Significance of source and size in the mechanical response of human cerebral blood vessels
Abstract
Cerebral blood vessels are frequently damaged in traumatic brain injury. Mechanical properties of fresh human cerebral vessels obtained through surgeries have been reported. Because surgical sources of human specimens are rare and produce a limited amount of material, we sought to compare the properties of more readily available cerebral arteries and veins obtained from cadavers to fresh vessel data. Additionally, because the previous study was limited to small vessels available in surgery, it was unknown how generally applicable the results were to larger cerebral arteries and veins. In the current study, large and small cerebral vessels from autopsy were stretched axially. Data from these and similar tests on fresh vessels were combined to determine the significance of source and size on mechanical properties. Structural comparisons of histological samples were additionally utilized to characterize differences. Results indicate that specimens from autopsy and surgery behave similarly except that vessels from autopsy tend to be less extensible. While tests on large vessels were limited, small arteries obtained from autopsy tended to be slightly stiffer than large arteries. In contrast, bridging veins from cadavers were typically stiffer and stretched less before structural failure than cortical veins from the same source. These effects are, however, secondary to differences identified between arteries and veins in the previous study.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Smaller peripheral vessels, such as the radial artery, exhibit similar mechanical behaviors to larger vessels like the aorta, carotid artery, and large coronary arteries.
“The mechanics of large vessels such as the aorta, carotid artery, and large coronary arteries has been studied extensively39–44 but several authors have noted that smaller peripheral vessels, such as the one under study here, exhibit similar mechanical behaviors to larger ones45,46.”
From Synthetic photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to body mass index (BMI) (2021) · cites this paper as [45]
Cites
Trends in death associated with traumatic brain injury, 1979 through 1992. Success and failure
Sosin, D. M. (1995) · JAMA · doi:10.1001/jama.273.22.1778 · Cited by 289 · see citing works
The Cranial Arachnoid and Pia Mater in Man: Anatomical and Ultrastructural Observations
Alcolado, R., Weller, R. O., Parrish, E. P., & Garrod, D. R. (1988) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1988.tb00862.x · Cited by 251 · see citing works
Why do bridging veins rupture into the virtual subdural space?
Yamashima, T., & Friede, R. L. (1984) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.47.2.121 · Cited by 216 · see citing works
Axial Mechanical Properties of Fresh Human Cerebral Blood Vessels
Monson, K. L., Goldsmith, W., Barbaro, N. M., et al. (2003) · Journal of Biomechanical Engineering · doi:10.1115/1.1554412 · Cited by 184 · see citing works
Self-citationLee, M.-C., & Haut, R. C. (1989) · Journal of Biomechanics · doi:10.1016/0021-9290(89)90005-5 · Cited by 159 · see citing works
Comparison of the Elastic Properties of Human Intracranial Arteries and Aneurysms
Scott, S., Ferguson, G. G., & Roach, M. R. (1972) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y72-049 · Cited by 156 · see citing works
Bandak, F. A., & Eppinger, R. H. (1994) · SAE technical papers on CD-ROM/SAE technical paper series · doi:10.4271/942215 · Cited by 149 · see citing works
Computational Study of the Contribution of the Vasculature on the Dynamic Response of the Brain
Zhang, L., Bae, J., Hardy, W. N., et al. (2002) · SAE technical papers on CD-ROM/SAE technical paper series · doi:10.4271/2002-22-0008 · Cited by 84 · see citing works
Epidemiology of Mild Brain Injury
Kraus, J. F., McArthur, D. L., & Silberman, T. (1994) · Seminars in Neurology · doi:10.1055/s-2008-1041052 · Cited by 71 · see citing works
THE EFFECT OF AGE ON THE ELASTICITY OF THE MAJOR BRAIN ARTERIES
Busby, D. E., & Burton, A. C. (1965) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y65-018 · Cited by 60 · see citing works
Biomechanical Properties of Porcine Cerebral Bridging Veins with Reference to the Zero-Stress State
Pang, Q., Lu, X., Gregersen, H. N., et al. (2001) · Journal of Vascular Research · doi:10.1159/000051033 · Cited by 32 · see citing works
The Effects of Cryopreservation on the Biaxial Mechanical Properties of Canine Saphenous Veins
Brossollet, L. J., & Vito, R. P. (1997) · Journal of Biomechanical Engineering · doi:10.1115/1.2796059 · Cited by 31 · see citing works
Gentner, J. M., Wentrup‐Byrne, E., Walker, P. J., et al. (1998) · PubMed · Cited by 15 · see citing works
Mechanical Characteristics of Vascular Tissue and Their Role in Brain Injury Modeling: A Review
Vossoughi, J., & Bandak, F. A. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.755 · Cited by 10 · see citing works
The Response of Unembalmed Cadaveric and Living Cerebral Vessels to Graded Injury-A Pilot Study
Smith, R. W. (1979) · SAE technical papers on CD-ROM/SAE technical paper series · doi:10.4271/791021 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Boonya-ananta, T., Rodriguez, A. J., Ajmal, A., Du Le, V. N., Hansen, A. K., Hutcheson, J. D., & Ramella-Roman, J. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-82124-4 · Cited by 70 · see citing works
- Authors
- Monson, K. L., Goldsmith, W., Barbaro, N. M., & Manley, G. T.
- Affiliations
- University of California, San Francisco (US)
- University of California, Berkeley (US)
- Corresponding author
- Monson, Kenneth L.
- ORCID
- Monson, Kenneth L.
- Venue
- Journal of Biomechanics
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 38
- Issue
- 4
- Pages
- 737-744
- ISSN
- 0021-9290 (ISSN-L)
- OpenAlex
- W2044988747
- Cited by
- 124
- References
- 15
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 10 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 10 · 2013: 7 · 2012: 12
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomechanics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention (R49 CCR919722-01)
- University of California, San Francisco
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- cerebral vasculature, mechanical properties, traumatic brain injury, vessel size, axial stretching, extensibility, stiffness, arteries, veins, cortical veins, bridging veins, histological structure, structural failure
- MeSH terms
- Adult, Aged, Autopsy, Biomechanical Phenomena, Cadaver, Cerebral Arteries, Cerebral Veins, Elasticity, Female, Humans, Male, Middle Aged, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
