Doxil® — The first FDA-approved nano-drug: Lessons learned
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- Leakage kinetics of the liposomal chemotherapeutic agent Doxil: The role of dissolution, protonation, and passive transport, and implications for mechanism of actionLuisa M. Russell, Margot Hultz, Peter C. Searson · 2017 · Journal of Controlled Release
- PEGylated hyaluronic acid-coated liposome for enhanced in vivo efficacy of sorafenib via active tumor cell targeting and prolonged systemic exposureLingxuan Mo, Jae Geun Song, Hankyu Lee, Mengjia Zhao, Hyeon Young Kim, Yoon Ji Lee, Hyuk Wan Ko, Hyo-Kyung Han · 2017 · Nanomedicine Nanotechnology Biology and Medicine
- Clinical translation of immunoliposomes for cancer therapy: recent perspectivesDi Wang, Yating Sun, Yange Liu, Fanchao Meng, Robert J. Lee · 2018 · Expert Opinion on Drug Delivery
- Nanoscale systems for local drug deliveryTianjiao Ji, Daniel S. Kohane · 2019 · Nano Today
- Immunogenicity of Polyethylene Glycol Based Nanomedicines: Mechanisms, Clinical Implications and Systematic ApproachNicola d’Avanzo, Christian Celia, Antonella Barone, Maria Carafa, Luisa Di Marzio, Hélder A. Santos, Massimo Fresta · 2020 · Advanced Therapeutics
- Production and isolation of pharmaceutical drug nanoparticlesVivek Verma, Kevin Michael Ryan, Luís Padrela · 2021 · International Journal of Pharmaceutics
- A Promising Future of Ferroptosis in Tumor TherapyHui Wang, Danfeng Lin, Qianqian Yu, Zhouqi Li, Cameron Lenahan, Ying Dong, Qichun Wei, Anwen Shao · 2021 · Frontiers in Cell and Developmental Biology
- Chemical Approaches to Synthetic Drug Delivery Systems for Systemic ApplicationsDaniel Braatz, Mariam Cherri, Michael Tully, Mathias Dimde, Guoxin Ma, Ehsan Mohammadifar, Felix Reisbeck, Vahid Ahmadi, Michael Schirner, Rainer Haag · 2022 · Angewandte Chemie International Edition
- Pharmaceutical liposomal delivery—specific considerations of innovation and challengesTaoxing Peng, Weihua Xu, Qianqian Li, Yang Ding, Yongzhuo Huang · 2022 · Biomaterials Science
- A nanoliposome delivery system to synergistically trigger TLR4 AND TLR7Christopher B. Fox, Sandra J. Sivananthan, Malcolm S. Duthie, Julie A. Vergara, Jeffrey A. Guderian, Elliot Moon, David Coblentz, Steven G. Reed, Darrick Carter · 2014 · Journal of Nanobiotechnology
- Tumour-vessel-on-a-chip models for drug deliveryDavid Caballero, Sophie M. Blackburn, Mar de Pablo, Josep Samitier, Lorenzo Albertazzi · 2017 · Lab on a Chip
- Protective Roles of Thymoquinone Nanoformulations: Potential Nanonutraceuticals in Human DiseasesAli H. El‐Far, Soad Khalil Al Jaouni, Weikun Li, Shaker A. Mousa · 2018 · Nutrients
- Targeted Engineering of Medicinal Chemistry for Cancer Therapy: Recent Advances and PerspectivesWeihua Chen, Zhen Sun, Lehui Lu · 2020 · Angewandte Chemie International Edition
- Understanding molecular mechanisms of biologics drug delivery and stability from NMR spectroscopyPyae Phyo, Xi Rong Zhao, Allen C. Templeton, Wei Xu, Jason K. Cheung, Yongchao Su · 2021 · Advanced Drug Delivery Reviews
- New advances in brain-targeting nano-drug delivery systems for Alzheimer's diseaseQin Ouyang, Yingcai Meng, Wenhu Zhou, Jianbin Tong, Zeneng Cheng, Qubo Zhu · 2021 · Journal of drug targeting
