The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Autoinflammatory and autoimmune conditions at the crossroad of COVID-19
Open accessAbstract
Coronavirus disease 2019 (COVID-19) has been categorized as evolving in overlapping phases. First, there is a viral phase that may well be asymptomatic or mild in the majority, perhaps 80% of patients. The pathophysiological mechanisms resulting in minimal disease in this initial phase are not well known. In the remaining 20% of cases, the disease may become severe and/or critical. In most patients of this latter group, there is a phase characterized by the hyperresponsiveness of the immune system. A third phase corresponds to a state of hypercoagulability. Finally, in the fourth stage organ injury and failure occur. Appearance of autoinflammatory/autoimmune phenomena in patients with COVID-19 calls attention for the development of new strategies for the management of life-threatening conditions in critically ill patients. Antiphospholipid syndrome, autoimmune cytopenia, Guillain-Barré syndrome and Kawasaki disease have each been reported in patients with COVID-19. Here we present a scoping review of the relevant immunological findings in COVID-19 as well as the current reports about autoinflammatory/autoimmune conditions associated with the disease. These observations have crucial therapeutic implications since immunomodulatory drugs are at present the most likely best candidates for COVID-19 therapy. Clinicians should be aware of these conditions in patients with COVID-19, and these observations should be considered in the current development of vaccines.
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1 retracted
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Metadata
- Authors
- Rodríguez, Y., Novelli, L., Rojas, M., De Santis, M., Acosta-Ampudia, Y., Monsalve, D. M., Ramírez-Santana, C., Costanzo, A., Ridgway, W. M., Ansari, A. A., Gershwin, M. E., Selmi, C., & Anaya, J.-M.
- Venue
- Journal of Autoimmunity
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 114
- Pages
- 102506
- ISSN
- 0896-8411 (ISSN-L)
- OpenAlex
- W3034241701
- Cited by
- 312
- References
- 173
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Rodríguez, Y., Novelli, L., Rojas, M., De Santis, M., Acosta-Ampudia, Y., Monsalve, D. M., Ramírez-Santana, C., Costanzo, A., Ridgway, W. M., Ansari, A. A., Gershwin, M. E., Selmi, C., & Anaya, J.-M. (2020). Autoinflammatory and autoimmune conditions at the crossroad of COVID-19. Journal of Autoimmunity. https://doi.org/10.1016/j.jaut.2020.102506
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