Transferrin modified ruthenium nanoparticles with good biocompatibility for photothermal tumor therapy
Abstract
In the past two decades, there were various kinds of photothermal agents being synthesised and investigated for their photothermal effect in antitumor applications. However, it is barely reported that the photothermal effect of Ruthenium (Ru) nanoparticles was researched in depth. In this work, we introduced Ru nanoparticles which possess excellent biocompatibility and metabolize easily to the photothermal therapy field. In addition, to improve the cells capacity of absorbing Ru nanoparticles, these Ru nanoparticles were modified by transferrin (Tf-RuNPs). Subsequently, as is expected, the RuNPs exhibit a remarkably integrated and high-quality photothermal property. On the other hand, it is significantly that Tf modification could also strengthen the cells absorptive ability to uptake Ru nanoparticles through endocytosis., Furthermore, both the in vitro cell ablation and in vivo tumor treatment verified that the Tf-RuNPs became ideal photothermal agents for photothermal tumor ablation therapy owing to their low toxicity and high cell destruction capability.
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Transferrin-coupled or covalently linked nanoparticles endow NPs function of targeting tumors, more effectively realize active targeting of drugs, and achieve tumor diagnosis or treatment.
“More studies have also proved that transferrin-coupled or covalently linked nanoparticles endow the NPs function of targeting tumors, which can more effectively realize the active targeting of drugs and achieve the purpose of tumor diagnosis or treatment.272–275”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [273]
Cites
Gold nanostructures: engineering their plasmonic properties for biomedical applications
Hu, M., Chen, J., Li, Z., Au, L., Hartland, G. V., Li, X. D., Márquez, M., & Younan Xia, A. (2006) · Chemical Society Reviews · doi:10.1039/b517615h · Cited by 1,758 · see citing works
Freestanding palladium nanosheets with plasmonic and catalytic properties
Huang, X., Tang, S., Mu, X., Dai, Y., Chen, G., Zhou, Z., Ruan, F., Yang, Z., & Zheng, N. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.235 · Cited by 1,602 · see citing works
Pathways and mechanisms of endocytic recycling
Grant, B. D., & Donaldson, J. G. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2755 · Cited by 1,468 · see citing works
Au nanoparticles target cancer
Jain, P. K., El‐Sayed, I. H., & El‐Sayed, M. A. (2007) · Nano Today · doi:10.1016/s1748-0132(07)70016-6 · Cited by 1,153 · see citing works
Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway
Qian, Z., Li, H., Sun, H., & Ho, K. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.4.561 · Cited by 1,021 · see citing works
Alkilany, A. M., Thompson, L. B., Boulos, S. P., Sisco, P. N., & Murphy, C. J. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.03.005 · Cited by 806 · see citing works
In Vivo Near-Infrared Mediated Tumor Destruction by Photothermal Effect of Carbon Nanotubes
Moon, H. K., Lee, S. H., & Choi, H. C. (2009) · ACS Nano · doi:10.1021/nn900904h · Cited by 796 · see citing works
Sheng, Z., Hu, D., Zheng, M., Zhao, P., Liu, H., Gao, D., Gong, P., Gao, G., Zhang, P., Ma, Y., et al. (2014) · ACS Nano · doi:10.1021/nn5062386 · Cited by 719 · see citing works
Gold Nanocages as Photothermal Transducers for Cancer Treatment
Chen, J., Glaus, C., Laforest, R. A., Zhang, Q., Miao-xian, Y., Gidding, M., Welch, M. J., & Younan Xia, A. (2010) · Small · doi:10.1002/smll.200902216 · Cited by 694 · see citing works
Gold Nanocages: Engineering Their Structure for Biomedical Applications
