
“Dietary supplements (pectin, guar gum, acarbose(25-30)), somatostatin analogs (pasireotide,(5,31-33) octreotide(31)), miglitol,(34-36) iraglutide,(37) exendin-(9-39),(38) and diazoxide(39) are prescribed for postprandial hypoglycemia or hyperglycemia caused by dumping syndrome.”
BackgroundIshii, M., Toda, T., Ikarashi, N., Kusunoki, Y., Kon, R., Ochiai, W., Machida, Y., & Sugiyama, K. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.09.017 · Cited by 9 · see citing works
[Dumping syndrome following gastric surgery].
Mala, T., Hewitt, S., Høgestøl, I., Kjellevold, K., Kristinsson, J., & Risstad, H. (2015) · Tidsskrift for Den Norske Laegeforening · doi:10.4045/tidsskr.14.0550 · Cited by 8 · see citing works
Walmsley, J., Ariyarathenam, A., Berrisford, R., Humphreys, L., Sanders, G., Tham, J. C., Wheatley, T., & Chan, D. S. Y. (2023) · Diseases of the Esophagus · doi:10.1093/dote/doad039 · Cited by 8 · see citing works
Yang, J., Lee, H., Alzahrani, F., Choi, S. J., Lee, W. K., Kong, S., Park, D. J., & Yang, H. (2020) · Journal of the Korean Gastric Cancer Association · doi:10.5230/jgc.2020.20.e24 · Cited by 7 · see citing works
“Previous studies reported higher incidences of early dumping syndrome in patients who underwent total gastrectomy than those in patients who underwent distal gastrectomy due to more accelerated nutrient delivery into the small intestine [1,29].”
BackgroundWang, Q., Yuan, H., Chen, Z., Wang, J., Yao, J., Zhu, M., Xue, H., & Zhang, X. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07154-8 · Cited by 7 · see citing works
“Especially the incidence of early dumping syndrome was more than 60%, which affected the eating process [35].”
BackgroundWashio, M., Hiki, N., Hosoda, K., Niihara, M., Chuman, M., Sakuraya, M., Wada, T., Harada, H., Sato, T., Tanaka, K., et al. (2021) · Surgical Case Reports · doi:10.1186/s40792-021-01325-1 · Cited by 7 · see citing works
“In addition, disorders, such as abdominal bloating, diarrhea, and dumping symptoms, may occur after gastrectomy, significantly reducing quality of life [4, 5].”
BackgroundTreatment of obesity: will incretin agonists make bariatric surgery a thing of the past?
Lah, S., & HOCKING, S. L. (2025) · Internal Medicine Journal · doi:10.1111/imj.16625 · Cited by 6 · see citing works
Kim, C. Y. (2022) · Foregut Surgery · doi:10.51666/fs.2022.2.e4 · Cited by 8 · see citing works
Large-Scale Investigation into Dumping Syndrome after Gastrectomy for Gastric Cancer
Eberlein, T. J. (2011) · Yearbook of Surgery · doi:10.1016/j.ysur.2011.02.009 · Cited by 6 · see citing works
Eom, B. W., Kim, Y., Nam, B., Ryu, K. W., Jeong, H. Y., Park, Y. K., Lee, Y., Yang, H., Yu, W., Yook, J. H., et al. (2016) · Journal of the Korean Gastric Cancer Association · doi:10.5230/jgc.2016.16.3.182 · Cited by 6 · see citing works
Roberts, G. P., Hardwick, R. H., & Fitzgerald, R. C. (2017) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2017.03.12 · Cited by 6 · see citing works
“Over 50% of 269 post-total gastrectomy patients complained of some dumping symptoms in a large Japanese study (9).”
BackgroundJeong, S., Park, M., Seo, K. W., Kim, R. B., & Min, J.-S. (2024) · Cancers · doi:10.3390/cancers16122203 · Cited by 4 · see citing works
Kunisaki, C., Tanaka, Y., Kosaka, T., Miyamoto, H., Sato, S., Suematsu, H., Yukawa, N., Sato, K. A., Izumisawa, Y., Akiyama, H., et al. (2017) · Digestion · doi:10.1159/000458755 · Cited by 4 · see citing works
Walmsley, J., Ariyarathenam, A., Berrisford, R., Humphreys, L., Sanders, G., Tham, J. C., Wheatley, T., & Chan, D. S. Y. (2023) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-023-05661-5 · Cited by 4 · see citing works
“While patients undergoing total gastrectomy do not usually undergo a thoracotomy, they may suffer with symptoms of dumping syndrome including nausea, diarrhoea, dizziness and sweating [9].”
