The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antidepressant and Risk of Dementia: Confounding by Indication
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Integrity signals
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Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Depression itself can be a risk factor for dementia.
“while depression itself can be a risk factor for dementia, making separating the drug effect from depression severity challenging [15].”
From Association between first-line antidepressant use and risk of dementia in older adults: a retrospective cohort study (2023) · cites this paper as [15]
Patients taking antidepressants are likely to suffer from more severe depression than nonusers.
“That is, patients taking antidepressants are likely to suffer from more severe depression than nonusers, while depression itself can be a risk factor for dementia, making separating the drug effect from depression severity challenging [15].”
From Association between first-line antidepressant use and risk of dementia in older adults: a retrospective cohort study (2023) · cites this paper as [15]
Prior studies are limited by only comparing antidepressant exposure with no exposure, which may be subject to confounding by indication and severity.
“Prior studies are limited by only comparing antidepressant exposure with no exposure, which may be subject to confounding by indication and severity [15].”
From Association between first-line antidepressant use and risk of dementia in older adults: a retrospective cohort study (2023) · cites this paper as [15]
This work is the first to compare first-line antidepressants (SSRI/SNRI) to an active comparator (psychotherapy) to reduce confounding by indication instead of comparing antidepressant use to no use in prior studies.
“We certify that this work is novel. This work is the first to compare first-line antidepressants (i.e., SSRI/SNRI) to an active comparator (i.e., psychotherapy) to reduce confounding by indication instead of comparing antidepressant use to no use in prior studies.”
From Association between first-line antidepressant use and risk of dementia in older adults: a retrospective cohort study (2023) · cites this paper as [15]
Citations
Cites
Chan, J. Y. C., Yiu, K. K. L., Kwok, T. C. Y., Wong, S. Y. S., & Tsoi, K. K. F. (2019) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.12.004 · Cited by 135
Flagged first, then by citations
Research works printed but not linked: 6
- Livingston, 2017, Dementia prevention, intervention, and care, Lancet, 390, 2673, 10.1016/S0140-6736(17)31363-6 · DOI · Paper page
- Kyriacou, 2016, Confounding by indication in clinical research, JAMA, 316, 1818, 10.1001/jama.2016.16435 · DOI · Paper page
- Wei, 2005, Use of psychotherapy for depression in older adults, Am J Psychiatry, 162, 711, 10.1176/appi.ajp.162.4.711 · DOI
- Loeb, 2012, Association of treatment modality for depression and burden of comorbid chronic illness in a nationally representative sample in the United States, Gen Hosp Psychiatry, 34, 588, 10.1016/j.genhosppsych.2012.07.004 · DOI
- Kessing, 2012, Depression and the risk for dementia, Curr Opin Psychiatry, 25, 457, 10.1097/YCO.0b013e328356c368 · DOI
- Liew, 2018, Comparative efficacy and acceptability of interventions for major depression in older persons: Protocol for Bayesian network meta-analysis, BMJ Open, 8, e019819, 10.1136/bmjopen-2017-019819 · DOI
Cited by
Sorted by citations
Wang, G. H.-M., Chen, W.-H., Chang, S.-H., Zhang, T., Shao, H., Guo, J., & Lo-Ciganic, W.-H. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04475-z · Cited by 13
Metadata
- Authors
- Liew, T. M.
- Affiliations
- National University of Singapore (SG)
- Corresponding author
- Liew, Tau Ming
- ORCID
- Liew, Tau Ming
- Venue
- Journal of the American Medical Directors Association
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 20
- Issue
- 7
- Pages
- 920-922
- ISSN
- 1525-8610 (ISSN-L)
- OpenAlex
- W2947150571
- Cited by
- 8
- References
- 1
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 2
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Medical Directors Association (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- antidepressants, dementia risk, depression, confounding by indication, confounding adjustment, dementia prevention, benefit-risk balance, observational study limitations, spurious association, confounder selection
- MeSH terms
- Antidepressive Agents, Dementia, Depression, Humans, Longitudinal Studies, Risk Factors
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