Chen, J., Wiley, B. J., Li, Z., et al. (2005) · Advanced Materials · doi:10.1002/adma.200500833 · Cited by 592 · see citing works
pH-Induced Aggregation of Gold Nanoparticles for Photothermal Cancer Therapy
Nam, J., Won, N., Jin, H., Chung, H., & Kim, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja902062j · Cited by 542 · see citing works
Guo, L., Yan, D. D., Yang, D., et al. (2014) · ACS Nano · doi:10.1021/nn5002112 · Cited by 532 · see citing works
Yuan, H., Fales, A. M., & Vo‐Dinh, T. (2012) · Journal of the American Chemical Society · doi:10.1021/ja304180y · Cited by 525 · see citing works
Near‐Infrared Light‐Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles
Yang, X., Liu, X., Liu, Z., Pu, F., Ren, J., & Qu, X. (2012) · Advanced Materials · doi:10.1002/adma.201104797 · Cited by 424 · see citing works
The effect of surface functionality on cellular trafficking of dendrimers
Perumal, O., Inapagolla, R., Kannan, S., & Kannan, R. M. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.038 · Cited by 379 · see citing works
Lee, J., Lee, K., Moon, S. H., Lee, Y., Park, T. G., & Cheon, J. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805998 · Cited by 369 · see citing works
Wang, J., Tian, S., Petros, R. A., Napier, M. E., & DeSimone, J. M. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1043177 · Cited by 333 · see citing works
Dong, K., Liu, Z., Li, Z., Ren, J., & Qu, X. (2013) · Advanced Materials · doi:10.1002/adma.201301232 · Cited by 326 · see citing works
Lee, Y., Lee, H., Kim, Y. B., Kim, J., Hyeon, T., Park, H., Messersmith, P. B., & Park, T. G. (2008) · Advanced Materials · doi:10.1002/adma.200800756 · Cited by 322 · see citing works
Multifunctional Mesoporous Silica Nanoparticles for Cancer‐Targeted and Controlled Drug Delivery
Zhang, Q., Liu, F., Nguyen, K. T., Ma, X., Wang, X., Xing, B., & Zhao, Y. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201201316 · Cited by 321 · see citing works
Zenke, M., Steinlein, P., Wagner, E., Cotten, M. L., Beug, H., & Birnstiel, M. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3655 · Cited by 272 · see citing works
Yang, Y., Liu, F., Liu, X., & Xing, B. (2013) · Nanoscale · doi:10.1039/c2nr32835f · Cited by 229 · see citing works
Cui, Y., Dong, H., Cai, X., Wang, D., & Li, Y. (2012) · ACS Applied Materials & Interfaces · doi:10.1021/am3005225 · Cited by 198 · see citing works
Qhattal, H. S. S., Hye, T., Alali, A. S., & Liu, X. (2014) · ACS Nano · doi:10.1021/nn405839n · Cited by 175 · see citing works
Xiao, J., Fan, S.-X., Wang, F. R., Sun, L., Zheng, X.-Y., & Yan, C. (2014) · Nanoscale · doi:10.1039/c3nr06843a · Cited by 163 · see citing works
Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy
Zhang, H., Wu, H., Wang, J., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.11.055 · Cited by 154 · see citing works
Zhang, F., Jiang, Y. L., Liu, X., Meng, J., Zhang, P., Liu, H., Gao, Y., Li, G., Jiang, L., Wan, L., et al. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b04731 · Cited by 134 · see citing works
Sun, D., Liu, Y., Yu, Q., Qin, X., Yang, L., Zhou, Y., Chen, L., & Liu, J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.007 · Cited by 126 · see citing works
Self-citationMultifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy
Shen, J., Kim, H., Mu, C., Gentile, E., Mai, J., Wolfram, J., Ji, L., Mauro Ferrari, B., Mao, Z., & Shen, H. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400103 · Cited by 108 · see citing works
Understanding of the major reactions in solution synthesis of functional nanomaterials
Wu, Y. S., Wang, D. S., & Li, Y. (2016) · Science China Materials · doi:10.1007/s40843-016-5112-0 · Cited by 104 · see citing works
