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JIP3 Activates Kinesin-1 Motility to Promote Axon Elongation

Watt, Dana, Dixit, Ram, Cavalli, Valeria·2015·Journal of Biological Chemistry
DOI 10.1074/jbc.m115.651885
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Crossref · 10.1074/jbc.m115.651885

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  • Alternative adaptor mechanisms on lysosomes for kinesins include the scaffolds JIP3 and JIP4.

    “Alternative adaptor mechanisms on lysosomes for kinesins have been described, among the scaffolds c-Jun NH2-terminal kinase (JNK)-interacting protein 3 (JIP3) and JIP4 (Vilela et al., 2026;Watt et al., 2015).”

    From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Watt et al., 2015

    The Discussion (page not available) shows that the scaffold JIP3 activates kinesin-1 motility through interactions with its light and heavy chains. Our copy does not establish this mechanism on lysosomes or describe JIP4 as a kinesin adaptor; lysosomes appear in the title of a cited work in the References, not in this paper’s reported findings. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • JIP3 can induce kinesin activity in vitro.

    “Accordingly, JIP3 (a paralog of JIP4) can induce kinesin activity in vitro (Vilela et al., 2026;Watt et al., 2015), and JIP3/4 can also activate dynein (Cason and Holzbaur, 2023).”

    From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Watt et al., 2015

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Research works printed but not linked: 73

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Cited by

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Metadata

Authors
Watt, D., Dixit, R., & Cavalli, V.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2015-06
Volume
290
Issue
25
Pages
15512-15525
ISSN
0021-9258
DOI
10.1074/jbc.m115.651885
Cited by
46
References
5
Language
en
Licence
Funders
National Institutes of Health (R01 NS082446)

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