Systematic review on costs and resource use of randomized clinical trials shows a lack of transparent and comprehensive data

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Budgeting of non-commercial clinical trials: development of a budget tool by a public funding agency

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Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications

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Resource use, costs, and approval times for planning and preparing a randomized clinical trial before and after the implementation of the new Swiss human research legislation

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Morphology Instruction in the Science Classroom for Students Who Are Deaf: A Multiple Probe Across Content Analysis

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Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project

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Characteristics, Progression, and Output of Randomized Platform Trials

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Coronary Artery Calcium to Improve the Efficiency of Randomized Controlled Trials in Primary Cardiovascular Prevention

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The PCORnet Blood Pressure Control Laboratory

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Cost-effectiveness of surgical treatment of thumb carpometacarpal joint arthritis: a value of information study

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Evidence Supports a Causal Model for Vitamin D in COVID-19 OutcomesPreprint

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Behavioural interventions designed to increase commuter cycling: A systematic review

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Endoscopic Procedures for Weight Loss

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Site-specific factors associated with clinical trial recruitment efficiency in general practice settings: a comparative descriptive analysis

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Composite outcome measures in high-impact critical care randomised controlled trials: a systematic review

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Maxillary sinus lift augmentation: A randomized clinical trial with histological data comparing deproteinized bovine bone grafting vs graftless procedure with a 5–12‐year follow‐up

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Programmatic Costs of the Telehealth Ostomy Self-Management Training: An Application of Time-Driven Activity-Based Costing

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Using the Barthel Index and modified Rankin Scale as Outcome Measures for Stroke Rehabilitation Trials; A Comparison of Minimum Sample Size Requirements

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Recommendations in the design and conduction of randomised controlled trials in human and veterinary homeopathic medicine

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LatenSeer

Zhang, Y., Isaacs, R., Yue, Y., Yang, J., Zhang, L., & Vigfússon, Ý. (2023) · ACM Symposium on Cloud Computing (SoCC) · doi:10.1145/3620678.3624787 · Cited by 13 · see citing works

Practical guidance for planning resources required to support publicly-funded adaptive clinical trials

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Resource use and costs of investigator-sponsored randomized clinical trials in Switzerland, Germany, and the United Kingdom: a metaresearch study

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A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna®

Speich, B., Chammartin, F., Smith, D. C., Stoeckle, M. P., Amico, P., Eichenberger, A. L., Hasse, B. K., Schuurmans, M. M., Müller, T., Tamm, M., et al. (2021) · Trials · doi:10.1186/s13063-021-05664-0 · Cited by 12 · see citing works

Are randomized controlled trials in urology being conducted with justification?

Shepard, S., Wise, A., Johnson, B. S., Sajjadi, N. B., Hartwell, M. L., & Vassar, M. B. (2021) · Journal of Osteopathic Medicine · doi:10.1515/jom-2021-0078 · Cited by 11 · see citing works

Systematic Review of Randomized Controlled Trials in Australian Nursing Homes from 2000 to 2018

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Describing, Evaluating, and Exploring Barriers to Adoption of Virtual Reality: An International Modified Delphi Consensus Study Involving Clinicians, Educators, and Industry Professionals

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Approaches to multiplicity in publicly funded pragmatic randomised controlled trials: a survey of clinical trials units and a rapid review of published trials

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A systematic review identifying common data items in neonatal trials and assessing their completeness in routinely recorded United Kingdom national neonatal data

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Is there resource wastage in the research for spinal diseases? An observational analysis of discontinuation and non-publication in randomised controlled trials

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Costing a population health management approach for participant recruitment to a diabetes prevention study

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Time distribution for pharmacists conducting a randomized controlled trial—An observational time and motion study

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Cannabis for Neuropathic Pain in Multiple Sclerosis—High Expectations, Poor Data

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COVID-19, equipoise and observational studies: a reminder of forgotten issues

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“And then I found $5”: Optimizing recruitment efficiency in remote clinical trials

