Doxil® — The first FDA-approved nano-drug: Lessons learned
Abstract
Doxil®, the first FDA-approved nano-drug (1995), is based on three unrelated principles: (i) prolonged drug circulation time and avoidance of the RES due to the use of PEGylated nano-liposomes; (ii) high and stable remote loading of doxorubicin driven by a transmembrane ammonium sulfate gradient, which also allows for drug release at the tumor; and (iii) having the liposome lipid bilayer in a "liquid ordered" phase composed of the high-T(m) (53 °C) phosphatidylcholine, and cholesterol. Due to the EPR effect, Doxil is "passively targeted" to tumors and its doxorubicin is released and becomes available to tumor cells by as yet unknown means. This review summarizes historical and scientific perspectives of Doxil development and lessons learned from its development and 20 years of its use. It demonstrates the obligatory need for applying an understanding of the cross talk between physicochemical, nano-technological, and biological principles. However, in spite of the large reward, ~2 years after Doxil-related patents expired, there is still no FDA-approved generic "Doxil" available.
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PEG coating on liposomes is a successful attempt to avoid RES recognition of the nanocarrier system.
“Among such attempts, polyethylene glycol (PEG) coating on liposomes is a successful attempt to avoid RES recognition of nanocarrier system (Barenholz, 2012; Wong et al., 2012).”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Barenholz, 2012
The successful listing of pegylated liposome Doxil in 1995 proved feasibility of PEG coating technology.
“The successful listing of pegylated liposome Doxil, the first nanoparticle therapeutic drug, in 1995 proved the feasibility of this technology.292”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [292]
Doxil, a PEG functionalized liposomal doxorubicin, was the first nanomedicine approved for anticancer medications (FDA in 1995).
“Doxil, a PEG functionalized liposomal doxorubicin, was the first nanomedicine that has been approved for anticancer medications (FDA in 1995).292”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [292]
Cites
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works
Minotti, G., Menna, P., Salvatorelli, E., Cairo, G., & Gianni, L. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.6 · Cited by 3,784 · see citing works
PEGylation, successful approach to drug delivery
Veronese, F. M., & Pasut, G. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03575-0 · Cited by 2,344 · see citing works
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030 · see citing works
Openings Between Defective Endothelial Cells Explain Tumor Vessel Leakiness
Hashizume, H., Baluk, P., Morikawa, S., McLean, J. W., Thurston, G., Roberge, S., Jain, R. K., & McDonald, D. M. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65006-7 · Cited by 1,689 · see citing works
Pharmacokinetics of Pegylated Liposomal Doxorubicin
Gabizón, A., Shmeeda, H., & Barenholz, Y. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342050-00002 · Cited by 1,639 · see citing works
Self-citationGabizón, A., Catane, R., Uziely, B., Kaufman, B., Safra, T., Cohen, R., Martin, F., Huang, A., & Barenholz, Y. (1994) · PubMed · Cited by 1,382 · see citing works
Self-citationTransport of molecules in the tumor interstitium: a review.
Jain, R. K. (1987) · PubMed · Cited by 1,357 · see citing works
Abuchowski, A., McCoy, J. R., Palczuk, N. C., Es, T. V., & Davis, F. F. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40292-4 · Cited by 1,276 · see citing works
Gordon, A. N., Fleagle, J., Guthrie, D., Parkin, D. E., Gore, M. E., & Lacave, Á. J. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.14.3312 · Cited by 1,212 · see citing works
Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
Maeda, H., Bharate, G. Y., & Daruwalla, J. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.11.010 · Cited by 1,171 · see citing works
Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.
