Coronary Atherosclerosis Imaging by Coronary CT Angiography
Open accessAbstract
Coronary computed tomography angiography (CTA) allows coronary artery visualization and the detection of coronary stenoses. In addition; it has been suggested as a novel, noninvasive modality for coronary atherosclerotic plaque detection, characterization, and quantification. Emerging data show that coronary CTA-based semiquantitative plaque characterization and quantification are sufficiently reproducible for clinical purposes, and fully quantitative approaches may be appropriate for use in clinical trials. Furthermore, several lines of investigation have validated plaque imaging by coronary CTA against other imaging modalities such as intravascular ultrasound/"virtual histology" and optical coherence tomography, and there are emerging data using biochemical modalities such as near-infrared spectroscopy. Finally, clinical validation in patients with acute coronary syndrome and in the outpatient setting has shown incremental value of CTA-based plaque characterization for the prediction of major cardiovascular events. With recent developments in image acquisition and reconstruction technologies, coronary CTA can be performed with relatively low radiation exposure. With further technological innovation and clinical research, coronary CTA may become an important tool in the quest to identify vulnerable plaques and the at-risk patient.
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Recent developments in contrast-enhanced coronary CT angiography allow detection of positive remodelling, increased plaque volumes and lipoprotein deposition in non-calcified plaques.
“Recent developments in contrast-enhanced coronary CT angiography allow the detection of positive remodelling, increased plaque volumes and lipoprotein deposition in non-calcified plaques124.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [124]
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Flagged first, then by citations
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Cited by
Sorted by citations
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
- Authors
- Voros, S., Rinehart, S., Qian, Z., Joshi, P., Vazquez, G., Fischer, C., Belur, P., Hulten, E., & Villines, T. C.
- Affiliations
- Piedmont Atlanta Hospital (US)
- Walter Reed Army Institute of Research (US)
- Venue
- JACC: Cardiovascular Imaging
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 4
- Issue
- 5
- Pages
- 537-548
- ISSN
- 1876-7591 (ISSN-L)
- 1936-878X
- OpenAlex
- W113768872
- Cited by
- 362
- References
- 39
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 18 · 2023: 20 · 2022: 18 · 2021: 16 · 2020: 18 · 2019: 22 · 2018: 22 · 2017: 25 · 2016: 29 · 2015: 41 · 2014: 40 · 2013: 36 · 2012: 25
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- JACC. Cardiovascular imaging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Abbott Vascular
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Coronary Artery Anomalies
- Keywords
- coronary CT angiography, coronary artery disease, coronary plaque, plaque characterization, plaque quantification, vulnerable plaque, coronary artery stenosis, acute coronary syndrome, cardiovascular event prediction, intravascular ultrasound, virtual histology, optical coherence tomography, near-infrared spectroscopy, radiation exposure
- MeSH terms
- Calcinosis, Coronary Artery Disease, Humans, Predictive Value of Tests, Prognosis, Severity of Illness Index, Tomography, X-Ray Computed, Reproducibility of Results, Observer Variation, Coronary Angiography, Ultrasonography, Interventional, Spectroscopy, Near-Infrared, Coronary Stenosis, Tomography, Optical Coherence
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