- Glycosylation-mediated targeting of carriersShigeru Kawakami, Mitsuru Hashida · 2014 · Journal of Controlled Release
- Strategies for triggered drug release from tumor targeted liposomesErik Oude Blenke, Enrico Mastrobattista, Raymond Michel Schiffelers · 2013 · Expert Opinion on Drug Delivery
- Virus-inspired nucleic acid delivery system: Linking virus and viral mimicryRong Ni, Junli Zhou, Naushad Hossain, Ying Chau · 2016 · Advanced Drug Delivery Reviews
- Nanotherapeutics in oral and parenteral drug delivery: Key learnings and future outlooks as we think smallPuneet Tyagi, J. Anand Subramony · 2018 · Journal of Controlled Release
- Synthesis and anticancer activity of carbosilane metallodendrimers based on arene ruthenium( ii ) complexesMarta Maroto-Díaz, Benelita T. Elie, Pilar Gómez‐Sal, Jorge Pérez‐Serrano, Rafael Gómez, Marı́a Contel, F. Javier de la Mata · 2016 · Dalton Transactions
- Supramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR ImagingYunkun Li, Yachao Li, Xiao Zhang, Xianghui Xu, Zhijun Zhang, Cheng Hu, Yiyan He, Zhongwei Gu · 2016 · Theranostics
- From Composition to Cure: A Systems Engineering Approach to Anticancer Drug CarriersSarah R. MacEwan, Ashutosh Chilkoti · 2016 · Angewandte Chemie International Edition
- Brain Targeting by Liposome–Biomolecular Corona Boosts Anticancer Efficacy of Temozolomide in Glioblastoma CellsAntonietta Arcella, Sara Palchetti, Luca Digiacomo, Daniela Pozzi, Anna Laura Capriotti, Luigi Frati, Maria Antonietta Oliva, Georgia Tsaouli, Rossella Rota, Isabella Screpanti et al. · 2018 · ACS Chemical Neuroscience
- Nanoliposomes Co-Encapsulating CT Imaging Contrast Agent and Photosensitizer for Enhanced, Imaging Guided Photodynamic Therapy of CancerHao Xu, Tymish Y. Ohulchanskyy, Artem Yakovliev, Roman Ziniuk, Jun Song, Liwei Liu, Junle Qu, Zhen Yuan · 2019 · Theranostics
- Targeted Exosomes for Drug Delivery: Biomanufacturing, Surface Tagging, and ValidationYingnan Si, Seulhee Kim, Eric Zhang, Yawen Tang, Renata Jaskula‐Sztul, James M. Markert, Herbert Chen, Lufang Zhou, Margaret Liu · 2019 · Biotechnology Journal
- Physical characterization of liposomal drug formulations using multi-detector asymmetrical-flow field flow fractionationJérémie Parot, Fanny Caputo, Dóra Méhn, Vincent A. Hackley, Luigi Calzolai · 2020 · Journal of Controlled Release
- Lipid-based microbubbles and ultrasound for therapeutic applicationDaiki Omata, Johan Unga, Ryo Suzuki, Kazuo Maruyama · 2020 · Advanced Drug Delivery Reviews
- Nanomedicine-based antimicrobial peptide delivery for bacterial infections: recent advances and future prospectsRaj Kumar Thapa, Dzung Bao Diep, Hanne Hjorth Tønnesen · 2021 · Journal of Pharmaceutical Investigation
- Effect of PEG Pairing on the Efficiency of Cancer-Targeting LiposomesPhei Er Saw, Jinho Park, Eunbeol Lee, Sukyung Ahn, Jinju Lee, Hyungjun Kim, Jinjoo Kim, Minsuk Choi, Omid Cameron Farokhzad, Sangyong Jon · 2015 · Theranostics
- Potential applications of nanotechnology for the diagnosis and treatment of pancreatic cancerJoshua A. McCarroll, Joann Teo, Cyrille Andre Boyer, David Goldstein, Maria Kavallaris, Phoebe A. Phillips · 2014 · Frontiers in Physiology