Gabizón, A., & Papahadjopoulos, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6949 · Cited by 1,134 · see citing works
Blum, R. H., & CARTER, S. K. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-2-249 · Cited by 1,059 · see citing works
Transport and Diffusion Across Cell Membranes
Stein, W. D., & Lieb, W. R. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-664660-3.x5001-7 · Cited by 1,029 · see citing works
Sterically stabilized liposomes
Woodle, M. C., & Lasiç, D. D. (1992) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(92)90038-c · Cited by 1,018 · see citing works
Haran, G., Cohen, R., Bar, L. K., & Barenholz, Y. (1993) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(93)90105-9 · Cited by 934 · see citing works
Self-citationTransport of molecules across tumor vasculature
Jain, R. K. (1987) · Cancer and Metastasis Reviews · doi:10.1007/bf00047468 · Cited by 869 · see citing works
Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma
McKelvey, E. M., Gottlieb, J. A., Wilson, H. E., Haut, A., Talley, R. W., Stephens, R. L., Lane, M., Gamble, J. F., Jones, S. E., Grozea, P. N., et al. (1976) · Cancer · doi:10.1002/1097-0142(197610)38:4 · Cited by 819 · see citing works
Needham, D., Anyarambhatla, G., Kong, G., & Dewhirst, M. W. (2000) · PubMed · Cited by 746 · see citing works
Diop-Frimpong, B., Chauhan, V. P., Krane, S., Boucher, Y., & Jain, R. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018892108 · Cited by 733 · see citing works
Griffith, L. G. (2000) · Acta Materialia · doi:10.1016/s1359-6454(99)00299-2 · Cited by 733 · see citing works
Large unilamellar liposomes with low uptake into the reticuloendothelial system
Allen, T. M., & Chonn, A. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80506-9 · Cited by 729 · see citing works
Liposomes for the sustained drug release in vivo
Blume, G., & Cevc, G. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90440-y · Cited by 701 · see citing works
Liposome application: problems and prospects.
Barenholz, Y. (2001) · Current Opinion in Colloid & Interface Science · doi:10.1016/s1359-0294(00)00090-x · Cited by 659 · see citing works
Self-citationFendler, J. H., & Romero, A. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90481-7 · Cited by 656 · see citing works
Jain, R. K., Tong, R. T., & Munn, L. L. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4102 · Cited by 612 · see citing works
Needham, D., & Dewhirst, M. W. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00233-2 · Cited by 572 · see citing works
The anthracyclines: will we ever find a better doxorubicin?
Weiss, R. B. (1992) · PubMed · Cited by 558 · see citing works
Schroeder, A., Kost, J., & Barenholz, Y. (2009) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2009.08.003 · Cited by 484 · see citing works
Self-citationSzebeni, J., Muggia, F. M., Gabizón, A., & Barenholz, Y. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.06.017 · Cited by 424 · see citing works
Self-citationThe use of differential scanning calorimetry as a tool to characterize liposome preparations
Biltonen, R. L., & Lichtenberg, D. A. (1993) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(93)90062-8 · Cited by 414 · see citing works
Liposomes: From Biophysics to Therapeutics
Martin, F. J. (1989) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600780223 · Cited by 354 · see citing works
Cancer Management: A Multidisciplinary Approach
Pazdur, R., Coia, L. R., Hoskins, W. J., & Wagman, L. D. (2007) · Cited by 354 · see citing works
Zucker, D., Marcus, D., Barenholz, Y., & Goldblum, A. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.05.036 · Cited by 340 · see citing works
Self-citationEffect of grafted PEG on liposome size and on compressibility and packing of lipid bilayer
Garbuzenko, O. B., Barenholz, Y., & Priev, A. (2005) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2005.02.003 · Cited by 319 · see citing works
Self-citationPoste, G. H., Bucana, C. D., Raz, A., Bugelski, P. J., Kirsh, R. L., & Fidler, I. J. (1982) · PubMed · Cited by 309 · see citing works
Ultrasound triggered release of cisplatin from liposomes in murine tumors
Schroeder, A., Honen, R., Turjeman, K., Gabizón, A., Kost, J., & Barenholz, Y. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.03.007 · Cited by 305 · see citing works
Self-citationHydration of Polyethylene Glycol-Grafted Liposomes
Tirosh, O., Barenholz, Y., Katzhendler, J., & Priev, A. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77849-x · Cited by 299 · see citing works
Self-citationLiposomes: Preparation, Characterization, and Preservation
Lichtenberg, D. A., & Barenholz, Y. (1988) · Methods of biochemical analysis · doi:10.1002/9780470110546.ch7 · Cited by 291 · see citing works
Self-citationThe response of fluorescent amines to pH gradients across liposome membranes
Deamer, D. W., Prince, R. C., & Crofts, A. R. (1972) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(72)90180-0 · Cited by 266 · see citing works
Gelation of liposome interior A novel method for drug encapsulation
Lasiç, D. D., Frederik, P. M., Stuart, M. C. A., Barenholz, Y., & McIntosh, T. J. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80947-f · Cited by 261 · see citing works
Self-citationControlling liposomal drug release with low frequency ultrasound: mechanism and feasibility.
