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Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method
Abstract
The development of a multifunctional envelope-type nano device (MEND) for use in a non-viral gene delivery system using a novel lipid film hydration method is described. This packaging method involves three steps: (i) DNA condensation with a polycation, (ii) lipid film hydration for the electrostatic binding of the condensed DNA, and (iii) sonication to package the condensed DNA with lipids. For DNA condensation, the optimum ratio of DNA to poly-L-lysine (PLL) was determined by titrating DNA and PLL. The condensed DNA/PLL complex (DPC) was coated with a lipid bilayer by lipid film hydration followed by sonication, which was confirmed by sucrose density gradient centrifugation. Packaging of DPC with lipids increased the transfection activity 10-fold over that of DPC. MEND, having octaarginine on the envelope as a device for membrane penetration to enhance cellular uptake, showed a 1000-fold higher transfection activity than DPC. The MEND developed in this study represents a promising non-viral gene delivery system.
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In the citing paper
“Packaging the DNA/PLL core with lipids increased transfection rates by ten-fold over bare DNA/PLL.”
From Delivering CRISPR: a review of the challenges and approaches (2018) · cites this paper as Kogure et al., 2004
In the citing paper
“MENDs, developed by the Harashima group at Hokkaido University, are a non-viral gene editing and therapeutic delivery system that is composed of condensed plasmid DNA, a PLL core, and a lipid film shell (Kogure et al., 2004).”
From Delivering CRISPR: a review of the challenges and approaches (2018) · cites this paper as Kogure et al., 2004
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Research works printed but not linked: 13
- Thomas, 2003, Non-viral gene therapy: polycation-mediated DNA delivery, Appl. Microbiol. Biotechnol., 62, 27, 10.1007/s00253-003-1321-8 · DOI
- Templeton, 2002, Cationic liposome-mediated gene delivery in vivo, Biosci. Rep., 22, 283, 10.1023/A:1020142823595 · DOI
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- Wheeler, 1999, Stabilized plasmid-lipid particles: construction and characterization, Gene Ther., 6, 271, 10.1038/sj.gt.3300821 · DOI
- Tam, 2000, Stabilized plasmid-lipid particles for systemic gene therapy, Gene Ther., 7, 1867, 10.1038/sj.gt.3301308 · DOI
- Saravolac, 2000, Encapsulation of plasmid DNA in stabilized plasmid-lipid particles composed of different cationic lipid concentration for optical transfection activity, J. Drug Target., 7, 423, 10.3109/10611860009102217 · DOI
- K. Kamiya, H. Akita, H. Harashima, Pharmacokinetic and pharmacodynamic considerations in gene therapy, Drug Discov. Today, in press. · DOI
- Kamiya, 2001, Intracellular trafficking and transgene expression of viral and non-viral gene vectors, Adv. Drug Deliv. Rev., 52, 153, 10.1016/S0169-409X(01)00216-2 · DOI
- M. Tanimoto, H. Kamiya, N. Minakawa, A. Matsuda, H. Harashima, No enhancement of nuclear entry by direct conjugation of nuclear localization signal peptide to linearized DNA, Bioconjug. Chem., in press. · DOI
- Futaki, 2001, Stearylated arginine-rich peptides: a new class of transfection system, Bioconjug. Chem., 12, 1005, 10.1021/bc015508l · DOI
- Sriwongsitanont, 2002, Physicochemical properties of PEG-grafted liposomes, Chem. Pharm. Bull., 50, 1238, 10.1248/cpb.50.1238 · DOI
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Cited by
Sorted by citations
Delivering CRISPR: a review of the challenges and approaches
Lino, C. A., Harper, J. C., Carney, J. P., & Timlin, J. A. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1474964 · Cited by 1,185
Wang, H.-X., Li, M., Lee, C. M., Chakraborty, S., Kim, H.-W., Bao, G., & Leong, K. W. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00799 · Cited by 560
Tahara, K. (2020) · Advanced Powder Technology · doi:10.1016/j.apt.2019.10.031 · Cited by 31
Metadata
- Authors
- Kogure, K., Moriguchi, R., Sasaki, K., Ueno, M., Futaki, S., & Harashima, H.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 98
- Issue
- 2
- Pages
- 317-323
- ISSN
- 0168-3659
- Cited by
- 218
- References
- 0
- Language
- en
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