Coronary artery and thoracic calcium on noncontrast thoracic CT scans: Comparison of ungated and gated examinations in patients from the COPD Gene cohort
Open accessAbstract
Objective Coronary artery calcification (CAC) and thoracic aortic calcification, (TAC) are frequently detected on ungated multidetector computed tomography (MDCT) performed for lung evaluations. We sought to evaluate concordance of CAC and TAC scores on ungated (thoracic) and electrocardiogaphically (ECG)-gated (cardiac) MDCT scans. Methods Fifty patients, enrolled in the Genetic Epidemiology of COPD study (COPDGene), were recruited to undergo gated CAC scans with 64-detector row CT, in addition to the ungated thoracic studies already being obtained as part of their study evaluation. Coronary and thoracic calcium were measured similarly (Agatston score, requiring 3 contiguous voxels of >130 Hounsfield units) with low-dose ungated studies and ECG-gated MDCT performed at the same scanning session. Intertechnique scoring variability and concordance were calculated. Results Correlations between gated and ungated CAC and TAC were excellent (r = 0.96). The relative differences (median variability) measured by ECG-gated versus ungated MDCT were relatively high for CAC (44%) but not for TAC (8%). Prevalence of depicted CAC (n = 33; 66%) and TAC (n = 21; 42%) were coincident between ECG-gated and ungated MDCT, respectively (intertechnique concordance, 100%). Bland-Altman plots for CAC showed mean differences of 354 (confidence interval, 169-538) and 16.1 (confidence interval, -89 to 121). Conclusion Low-dose ungated MDCT is reliable for prediction of the presence of CAC and assessment of Agatston score. Concordance between methods and between TAC and CAC is high. This technique should allow for atherosclerotic disease risk stratification among patients undergoing ungated lung CT evaluation without requiring additional scanning. Measurement of TAC is almost as accurate from gated CT, and CAC scores are highly concordant.
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Calcium scores on non-gated CT have reasonably good agreement with dedicated calcium scoring CT.
“despite the fact that calcium scores on non-gated CT have reasonably good agreement with dedicated calcium scoring CT30,31.”
From Deep convolutional neural networks to predict cardiovascular risk from computed tomography (2021) · cites this paper as [31]
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Research works printed but not linked: 14
- [1]Brenner DJ Hall EJ Computed tomography — An increasing source of radiation exposure N Engl J Med 2007 357 2277 2284 18046031
- [2]Greenland P Bonow RO Brundage BH Budoff MJ Eisenberg MJ Grundy SM Lauer MS Post WS Raggi P Redberg RF Rodgers GP Shaw LJ Taylor AJ Weintraub WS Harrington RA Abrams J Anderson JL Bates ER Eisenberg MJ Grines CL Hlatky MA Lichtenberg RC Lindner JR Pohost GM Schofield RS Shubrooks SJ Jr Stein JH Tracy CM Vogel RA Wesley DJ Coronary artery calcium scoring: ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain J Am Coll Cardiol 2007 49 378 402 17239724
- [3]Budoff MJ Shaw LJ Liu ST Weinstein SR Mosler TP Tseng PH Flores FR Callister TQ Raggi P Berman DS Long-Term Prognosis Associated With Coronary Calcification: Observations From a Registry of 25,253 Patients J Am Coll Cardiol 2007 49 1860 1870 17481445
- [4]Greenland P Alpert JS Beller GA Benjamin EJ Budoff MJ Fayad ZA Foster E Hlatky MA Hodgson JMcB Kushner FG Lauer MS Shaw LJ Smith SC Jr Taylor AJ Weintraub WS Wenger NK 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults: Executive Summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol xx xxx xxx 21098427
- [5]Budoff MJ Achenbach S Blumenthal RS Carr JJ Goldin JG Greenland P Guerci AD Lima JAC Rader DJ Rubin GD Shaw LJ Wiegers SE Assessment of Coronary Artery Disease by Cardiac Computed Tomography, A Scientific Statement From the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology Circulation 2006 114 16 1761 91 17015792