Schroeder, A., Avnir, Y., Weisman, S., Najajreh, Y., Gabizon, A., Talmon, Y., Kost, J., & Barenholz, Y. (2007) · Langmuir · doi:10.1021/la0631668 · Cited by 239 · see citing works
Self-citationGabizón, A., Barenholz, Y., & Bialer, M. (1993) · Pharmaceutical Research · doi:10.1023/a:1018907715905 · Cited by 238 · see citing works
Self-citationIntroduction and overview of peptide and protein pegylation
Veronese, F. M., & Harris, J. M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00020-0 · Cited by 235 · see citing works
Szebeni, J., Bedöcs, P., Rozsnyay, Z., Weiszhár, Z., Urbanics, R., Rosivall, L., Cohen, R., Garbuzenko, O. B., Báthori, G., Tóth, M., et al. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.06.003 · Cited by 220 · see citing works
Self-citationSelective delivery of doxorubicin to patients with breast carcinoma metastases by stealth liposomes
Symon, Z., PEYSER, A. B., Tzemach, D., Lyass, O., Sucher, E., Shezen, E., & Gabizón, A. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990701)86:1 · Cited by 214 · see citing works
Transmembrane gradient driven phase transitions within vesicles: lessons for drug delivery.
Lasic, D. D., Čeh, B., Stuart, M. C. A., Guo, L., Frederik, P. M., & Barenholz, Y. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00159-z · Cited by 209 · see citing works
Self-citationBolotin, E. M., Cohen, R., Bar, L. K., Emanuel, N., Ninio, S., Barenholz, Y., & Lasiç, D. D. (1994) · Journal of Liposome Research · doi:10.3109/08982109409037057 · Cited by 207 · see citing works
Self-citationClinical Pharmacology of Liposomal Anthracyclines: Focus on Pegylated Liposomal Doxorubicin
Solomon, R. O., & Gabizón, A. (2008) · Clinical Lymphoma & Myeloma · doi:10.3816/clm.2008.n.001 · Cited by 200 · see citing works
Szebeni, J., Alving, C. R., Rosivall, L., Bünger, R., Baranyi, L., Bedöcs, P., Tóth, M., & Barenholz, Y. (2007) · Journal of Liposome Research · doi:10.1080/08982100701375118 · Cited by 199 · see citing works
Self-citationA Novel Liposomal Bupivacaine Formulation to Produce Ultralong-Acting Analgesia
Grant, G. J., Barenholz, Y., Bolotin, E. M., Bansinath, M., Turndorf, H., Piskoun, B., & Davidson, E. M. (2004) · Anesthesiology · doi:10.1097/00000542-200407000-00021 · Cited by 170 · see citing works
Self-citationZamboni, W. C., Gervais, A. C., Egorin, M. J., Schellens, J. H. M., Zuhowski, E. G., Pluim, D., Joseph, E., Hamburger, D. R., Working, P. K., Colbern, G. T., et al. (2004) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0719-4 · Cited by 166 · see citing works
Liposomes in the therapy of infectious diseases and cancer
Borek, F. (1990) · Journal of Immunological Methods · doi:10.1016/0022-1759(90)90331-o · Cited by 165 · see citing works
Liposomal protection of adriamycin-induced cardiotoxicity in mice.