Prior, R., Reifenberger, G., & Wechsler, W. (1990) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01600299 · Cited by 85 · see citing works
Lee, J., Lee, K., Moon, S. H., Lee, Y., Park, T. G., & Cheon, J. (2009) · Angewandte Chemie · doi:10.1002/ange.200805998 · Cited by 69 · see citing works
Yhee, J. Y., Lee, S. J., Lee, S., Song, S.-Y., Min, H. S., Kang, S., Son, S., Jeong, S. Y., Kwon, I. C., Kim, S. H., et al. (2013) · Bioconjugate Chemistry · doi:10.1021/bc400226b · Cited by 68 · see citing works
Mesoporous carbon biomaterials
Chen, Y., & Shi, J. (2015) · Science China Materials · doi:10.1007/s40843-015-0037-2 · Cited by 65 · see citing works
Shao, Q., Li, X., Hua, P., et al. (2016) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2016.09.067 · Cited by 63 · see citing works
Zhen, M., Shu, C., Li, J., Zhang, G., Wang, T., Luo, Y., Zou, T., Deng, R., Fang, F., Lei, H. C., et al. (2015) · Science China Materials · doi:10.1007/s40843-015-0089-3 · Cited by 54 · see citing works
Wang, W., Cui, H., Zhang, P., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b01147 · Cited by 51 · see citing works
Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles
Cheng, Q., Shi, H., Huang, H., et al. (2015) · Chemical Communications · doi:10.1039/c5cc07853a · Cited by 49 · see citing works
Near-infrared (NIR) controlled reversible cell adhesion on a responsive nano-biointerface
Cui, H., Zhang, P., Wang, W., Li, G., Hao, Y., Wang, L., & Wang, S. (2017) · Nano Research · doi:10.1007/s12274-017-1446-1 · Cited by 44 · see citing works
Zhao, S., Ma, L., Cao, C., Yu, Q., Chen, L., & Liu, J. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s123190 · Cited by 43 · see citing works
Self-citationMou, J., Chen, Y., Ma, M., et al. (2015) · Science China Materials · doi:10.1007/s40843-015-0044-3 · Cited by 25 · see citing works
Du, X., Li, Z., Liu, Y., et al. (2015) · Dalton Transactions · doi:10.1039/c5dt01682g · Cited by 22 · see citing works
Rapid Cell Patterning Induced by Differential Topography on Silica Nanofractal Substrates
Li, G., Gao, Y., Zhang, P., Li, Y., Meng, J., Liu, H., & Wang, S. (2015) · Small · doi:10.1002/smll.201502085 · Cited by 16 · see citing works
Li, Z., Zhu, L. H., Liu, Q., et al. (2013) · Nanoscale Research Letters · doi:10.1186/1556-276x-8-435 · Cited by 3 · see citing works
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
- Authors
- Zhao, S., Zhu, X., Cao, C., Sun, J., & Liu, J.
- Affiliations
- Jinan University (CN)
- Corresponding author
- Liu, Jie
- Venue
- Journal of Colloid and Interface Science
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 511
- Pages
- 325-334
- ISSN
- 0021-9797 (ISSN-L)
- OpenAlex
- W2762810435
- Cited by
- 54
- References
- 45
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 5 · 2021: 11 · 2020: 4 · 2019: 6 · 2018: 7
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Colloid and Interface Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21171070, 21371075)
- Natural Science Foundation of Guangdong Province (2014A030311025)
- Planned Item of Science and Technology of Guangdong Province (2016A020217011)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Keywords
- ruthenium nanoparticles, photothermal therapy, tumor ablation, biocompatibility, endocytosis, nanoparticle uptake, photothermal agents, nanoparticle toxicity
- MeSH terms
- A549 Cells, Animals, Humans, Hyperthermia, Induced, Male, Neoplasms, Experimental, Phototherapy, Ruthenium, Transferrin, Mice, SCID, Coated Materials, Biocompatible, Xenograft Model Antitumor Assays, Mice, Metal Nanoparticles, HEK293 Cells
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