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Cited by 135Dementia and Cognitive Impairment ResearchTreatment of Major DepressionPharmaceutical Practices and Patient Outcomes

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Depression and Antidepressants as Potential Risk Factors in Dementia: A Systematic Review and Meta-analysis of 18 Longitudinal Studies

Chan, Joyce Y.C., Yiu, Karen K.L., Kwok, Timothy C.Y., Wong, Samuel Y.S., Tsoi, Kelvin K.F.·2019·Journal of the American Medical Directors Association
DOI 10.1016/j.jamda.2018.12.004
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Abstract

OBJECTIVE To investigate whether depression and/or antidepressants can be a potential risk factor for the development of dementia and mild cognitive impairment (MCI). DESIGN Systematic review and meta-analysis of longitudinal studies. SETTING AND PARTICIPANTS Community or clinical settings. Participants included patients with depression, antidepressant users, and the general population. MEASURES Longitudinal studies evaluating the risks of dementia or MCI in patients with depression and/or antidepressant users were identified from the OVID database. The outcomes were the number of patients who developed dementia or MCI among the antidepressant users and nonusers. Relative risk (RR) with 95% confidence interval (95% CI) was used to evaluate the association between the use of antidepressants and the risk of dementia and MCI. Meta-analysis was used for combining the effect sizes of individual studies, and the heterogeneity test was performed. Risk of bias and reporting quality of included studies was assessed. Subgroup analyses were conducted for different types of antidepressants. RESULTS A total of 18 studies with 2,119,627 participants with mean age ranging from 55 to 81 years were included. Among patients with depression, antidepressant users showed a significantly higher risk of dementia (RR = 1.37, 95% CI = 1.11-1.70) and MCI (RR = 1.20, 95% CI = 1.02-1.42) than the nonusers. Besides, patients with depression who used antidepressants and who did not use antidepressants also showed significantly higher risk of dementia than the general population (RR = 1.50, 95% CI = 1.26-1.78, and RR = 1.31, 95% CI = 1.15-1.51, respectively). CONCLUSIONS/IMPLICATIONS Patients with depression are associated with a higher risk of dementia, and the use of antidepressants is not shown to be a protective factor of dementia. Further large-scale trials are required for investigation of the benefit-risk ratio between depression relapse and dementia when prescribing antidepressants.

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Crossref · 10.1016/j.jamda.2018.12.004

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Metadata

Authors
Chan, J. Y. C., Yiu, K. K. L., Kwok, T. C. Y., Wong, S. Y. S., & Tsoi, K. K. F.
Affiliations
Chinese University of Hong Kong (HK)
Corresponding author
Tsoi, Kelvin K.F.
ORCID
Venue
Journal of the American Medical Directors Association
Publisher
Elsevier BV
Published
2019-03
Volume
20
Issue
3
Pages
279-286.e1
ISSN
1525-8610 (ISSN-L)
DOI
10.1016/j.jamda.2018.12.004
OpenAlex
W2912770458
Semantic Scholar
7b75f2d9b1ae82094bea681b1bbf0a3fbdc8a2b8
Cited by
135
References
43
Citations by year
2026: 12 · 2025: 15 · 2024: 16 · 2023: 53 · 2022: 9 · 2021: 11 · 2020: 16 · 2019: 3
FWCI
1.39
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of the American Medical Directors Association (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
depression, antidepressants, dementia risk, mild cognitive impairment, antidepressant safety, depression relapse, dementia risk factors
MeSH terms
Aged, Aged, 80 and over, Antidepressive Agents, Dementia, Depression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors

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