Prevalence, determinants and patterns of multimorbidity in primary care: a systematic review of observational studies
Open accessAbstract
INTRODUCTION: Multimorbidity is a major concern in primary care. Nevertheless, evidence of prevalence and patterns of multimorbidity, and their determinants, are scarce. The aim of this study is to systematically review studies of the prevalence, patterns and determinants of multimorbidity in primary care. METHODS: Systematic review of literature published between 1961 and 2013 and indexed in Ovid (CINAHL, PsychINFO, Medline and Embase) and Web of Knowledge. Studies were selected according to eligibility criteria of addressing prevalence, determinants, and patterns of multimorbidity and using a pretested proforma in primary care. The quality and risk of bias were assessed using STROBE criteria. Two researchers assessed the eligibility of studies for inclusion (Kappa= 0.86). RESULTS: We identified 39 eligible publications describing studies that included a total of 70,057,611 patients in 12 countries. The number of health conditions analysed per study ranged from 5 to 335, with multimorbidity prevalence ranging from 12.9% to 95.1%. All studies observed a significant positive association between multimorbidity and age (odds ratio [OR], 1.26 to 227.46), and lower socioeconomic status (OR, 1.20 to 1.91). Positive associations with female gender and mental disorders were also observed. The most frequent patterns of multimorbidity included osteoarthritis together with cardiovascular and/or metabolic conditions. CONCLUSIONS: Well-established determinants of multimorbidity include age, lower socioeconomic status and gender. The most prevalent conditions shape the patterns of multimorbidity. However, the limitations of the current evidence base means that further and better designed studies are needed to inform policy, research and clinical practice, with the goal of improving health-related quality of life for patients with multimorbidity. Standardization of the definition and assessment of multimorbidity is essential in order to better understand this phenomenon, and is a necessary immediate step.
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Multimorbidity is now considered the norm rather than exception in primary care patients.
“as Violan et al 4 highlight, multimorbidity is now considered the norm rather than exception in primary care patients”
From Investigating the effectiveness of an online acceptance and commitment therapy (ACT) intervention versus a waiting list control condition on pain interference and quality of life in adults with chronic pain and multimorbidity: Protocol for a randomised controlled trial (2019) · cites this paper as [4]
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859 · see citing works
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,759 · see citing works
Vandenbroucke, J. P., von Elm, E., Altman, D. G., Gøtzsche, P. C., Mulrow, C. D., Pocock, S. J., Poole, C., Schlesselman, J. J., Egger, M., & Initiative, F. T. S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040297 · Cited by 8,613 · cited 1× · see citing works
“Two authors (CV and QFB) used the STROBE checklist for observational studies to assess the quality of each study (Table S2) [13].”
MethodBarnett, K., Mercer, S. W., Norbury, M., Watt, G., Wyke, S., & Guthrie, B. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60240-2 · Cited by 6,972 · see citing works
Vandenbroucke, J. P., Elm, E. V., Altman, D. G., Gøtzsche, P. C., Mulrow, C. D., Pocock, S. J., Poole, C., Schlesselman, J. J., Egger, M., & initiative, F. T. S. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-8-200710160-00010-w1 · Cited by 3,543 · see citing works
Aging with multimorbidity: A systematic review of the literature
Marengoni, A., Angleman, S., Melis, R., Mangialasche, F., Karp, A., Garmen, A., Meinow, B., & Fratiglioni, L. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.03.003 · Cited by 3,092 · see citing works
Prevalence, Expenditures, and Complications of Multiple Chronic Conditions in the Elderly
Wolff, J. L., Starfield, B. H., & Anderson, G. F. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.20.2269 · Cited by 2,237 · see citing works
Defining Comorbidity: Implications for Understanding Health and Health Services
Valderas, J. M., Starfield, B. H., Sibbald, B., Salisbury, C., & Roland, M. O. (2009) · The Annals of Family Medicine · doi:10.1370/afm.983 · Cited by 1,730 · see citing works
Self-citationVogeli, C., Shields, A. E., Lee, T. A., Gibson, T. B., Marder, W. D., Weiss, K. B., & Blumenthal, D. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0322-1 · Cited by 1,150 · see citing works
A Systematic Review of Prevalence Studies on Multimorbidity: Toward a More Uniform Methodology
Fortin, M., Stewart, M., Poitras, M.-È., Almirall, J., & Maddocks, H. L. (2012) · The Annals of Family Medicine · doi:10.1370/afm.1337 · Cited by 1,131 · see citing works
van den Akker, M., Buntinx, F., Metsemakers, J. F. M., Roos, S., & Knottnerus, J. A. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(97)00306-5 · Cited by 1,022 · see citing works
Prevalence of multimorbidity among adults seen in family practice
Fortin, M. (2005) · The Annals of Family Medicine · doi:10.1370/afm.272 · Cited by 987 · cited 5× · see citing works
“Age was the most frequently studied determinant of multimorbidity [16,18,20,22,25,27,30,32,34,37,41,47,51,52].”