Rahman, A., Kessler, A., More, N., Sikic, B. I., Rowden, G., Woolley, P. V., & Schein, P. S. (1980) · PubMed · Cited by 160 · see citing works
A New Look at Lipid-Membrane Structure in Relation to Drug Research
Mouritsen, O. G., & Jørgensen, K. (1998) · Pharmaceutical Research · doi:10.1023/a:1011986613392 · Cited by 159 · see citing works
Enzymatic Hydrolysis of Sphingolipids
Barnholz, Y., Roitman, A., & Gátt, S. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99833-9 · Cited by 159 · see citing works
Handbook of cancer chemotherapy
(1993) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(93)90321-b · Cited by 158 · see citing works
Relevancy of Drug Loading to Liposomal Formulation Therapeutic Efficacy
Barenholz, Y. (2003) · Journal of Liposome Research · doi:10.1081/lpr-120017482 · Cited by 157 · see citing works
Self-citationPharmacological-toxicological expert report. CAELYX. (Stealth liposomal doxorubicin HCl).
Working, P. K., & Dayan, A. D. (1996) · PubMed · Cited by 156 · see citing works
Gabizón, A., Chisin, R., Amselem, S., Druckmann, S., Cohen, R., Goren, D., Fromer, I. R., Peretz, T., Sulkes, A., & Barenholz, Y. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.476 · Cited by 144 · see citing works
Self-citationWoodle, M. C. (1993) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(93)90069-f · Cited by 140 · see citing works
Horowitz, A. T., Barenholz, Y., & Gabizón, A. (1992) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(92)90084-y · Cited by 139 · see citing works
Self-citationChisti, Y. (1999) · Biotechnology Advances · doi:10.1016/s0734-9750(99)00009-9 · Cited by 135 · see citing works
Comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes.
Rahman, A., Carmichael, D. C., Harris, M. H., & Roh, J. K. (1986) · PubMed · Cited by 133 · see citing works
Enzymes of Complex Lipid Metabolism
Gatt, S., & Barenholz, Y. (1973) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.42.070173.000425 · Cited by 132 · see citing works
Self-citationPeng, X. (2005) · Molecular Interventions · doi:10.1124/mi.5.3.6 · Cited by 131 · see citing works
Systemic administration of doxorubicin-containing liposomes in cancer patients: a phase I study
Gabizón, A., Peretz, T., Sulkes, A., Amselem, S., Ben‐Yosef, R., Ben-Baruch, N. E., Catane, R., Biran, S., & Barenholz, Y. (1989) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(89)90350-7 · Cited by 130 · see citing works
Self-citationCatecholamine uptake and concentration by liposomes maintaining pH gradients
Nichols, J. L., & Deamer, D. W. (1976) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(76)90169-3 · Cited by 130 · see citing works
Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin
Terwogt, J. M. M., Groenewegen, G., Pluim, D., Maliepaard, M., Tibben, M. M., Huisman, A., Huinink, W. W. T. B., Schot, M. E., Welbank, H., Voest, E. E., et al. (2002) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800100371 · Cited by 124 · see citing works
Handbook of cancer chemotherapy
Griffiths, M. (1996) · European Journal of Cancer Part B Oral Oncology · doi:10.1016/s0964-1955(96)90004-4 · Cited by 121 · see citing works
Optimization and Upscaling of Doxorubicin-Containing Liposomes for Clinical Use
