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Insights into how JIP3 and JIP4 adaptor proteins relieve the auto-inhibited form of the kinesin-1 motor
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Alternative adaptor mechanisms on lysosomes for kinesins include the scaffolds JIP3 and JIP4.
“Alternative adaptor mechanisms on lysosomes for kinesins have been described, among the scaffolds c-Jun NH2-terminal kinase (JNK)-interacting protein 3 (JIP3) and JIP4 (Vilela et al., 2026;Watt et al., 2015).”
From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Vilela et al., 2026
JIP3 can induce kinesin activity in vitro.
“Accordingly, JIP3 (a paralog of JIP4) can induce kinesin activity in vitro (Vilela et al., 2026;Watt et al., 2015), and JIP3/4 can also activate dynein (Cason and Holzbaur, 2023).”
From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Vilela et al., 2026
Binding of either dynein or kinesin-1 to JIPs is not exclusive and is non-competitive.
“Binding of either dynein or kinesin-1 to JIPs is not exclusive and is non-competitive (Vilela et al., 2026).”
From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Vilela et al., 2026
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Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
Johansson, M., Rocha, N., Zwart, W., Jordens, I., Janssen, L., Kuijl, C., Olkkonen, V. M., & Neefjes, J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606077 · Cited by 505
Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3
Kelkar, N., Gupta, S., Dickens, M., & Davis, R. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1030-1043.2000 · Cited by 281
Willett, R., Martina, J. A., Zewe, J. P., Wills, R., Hammond, G. R. V., & Puertollano, R. (2017) · Nature Communications · doi:10.1038/s41467-017-01871-z · Cited by 201
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Cited by
Sorted by citations
TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles
Rudnik, S., Li, C. H., Gottschling, D.-C., Veh, A., Barbosa, D. J., Richter, J., Stroobants, S., Schuster, B., Beck, I. M., Sedlack, R., et al. (2026) · doi:10.64898/2026.10.27.762112
Metadata
- Authors
- Vilela, F., Chenon, M., Campanacci, V., Alik, A., Velours, C., Andreani, J., Llinas, P., & Ménétrey, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2026-09
- Volume
- 302
- Issue
- 9
- Pages
- 113355
- ISSN
- 0021-9258
- PMC
- PMC13499124
- Cited by
- 2
- References
- 4
- Language
- en
- Licence
- Funders
- French National Research Agency
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