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The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Outcome in Dilated Cardiomyopathy Related to the Extent, Location, and Pattern of Late Gadolinium Enhancement

Open access
Halliday, Brian P., Baksi, A. John, Gulati, Ankur, Ali, Aamir, Newsome, Simon, Izgi, Cemil, Arzanauskaite, Monika, Lota, Amrit, Tayal, Upasana, Vassiliou, Vassilios S., Gregson, John, Alpendurada, Francisco, Frenneaux, Michael P., Cook, Stuart A., Cleland, John G.F., Pennell, Dudley J., Prasad, Sanjay K.·2019·JACC: Cardiovascular Imaging
DOI 10.1016/j.jcmg.2018.07.015
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Abstract

OBJECTIVES: This study sought to investigate the association between the extent, location, and pattern of late gadolinium enhancement (LGE) and outcome in a large dilated cardiomyopathy (DCM) cohort. BACKGROUND: The relationship between LGE and prognosis in DCM is incompletely understood. METHODS: The authors examined the association between LGE and all-cause mortality and a sudden cardiac death (SCD) composite based on the extent, location, and pattern of LGE in DCM. RESULTS: Of 874 patients (588 men, median age 52 years) followed for a median of 4.9 years, 300 (34.3%) had nonischemic LGE. Estimated adjusted hazard ratios for patients with an LGE extent of 0 to 2.55%, 2.55% to 5.10%, and >5.10%, respectively, were 1.59 (95% confidence interval [CI]: 0.99 to 2.55), 1.56 (95% CI: 0.96 to 2.54), and 2.31 (95% CI: 1.50 to 3.55) for all-cause mortality, and 2.79 (95% CI: 1.42 to 5.49), 3.86 (95% CI: 2.09 to 7.13), and 4.87 (95% CI: 2.78 to 8.53) for the SCD endpoint. There was a marked nonlinear relationship between LGE extent and outcome such that even small amounts of LGE predicted a substantial increase in risk. The presence of septal LGE was associated with increased mortality, but SCD was most associated with the combined presence of septal and free-wall LGE. Predictive models using LGE presence and location were superior to models based on LGE extent or pattern. CONCLUSIONS: In DCM, the presence of septal LGE is associated with a large increase in the risk of death and SCD events, even when the extent is small. SCD risk is greatest with concomitant septal and free-wall LGE. The incremental value of LGE extent beyond small amounts and LGE pattern is limited.

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Metadata

Authors
Halliday, B. P., Baksi, A. J., Gulati, A., Ali, A., Newsome, S., Izgi, C., Arzanauskaite, M., Lota, A., Tayal, U., Vassiliou, V. S., Gregson, J., Alpendurada, F., Frenneaux, M. P., Cook, S. A., Cleland, J. G. F., Pennell, D. J., & Prasad, S. K.
Venue
JACC: Cardiovascular Imaging
Publisher
Elsevier BV
Published
2019-08
Volume
12
Issue
8
Pages
1645-1655
ISSN
  • 1876-7591 (ISSN-L)
  • 1936-878X
DOI
10.1016/j.jcmg.2018.07.015
OpenAlex
W2884439541
Cited by
331
References
22
FWCI
18.92
Type
journal article
Language
en
Open access
hybrid

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The paper
Halliday, B. P., Baksi, A. J., Gulati, A., Ali, A., Newsome, S., Izgi, C., Arzanauskaite, M., Lota, A., Tayal, U., Vassiliou, V. S., Gregson, J., Alpendurada, F., Frenneaux, M. P., Cook, S. A., Cleland, J. G. F., Pennell, D. J., & Prasad, S. K. (2019). Outcome in Dilated Cardiomyopathy Related to the Extent, Location, and Pattern of Late Gadolinium Enhancement. JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2018.07.015

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.