Amselem, S., Barenholz, Y., & Gabizon, A. (1990) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600791202 · Cited by 115 · see citing works
Self-citationAlberts, D. S., Liu, P. Y., Wilczynski, S. P., Clouser, M. C., López, A. M., Michelin, D. P., Lanzotti, V. J., & Markman, M. M. (2007) · Gynecologic Oncology · doi:10.1016/j.ygyno.2007.08.075 · Cited by 115 · see citing works
Gabizon, A., Meshorer, A., & Barenholz, Y. (1986) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/77.2.459 · Cited by 114 · see citing works
Self-citationA Quantitative Model for Using Acridine Orange as a Transmembrane pH Gradient Probe
Clerc, S., & Barenholz, Y. (1998) · Analytical Biochemistry · doi:10.1006/abio.1998.2639 · Cited by 111 · see citing works
Self-citationGabizón, A., Goren, D., FUKS, Z. Y., Barenholz, Y., Dagan, A., & Meshorer, A. (1983) · PubMed · Cited by 111 · see citing works
Self-citationPrinciples of Oncologic Pharmacotherapy
Takimoto, C. H. M., & Calvo, E. (2005) · Cited by 110 · see citing works
Cui, J., Li, C., Guo, W., Li, Y., Wang, C., Zhang, L., Zhang, L., Hao, Y., & Wang, Y. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.12.002 · Cited by 109 · see citing works
In Vitro and In Vivo Characterizations of Pegylated Liposomal Doxorubicin
Jiang, W., Lionberger, R. A., & Yu, L. X. (2011) · Bioanalysis · doi:10.4155/bio.10.204 · Cited by 101 · see citing works
Rahman, A., White, G. H., More, N., & Schein, P. S. (1985) · PubMed · Cited by 100 · see citing works
Superior therapeutic activity of liposome-associated adriamycin in a murine metastatic tumour model
Gabizón, A., Goren, D., FUKS, Z. Y., Meshorer, A., & Barenholz, Y. (1985) · British Journal of Cancer · doi:10.1038/bjc.1985.103 · Cited by 94 · see citing works
Self-citationQuantitative structure - property relationship modeling of remote liposome loading of drugs
Cern, A., Golbraikh, A., Sedykh, A., Tropsha, A., Barenholz, Y., & Goldblum, A. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.11.029 · Cited by 93 · see citing works
Self-citationUlmansky, R., Turjeman, K., Baru, M., Katzavian, G., Harel, M., Sigal, A., Naparstek, Y., & Barenholz, Y. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.024 · Cited by 88 · see citing works
Self-citationAndrews, P. A., Brenner, D. E., Chou, F. T., Kubo, H., & Bachur, N. R. (1980) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)00245-4 · Cited by 87 · see citing works
Stability of liposomal doxorubicin formulations: Problems and prospects
Barenholz, Y., Amselem, S., Goren, D., Cohen, R., Gelvan, D., Samuni, A., Golden, E. B., & Gabizón, A. (1993) · Medicinal Research Reviews · doi:10.1002/med.2610130404 · Cited by 86 · see citing works
Self-citationZucker, D., Andriyanov, A. V., Steiner, A., Raviv, U., & Barenholz, Y. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.10.003 · Cited by 84 · see citing works
Self-citationElectrostatics of PEGylated micelles and liposomes containing charged and neutral lipopolymers.
Garbuzenko, O., Zalipsky, S., Qazen, M., & Barenholz, Y. (2005) · Langmuir · doi:10.1021/la0479105 · Cited by 84 · see citing works
Self-citationSterically stabilized liposomes in cancer therapy and gene delivery.
