Non-viral gene delivery systems

Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency

Mao, H., Roy, K., Troung-Le, V. L., Janes, K. A., Lin, K., Wang, Y., August, J. T., & Leong, K. W. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00361-8 · Cited by 1,229 · see citing works

A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity

Fischer, D., Bieber, T., Li, Y., Elsässer, H., & Kissel, T. (1999) · Pharmaceutical Research · doi:10.1023/a:1014861900478 · Cited by 1,219 · see citing works

Cationic Polymer Based Gene Delivery Systems

Smedt, S. C. D., Demeester, J., & Hennink, W. E. (2000) · Pharmaceutical Research · doi:10.1023/a:1007548826495 · Cited by 886 · see citing works

Size-dependent DNA Mobility in Cytoplasm and Nucleus

Lukács, G. L., Haggie, P. M., Seksek, O., Lechardeur, D., Freedman, N. D., & Verkman, A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1625 · Cited by 752 · see citing works

Different behavior of branched and linear polyethylenimine for gene deliveryin vitro andin vivo

Wightman, L., Kircheis, R., R�ssler, V., Carotta, S., Ruzicka, R., Kursa, M., & Wagner, E. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.187 · Cited by 696 · see citing works

Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus

Brunner, S., Sauer, T., Carotta, S., Cotten, M. L., Saltik, M., & Wagner, E. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301102 · Cited by 534 · see citing works

Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA

Richardson, S. C. W. (1999) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(98)00378-0 · Cited by 533 · see citing works

Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery

Schaffer, D. V., Fidelman, N. A., Dan, N. R., & Lauffenburger, D. A. (2000) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(20000305)67:5 · Cited by 525 · see citing works

Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini

Putnam, D. A., Gentry, C. A., Pack, D. W., & Langer, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1200 · Cited by 510 · see citing works

Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes

Midoux, P., & Monsigny, M. L. P. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801070 · Cited by 503 · see citing works

Efficient Gene Transfer Using Reversibly Cross-Linked Low Molecular Weight Polyethylenimine

Gosselin, M. A., Guo, W., & Lee, R. J. (2001) · Bioconjugate Chemistry · doi:10.1021/bc0100455 · Cited by 455 · see citing works

Different Strategies for Formation of PEGylated EGF-Conjugated PEI/DNA Complexes for Targeted Gene Delivery

Blessing, T., Kursa, M., Holzhauser, R., et al. (2001) · Bioconjugate Chemistry · doi:10.1021/bc0001488 · Cited by 245 · see citing works

Overcoming the Nuclear Barrier: Cell Cycle Independent Nonviral Gene Transfer with Linear Polyethylenimine or Electroporation

Brunner, S., Fuertbauer, E., Sauer, T., Kursa, M., & Wagner, E. (2002) · Molecular Therapy · doi:10.1006/mthe.2001.0509 · Cited by 244 · see citing works

Development of a Nonviral Gene Delivery Vehicle for Systemic Application

Pun, S. H., & Davis, M. E. (2002) · Bioconjugate Chemistry · doi:10.1021/bc0155768 · Cited by 223 · see citing works

Effects of Structure of β-Cyclodextrin-Containing Polymers on Gene Delivery

Hwang, S. J., Bellocq, N. C., & Davis, M. E. (2001) · Bioconjugate Chemistry · doi:10.1021/bc0001084 · Cited by 217 · see citing works

Application of membrane-active peptides for nonviral gene delivery

Wagner, E. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00033-2 · Cited by 194 · see citing works

Stabilization of lipid/DNA complexes during the freezing step of the lyophilization process: the particle isolation hypothesis

Allison, S., Molina, M. D. C., & Anchordoquy, T. J. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00251-0 · Cited by 179 · see citing works

A pH-Sensitive Polymer That Enhances Cationic Lipid-Mediated Gene Transfer

Cheung, C., Murthy, N., Stayton, P. S., & Hoffman, A. S. (2001) · Bioconjugate Chemistry · doi:10.1021/bc0100408 · Cited by 164 · see citing works

Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin

Dash, P. R., Read, M. L., Fisher, K., Howard, K. A., Wolfert, M. A., Oupický, D., Šubr, V., Strohalm, J., Ulbrich, K., & Seymour, L. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.3793 · Cited by 161 · see citing works

Tumor targeting with surface-shielded ligand–polycation DNA complexes

Kircheis, R., Blessing, T., Brunner, S., Wightman, L., & Wagner, E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00272-3 · Cited by 146 · see citing works

Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer

Escriou, V., Carri�re, M., Bussone, F., Wils, P., & Scherman, D. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.174 · Cited by 136 · see citing works

Steric Stabilization of poly- l -Lysine/DNA Complexes by the Covalent Attachment of Semitelechelic poly[N-(2-Hydroxypropyl)methacrylamide]

Oupický, D., Howard, K. A., Koňák, Č., Dash, P. R., Ulbrich, K., & Seymour, L. W. (2000) · Bioconjugate Chemistry · doi:10.1021/bc990143e · Cited by 110 · see citing works

A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression

Fisher, K. D., Ulbrich, K., Šubr, V., Ward, C. M., Mautner, V., Blakey, D. C., & Seymour, L. W. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301230 · Cited by 110 · see citing works