BackgroundAgnes, A., Biondi, A., Carannante, M., Strippoli, A., Belia, F., Lorenzon, L., Pezzuto, R., Tirelli, F., Ferri, L. E., Neri, I., et al. (2025) · Updates in Surgery · doi:10.1007/s13304-025-02440-6 · Cited by 4 · see citing works
“Several studies have identified predictors of dumping after gastrectomy, associating weight loss, a younger age and total gastrectomy with early dumping syndrome, and weight loss, female gender, BI and total gastrectomy with late dumping syndrome [3].”
Anand, A., Dilip, T. R., Craig, L. C. A., BHANDARE, M. S., MacLennan, S. J., & Guntupalli, A. M. (2026) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-025-01388-5 · Cited by 3 · see citing works
“It accounts for approximately 6% of all cancer diagnoses and around Aravinda Meera Guntupalli aravinda.guntupalli@abdn.ac.uk further complicates post-surgical nutritional behaviours [8].”
Kitagawa, M., Uesugi, Y., Kawata, N., & Shimamura, Y. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.03.005 · Cited by 3 · see citing works
“Approximately 70% of the patients had experienced early dumping symptoms after discharge [20].”
BackgroundManejo nutricional del paciente con cáncer gástrico
Lozano, E. C., Zárate, V. O., & del Portillo, R. C. (2020) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2020.09.004 · Cited by 3 · see citing works
Nakada, K., Ikeda, M., Takahashi, M., Kinami, S., Yoshida, M., Uenosono, Y., Terashima, M., Oshio, A., & Kodera, Y. (2021) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v13.i11.1484 · Cited by 2 · see citing works
Taki, T., Hoya, Y., Nakada, K., Kawamura, M., Iwasaki, T., Murakami, K., Okamoto, T., Mitsumori, N. N. M., & Yanaga, K. K. (2019) · Anticancer Research · doi:10.21873/anticanres.13463 · Cited by 2 · see citing works
Honda, M., Ri, M., Kinoshita, T., Kawakubo, H., Aizawa, M., Bamba, T., Matsuda, S., Kawamura, H., Yoshida, M., & Nunobe, S. (2024) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12779 · Cited by 2 · see citing works
Szabó, M., Kalmár, K., & Horváth, Ö. P. (2011) · Magyar Sebészet (Hungarian Journal of Surgery) · doi:10.1556/maseb.64.2011.6.2 · Cited by 1 · see citing works
Gallanis, A. F., Mannes, A. J., & Davis, J. L. (2023) · Springer eBooks · doi:10.1007/978-3-031-50977-3_38 · Cited by 2 · see citing works
Nutritional Experiences of Patients Undergoing Total Gastrectomy Surgery
Şayır, D., & Karacabay, K. (2024) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000800 · Cited by 2 · see citing works
“Mine et al. (2010) investigated dumping syndrome after gas-trectomy and reported that early dumping syndrome is more common in patients and they have difficulty in coping with this situation.”
BackgroundManaging Early and Late Postoperative Complications Following Gastric Surgery
Badgwell, B., Day, R., & Aloia, T. (2015) · Springer eBooks · doi:10.1007/978-3-319-15826-6_17 · Cited by 1 · see citing works
Stewart, C. L. (2024) · Annals of Surgical Oncology · doi:10.1245/s10434-024-16289-3
Präventive Magenchirurgie bei hereditärem Magenkarzinom und genetischer Prädisposition
Lee, H., Stein, H. J., Heiliger, C., von Frankenberg, J., Hoefele, J., Bik-Multanowski, M., Werner, J., & Zimmermann, P. (2025) · Zentralblatt für Chirurgie - Zeitschrift für Allgemeine Viszeral- Thorax- und Gefäßchirurgie · doi:10.1055/a-2731-7680 · Cited by 1 · see citing works
Seo, H., Son, S.-Y., Hur, H., Park, Y. S., Han, D.-S., & Lee, H. H. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000004490 · Cited by 2 · see citing works
Migdanis, A., Koukoulis, G., Chougias, D., Migdanis, I., Armeni, E., Kanellakis, S., Manouras, A., Kapsoritakis, A. N., & Potamianos, S. (2023) · Cureus · doi:10.7759/cureus.48871 · Cited by 1 · see citing works
“The present study agrees with the findings of previous studies that after certain types of gastric surgery patients often develop postprandial symptoms related to DS [1,8,21,22,23].”