BackgroundResultInfluentialEpidemiology and impact of multimorbidity in primary care: a retrospective cohort study
Salisbury, C., Johnson, L., Purdy, S., Valderas, J. M., & Montgomery, A. A. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x548929 · Cited by 883 · see citing works
Self-citationSmith, S. M., Soubhi, H., Fortin, M., Hudon, C., & O'Dowd, T. C. (2012) · BMJ · doi:10.1136/bmj.e5205 · Cited by 744 · see citing works
The prevalence of multimorbidity in primary care and its effect on health care utilization and cost
Glynn, L. G., Valderas, J. M., Healy, P., Burke, E., Newell, J., Gillespie, P., & Murphy, A. W. (2011) · Family Practice · doi:10.1093/fampra/cmr013 · Cited by 669 · see citing works
Self-citationHuntley, A. L., Johnson, R., Purdy, S., Valderas, J. M., & Salisbury, C. (2012) · The Annals of Family Medicine · doi:10.1370/afm.1363 · Cited by 619 · see citing works
Self-citationAdapting clinical guidelines to take account of multimorbidity
Guthrie, B., Payne, K., Alderson, P., McMurdo, M. E. T., & Mercer, S. W. (2012) · BMJ · doi:10.1136/bmj.e6341 · Cited by 530 · see citing works
Multimorbidity in primary care: prevalence and trend over the last 20 years
Uijen, A. A., & van de Lisdonk, E. H. (2008) · European Journal of General Practice · doi:10.1080/13814780802436093 · Cited by 505 · see citing works
Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden
Marengoni, A., Winblad, B., Karp, A., & Fratiglioni, L. (2008) · American Journal of Public Health · doi:10.2105/ajph.2007.121137 · Cited by 429 · see citing works
Patterns of Chronic Multimorbidity in the Elderly Population
Marengoni, A., Rizzuto, D., Wang, H., Winblad, B. G., & Fratiglioni, L. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02109.x · Cited by 421 · see citing works
Prevalence and patterns of multimorbidity in Australia
Britt, H. C., Harrison, C. M., Miller, G. C., & Knox, S. A. (2008) · Medical Journal of Australia · doi:10.5694/j.1326-5377.2008.tb01919.x · Cited by 402 · see citing works
Schäfer, I., von Leitner, E.-C., Schön, G., Koller, D., Hansen, H., Kolonko, T., Kaduszkiewicz, H., Wegscheider, K., Glaeske, G., & van den Bussche, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015941 · Cited by 387 · see citing works
Defining chronic conditions for primary care with ICPC-2
O’Halloran, J., Miller, G. C., & Britt, H. C. (2004) · Family Practice · doi:10.1093/fampra/cmh407 · Cited by 337 · see citing works
Multimorbidity: redesigning health care for people who use it
Salisbury, C. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60482-6 · Cited by 326 · see citing works
Self-citationPrevalence of multiple chronic conditions in the United States' Medicare population
Schneider, K. M., O'Donnell, B. E., & Dean, D. (2009) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-7-82 · Cited by 315 · see citing works
Comorbidity of chronic diseases in general practice
Schellevis, F., van der Velden, J., de Lisdonk, E. V., van Eijk, J. T. M., & van Weel, C. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90024-u · Cited by 304 · see citing works
Schäfer, I., Hansen, H., Schön, G., Höfels, S., Altiner, A., Dahlhaus, A., Gensichen, J., Riedel-Heller, S., Weyerer, S., Blank, W. A., et al. (2012) · BMC Health Services Research · doi:10.1186/1472-6963-12-89 · Cited by 296 · see citing works
Multimorbidity Patterns in Primary Care: Interactions among Chronic Diseases Using Factor Analysis
Prados‐Torres, A., Poblador‐Plou, B., Calderón‐Larrañaga, A., Gimeno-Feliú, L. A., González‐Rubio, F., Poncel-Falcó, A., Sicras‐Mainar, A., & Nalvaiz, J. T. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032190 · Cited by 280 · see citing works
Computerized health information in The Netherlands: a registration network of family practices.
Metsemakers, J. F. M., Höppener, P., Knottnerus, J. A., Kocken, R. J. J., & Limonard, C. (1992) · Europe PMC (PubMed Central) · Cited by 272 · see citing works
Multimorbidity and comorbidity in the Dutch population – data from general practices
van Oostrom, S. H., Picavet, H. S. J., van Gelder, B. M., Lemmens, L. C., Hoeymans, N., van Dijk, C. E., Verheij, R. A., Schellevis, F., & Baan, C. A. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-715 · Cited by 253 · see citing works
Reste, J. Y. L., Nabbé, P., Manceau, B., Lygidakis, C., Doerr, C., Lingner, H., Czachowski, S., Muñoz, M. Á., Argyriadou, S., Clavería, A., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.01.001 · Cited by 243 · see citing works
Prevalence of Multiple Chronic Conditions Among Medicare Beneficiaries, United States, 2010
Lochner, K. A., & Cox, C. S. (2013) · Preventing Chronic Disease · doi:10.5888/pcd10.120137 · Cited by 212 · see citing works
Kadam, U. T., & Croft, P. R. (2007) · Family Practice · doi:10.1093/fampra/cmm049 · Cited by 209 · see citing works
Multimorbidity in primary care: a systematic review of prospective cohort studies
France, E. F., Wyke, S., Gunn, J. M., Mair, F. S., McLean, G., & Mercer, S. W. (2012) · British Journal of General Practice · doi:10.3399/bjgp12x636146 · Cited by 190 · see citing works