Lasiç, D. D., Jj, V., & Working, P. K. (1999) · PubMed · Cited by 81 · see citing works
Characterization of sterically stabilized cisplatin liposomes by nuclear magnetic resonance
Peleg‐Shulman, T., Gibson, D., Cohen, R., Abra, R. M., & Barenholz, Y. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00359-x · Cited by 80 · see citing works
Self-citationDruckmann, S., Gabizón, A., & Barenholz, Y. (1989) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(89)90329-5 · Cited by 77 · see citing works
Self-citationZucker, D., & Barenholz, Y. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.05.024 · Cited by 77 · see citing works
Self-citationDRV Liposomal Bupivacaine: Preparation, Characterization, and In Vivo Evaluation in Mice
Grant, G. J., Barenholz, Y., Piskoun, B., Bansinath, M., Turndorf, H., & Bolotin, E. M. (2001) · Pharmaceutical Research · doi:10.1023/a:1011059131348 · Cited by 76 · see citing works
Self-citationJoly, F., Ray-Coquard, I. L., Fabbro, M., Donoghoe, M. W., Boman, K., Sugimoto, A. K., Vaughan, M. M., Reinthaller, A., Vergote, I. B., Ferrandina, G., et al. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.04.019 · Cited by 71 · see citing works
Veal, G. J., Griffin, M. J., Price, E., Parry, A., Dick, G., Little, M., Yule, S. M., Morland, B. J., Estlin, E., Hale, J., et al. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1723 · Cited by 69 · see citing works
Abra, R. M., Bankert, R. B., Chen, F., Egilmez, N. K., Huang, K., Saville, R., Slater, J. L., Sugano, M., & Yokota, S. J. (2002) · Journal of Liposome Research · doi:10.1081/lpr-120004770 · Cited by 69 · see citing works
Emanuel, N., Kedar, E., Bolotin, E. M., Smorodinsky, N. I., & Barenholz, Y. (1996) · Pharmaceutical Research · doi:10.1023/a:1016096910822 · Cited by 64 · see citing works
Self-citationGoren, D., Gabizón, A., & Barenholz, Y. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90165-k · Cited by 63 · see citing works
Self-citation(2010) · CRC Press eBooks · doi:10.1201/9780849397264 · Cited by 61 · see citing works
Rahman, A., Fumagalli, A., Barbieri, B., Schein, P., & Casazza, A. (1986) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00255281 · Cited by 58 · see citing works
Kedar, E., Rutkowski, Y., Braun, E., Emanuel, N., & Barenholz, Y. (1994) · Journal of Immunotherapy · doi:10.1097/00002371-199407000-00005 · Cited by 58 · see citing works
Self-citationCohen, R., Kanaan, H., Grant, G. J., & Barenholz, Y. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.030 · Cited by 57 · see citing works
Self-citationWeekly Adriamycin versus VAC in advanced breast cancer. A randomized trial
Gundersen, S., Kvinnsland, S., Klepp, O., Kvaløy, S., Lund, E., & Høst, H. (1986) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(86)90075-1 · Cited by 56 · see citing works
Reduced UV-Induced Degradation of Doxorubicin Encapsulated in Polyethyleneglycol-Coated Liposomes
Bandak, S., Ramu, A., Barenholz, Y., & Gabizon, A. (1999) · Pharmaceutical Research · doi:10.1023/a:1018869818282 · Cited by 53 · see citing works
Self-citationMamidi, R. N. V. S., WENG, S., Stellar, S., Wang, C., Yu, N. Y., Huang, T. J., Tonelli, A. P., Kelley, M. F., Angiuoli, A., & Fung, M. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1406-x · Cited by 52 · see citing works
Cabanes, A., Even‐Chen, S., Zimberoff, J., Barenholz, Y., Kedar, E., & Gabizón, A. (1999) · PubMed · Cited by 52 · see citing works
Self-citationShmeeda, H., Even‐Chen, S., Honen, R., Cohen, R., Weintraub, C., & Barenholz, Y. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)67017-5 · Cited by 47 · see citing works
Self-citationTargeting of drugs with synthetic systems
Peppas, N. A. (1987) · Journal of Controlled Release · doi:10.1016/0168-3659(87)90044-7 · Cited by 44 · see citing works
Preparation and Characterization of Doxorubicin-Loaded Sterically Stabilized Immunoliposomes
Emanuel, N., Kedar, E., Bolotin, E. M., Smorodinsky, N. I., & Barenholz, Y. (1996) · Pharmaceutical Research · doi:10.1023/a:1016028106337 · Cited by 43 · see citing works
Self-citationIn vitro tests to predict in vivo performance of liposomal dosage forms
Amselem, S., Cohen, R., & Barenholz, Y. (1993) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(93)90067-d · Cited by 42 · see citing works