- DNA Origami: Folded DNA‐Nanodevices That Can Direct and Interpret Cell BehaviorCathal John Kearney, Christopher R. Lucas, Fergal J. O’Brien, Carlos Ernesto Castro · 2016 · Advanced Materials
- Multivalent Polymers for Drug Delivery and Imaging: The Challenges of ConjugationMallory A. van Dongen, Casey A. Dougherty, Mark M. Banaszak Holl · 2014 · Biomacromolecules
- Analytical ultracentrifugation for analysis of doxorubicin loaded liposomesDóra Méhn, Patrizia Iavicoli, Noelia Cabaleiro, Sven Even Borgos, Fanny Caputo, Otmar Geiss, Luigi Calzolai, François Rossi, Douglas D. Gilliland · 2017 · International Journal of Pharmaceutics
- Advances in delivery of Irinotecan (CPT-11) active metabolite 7-ethyl-10-hydroxycamptothecinJingxing Si, Xiaobao Zhao, Shan Gao, Dongsheng Huang, Meihua Sui · 2019 · International Journal of Pharmaceutics
- Recent Trends in Nanocarrier-Based Targeted Chemotherapy: Selective Delivery of Anticancer Drugs for Effective Lung, Colon, Cervical, and Breast Cancer TreatmentKetao Jin, Ze-Bei Lu, Jinyang Chen, Yu‐Yao Liu, Huanrong Lan, Haiying Dong, Fan Yang, Yuanyuan Zhao, Xiaoyi Chen · 2020 · Journal of Nanomaterials
- Clinical Relevance of Pre-Existing and Treatment-Induced Anti-Poly(Ethylene Glycol) AntibodiesHelena Freire Haddad, Jacqueline A. Burke, Evan Alexander Scott, Guillermo Antonio Ameer · 2021 · Regenerative Engineering and Translational Medicine
- Anti-cancer peptides: their current trends in the development of peptide-based therapy and anti-tumor drugsAmit Lath, Anita Rani Santal, Nameet Kaur, Poonam Kumari, Nater Pal Singh · 2022 · Biotechnology and Genetic Engineering Reviews
- Recent Studies and Progress in the Intratumoral Administration of Nano-Sized Drug Delivery SystemsWan Su Yun, Jeongrae Kim, Dong‐Kwon Lim, Dong‐Hwee Kim, Seong Ik Jeon, Kwangmeyung Kim · 2023 · Nanomaterials
- Aqueous-core PEG-coated PLA nanocapsules for an efficient entrapment of water soluble anticancer drugs and a smart therapeutic responseDonato Cosco, Donatella Paolino, Francesco De Angelis, Felisa Cilurzo, Christian Celia, Luisa Di Marzio, Diego Russo, Nicolas Tsapis, Elias Fattal, Massimo Fresta · 2014 · European Journal of Pharmaceutics and Biopharmaceutics
- Radiofrequency ablation-combined multimodel therapies for hepatocellular carcinoma: Current statusLumin Chen, Jihong Sun, Xiaoming Yang · 2015 · Cancer Letters
- Improvement in the drug delivery and anti-tumor efficacy of PEGylated liposomal doxorubicin by targeting RNA aptamers in mice bearing breast tumor modelSeyedeh Alia Moosavian, Khalil Abnous, Ali Badiee, Mahmoud Reza Jaafari · 2015 · Colloids and Surfaces B Biointerfaces
- Methods for Implant Acceptance and Wound Healing: Material Selection and Implant Location Modulate Macrophage and Fibroblast PhenotypesAnuraag Boddupalli, Lida Zhu, Kaitlin M. Bratlie · 2016 · Advanced Healthcare Materials
- Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapyYu-Cheng Su, Pierre‐Alain Burnouf, Kuo-Hsiang Chuang, Bing‐Mae Chen, Tian‐Lu Cheng, Steve R. Roffler · 2017 · Nature Communications
- Biologically Inspired and Chemically Derived Methods for Glucose‐Responsive Insulin TherapyMichael A. VandenBerg, Matthew J. Webber · 2019 · Advanced Healthcare Materials