Harkness, E., Macdonald, W., Valderas, J., Coventry, P., Gask, L., & Bower, P. (2010) · Diabetes Care · doi:10.2337/dc09-1519 · Cited by 188 · see citing works
Self-citationViolán, C., Boreu, Q. F., Hermosilla, E., Valderas, J. M., Bolíbar, B., Escurriola, M. F., Brugulat-Guiteras, P., & Muñoz, M. Á. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-251 · Cited by 181 · see citing works
Self-citationSchram, M. T., Frijters, D. H. M., van de Lisdonk, E. H., Ploemacher, J., de Craen, A. J. M., de Waal, M. W. M., van Rooij, F. J. A., Heeringa, J., Albert Hofman, D., Deeg, D. J. H., et al. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.11.021 · Cited by 168 · see citing works
Patterns of comorbidity and multimorbidity in the oldest old: The Octabaix study
Formiga, F., Ferrer, A., Sanz, H., Marengoni, A., Alburquerque, J., & Pujol, R. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.11.003 · Cited by 155 · see citing works
van den Bussche, H., Schön, G., Kolonko, T., Hansen, H., Wegscheider, K., Glaeske, G., & Koller, D. (2011) · BMC Geriatrics · doi:10.1186/1471-2318-11-54 · Cited by 152 · see citing works
Laux, G., Kuehlein, T., Rosemann, T. J., & Szécsényi, J. (2008) · BMC Health Services Research · doi:10.1186/1472-6963-8-14 · Cited by 144 · see citing works
Patterns of Multimorbidity in Elderly Veterans
Steinman, M. A., Lee, S. J., Boscardin, W. J., Miao, Y., Fung, K. Z., Moore, K. L., & Schwartz, J. B. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04158.x · Cited by 140 · see citing works
Age- and gender-related prevalence of multimorbidity in primary care: the swiss fire project
Rizza, A., Kaplan, V., Senn, O., Rosemann, T. J., Bhend, H., & Tandjung, R. (2012) · BMC Family Practice · doi:10.1186/1471-2296-13-113 · Cited by 130 · see citing works
Comorbidity Patterns in Patients with Chronic Diseases in General Practice
García-Olmos, L., Salvador, C. H., Alberquilla, Á., Lora, D., Carmona, M., García-Sagredo, P., Carrasco, M., Carrero, A. M., Monteagudo, J. L., & López, F. J. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032141 · Cited by 128 · see citing works
Muggah, E., Graves, E., Bennett, C. L., & Manuel, D. G. (2012) · BMC Health Services Research · doi:10.1186/1472-6963-12-452 · Cited by 97 · see citing works
Identifying subgroups of complex patients with cluster analysis.
Newcomer, S. R., Steiner, J. F., & Bayliss, E. A. (2011) · PubMed · Cited by 95 · see citing works
Implications of comorbidity for primary care costs in the UK: a retrospective observational study
Brilleman, S. L., Purdy, S., Salisbury, C., Windmeijer, F., Gravelle, H., & Hollinghurst, S. (2013) · British Journal of General Practice · doi:10.3399/bjgp13x665242 · Cited by 87 · cited 4× · see citing works
“Of the 44 studies, 33 were conducted in Europe [15–17,19,21–24,26–30,34–35,37,39–41,43,45–52], of which the majority were conducted in the Netherlands (12 studies) [29,41,43,45–48,51], Germany (6 studies) [24,39,40,49,50], and the United Kingdom (5 studies) [16,17,23,26,37]).”
BackgroundMethodInfluentialSelf-citationEffect of multiple chronic conditions among working-age adults.
Naessens, J. M., Stroebel, R. J., Finnie, D. M., Shah, N. D., Wagie, A. E., Litchy, W. J., Killinger, P. J. F., O'Byrne, T. J., Wood, D. L., & Nesse, R. E. (2011) · PubMed · Cited by 77 · see citing works
Minas, M., Koukosias, N., Zintzaras, E., Κostikas, Κ., & Gourgoulianis, K. I. (2010) · BMC Health Services Research · doi:10.1186/1472-6963-10-252 · Cited by 44 · see citing works
Macleod, U., Mitchell, E., Black, M., & Spence, G. (2004) · European Journal of General Practice · doi:10.3109/13814780409094223 · Cited by 44 · see citing works
van den Bussche, H., Schäfer, I., Wiese, B., Dahlhaus, A., Fuchs, Â., Gensichen, J. S., Höfels, S., Hansen, H., Leicht, H., Koller, D., et al. (2012) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2012.07.019 · Cited by 42 · see citing works
El programa epidat: usos y perspectivas
Santiago-Pérez, M. I., Vidal, X. H., Barbeito, G. N., Silva, L. C., Fariñas, H., Vázquez, E., Bacallao, J., & Mújica, Ó. J. (2010) · Revista Panamericana de Salud Pública · doi:10.1590/s1020-49892010000100012 · Cited by 36 · see citing works
Co-morbidity in general practice
Saltman, D. C., Sayer, G. P., & Whicker, S. D. (2005) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.028530 · Cited by 28 · see citing works
In This Issue: Challenges of Managing Multimorbidity
Stange, K. C. (2012) · The Annals of Family Medicine · doi:10.1370/afm.1354 · Cited by 26 · see citing works
GBD 2.0: a continuously updated global resource
Murray, C. J. L., Frenk, J., Piot, P. K., & Mundel, T. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60225-1 · Cited by 23 · see citing works
van den Akker, M., Vos, R., & Knottnerus, J. A. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.02.009 · Cited by 17 · see citing works
[Increased multimorbidity in patients in general practice in the period 2003-2009].