BackgroundResultTolan, D. J. M., Harris, K. M., Prasad, D., & Mehta, S. P. (2012) · Springer eBooks · doi:10.1007/978-1-4471-2775-8_3 · Cited by 1 · see citing works
Honda, M., Todate, Y., Hori, S., Kobayashi, H., Cong, Y., Hamada, K., Yamaguchi, H., Kawamura, H., Hashimoto, K., Usuki, S., et al. (2018) · Annals of Cancer Research and Therapy · doi:10.4993/acrt.26.66 · Cited by 1 · see citing works
Post-gastrectomy Complications
Samarasam, I., & George, S. V. (2018) · GI surgery annual · doi:10.1007/978-981-13-0161-2_2 · Cited by 1 · see citing works
Shaw, C. (2014) · doi:10.1002/9781118872796.ch3.5 · Cited by 1 · see citing works
Rushdi, T. A., El-Ela, M. M. A., & Youssef, W. (2011) · Egyptian Journal of Anaesthesia · doi:10.1016/j.egja.2011.05.001
“The recumbent position is the most beneficial if the patient can arrange for it [3,4].”
BackgroundOn the Impact of Bariatric Surgery on Glucose Homeostasis
Abrahamsson, N. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
About reduodenization of digestive tract in gastrectomy
Валентинович, О. В., Efetov, S. V., & Aliev, K. A. (2017) · Pirogov Russian Journal of Surgery · doi:10.17116/hirurgia2017895-100
Generation and use of new tools for the characterisation of gut hormone receptors
Biggs, E. K. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.37487
Management of Late Postoperative Complications
Terashima, M. (2019) · Springer eBooks · doi:10.1007/978-3-662-45583-8_27
Dumping syndrome after bariatric surgery
Emous, M. (2019) · doi:10.33612/diss.106406421
Ingenuos y generosos socialismos
Muru, V. M. A. (1976) · El Ciervo: revista mensual de pensamiento y cultura
消化器がん手術(上部消化管手術)療法における栄養障害のアップデート
真司, 峯., & 比企直樹 (2011) · 静脈経腸栄養 · doi:10.11244/jjspen.26.1241
Lauscher, J. (2017) · Springer eBooks · doi:10.1007/978-3-662-53188-4_22
(2012) · Elsevier eBooks · doi:10.1016/b978-0-323-08373-7.00013-3
51/m mit rezidivierenden, unspezifischen Oberbauchbeschwerden und Gewichtsverlust
Datta, R. R., Bohle, J., & Bruns, C. J. (2022) · Die Chirurgie · doi:10.1007/s00104-022-01731-7
Quality of life in gastric cancer patients after laparoscopic total gastrectomy
Tran, A. T. N., Pham, V. A., Tran, M. H., Nguyen, T. M., & Dang, T. (2023) · Annals of Cancer Research and Therapy · doi:10.4993/acrt.31.32
Brunner, M., Buniatov, T., Grützmann, R., & Krautz, C. (2023) · Springer Reference Medizin · doi:10.1007/978-3-662-61724-3_98-1
Side Effects of Gastric Cancer Surgery: Prevention and Treatment
Chevallay, M., Marcelis, J., & Mönig, S. (2023) · Springer eBooks · doi:10.1007/978-3-030-93702-7_29-1
- Authors
- Mine, S., Sano, T., Tsutsumi, K., Murakami, Y., Ehara, K., Saka, M., Hara, K., Fukagawa, T., Udagawa, H., & Katai, H.
- Affiliations
- The Cancer Institute Hospital (JP)
- Toranomon Hospital (JP)
- Shiga University of Medical Science (JP)
- National Cancer Center Hospital (JP)
- The University of Tokyo (JP)
- Corresponding author
- Mine, Shinji
- ORCID
- Venue
- Journal of the American College of Surgeons
- Published
- 2010-11
- Volume
- 211
- Issue
- 5
- Pages
- 628-636
- ISSN
- 1072-7515 (ISSN-L)
- OpenAlex
- W2077139301
- Cited by
- 106
- References
- 19
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 11 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- green
- pure.teikyo.jp
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Journal of the American College of Surgeons (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- dumping syndrome, gastric cancer, gastrectomy, early dumping syndrome, late dumping syndrome, pylorus-preserving gastrectomy, distal gastrectomy, Billroth I reconstruction, proximal gastrectomy, weight loss, risk factors
- MeSH terms
- Dumping Syndrome, Female, Follow-Up Studies, Gastrectomy, Humans, Male, Middle Aged, Pain Measurement, Population Surveillance, Surveys and Questionnaires, Stomach Neoplasms, Reproducibility of Results, Causality, Incidence, Logistic Models, Disease-Free Survival
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