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Stimuli-responsive charge-reversal MOF@polymer hybrid nanocomposites for enhanced co-delivery of chemotherapeutics towards combination therapy of multidrug-resistant cancer

Hu, Liefeng, Xiong, Chuxiao, Wei, Gaohui, Yu, Yunhao, Li, Sihui, Xiong, Xiaoxing, Zou, Jun-Jie, Tian, Jian·2022·Journal of Colloid and Interface Science
DOI 10.1016/j.jcis.2021.10.070
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Abstract

Combination chemotherapy is a promising strategy for cancer treatment in clinics especially when multidrug-resistant cancer is emerging. One significant challenge remains in achieving sufficient multi-drug delivery into tumor cells to maximize the synergetic therapeutic effect, as it is hard to concentrate drugs in drug-resistant cancer. Therefore herein, metal-organic framework (MOF)-based polymer-coated hybrid nanoparticles (NPs) were devised and constructed for the co-delivery of doxorubicin and cisplatin to enhance combination therapy of multidrug-resistant cancer. The MOF@polymer nanocarrier combined the merits of high multi-drug loading capacity, physiological stability, and tumor microenvironment pH-responsiveness, facilitating simultaneous delivery of drugs into cancer cells and making the most of synergistic antitumor effect. Remarkably, this hybrid nanocarrier maintains a negative surface charge during circulation to guarantee a stable and prolonged process in vivo, and then exposes inner positive MOF after degradation of the outer polymer in the acidic tumor microenvironment to promote multi-drug release, cellular internalization, nuclear localization, and tumor penetration. In vitro and in vivo studies with drug-resistant MCF-7/ADR cancer suggested that the nanocarrier could achieve increased accumulation of drugs in solid tumors, remarkable tumor elimination results as well as minimized side effects, indicating an improved efficacy and safety of combination chemo…

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Metadata

Authors
Hu, L., Xiong, C., Wei, G., Yu, Y., Li, S., Xiong, X., Zou, J.-J., & Tian, J.
Venue
Journal of Colloid and Interface Science
Publisher
Elsevier BV
Published
2022-02
Volume
608
Pages
1882-1893
ISSN
0021-9797
DOI
10.1016/j.jcis.2021.10.070
Cited by
78
References
0
Language
en
Licence
Funders
  • State Key Laboratory of Bioelectronics
  • Fundamental Research Funds for the Central Universities (2042017kf0186)
  • National Natural Science Foundation of China (NSFC 21601140, 21871214)
  • Southeast University

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CoChat. (2026). Citation check: Stimuli-responsive charge-reversal MOF@polymer hybrid nanocomposites for enhanced co-delivery of chemotherapeutics towards combination therapy of multidrug-resistant cancer. https://app.cochat.ai/papers/10.1016/j.jcis.2021.10.070
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Hu, L., Xiong, C., Wei, G., Yu, Y., Li, S., Xiong, X., Zou, J.-J., & Tian, J. (2022). Stimuli-responsive charge-reversal MOF@polymer hybrid nanocomposites for enhanced co-delivery of chemotherapeutics towards combination therapy of multidrug-resistant cancer. Journal of Colloid and Interface Science. https://doi.org/10.1016/j.jcis.2021.10.070