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Cited by 269Fatty Acid Research and HealthInflammatory mediators and NSAID effectsNutritional Studies and Diet

The DOI matches its Crossref record; 82 of the 85 references it cites were found in a registry or an index.

Effect of Dietary Linoleic Acid on Markers of Inflammation in Healthy Persons: A Systematic Review of Randomized Controlled Trials

Johnson, Guy H., Fritsche, Kevin·2012·Journal of the Academy of Nutrition and Dietetics
DOI 10.1016/j.jand.2012.03.029
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Abstract

The majority of evidence suggests that n-6 polyunsaturated fatty acids, including linoleic acid (LA), reduce the risk of cardiovascular disease as reflected by current dietary recommendations. However, concern has been expressed that a high intake of dietary n-6 polyunsaturated fatty acid contributes to excess chronic inflammation, primarily by prompting the synthesis of proinflammatory eicosanoids derived from arachidonic acid and/or inhibiting the synthesis of anti-inflammatory eicosanoids from eicosapentaenoic and/or docosahexaenoic acids. A systematic review of randomized controlled trials that permitted the assessment of dietary LA on biologic markers of chronic inflammation among healthy noninfant populations was conducted to examine this concern. A search of the English- and non-English-language literature using MEDLINE, the Cochrane Controlled Trials Register, and EMBASE was conducted to identify relevant articles. Fifteen studies (eight parallel and seven crossover) met inclusion criteria. None of the studies reported significant findings for a wide variety of inflammatory markers, including C-reactive protein, fibrinogen, plasminogen activator inhibitor type 1, cytokines, soluble vascular adhesion molecules, or tumor necrosis factor-α. The only significant outcome measures reported for higher LA intakes were greater excretion of prostaglandin E2 and lower excretion of 2,3-dinor-thromboxane B(2) in one study and higher excretion of tetranorprostanedioic acid in another. However, the authors of those studies both observed that these effects were not an indication of increased inflammation. We conclude that virtually no evidence is available from randomized, controlled intervention studies among healthy, noninfant human beings to show that addition of LA to the diet increases the concentration of inflammatory markers.

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  1. Junker, 2001, Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system, Throm Haemost, 280
  2. Schulz, 1995, Empirical evidence of bias, JAMA, 273, 408, 10.1001/jama.273.5.408 · DOI
  3. Minihane, 2005, Lack of effect of dietary n-6:n-3 PUFA ratio on plasma lipids and markers of insulin responses in Indian Asians living in the UK, Eur J Nutr, 44, 26, 10.1007/s00394-004-0488-9 · DOI

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Metadata

Authors
Johnson, G. H., & Fritsche, K.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Johnson, Guy H.
ORCID
Venue
Journal of the Academy of Nutrition and Dietetics
Publisher
Elsevier BV
Published
2012-07
Volume
112
Issue
7
Pages
1029-1041.e15
ISSN
2212-2672 (ISSN-L)
DOI
10.1016/j.jand.2012.03.029
OpenAlex
W2116488160
Cited by
268
References
85
Citations by year
2026: 28 · 2025: 15 · 2024: 17 · 2023: 15 · 2022: 12 · 2021: 16 · 2020: 22 · 2019: 15 · 2018: 15 · 2017: 20 · 2016: 23 · 2015: 26 · 2014: 24 · 2013: 18 · 2012: 1
FWCI
2.73
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the Academy of Nutrition and Dietetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
linoleic acid, omega-6 fatty acids, chronic inflammation, inflammatory markers, eicosanoids, prostaglandin E2, thromboxane B2, C-reactive protein, fibrinogen, plasminogen activator inhibitor-1, cytokines, TNF-α, dietary fatty acid supplementation, cardiovascular risk
MeSH terms
C-Reactive Protein, Dietary Fats, Unsaturated, Fibrinogen, Humans, Inflammation, Tumor Necrosis Factor-alpha, Biomarkers, Randomized Controlled Trials as Topic, Cytokines, Plasminogen Activator Inhibitor 1, Linoleic Acid

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