Fahey, M. C., Dahne, J., Chen, B., Smith, T. T., Wahlquist, A. E., & Carpenter, M. J. (2023) · Journal of Clinical and Translational Science · doi:10.1017/cts.2023.533 · Cited by 8 · see citing works

The use of healthcare systems data for RCTs

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Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience

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Attitudes About Artificially Intelligent Interactive Voice Response Systems Using Amazon Alexa in Cardiovascular Clinics: Insights from the VOICE-COVID-19 Study

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Characterizing atrial fibrillation symptom improvement following de novo catheter ablation

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Emulation of the control cohort of a randomized controlled trial in pediatric kidney transplantation with Real-World Data from the CERTAIN Registry

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The Impact of Senior Author Profile on Publication Level of Evidence in Plastic and Reconstructive Surgery

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Reporting of post-protocol therapies in metastatic breast cancer registration clinical trials: A systematic review

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Participant Recruitment From Low- and Middle-Income Countries for Pivotal Trials of Drugs Approved by the U.S. Food and Drug Administration

Awan, F. A., Becker, A. B., Wang, Y., & Kimmelman, J. (2022) · Annals of Internal Medicine · doi:10.7326/m22-1857 · Cited by 6 · see citing works

Research methodology: the Bayesian statistical framework and the future of trial design

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Cost-effectiveness analysis of recruitment strategies in a large diabetes prevention trial conducted across two sites in Sydney, Australia

Bessell, E., Markovic, T., Caterson, I. D., Hendy, C., Burk, J., Picone, T., & Fuller, N. R. (2023) · Contemporary Clinical Trials · doi:10.1016/j.cct.2023.107421 · Cited by 5 · see citing works

A methodological review identified several options for utilizing registries for randomized controlled trials

Urban, L., Haller, N., Pieper, D., & Mathes, T. (2024) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2024.111614 · Cited by 5 · see citing works

Evidenz der Wirksamkeit und Sicherheit von Cannabispräparaten bei chronischen Schmerzen

Häuser, W., & Petzke, F. W. (2019) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-019-02966-2 · Cited by 6 · see citing works

Investigational medicinal products, related costs and hospital pharmacy services for investigator-initiated trials: A mixed-methods study

Heravi, A. T., Henn, A., Deuster, S., McLennan, S., Gloy, V., Mitter, V. R., Briel, M., & for the MAking Randomized Trials Affordable (MARTA) Group (2022) · PLoS ONE · doi:10.1371/journal.pone.0264427 · Cited by 5 · see citing works

Decision architecture randomisation: extremely efficient clinical trials that preserve clinician and patient choice?

Flory, J., Ancker, J. S., Kim, S. Y. H., Kuperman, G. J., & Vickers, A. J. (2023) · BMJ Evidence-Based Medicine · doi:10.1136/bmjebm-2023-112386 · Cited by 5 · see citing works

Evaluating registry-based trial economics: Results from the STRESS clinical trial

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Ethics of Pharma Clinical Trials in the Era of Precision Oncology

Turner, J. H. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2020.4129 · Cited by 5 · see citing works

How much did it cost to develop and implement an eHealth intervention for a minority children population that overlapped with the COVID-19 pandemic?

Monashefsky, A., Alon, D., Baranowski, T., Barreira, T. V., Chiu, K., Fleischman, A., Green, M. C., Huang, S. H., Samuels, R. C., Sousa, C. V., et al. (2022) · Contemporary Clinical Trials · doi:10.1016/j.cct.2022.107044 · Cited by 5 · see citing works

A Randomized Case Series Approach to Testing Efficacy of Interventions for Minimally Verbal Autistic Children

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Investigator-initiated versus industry-sponsored trials – visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT)

Hecht, M., Blümle, A., Binder, H., Schumacher, M. C., & Binder, N. (2025) · BMC Medical Research Methodology · doi:10.1186/s12874-025-02535-z · Cited by 4 · see citing works

Vedolizumab and Adalimumab in Biologic-Naïve Ulcerative Colitis: Comparison of Patient-Level Clinical Trial Data and VARSITY for Week 6 Clinical Remission