- General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluationSakai-Kato, Kumiko, Nishiyama, Nobuhiro, Kozaki, Masato, Nakanishi, Takeshi, Matsuda, Yoshihiro, Hirano, Mai, Hanada, Hiroyuki, Hisada, Shigeru, Onodera, Hiroshi, Harashima, Hideyoshi et al. · 2015 · Journal of Controlled Release
- Bringing Again Noble Metal Nanoparticles to the Forefront of Cancer TherapyYlea Vlamidis, Valerio Voliani · 2018 · Frontiers in Bioengineering and Biotechnology
- A glance over doxorubicin based-nanotherapeutics: From proof-of-concept studies to solutions in the marketMara Gonçalves, Serge M. Mignani, João Rodrigues, Helena Tomás · 2019 · Journal of Controlled Release
- Development and Characterization of a Fucoidan-Based Drug Delivery System by Using Hydrophilic Anticancer Polysaccharides to Simultaneously Deliver Hydrophobic Anticancer DrugsYen‐Ho Lai, Chih-Sheng Chiang, Chin-Hao Hsu, Hung‐Wei Cheng, San‐Yuan Chen · 2020 · Biomolecules
- Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone TumorsMeng Zhang, Fuqiang Zhang, Te Liu, Pu Shao, Lian Duan, Jun Yan, Xupeng Mu, Jinlan Jiang · 2020 · International Journal of Nanomedicine
- Protein and mRNA Delivery Enabled by Cholesteryl‐Based Biodegradable Lipidoid NanoparticlesLi, Yamin, Jarvis, Rachel, Zhu, Kuixin, Glass, Zachary, Ogurlu, Roza, Gao, Peiyang, Li, Peixuan, Chen, Jinjin, Yu, Yingjie, Yang, Yongjie et al. · 2020 · Angewandte Chemie International Edition
- Photoresponsive Drug Delivery Systems: Challenges and ProgressYang Yang, Kaiqi Long, Yuxiu Chu, Huiping Lu, Weiping Wang, Changyou Zhan · 2024 · Advanced Functional Materials
- Radical innovation from the confluence of technologies: Innovation management strategies for the emerging nanobiotechnology industryElicia Maine, Varkey Jon Thomas, James M. Utterback · 2013 · Journal of Engineering and Technology Management
- Improved antitumor activity and reduced cardiotoxicity of epirubicin using hepatocyte-targeted nanoparticles combined with tocotrienols against hepatocellular carcinoma in miceMagda Nasr, Noha Adel Nafee, Hoda Saad, Amani Hussein Kazem · 2014 · European Journal of Pharmaceutics and Biopharmaceutics
- Dual Carfilzomib and Doxorubicin–Loaded Liposomal Nanoparticles for Synergistic Efficacy in Multiple MyelomaJonathan D. Ashley, Charissa J. Quinlan, Valerie A. Schroeder, Mark A. Suckow, Vincenzo J. Pizzuti, Tanyel Kiziltepe, Başar Bilgiçer · 2016 · Molecular Cancer Therapeutics
- Nanomedicines for developing cancer nanotherapeutics: from benchtop to bedside and beyondJaved Iqbal, Banzeer Ahsan Abbasi, Riaz Ahmad, Tariq Mahmood, Barkat Ali, Ali Talha Khalil, Sobia Kanwal, Sayed Afzal Shah, Muhammad Maqsood Alam, Hussain Badshah et al. · 2018 · Applied Microbiology and Biotechnology
- Toxicological study of doxorubicin-loaded PLGA nanoparticles for the treatment of glioblastomaЭлеонора Рафаиловна Переверзева, Иван Дмитриевич Трещалин, M. I. Treschalin, Diana Arantseva, Yu. V. Ermolenko, Natalya Kumskova, Olga Maksimenko, Vadim Yu. Balabanyan, J. Kreuter, Svetlana Emmanuilovna Gelperina · 2018 · International Journal of Pharmaceutics
- Imaging-assisted anticancer nanotherapyDasgupta, Anshuman, Biancacci, Ilaria, Kiessling, Fabian, Lammers, Twan · 2020 · Theranostics
- Promising effects of nanomedicine in cancer drug deliveryRajesh R. Wakaskar · 2017 · Journal of drug targeting