Tacken, M. A. J. B., Opstelten, W., Vossen, I., Smeele, I. J. M., Calsbeek, H., Jacobs, J., & Braspenning, J. C. C. (2011) · PubMed · Cited by 15 · see citing works
Chronic Illness in a General Practice
Rose, A. T. (1984) · Family Practice · doi:10.1093/fampra/1.3.162 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Skou, S. T., Mair, F. S., Fortin, M., Guthrie, B., Nunes, B. P., Miranda, J. J., Boyd, C. M., Pati, S., Mtenga, S., & Smith, S. M. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00376-4 · Cited by 1,430 · see citing works
The global burden of multiple chronic conditions: A narrative review
Hajat, C., & Stein, E. M. (2018) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2018.10.008 · Cited by 980 · see citing works
Chowdhury, S. R., Das, D. C., Sunna, T. C., Beyene, J., & Hossain, A. (2023) · EClinicalMedicine · doi:10.1016/j.eclinm.2023.101860 · Cited by 887 · see citing works
Defining and measuring multimorbidity: a systematic review of systematic reviews
Johnston, M. C., Crilly, M., Black, C., Prescott, G. J., & Mercer, S. W. (2018) · European Journal of Public Health · doi:10.1093/eurpub/cky098 · Cited by 860 · see citing works
Managing patients with multimorbidity in primary care
Wallace, E., Salisbury, C., Guthrie, B., Lewis, C., Fahey, T. P., & Smith, S. M. (2015) · BMJ · doi:10.1136/bmj.h176 · Cited by 752 · see citing works
Self-citationNguyen, H., Manolova, G., Daskalopoulou, C., Vitoratou, S., Prince, M. J., & Prina, M. A. (2019) · Journal of Comorbidity · doi:10.1177/2235042x19870934 · Cited by 610 · see citing works
Adverse drug reactions in special populations – the elderly
Davies, E., & O'Mahony, M. S. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12596 · Cited by 577 · see citing works
Fabbri, E., Zoli, M., González‐Freire, M., Salive, M. E., Studenski, S. A., & Ferrucci, L. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.03.013 · Cited by 560 · see citing works
Perianayagam, A., Uttamacharya, U., Jain, K., Biritwum, R. B., Yawson, A. E., Wu, F., Guo, Y., Maximova, T., Manrique-Espinoza, B. S., Salinas‐Rodríguez, A., et al. (2015) · BMC Medicine · doi:10.1186/s12916-015-0402-8 · Cited by 484 · see citing works
Socioeconomic status and multimorbidity: a systematic review and meta‐analysis
Pathirana, T. I., & Jackson, C. A. (2018) · Australian and New Zealand Journal of Public Health · doi:10.1111/1753-6405.12762 · Cited by 475 · see citing works
Calderón‐Larrañaga, A., Vetrano, D. L., Ferrucci, L., Mercer, S. W., Marengoni, A., Onder, G., Eriksdotter, M., & Fratiglioni, L. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12843 · Cited by 419 · see citing works
Evidence on multimorbidity from definition to intervention: An overview of systematic reviews
Xu, X., Mishra, G. D., & Jones, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.003 · Cited by 397 · see citing works
Active Aging and Public Health: Evidence, Implications, and Opportunities
Dogra, S., Dunstan, D. W., Sugiyama, T., Stathi, A., Gardiner, P. A., & Owen, N. G. (2021) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-052620-091107 · Cited by 362 · see citing works
Challenges of managing people with multimorbidity in today’s healthcare systems
Moffat, K., & Mercer, S. W. (2015) · BMC Family Practice · doi:10.1186/s12875-015-0344-4 · Cited by 355 · see citing works
Prevalence of sarcopenia as a comorbid disease: A systematic review and meta-analysis
Pacifico, J., Geerlings, M. A. J., Reijnierse, E. M., Phassouliotis, C., Lim, W. K., & Maier, A. B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110801 · Cited by 339 · see citing works
Ho, I., Azcoaga-Lorenzo, A., Akbari, A., Black, C., Davies, J., Hodgins, P., Khunti, K. K., Kadam, U. T., Lyons, R. A., McCowan, C., et al. (2021) · The Lancet Public Health · doi:10.1016/s2468-2667(21)00107-9 · Cited by 339 · see citing works
Nowakowska, M., Zghebi, S. S., Ashcroft, D. M., Buchan, I. E., Chew-Graham, C. A., Holt, T., Mallen, C. D., van Marwijk, H., Peek, N. B., Perera, R., et al. (2019) · BMC Medicine · doi:10.1186/s12916-019-1373-y · Cited by 336 · see citing works
Multimorbidity: What Do We Know? What Should We Do?