Narula, N., Wong, E. C. L., Dulai, P. S., Marshall, J. K., Jairath, V., & Reinisch, W. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-07825-4 · Cited by 4 · see citing works

Do single‐case experimental designs lead to randomised controlled trials of cognitive behavioural therapy interventions for adolescent anxiety and related disorders recommended in the National Institute of Clinical Excellence guidelines? A systematic review

Cawthorne, T., Käll, A., Bennett, S. D., Baker, E., Cheung, E. Y., & Shafran, R. (2023) · JCPP Advances · doi:10.1002/jcv2.12181 · Cited by 4 · see citing works

The cost of emulated target trials: Is real‐world data cheaper than randomized studies?

Barosa, M., & Prasad, V. K. (2025) · European Journal of Clinical Investigation · doi:10.1111/eci.70035 · Cited by 4 · see citing works

Closing the cycle of innovation in healthcare in Europe

Hulstaert, F., Ruether, A., Demotes‐Mainard, J., & Melien, Ø. (2020) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462319003532 · Cited by 4 · see citing works

Recruitment and enrollment of participants in an online diabetes self-management intervention in a virtual environment

Vorderstrasse, A. A., Reagan, L., Melkus, G. D., Nowlin, S. Y., Birdsall, S. B., Burd, A., Cho, Y. H., Jang, M., & Johnson, C. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106399 · Cited by 4 · see citing works

Designing and Implementing “Living and Breathing” Clinical Trials

Horvat, C. M., King, A. J., & Huang, D. T. (2023) · Critical Care Clinics · doi:10.1016/j.ccc.2023.02.002 · Cited by 4 · see citing works

Personalized nutrition: from science to consumer

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Accuracy of heart failure ascertainment using routinely collected healthcare data: a systematic review and meta-analysis

Goonasekera, M. A., Offer, A. R., Karsan, W., El-Nayir, M., Mallorie, A. E., Parish, S., Haynes, R., & Mafham, M. M. (2024) · Systematic Reviews · doi:10.1186/s13643-024-02477-5 · Cited by 4 · see citing works

WOUND MANAGEMENT, HEALING, AND EARLY PROSTHETIC REHABILITATION: PART 1 - A SCOPING REVIEW OF HEALING AND NON-HEALING DEFINITIONS

Williams-Reid, H., Johannesson, A. G., & Buis, A. W. P. (2024) · Canadian Prosthetics & Orthotics Journal · doi:10.33137/cpoj.v7i2.43715 · Cited by 4 · see citing works

Pragmatic Clinical Trials—Ready for Prime Time?

Rifai, M. A., Itchhaporia, D., & Virani, S. S. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.40212 · Cited by 4 · see citing works

Choosing the right antihypertensive drug to avoid intradialytic hypotension

Zoccali, C., Tripepi, G. L., Mallamaci, F., Usvyat, L. S., Maddux, F. W., & Stuard, S. (2025) · Clinical Kidney Journal · doi:10.1093/ckj/sfaf315 · Cited by 3 · see citing works

Intervention research in anorexia nervosa – a plea for single case experimental designs

Melles, H., Lemmens, L. H. J. M., & Jansen, A. T. M. (2025) · Eating Disorders · doi:10.1080/10640266.2025.2471218 · Cited by 3 · see citing works

Cost analysis of the TB-PRACTECAL clinical trial on novel tuberculosis treatment regimens

Gotham, D., Martin, M., Barber, M., Kazounis, E., Batts, C., Scourse, R., Elder, G., & Nyang’wa, B.-T. (2025) · PLOS Global Public Health · doi:10.1371/journal.pgph.0003759 · Cited by 3 · see citing works

Contribution of countries to main neurosurgical journals with particular emphasis on turkey

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Effectiveness and cost analysis of methods used to recruit older adult sedative users to a deprescribing randomized controlled trial during the COVID-19 pandemic

