The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression
Open accessAbstract
Background Pseudomonas aeruginosa with mutations in the transcriptional regulator LasR chronically infect the airways of people with cystic fibrosis (CF), yet the prevalence and clinical implications of lasR mutant infection are unknown. Methods In an exploratory study, we screened 166 P. aeruginosa isolates from 58 CF patients for LasR inactivation and mucoidy, and compared clinical characteristics among source patients. Results lasR mutation prevalence was comparable to that of mucoidy, the best-described CF-adapted phenotype, but affected patients were on average approximately 2 years younger. In a regression analysis, lung function decline with age was worse among patients with lasR mutant infection than in those without, similar to the effect of mucoidy. Conclusions Culture positivity for lasR mutant P. aeruginosa may serve as a marker of early CF adaptive change of prognostic significance. Furthermore, as LasR inactivation alters susceptibility to antibiotics, infection with lasR mutant P. aeruginosa may impact response to therapy.
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“lasR variants are common in CF airways and can maintain or restructure QS-controlled pathways, which supports chronic infection [59,63].”
From Understanding Pseudomonas aeruginosa Biofilms: Quorum Sensing, c-di-GMP Signaling, and Emerging Antibiofilm Approaches (2026) · cites this paper as [63]
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“Increased fitness of lasR mutants has been observed in the presence of specific amino acids, low oxygen levels, high nitrogen levels, alkaline stress and antibiotics, all conditions characteristic of cystic fibrosis infections60–65.”
From Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility (2025) · cites this paper as [65]
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Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia
Govan, J. R. W., & Deretic, V. P. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.3.539-574.1996 · Cited by 1,812
Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis
Gibson, R. L., Burns, J. L., & Ramsey, B. W. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200304-505so · Cited by 1,633
Self-citationAttenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors
Hentzer, M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg366 · Cited by 1,422
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
Smith, E. E., Buckley, D. G., Wu, Z., Saenphimmachak, C., Hoffman, L. R., D’Argenio, D. A., Miller, S. I., Ramsey, B. W., Speert, D. P., Moskowitz, S. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602138103 · Cited by 1,319
Self-citationLongitudinal Assessment of Pseudomonas aeruginosa in Young Children with Cystic Fibrosis
Burns, J. L., Gibson, R. L., McNamara, S., Yim, D., Emerson, J., Rosenfeld, M., Hiatt, P., McCoy, K., Castile, R., Smith, A. L., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/318075 · Cited by 555
Self-citationBjarnsholt, T., Jensen, P. Ø., Burmølle, M., Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, C., Molin, S., et al. (2005) · Microbiology · doi:10.1099/mic.0.27463-0 · Cited by 500
D'Argenio, D. A., Wu, M., Hoffman, L. R., Kulasekara, H. D., Déziel, E., Smith, E. E., Nguyen, H., Ernst, R. K., Larson Freeman, T. J., Spencer, D. H., et al. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05678.x · Cited by 342
Self-citationSmith, A. L., Fiel, S. B., Mayer-Hamblett, N., Ramsey, B., & Burns, J. L. (2003) · Chest · doi:10.1378/chest.123.5.1495 · Cited by 307
Self-citationBurns, J. L., Van Dalfsen, J. M., Shawar, R. M., Otto, K. L., Garber, R. L., Quan, J. M., Montgomery, A. B., Albers, G. M., Ramsey, B. W., & Smith, A. L. (1999) · The Journal of Infectious Diseases · doi:10.1086/314727 · Cited by 289
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Cited by
Quorum sensing signal-response systems in Gram-negative bacteria
Papenfort, K., & Bassler, B. L. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.89 · Cited by 2,256
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Moradali, M. F., Ghods, S., & Rehm, B. H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00039 · Cited by 1,537
Progress in and promise of bacterial quorum sensing research
Whiteley, M., Diggle, S. P., & Greenberg, E. P. (2017) · Nature · doi:10.1038/nature24624 · Cited by 1,285
Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors
Jurado-Martín, I., Sainz-Mejías, M., & McClean, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063128 · Cited by 698
Mulcahy, L. R., Burns, J. L., Lory, S., & Lewis, K. (2010) · Journal of Bacteriology · doi:10.1128/jb.01651-09 · Cited by 631
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Metadata
- Authors
- Hoffman, L. R., Kulasekara, H. D., Emerson, J., Houston, L. S., Burns, J. L., Ramsey, B. W., & Miller, S. I.
- Venue
- Journal of Cystic Fibrosis
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 8
- Issue
- 1
- Pages
- 66-70
- ISSN
- 1569-1993 (ISSN-L)
- OpenAlex
- W2108862719
- Cited by
- 301
- References
- 21
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hoffman, L. R., Kulasekara, H. D., Emerson, J., Houston, L. S., Burns, J. L., Ramsey, B. W., & Miller, S. I. (2009). Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression. Journal of Cystic Fibrosis. https://doi.org/10.1016/j.jcf.2008.09.006
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