Navickas, R., Petric, V.-K., Feigl, A. B., & Seychell, M. (2016) · Journal of Comorbidity · doi:10.15256/joc.2016.6.72 · Cited by 300 · see citing works
The Ariadne principles: how to handle multimorbidity in primary care consultations
Muth, C., van den Akker, M., Blom, J. W., Mallen, C. D., Rochon, J., Schellevis, F., Becker, A., Beyer, M., Gensichen, J. S., Kirchner, H., et al. (2014) · BMC Medicine · doi:10.1186/s12916-014-0223-1 · Cited by 298 · see citing works
Self-citationWang, H., Wang, J. J., Wong, S. Y. S., Wong, M. C. S., Li, F. J., Wang, P. X., Zhou, Z. H., Zhu, C., Griffiths, S. M., & Mercer, S. W. (2014) · BMC Medicine · doi:10.1186/s12916-014-0188-0 · Cited by 285 · see citing works
Khandaker, G. M., Zuber, V., Rees, J. M. B., Carvalho, L. A., Mason, A. M., Foley, C. N., Gkatzionis, A., Jones, P. B., & Burgess, S. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0395-3 · Cited by 279 · see citing works
Yao, S., Cao, G., Han, L., Chen, Z., Huang, Z.-T., Gong, P., Hu, Y., & Xu, B. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz185 · Cited by 265 · see citing works
Jani, B., Hanlon, P., Nicholl, B. I., McQueenie, R., Gallacher, K., Lee, D., & Mair, F. S. (2019) · BMC Medicine · doi:10.1186/s12916-019-1305-x · Cited by 264 · see citing works
Rosbach, M., & Andersen, J. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179916 · Cited by 245 · see citing works
Measuring multimorbidity in research: Delphi consensus study
Ho, I., Azcoaga-Lorenzo, A., Akbari, A., Davies, J., Khunti, K. K., Kadam, U. T., Lyons, R. A., McCowan, C., Mercer, S. W., Nirantharakumar, K., et al. (2022) · BMJ Medicine · doi:10.1136/bmjmed-2022-000247 · Cited by 241 · see citing works
Multimorbidity and Risk of Mild Cognitive Impairment
Vassilaki, M. E., Aakre, J. A., Cha, R. H., Kremers, W. K., Sauver, J. L. S., Mielke, M. M., Geda, Y. E., Machulda, M. M., Knopman, D. S., Petersen, R. C., et al. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13612 · Cited by 227 · see citing works
Asogwa, O. A., Boateng, D., Marzà-Florensa, A., Peters, S., Levitt, N., van Olmen, J., & Klipstein-Grobusch, K. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-049133 · Cited by 221 · see citing works
Socioeconomic Status and Cardiovascular Disease: an Update
de Mestral, C., & Stringhini, S. (2017) · Current Cardiology Reports · doi:10.1007/s11886-017-0917-z · Cited by 219 · see citing works
A Core Outcome Set for Multimorbidity Research (COSmm)
Smith, S. M., Wallace, E., Salisbury, C., Sasseville, M., Bayliss, E. A., & Fortin, M. (2018) · The Annals of Family Medicine · doi:10.1370/afm.2178 · Cited by 218 · see citing works
Self-citationCosts of multimorbidity: a systematic review and meta-analyses
Tran, P. B., Kazibwe, J., Nikolaidis, G. F., Linnosmaa, I., Rijken, M., & van Olmen, J. (2022) · BMC Medicine · doi:10.1186/s12916-022-02427-9 · Cited by 208 · see citing works
The Association Between Multimorbidity and Quality of Life, Health Status and Functional Disability
Williams, J. S., & Egede, L. E. (2016) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2016.03.004 · Cited by 194 · see citing works
Recent Patterns of Multimorbidity Among Older Adults in High-Income Countries
Ofori‐Asenso, R., Chin, K. L., Curtis, A. J., Zomer, E., Zoungas, S., & Liew, D. (2018) · Population Health Management · doi:10.1089/pop.2018.0069 · Cited by 193 · see citing works
Patterns of Multimorbidity in Middle-Aged and Older Adults: An Analysis of the UK Biobank Data
Zemedikun, D. T., Gray, L. J., Khunti, K. K., Davies, M. J., & Dhalwani, N. N. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.02.012 · Cited by 190 · see citing works
Browne, J., Edwards, D. A., Rhodes, K. M., Brimicombe, D. J., & Payne, R. A. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-012546 · Cited by 186 · see citing works
Ho, I., Azcoaga-Lorenzo, A., Akbari, A., Davies, J., Hodgins, P., Khunti, K. K., Kadam, U. T., Lyons, R. A., McCowan, C., Mercer, S. W., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-057017 · Cited by 184 · see citing works
Social determinants of multimorbidity patterns: A systematic review
Álvarez‐Gálvez, J., Ortega‐Martin, E., Carretero-Bravo, J., Pérez-Muñoz, C., Suárez-Lledó, V., & Ramos-Fiol, B. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1081518 · Cited by 183 · see citing works
Vancampfort, D., Koyanagi, A., Ward, P. B., Rosenbaum, S., Schuch, F. B., Mugisha, J., Richards, J. A., Firth, J., & Stubbs, B. (2017) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-017-0463-5 · Cited by 181 · see citing works
Social disparities in the prevalence of multimorbidity – A register-based population study
Schiøtz, M. L., Stockmarr, A., Høst, D., Glümer, C., & Frølich, A. (2017) · BMC Public Health · doi:10.1186/s12889-017-4314-8 · Cited by 179 · see citing works
A Systematic Review of Cost-of-Illness Studies of Multimorbidity