Murphy, A. L., Turner, J. P., Rajda, M., Allen, K. G., Pinter, K., & Gardner, D. M. (2022) · Exploratory Research in Clinical and Social Pharmacy · doi:10.1016/j.rcsop.2022.100214 · Cited by 3 · see citing works

Gaps in evidence on treatment of male osteoporosis: a Research Agenda

Rose, A. J., Greenspan, S. L., & Jasuja, G. K. (2023) · The Aging Male · doi:10.1080/13685538.2023.2223699 · Cited by 3 · see citing works

Use of Evidence-Based Research Approach in RCTs of Acupuncture-Related Therapies for Primary Dysmenorrhea: A Meta-Research

Hu, X.-Y., Tian, Z., Chen, H., Xiang-yu, H., Ming, T., Peng, H.-X., Jiao, R., Shi, L.-J., Xiu, W.-C., Yang, J., et al. (2023) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-023-3711-3 · Cited by 3 · see citing works

Common misconceptions of randomized controlled trials in oncology

Powell, K., & Prasad, V. K. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13832 · Cited by 3 · see citing works

Predicting Success of Phase III Trials in OncologyPreprint

Hegge, S. J., Thunecke, M., Krings, M., Ruedin, L., Mueller, J. S., & von Bünau, P. (2020) · medRxiv · doi:10.1101/2020.12.15.20248240 · Cited by 3 · see citing works

The role of national population-based registries in pancreatic cancer surgery research

Jonas, E., & Kloppers, C. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001405 · Cited by 2 · see citing works

Systematic Review of Surgical Site Infection Prevention Guideline Recommendations for Maintenance of Homeostasis in the Perioperative Period

Couteur, J. L., Druce, P., Myles, P. S., & Peel, T. N. (2025) · Anesthesiology · doi:10.1097/aln.0000000000005438 · Cited by 2 · see citing works

Success and cost-effectiveness of strategies to recruit older adults to a behavioral intervention research study

Nelson, E., Hand, L. K., Glaser, A., Lewandowski, T., Burns, J. M., Phadnis, M. A., Bruce, J. M., & Siengsukon, C. F. (2025) · Contemporary Clinical Trials · doi:10.1016/j.cct.2025.108010 · Cited by 2 · see citing works

Embedding randomised controlled trials in renal registries

Caskey, F. J., Jardine, T., & Davids, M. R. (2019) · African Journal of Nephrology · doi:10.21804/22-1-3766 · Cited by 2 · see citing works

Improving Prostate Cancer Care through Quality Assurance Programs

Veerman, H., Hagens, M. J., Vis, A. N., van Moorselaar, R. J. A., van Leeuwen, P. J., Wouters, M. W. J. M., & van der Poel, H. G. (2022) · Exon Publications eBooks · doi:10.36255/exon-publications-urologic-cancers-prostate-cancer-care · Cited by 2 · see citing works

Randomised controlled trials in women’s health in the last two decades: A meta-review

Nielsen, J., Sleaby, R., Kumarakurusingham, E., & Mol, B. W. (2022) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2022.09.001 · Cited by 2 · see citing works

InterSynth: A Semi-Synthetic Framework for Benchmarking Prescriptive Inference from Observational Data

Giles, D., Gray, R., Foulon, C., Pombo, G., Xu, T., Ruffle, J. K., Jäger, H. R., Cardoso, M. J., Sebastien Ourselin, A., Rees, G. E., et al. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-47679-2_13 · Cited by 1 · see citing works

Bending pharmaceutical science: epistemic diversity and regulation

Beyermann, J. (2025) · Synthese · doi:10.1007/s11229-024-04910-7 · Cited by 1 · see citing works

REVERSE model: a novel approach in medical research

Saba, L., Rubeis, G. D., & Pisu, F. (2025) · Trials · doi:10.1186/s13063-025-08974-9 · Cited by 1 · see citing works

Clinical Decision Support Tool for Early Pancreatic Cancer Detection in Primary Care: Simulation Study

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MVGAE: A Multi-View Graph Auto-Encoder Model for Drug Prediction of Non-Small Cell Lung Cancer Based on Synthetic Lethality

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