- A size switchable nanoplatform for targeting the tumor microenvironment and deep tumor penetrationXingli Cun, Man Li, Shuying Wang, Yifei Wang, Jialing Wang, Zhengze Lu, Ruixin Yang, Xian Tang, Zhirong Zhang, Qin Shu He · 2018 · Nanoscale
- Development of Zwitterionic Polypeptide Nanoformulation with High Doxorubicin Loading Content for Targeted Drug DeliveryWeifeng Lin, Guanglong Ma, Zhefan Yuan, Haofeng Qian, Liangbo Xu, Elie Sidransky, Shengfu Chen · 2018 · Langmuir
- Assemblies of Peptide‐Cytotoxin Conjugates for Tumor‐Homing ChemotherapyJinqiang Wang, Shiqi Hu, Weiwei Mao, Jiajia Xiang, Zhuxian Zhou, Xiangrui Liu, Jianbin Tang, Youqing Shen · 2019 · Advanced Functional Materials
- Dual-Ligand Functionalized Core-Shell Chitosan-Based Nanocarrier for Hepatocellular Carcinoma-Targeted Drug DeliveryAmr Hefnawy, Islam Ahmed Hamed Khalil, Kholoud K. Arafa, Marwan Emara, Ibrahim mohammed El-sherbiny · 2020 · International Journal of Nanomedicine
- Nanotechnology for delivery of natural therapeutic substances: a reviewSaka, Raju, Chella, Naveen · 2021 · Environmental Chemistry Letters
- Engineering in Medicine To Address the Challenge of Cancer Drug Resistance: From Micro- and Nanotechnologies to Computational and Mathematical ModelingMorgan Craig, Adrianne L. Jenner, Bumseok Namgung, Luke P. Lee, Aaron J. Goldman · 2020 · Chemical Reviews
- Potential immuno-nanomedicine strategies to fight COVID-19 like pulmonary infectionsSrinivasa Reddy Bonam, Niranjan Goud Kotla, Raghvendra Ashok Bohara, Yury A. Rochev, Thomas Joseph Webster, Jagadeesh Bayry · 2020 · Nano Today
- Quantitative Cryo-TEM Reveals New Structural Details of Doxil-Like PEGylated Liposomal Doxorubicin FormulationRickard Nordström, Lin Zhu, Johan Härmark, Yael Levi‐Kalisman, Erez Koren, Yechezkel Barenholz, Genia Levinton, Dimitri Shamrakov · 2021 · Pharmaceutics
- Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A ReviewJoanna Szymczak, Judyta Cielecka‐Piontek · 2023 · International Journal of Molecular Sciences
- Surface engineering of lipid nanoparticles: targeted nucleic acid delivery and beyondYi Lin, Qiang Cheng, Tuo Wei · 2023 · Biophysics Reports
- Delivery Strategy to Enhance the Therapeutic Efficacy of Liver Fibrosis via Nanoparticle Drug Delivery SystemsLiu, Jie, Liu, Jinhu, Mu, Weiwei, Ma, Qingping, Zhai, Xiangyu, Jin, Bin, Liu, Yongjun, Zhang, Na · 2024 · ACS Nano
- Current state of nanomedicine drug products: An industry perspectiveJeffrey D. Clogston, Willard R. Foss, David Harris, Hardeep S. Oberoi, Jiayi Pan, Elaine Pu, Elisa A. Torrico Guzmán, Katrin Walter, Scott Brown, Patrick Lim Soo · 2024 · Journal of Pharmaceutical Sciences
- Nanomedicines as a cutting-edge solution to combat antimicrobial resistanceRaghu Solanki, Nilesh Makwana, Rahul Kumar, Madhvi N. Joshi, Ashish Patel, Dhiraj Devidas Bhatia, Dipak Kumar Sahoo · 2024 · RSC Advances
- Advancements in Nanoemulsion-Based Drug Delivery Across Different Administration RoutesMaria D. Chatzidaki, Evgenia Mitsou · 2025 · Pharmaceutics
- The role of nanomedicine and artificial intelligence in cancer health care: individual applications and emerging integrations—a narrative reviewSamathoti Prasanthi, Rajasekhar Komarla Kumarachari, Sarad Pawar Naik Bukke, Eashwar Sai Komarla Rajasekhar, Jaiswal Ashish Ashokkumar, Zohre Eftekhari · 2025 · Discover Oncology