Wang, L., Si, L., Cocker, F., Palmer, A. J., & Sanderson, K. (2018) · Applied Health Economics and Health Policy · doi:10.1007/s40258-017-0346-6 · Cited by 178 · see citing works
Association of Depression and Anxiety With the Accumulation of Chronic Conditions
Bobo, W. V., Grossardt, B. R., Virani, S., Sauver, J. L. S., Boyd, C. M., & Rocca, W. A. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.9817 · Cited by 177 · see citing works
Eyowas, F. A., Schneider, M., Asrat, B., & Ambaw, F. (2020) · Journal of Comorbidity · doi:10.1177/2235042x20961919 · Cited by 173 · see citing works
Drapkina, O. M., Васильевна, К. А., Калинина, А. М., Avdeev, S. M., Викторович, А. М., Alexandrova, L. M., Анциферова, А. А., Dm, A., Ахмеджанов, Н. М., Balanova, Y. А., et al. (2022) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2022-3235 · Cited by 172 · see citing works
Sakib, M. N., Shooshtari, S., John, P. S., & Menec, V. H. (2019) · BMC Public Health · doi:10.1186/s12889-019-6567-x · Cited by 170 · see citing works
Katikireddi, S. V., Skivington, K., Leyland, A. H., Hunt, K., & Mercer, S. W. (2017) · BMC Medicine · doi:10.1186/s12916-017-0913-6 · Cited by 169 · see citing works
Duffield, S. J., Ellis, B. M., Goodson, N., Walker-Bone, K., Conaghan, P. G., Margham, T., & Loftis, T. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2017.09.004 · Cited by 167 · see citing works
Mavaddat, N., Valderas, J. M., van der Linde, R. M., Khaw, K., & Kinmonth, A. L. (2014) · BMC Family Practice · doi:10.1186/s12875-014-0185-6 · Cited by 165 · see citing works
Self-citationHead, A., Fleming, K. M., Kypridemos, C., Schofield, P., Pearson‐Stuttard, J., & O’Flaherty, M. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00146-x · Cited by 162 · see citing works
Multimorbidity patterns in the elderly: a prospective cohort study with cluster analysis
Guisado‐Clavero, M., Roso‐Llorach, A., López‐Jiménez, T., Pons‐Vigués, M., Boreu, Q. F., Muñoz, M. Á., & Violán, C. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0705-7 · Cited by 161 · see citing works
Nunes, B. P., Batista, S. R., de Andrade, F. B., Júnior, P. R. B. D. S., Lima‐Costa, M. F., & Facchini, L. A. (2019) · Revista de Saúde Pública · doi:10.11606/s1518-8787.2018052000637 · Cited by 161 · see citing works
Mini, G., & Thankappan, K. R. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-013529 · Cited by 155 · see citing works
Prazeres, F., & Santiago, L. M. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-009287 · Cited by 154 · see citing works
Damarell, R., Morgan, D. D., & Tieman, J. (2020) · BMC Family Practice · doi:10.1186/s12875-020-01197-8 · Cited by 151 · see citing works
Willadsen, T. G., Siersma, V., Nicolaisdóttir, D., Køster‐Rasmussen, R., Jarbøl, D. E., Reventlow, S. D., Mercer, S. W., & Olivarius, N. D. F. (2018) · Journal of Comorbidity · doi:10.1177/2235042x18804063 · Cited by 150 · see citing works
Mercer, S. W., Fitzpatrick, B., Guthrie, B., Fenwick, E. A. L., Grieve, E., Lawson, K. D., Boyer, N., McConnachie, A., Lloyd, S. M., O’Brien, R., et al. (2016) · BMC Medicine · doi:10.1186/s12916-016-0634-2 · Cited by 144 · see citing works
Cezard, G. I., McHale, C., Sullivan, F., Bowles, J., & Keenan, K. L. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-048485 · Cited by 141 · see citing works
Khandaker, G. M., Zuber, V., Rees, J. M. B., Carvalho, L. A., Mason, A. M., Foley, C. N., Gkatzionis, A., Jones, P. B., & Burgess, S. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0857-7 · Cited by 139 · see citing works
Koyanagi, A., Lara, E., Stubbs, B., Carvalho, A. F., Oh, H. Y., Stickley, A., Veronese, N., & Vancampfort, D. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15288 · Cited by 131 · see citing works
du Vaure, C. B., Dechartres, A., Battin, C., Ravaud, P., & Boutron, I. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012265 · Cited by 122 · see citing works
Chamberlain, A. M., Rutten, L. J. F., Wilson, P. M., Fan, C. L., Boyd, C. M., Jacobson, D. J., Rocca, W. A., & Sauver, J. L. S. (2020) · BMC Public Health · doi:10.1186/s12889-019-8123-0 · Cited by 121 · see citing works
Multimorbidity and quality of life at mid-life: A systematic review of general population studies
Kanesarajah, J., Waller, M., Whitty, J. A., & Mishra, G. D. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.12.004 · Cited by 119 · see citing works
Multimorbidity and Patient Safety Incidents in Primary Care: A Systematic Review and Meta-Analysis
Panagioti, M., Stokes, J., Esmail, A., Coventry, P. A., Cheraghi‐Sohi, S., Alam, R., & Bower, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135947 · Cited by 119 · see citing works
de Souza, D. L. B., Oliveras-Fàbregas, A., Minobes‐Molina, E., Cancela, M. D. C., Galbany‐Estragués, P., & Jerez‐Roig, J. (2021) · BMC Public Health · doi:10.1186/s12889-020-10084-x · Cited by 118 · see citing works
Puth, M., Weckbecker, K., Schmid, M. C., & Münster, E. (2017) · BMC Public Health · doi:10.1186/s12889-017-4833-3 · Cited by 114 · see citing works