- [6]Kim SM Chung MJ Lee KS Choe YH Yi CA Choe BK Coronary Calcium Screening Using Low-Dose Lung Cancer Screening: Effectiveness of MDCT with Retrospective Reconstruction AJR 2008 190 917 922 18356437
- [7]Regan EA Hokanson JE Murphy JR Make B Lynch DA Beaty TH Curran-Everett D Silverman EK Crapo JD Genetic epidemiology of COPD (COPDGene) study design COPD 2010 7 1 32 43 20214461 PMC2924193
- [8]Santos RD Rumberger JA Budoff MJ Shaw LJ Orakzai SH Berman D Raggi P Blumenthal RS Nasir K Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality Atherosclerosis 2010 209 1 131 5 19782363
- [9]Takasu J Katz R Shavelle DM O’Brien K Mao S Carr JJ Cushman M Budoff MJ Inflammation and descending thoracic aortic calcification as detected by computed tomography: The Multi-Ethnic Study of Atherosclerosis Atherosclerosis 2008 199 201 206 18191862
- [10]Takasu J Budoff MJ O’Brien KD Shavelle DM Probstfield JL Carr JJ Katz R Relationship between coronary artery and descending thoracic aortic calcification as detected by computed tomography: The Multi-Ethnic Study of Atherosclerosis Atherosclerosis 2009 204 2 440 6 19027115 PMC2732017
- [11]Takasu J Katz R Nasir K Carr JJ Wong N Detrano R Budoff MJ Relationships of thoracic aortic wall calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis Am Heart J 2008 155 765 771 18371491 PMC2323597
- [12]Wu MT Yang P Huang YL Chen JS Chuo CC Yeh C Chang RS Coronary Arterial Calcification on Low-Dose Ungated MDCT for Lung Cancer Screening: Concordance Study with Dedicated Cardiac CT AJR 2008 190 923 928 18356438
- [13]Shemesh J Henschke CI Shaham D Ordinal Scoring of Coronary Artery Calcifications on Low-Dose CT Scans of the Chest is Predictive of Death from Cardiovascular Disease Radiology 2010 257 541 548 20829542
- [14]Manser R Dalton A Carter R Byrnes G Elwood M Campbell DA Cost-effectiveness analysis of screening for lung cancer with low dose spiral CT (computed tomography) in the Australian setting Lung Cancer 2005 48 171 185 15829317
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- Authors
- Budoff, M. J., Nasir, K., Kinney, G. L., Hokanson, J. E., Barr, R. G., Steiner, R., Nath, H., Lopez-Garcia, C., Black-Shinn, J., & Casaburi, R.
- Affiliations
- The Lundquist Institute (US)
- Columbia University (US)
- Temple University (US)
- University of Alabama at Birmingham (US)
- Corresponding author
- Budoff, Matthew J.
- ORCID
- Venue
- Journal of Cardiovascular Computed Tomography
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 5
- Issue
- 2
- Pages
- 113-118
- ISSN
- 1876-861X (ISSN-L)
- 1934-5925
- PMC
- PMC3075464
- OpenAlex
- W2046095585
- Cited by
- 228
- References
- 0
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 20 · 2023: 12 · 2022: 17 · 2021: 24 · 2020: 16 · 2019: 18 · 2018: 21 · 2017: 19 · 2016: 13 · 2015: 19 · 2014: 11 · 2013: 9 · 2012: 2
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of cardiovascular computed tomography (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL071739, U01HL089856, U01HL089897)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Medical Imaging and Pathology Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Keywords
- coronary artery calcification, thoracic aortic calcification, ECG-gated CT, Agatston score, chronic obstructive pulmonary disease, atherosclerosis, low-dose CT, COPDGene
- MeSH terms
- Aorta, Thoracic, Aortic Diseases, Calcinosis, Coronary Artery Disease, Electrocardiography, Female, Humans, Male, Predictive Value of Tests, Radiography, Thoracic, Tomography, X-Ray Computed, Chi-Square Distribution, Molecular Epidemiology, Risk Assessment, Pulmonary Disease, Chronic Obstructive
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