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Cited by 312

The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.

Autoinflammatory and autoimmune conditions at the crossroad of COVID-19

Open access
Rodríguez, Yhojan, Novelli, Lucia, Rojas, Manuel, De Santis, Maria, Acosta-Ampudia, Yeny, Monsalve, Diana M., Ramírez-Santana, Carolina, Costanzo, Antonio, Ridgway, William M., Ansari, Aftab A., Gershwin, M. Eric, Selmi, Carlo, Anaya, Juan-Manuel·2020·Journal of Autoimmunity

Abstract

Coronavirus disease 2019 (COVID-19) has been categorized as evolving in overlapping phases. First, there is a viral phase that may well be asymptomatic or mild in the majority, perhaps 80% of patients. The pathophysiological mechanisms resulting in minimal disease in this initial phase are not well known. In the remaining 20% of cases, the disease may become severe and/or critical. In most patients of this latter group, there is a phase characterized by the hyperresponsiveness of the immune system. A third phase corresponds to a state of hypercoagulability. Finally, in the fourth stage organ injury and failure occur. Appearance of autoinflammatory/autoimmune phenomena in patients with COVID-19 calls attention for the development of new strategies for the management of life-threatening conditions in critically ill patients. Antiphospholipid syndrome, autoimmune cytopenia, Guillain-Barré syndrome and Kawasaki disease have each been reported in patients with COVID-19. Here we present a scoping review of the relevant immunological findings in COVID-19 as well as the current reports about autoinflammatory/autoimmune conditions associated with the disease. These observations have crucial therapeutic implications since immunomodulatory drugs are at present the most likely best candidates for COVID-19 therapy. Clinicians should be aware of these conditions in patients with COVID-19, and these observations should be considered in the current development of vaccines.

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Metadata

Authors
Rodríguez, Y., Novelli, L., Rojas, M., De Santis, M., Acosta-Ampudia, Y., Monsalve, D. M., Ramírez-Santana, C., Costanzo, A., Ridgway, W. M., Ansari, A. A., Gershwin, M. E., Selmi, C., & Anaya, J.-M.
Venue
Journal of Autoimmunity
Publisher
Elsevier BV
Published
2020-11
Volume
114
Pages
102506
ISSN
0896-8411 (ISSN-L)
OpenAlex
W3034241701
Cited by
312
References
173
FWCI
8.45
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Autoinflammatory and autoimmune conditions at the crossroad of COVID-19. https://app.cochat.ai/papers/10.1016/j.jaut.2020.102506
The paper
Rodríguez, Y., Novelli, L., Rojas, M., De Santis, M., Acosta-Ampudia, Y., Monsalve, D. M., Ramírez-Santana, C., Costanzo, A., Ridgway, W. M., Ansari, A. A., Gershwin, M. E., Selmi, C., & Anaya, J.-M. (2020). Autoinflammatory and autoimmune conditions at the crossroad of COVID-19. Journal of Autoimmunity. https://doi.org/10.1016/j.jaut.2020.102506

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.