Household and area-level social determinants of multimorbidity: a systematic review
Ingram, E., Ledden, S., Beardon, S., Gomes, M., Hogarth, S., McDonald, H. I., Osborn, D., & Sheringham, J. (2020) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2020-214691 · Cited by 114 · see citing works
Stanley, J., & Sarfati, D. (2017) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2017.08.005 · Cited by 112 · see citing works
Multimorbidity in older adults: magnitude and challenges for the Brazilian health system
Nunes, B. P., Thumé, E., & Facchini, L. A. (2015) · BMC Public Health · doi:10.1186/s12889-015-2505-8 · Cited by 107 · see citing works
Alimohammadian, M., Majidi, A., Yaseri, M., Ahmadi, B., Islami, F., Derakhshan, M. H., Delavari, A., Amani, M., Feyz-Sani, A., Poustchi, H., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-013548 · Cited by 105 · see citing works
Muth, C., Uhlmann, L., Haefeli, W. E., Rochon, J., van den Akker, M., Perera, R., Güthlin, C., Beyer, M., Oswald, F., Valderas, J. M., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-017740 · Cited by 103 · see citing works
Self-citationNunes, B. P., Filho, A. D. P. C., Pati, S., Teixeira, D. S. D. C., Flores, T. R., Camargo‐Figuera, F. A., Munhoz, T. N., Thumé, E., Facchini, L. A., & Batista, S. R. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-015885 · Cited by 101 · see citing works
Patterns of Co-Occurrence of Chronic Disease Among Older Adults in Tokyo, Japan
Mitsutake, S., Ishizaki, T., Teramoto, C., Shimizu, S., & Ito, H. (2019) · Preventing Chronic Disease · doi:10.5888/pcd16.180170 · Cited by 96 · see citing works
Valabhji, J., Barron, E., Pratt, A. C., Hafezparast, N., Dunbar-Rees, R., Turner, E. B., Roberts, K., Mathews, J., Deegan, R., Cornelius, V. R., et al. (2023) · Journal of the Royal Society of Medicine · doi:10.1177/01410768231206033 · Cited by 96 · see citing works
Predicting Incident Multimorbidity
Mounce, L. T. A., Campbell, J. L., Henley, W., Arreal, M. C. T., Porter, I. H., & Valderas, J. M. (2018) · The Annals of Family Medicine · doi:10.1370/afm.2271 · Cited by 95 · see citing works
Self-citationFoy, R., Leaman, B., McCrorie, C., Petty, D. R., House, A. O., Bennett, M., Carder, P., Faulkner, S., Glidewell, L., & West, R. M. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010276 · Cited by 95 · see citing works
Lorenc, A., Feder, G. S., MacPherson, H., Little, P. S., Mercer, S. W., & Sharp, D. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-020222 · Cited by 94 · see citing works
Storeng, S. H., Vinjerui, K. H., Sund, E. R., & Krokstad, S. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-1425-3 · Cited by 92 · see citing works
Inacio, M. C., Lang, C., Bray, S. C. E., Visvanathan, R., Whitehead, C., Griffith, E. C., Evans, K., Corlis, M., & Wesselingh, S. (2021) · Internal Medicine Journal · doi:10.1111/imj.14871 · Cited by 91 · see citing works
Kaluvu, L. M., Asogwa, O. A., Florensa, A. M., Kyobutungi, C. K., Levitt, N. S., Boateng, D., & Klipstein‐Grobusch, K. (2022) · Journal of Multimorbidity and Comorbidity · doi:10.1177/26335565221112593 · Cited by 91 · see citing works
Terwee, C. B., Crins, M. H. P., Boers, M., de Vet, H. C. W., & Roorda, L. D. (2018) · Quality of Life Research · doi:10.1007/s11136-018-1995-0 · Cited by 90 · see citing works
Multimorbidity patterns with K-means nonhierarchical cluster analysis
Violán, C., Roso‐Llorach, A., Boreu, Q. F., Guisado‐Clavero, M., Pons‐Vigués, M., Ribera, E. P., & Valderas, J. M. (2018) · BMC Family Practice · doi:10.1186/s12875-018-0790-x · Cited by 88 · see citing works
Self-citationKastner, M., Hayden, L., Wong, G., Lai, Y., Makarski, J., Treister, V., Chan, J., Lee, J. H., Ivers, N. M., Holroyd-Leduc, J. M., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025009 · Cited by 87 · see citing works
Measuring multimorbidity in older adults: comparing different data sources
Guerra, S. G., Berbiche, D., & Vasiliadis, H. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1173-4 · Cited by 87 · see citing works
Griffith, L. E., Gruneir, A., Fisher, K., Panjwani, D., Gandhi, S., Li, S., Gafni, A., Patterson, C., Markle‐Reid, M., & Ploeg, J. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0351-x · Cited by 86 · see citing works
Which patients miss appointments with general practice and the reasons why: a systematic review
Parsons, J., Bryce, C., & Atherton, H. (2021) · British Journal of General Practice · doi:10.3399/bjgp.2020.1017 · Cited by 86 · see citing works
Musaeus, C. S., Gleerup, H. S., Høgh, P., Waldemar, G., Hasselbalch, S. G., & Simonsen, A. H. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200168 · Cited by 85 · see citing works
Dogra, S., Copeland, J. L., Altenburg, T. M., Heyland, D. K., Owen, N. G., & Dunstan, D. W. (2021) · Patient Education and Counseling · doi:10.1016/j.pec.2021.09.019 · Cited by 85 · see citing works
Mounce, L. T. A., Price, S. J., Valderas, J. M., & Hamilton, W. T. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.127 · Cited by 84 · see citing works
