The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Nucleic acid delivery with chitosan and its derivatives
Open accessAbstract
Chitosan is a naturally occurring cationic mucopolysaccharide. It is generally biocompatible, biodegradable, mucoadhesive, non-immunogenic and non-toxic. Although chitosan is able to condense nucleic acids (NA) (both DNA and RNA) and protect them from nuclease degradation, its poor water solubility and low transfection efficacy have impeded its use as an NA carrier. In order to overcome such limitations, a multitude of strategies for chitosan modification and formulation have been proposed. In this article, we will first give a brief overview of the physical and biological properties of chitosan. Then, with a special focus on plasmid DNA delivery, we will have a detailed discussion of the latest advances in chitosan-mediated NA transfer. For future research, the following three important areas will be discussed: chitosan-mediated therapeutic small RNA transfer, structure-activity relationships (SAR) in chitosan vector design, and chitosan-mediated oral/nasal NA therapy.
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Cites
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
Virus treatment questioned after gene therapy death
Lehrman, S. (1999) · Nature · doi:10.1038/43977 · Cited by 576 · cited 1×
“Though viral vectors have the merit of high transfectability, their potential safety risks [5,6] as well as immunogenicity warrant the search for alternative non-viral vectors [7].”
BackgroundNon-viral gene delivery systems
Davis, M. E. (2002) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(02)00294-x · Cited by 419
Immune responses to adeno-associated virus and its recombinant vectors.
Sun, J. Y., Anand-Jawa, V, Chatterjee, S., & Wong, K. K. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302039 · Cited by 215
Cited by
Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-Carriers
Jin, L., Zeng, X., Liu, M., Deng, Y., & He, N. (2014) · Theranostics · doi:10.7150/thno.6914 · Cited by 388
Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering
Riva, R., Ragelle, H., des Rieux, A., Duhem, N., Jérôme, C., & Préat, V. (2011) · Advances in Polymer Science · doi:10.1007/12_2011_137 · Cited by 358
Metadata
- Authors
- Lai, W.-F., & Lin, M. C.-M.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 134
- Issue
- 3
- Pages
- 158-168
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2019267098
- Cited by
- 241
- References
- 4
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
