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Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research

Open access
Fabbri, Elisa, Zoli, Marco, Gonzalez-Freire, Marta, Salive, Marcel E., Studenski, Stephanie A., Ferrucci, Luigi·2015·Journal of the American Medical Directors Association

Abstract

Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for multimorbidity. From a gerontological perspective, the progressive accumulation of multiple diseases, which significantly accelerates at older ages, is a milestone for progressive loss of resilience and age-related multisystem homeostatic dysregulation. Because it is most likely that the same mechanisms that drive aging also drive multiple age-related chronic diseases, addressing those mechanisms may reduce the development of multimorbidity. According to this vision, studying multimorbidity may help to understand the biology of aging and, at the same time, understanding the underpinnings of aging may help to develop strategies to prevent or delay the burden of multimorbidity. As a consequence, we believe that it is time to build connections and dialogue between the clinical experience of general practitioners and geriatricians and the scientists who study aging, so as to stimulate innovative research projects to improve the management and the treatment of older patients with multiple morbidities.

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Metadata

Authors
Fabbri, E., Zoli, M., Gonzalez-Freire, M., Salive, M. E., Studenski, S. A., & Ferrucci, L.
Venue
Journal of the American Medical Directors Association
Publisher
Elsevier BV
Published
2015-08
Volume
16
Issue
8
Pages
640-647
ISSN
1525-8610 (ISSN-L)
OpenAlex
W1654360807
Cited by
563
References
18
FWCI
20.18
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research. https://app.cochat.ai/papers/10.1016/j.jamda.2015.03.013
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Fabbri, E., Zoli, M., Gonzalez-Freire, M., Salive, M. E., Studenski, S. A., & Ferrucci, L. (2015). Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research. Journal of the American Medical Directors Association. https://doi.org/10.1016/j.jamda.2015.03.013

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.