Self-citationAtherton, H., Brant, H., Ziébland, S., Bikker, A., Campbell, J., Gibson, A., McKinstry, B., Porqueddu, T., & Salisbury, C. (2018) · Health Services and Delivery Research · doi:10.3310/hsdr06200 · Cited by 83 · see citing works
Self-citationChronic Pain and Sleep Disorders in Primary Care
Jank, R., Gallee, A., Boeckle, M., Fiegl, S., & Pieh, C. (2017) · Pain Research and Treatment · doi:10.1155/2017/9081802 · Cited by 83 · see citing works
Hussain, M. A., Huxley, R., & Mamun, A. A. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-009810 · Cited by 82 · see citing works
Sindi, S., Pérez, L. M., Vetrano, D. L., Triolo, F., Kåreholt, I., Sjöberg, L., Darin‐Mattsson, A., Kivipelto, M., Inzitari, M., & Calderón‐Larrañaga, A. (2020) · BMC Medicine · doi:10.1186/s12916-020-01846-w · Cited by 81 · see citing works
Pasanen, T., Tolvanen, S., Heinonen, A. O., & Kujala, U. M. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-097132 · Cited by 81 · see citing works
Frailty profile in Brazilian older adults
Andrade, J. M., Duarte, Y. A. D. O., Alves, L. C., Andrade, F. C. D., Júnior, P. R. B. D. S., Lima‐Costa, M. F., & de Andrade, F. B. (2019) · Revista de Saúde Pública · doi:10.11606/s1518-8787.2018052000616 · Cited by 81 · see citing works
Sennfält, S., Pihlsgård, M., Petersson, J., Norrving, B. G., & Ullberg, T. (2019) · European Stroke Journal · doi:10.1177/2396987319883154 · Cited by 80 · see citing works
Relationships of Multimorbidity and Income With Hospital Admissions in 3 Health Care Systems
Wang, H., Wang, J. J., Lawson, K. D., Wong, S. Y. S., Wong, M. C. S., Li, F. J., Wang, P., Zhou, Z. H., Zhu, C. Y., Yeong, Y. Q., et al. (2015) · The Annals of Family Medicine · doi:10.1370/afm.1757 · Cited by 79 · see citing works
Chen, H., Cheng, M., Zhuang, Y., & Broad, J. (2018) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13510 · Cited by 79 · see citing works
The Neural Mechanisms of Meditative Practices: Novel Approaches for Healthy Aging
Acevedo, B. P., Pospos, S., & Lavretsky, H. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0098-x · Cited by 78 · see citing works
de Souza, D. L. B., Oliveras-Fàbregas, A., Espelt, A., Bosque‐Prous, M., Cancela, M. D. C., Teixidó‐Compañó, E., & Jerez‐Roig, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246623 · Cited by 78 · see citing works
Prevalência e fatores associados a multimorbidades em idosos brasileiros
de Melo, L. A., & de Lima, K. C. (2020) · Ciência & Saúde Coletiva · doi:10.1590/1413-812320202510.34492018 · Cited by 76 · see citing works
Srivastava, S., Joseph, V. J. K., Dristhi, D., & Muhammad, T. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-050245 · Cited by 76 · see citing works
Multimorbidity, Function, and Cognition in Aging
Kadambi, S. G., Abdallah, M. M., & Loh, K. P. (2020) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2020.06.002 · Cited by 76 · see citing works
- Authors
- Violan, C., Foguet-Boreu, Q., Flores-Mateo, G., Salisbury, C., Blom, J., Freitag, M., Glynn, L., Muth, C., & Valderas, J. M.
- Affiliations
- University of Bristol (GB)
- Leiden University Medical Center (NL)
- Jena University Hospital (DE)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Goethe University Frankfurt (DE)
- Corresponding author
- Salisbury, Chris
- Blom, Jeanet
- Freitag, Michael
- Glynn, Liam
- Muth, Christiane
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-07-21
- Volume
- 9
- Issue
- 7
- Pages
- e102149
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4105594
- OpenAlex
- W2080696239
- Cited by
- 1,125
- References
- 59
- Citations by year
- 2026: 69 · 2025: 80 · 2024: 101 · 2023: 137 · 2022: 151 · 2021: 163 · 2020: 116 · 2019: 102 · 2018: 72 · 2017: 56 · 2016: 40 · 2015: 35 · 2014: 3
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open Research Exeter (University of Exeter) (publishedVersion, other-oa)
- Explore Bristol Research (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Figshare (submittedVersion, cc-by-nc-sa)
- Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by)
- University of Limerick Institutional Repository (University of Limerick) (submittedVersion, cc-by-nc-sa)
- Funders
- National Institute for Health and Care Research (NIHR/CS/010/024)
- Ministerio de Ciencia e Innovación
- Topics
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Health Sciences › Health Professions › General Health Professions › Primary Care and Health Outcomes
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- multimorbidity, prevalence, primary care, socioeconomic status, age, gender differences, mental illness, osteoarthritis, cardiovascular conditions, metabolic disorders
- MeSH terms
- Age Factors, Female, Humans, Male, Primary Health Care, Quality of Life, Sex Factors, Socioeconomic Factors, Comorbidity, Prevalence, Observational Studies as Topic
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