Nuclear-Associated Plasmid, but Not Cell-Associated Plasmid, Is Correlated with Transgene Expression in Cultured Mammalian Cells

James, M. B., & Giorgio, T. D. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0054 · Cited by 109 · see citing works

Polymer chemical structure is a key determinant of physicochemical and colloidal properties of polymer–DNA complexes for gene delivery

Jones, N. A., Hill, I. R., Stolnik, S., Bignotti, F., Davis, S. S., & Garnett, M. C. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00220-7 · Cited by 89 · see citing works

Observation of DNA–polymer condensate formation in real time at a molecular level

Martin, A. L., Davies, M. C., Rackstraw, B. J., Roberts, C. J., Stolnik, S., Tendler, S. J. B., & Williams, P. M. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01894-9 · Cited by 88 · see citing works

Caged DNA Does Not Aggregate in High Ionic Strength Solutions

Trubetskoy, V. S., Loomis, A., Slattum, P. M., et al. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801530 · Cited by 86 · see citing works

Formulation of highly soluble poly(ethylene glycol)‐peptide DNA condensates

Kwok, K. Y., McKenzie, D. L., Evers, D. L., et al. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js990072s · Cited by 64 · see citing works

Nuclear Translocation of Lactosylated Poly-l-lysine/cDNA Complex in Cystic Fibrosis Airway Epithelial Cells

Klink, D. T., Chao, S., Glick, M. C., et al. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0332 · Cited by 60 · see citing works

Physical stabilization of DNA-based therapeutics

Anchordoquy, T. J., Allison, S., Molina, M. D. C., et al. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(01)01739-1 · Cited by 49 · see citing works

The Hexadentate Hydroxypyridinonate TREN‐(Me‐3,2‐HOPO) is a More Orally Active Iron Chelator Than Its Bidentate Analogue

Yokel, R. A., Fredenburg, A. M., Durbin, P. W., Xu, J., Rayens, M. K., & Raymond, K. N. (2000) · Journal of Pharmaceutical Sciences · doi:10.1002/(sici)1520-6017(200004)89:4 · Cited by 39 · see citing works

Strategies for maintaining the particle size of peptide DNA condensates following freeze-drying

Kwok, K. Y., Adami, R. C., Hester, K. C., et al. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00435-x · Cited by 30 · see citing works

POLY-L-LYSINE-GRAFT-PEG COMB-TYPE POLYCATION COPOLYMERS FOR GENE DELIVERY

Banaszczyk, M., Lollo, C. P., Kwoh, D. Y., Phillips, A. T., Amini, A., Wu, D. P., Mullen, P. M., COFFIN, C. C., Brostoff, S. W., & Carlo, D. J. (1999) · Journal of Macromolecular Science Part A · doi:10.1080/10601329908951200 · Cited by 16 · see citing works

POLY-L-LYSINE-GRAFT-PEG COMB-TYPE POLYCATION COPOLYMERS FOR GENE DELIVERY

Banaszczyk, M., Lollo, C. P., Kwoh, D. Y., Phillips, A. T., Amini, A., Wu, D., Mullen, P. M., COFFIN, C., BROSTOFF, S., & Carlo, D. J. (1999) · Journal of Macromolecular Science Part A · doi:10.1081/ma-100101583 · Cited by 15 · see citing works

Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities

Li, L., Hu, S., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.031 · Cited by 415 · see citing works

Cytotoxic Impacts of Linear and Branched Polyethylenimine Nanostructures in A431 Cells

Kafil, V., & Omidi, Y. (2011) · Tabriz University of Medical Sciences · doi:10.5681/bi.2011.004 · Cited by 215 · see citing works

The effect of endosomal escape peptides on <i>in vitro</i> gene delivery of polyethylene glycol‐based vehicles

Moore, N. M., Sheppard, C. L., Barbour, T. R., & Sakiyama‐Elbert, S. E. (2008) · The Journal of Gene Medicine · doi:10.1002/jgm.1234 · Cited by 63 · see citing works

The road towards gene therapy for X-linked juvenile retinoschisis: a systematic review of preclinical gene therapy in cell-based and rodent models of xlrs

van der Veen, I., Heredero Berzal, A., Koster, C., ten Asbroek, A. L. M. A., Bergen, A. A., & Boon, C. J. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021267 · Cited by 14 · see citing works

Advanced gene delivery : from concepts to pharmaceutical products

Rolland, A. P. (1999) · Cited by 25 · see citing works

Measurements of nucleic bases released after gamma irradiation of DNA in solution in air.

Roots, R., Henle, E. S., Holley, W. R., et al. (1991) · PubMed · Cited by 10 · see citing works

Targeting of drugs 5 : strategies for oligonucleotide and gene delivery in therapy

Gregoriadis, G. C., & McCormack, B. (1996) · Plenum Press eBooks · Cited by 13 · see citing works

Gene therapy for cardiovascular applications

Pacak, C. A., Mah, C. S., & Byrne, B. J. (2005) · Laboratory techniques in biochemistry and molecular biology · doi:10.1016/s0075-7535(05)31009-6

Bacteria in gene therapy: bactofection versus alternative gene therapy

Pálffy, R., Gardlík, R., Hodosy, J., Behuliak, M., Resko, P., Radvánský, J., & Celec, P. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302635 · Cited by 103 · see citing works