- Nanomedicine as an emerging platform for metastatic lung cancer therapyDalit Landesman‐Milo, Srinivas Ramishetti, Dan Peer · 2015 · Cancer and Metastasis Reviews
- Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicinTakuya Suzuki, Masako Ichihara, Kenji Hyodo, Eiichi Yamamoto, Tatsuhiro Ishida, Hiroshi Kiwada, Hiroshi Kikuchi, Hiroshi Ishihara · 2014 · International Journal of Pharmaceutics
- Just so stories: The random acts of anti-cancer nanomedicine performanceSeyed Moein Moghimi, Z. Shadi Farhangrazi · 2014 · Nanomedicine Nanotechnology Biology and Medicine
- Small molecule therapeutic-loaded liposomes as therapeutic carriers: from development to clinical applicationsJae Yoon Hwang, Zibiao Li, Xian Jun Loh · 2016 · RSC Advances
- Nanocarriers in cancer clinical practice: a pharmacokinetic issueLuciana Giodini, Francesco Lo Re, Davide Campagnol, Elena Marangon, Bianca Posocco, Eva Dreussi, Giuseppe Toffoli · 2016 · Nanomedicine Nanotechnology Biology and Medicine
- Extensive preclinical investigation of polymersomal formulation of doxorubicin versus Doxil-mimic formulationMona Alibolandi, Khalil Abnous, Marzieh Mohammadi, Farzin Hadizadeh, Fatemeh Sadeghi, Sahar Taghavi, Mahmoud Reza Jaafari, Mohammad Ramezani · 2017 · Journal of Controlled Release
- Antimicrobial peptides, nanotechnology, and natural metabolites as novel approaches for cancer treatmentMichel Lopes Leite, Nicolau Brito da Cunha, Fabrício Falconi Costa · 2017 · Pharmacology & Therapeutics
- Microfluidic self-assembly of a combinatorial library of single- and dual-ligand liposomes for in vitro and in vivo tumor targetingRui Ran, Haofei Wang, Yun Liu, Yue Hui, Qi Sun, Arjun Seth, David Wibowo, Dong Chen, Chun‐Xia Zhao · 2018 · European Journal of Pharmaceutics and Biopharmaceutics
- Remote Actuation of Apoptosis in Liver Cancer Cells via Magneto-Mechanical Modulation of Iron Oxide NanoparticlesOleg Lunov, Mariia Uzhytchak, Barbora Smolková, Mariia Lunová, Milan Jirsa, Nora M. Dempsey, André Dias, Marlio J. C. Bonfim, Martin Hof, Piotr Jurkiewicz et al. · 2019 · Cancers
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- Cardinal Role of Intraliposome Doxorubicin-Sulfate Nanorod Crystal in Doxil Properties and PerformanceXiaohui Wei, Dima Shamrakov, Nudelman Sioma, Sivan Peretz-Damari, Einat Nativ‐Roth, Oren Regev, Yechezkel Barenholz · 2018 · ACS Omega
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- Liposomal carfilzomib nanoparticles effectively target multiple myeloma cells and demonstrate enhanced efficacy in vivoJonathan D. Ashley, Jared F. Stefanick, Valerie A. Schroeder, Mark A. Suckow, Nathan J. Alves, Rikio Suzuki, Shohei Kikuchi, Teru Hideshima, Kenneth Carl Anderson, Tanyel Kiziltepe et al. · 2014 · Journal of Controlled Release
- Modulating cancer multidrug resistance by sertraline in combination with a nanomedicineVelthe Drinberg, Rivka Bitcover, Wolf Rajchenbach, Dan Peer · 2014 · Cancer Letters
- Simple nanoliposomes encapsulating Lycium barbarum polysaccharides as adjuvants improve humoral and cellular immunity in miceRuonan Bo, Yaqin Sun, Shuzhen Zhou, Ning Ou, Pengfei Gu, Zhenguang Liu, Yuanliang Hu, Jiaguo Liu, Deyun Wang · 2017 · International Journal of Nanomedicine