Self-citationKedar, E., Braun, E., Rutkowski, Y., Emanuel, N., & Barenholz, Y. (1994) · Journal of Immunotherapy · doi:10.1097/00002371-199408000-00005 · Cited by 39 · see citing works
Self-citationHydrolysis of sphingomyelin liposomes by sphingomyelinase
Gátt, S., Herzl, A., & Barenholz, Y. (1973) · FEBS Letters · doi:10.1016/0014-5793(73)80670-2 · Cited by 37 · see citing works
Self-citationMadden, T. D., Janoff, A. S., & Cullis, P. R. (1990) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(90)90114-7 · Cited by 30 · see citing works
Barenholz, Y. (2016) · CRC Press eBooks · doi:10.1201/9780849397271-5 · Cited by 30 · see citing works
Self-citationDoxil® — The First FDA-Approved Nano-Drug: From an Idea to a Product
Barenholz, Y. (2020) · doi:10.1201/9781003125259-16 · Cited by 30 · see citing works
Self-citationTirosh, O., Kohen, R., Katzhendler, J., Alon, A., & Barenholz, Y. (1997) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(97)00019-4 · Cited by 29 · see citing works
Self-citationRational design of amphiphile-based drug carriers and sterically stabilized carriers
Barenholz, Y., & Cohen, R. (1995) · Journal of Liposome Research · doi:10.3109/08982109509012690 · Cited by 28 · see citing works
Self-citationZhang, B. (2001) · CRC Press eBooks · doi:10.1201/9780203904671-31 · Cited by 28 · see citing works
Wasserman, V., Kizelsztein, P., Garbuzenko, O. B., Kohen, R., Ovadia, H., Tabakman, R., & Barenholz, Y. (2007) · Langmuir · doi:10.1021/la060218k · Cited by 25 · see citing works
Self-citationComplement Activation, Immunogenicity, and Immune Suppression as Potential Side Effects of Liposomes
Szebeni, J., & Barenholz, Y. (2020) · doi:10.1201/9781003125259-12 · Cited by 23 · see citing works
Self-citationStability of anthracycline antitumour agents in infusion fluids.
Beijnen, J. H., Rosing, H., Pa, D. V., & UNDERBERG, W. J. M. (1985) · PubMed · Cited by 19 · see citing works
Investigations on the antitumor efficacy of liposome-associated doxorubicin in murine tumor models.
Gabizón, A., Goren, D., & Barenholz, Y. (1989) · PubMed · Cited by 18 · see citing works
Self-citationTirosh, O., Kohen, R., Katzhendler, J., Gorodetsky, R., & Barenholz, Y. (1997) · Journal of the Chemical Society Perkin Transactions 2 · doi:10.1039/a601955b · Cited by 17 · see citing works
Self-citationBassermann, R. (1986) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-82635-1_32 · Cited by 15 · see citing works
Qualitative aspects of the degradation of mitomycins in alkaline solution
Beijnen, J. H., den Hartigh, J., & Underberg, W. J. M. (1985) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/0731-7085(85)80008-x · Cited by 15 · see citing works
(2018) · CRC Press eBooks · doi:10.1201/9781420005875-27 · Cited by 12 · see citing works
Design, Characterization and Anti-Tumor Activity of Adriamycin-Containing Phospholipid Vesicles
Gabizón, A., Goren, D., Ramu, A., & Barenholz, Y. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5185-6_17 · Cited by 9 · see citing works
Self-citationZhang, Y., eh, B. C., & Lasiç, D. D. (2001) · CRC Press eBooks · doi:10.1201/9780203904671.ch29 · Cited by 6 · see citing works
From fusion to magic bullets: The influence of dimitri papahadjopoulos
Allen, T. M. (1995) · Journal of Liposome Research · doi:10.3109/08982109509012671 · Cited by 2 · see citing works
Flagged first, then by citations
13 of the 140 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002 · see citing works
Nano based drug delivery systems: recent developments and future prospects
Patra, J. K., Das, G., Fraceto, L. F., Campos, E. V. R., Rodríguez-Torres, M. D. P., Acosta‐Torres, L. S., Diaz-Torres, L. A., Grillo, R., Swamy, M. K., Sharma, S., et al. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0392-8 · Cited by 6,720 · see citing works
Cancer nanomedicine: progress, challenges and opportunities
Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works
Analysis of nanoparticle delivery to tumours
Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218 · see citing works
Liposomal drug delivery systems: From concept to clinical applications
Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839 · see citing works
Cellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859 · see citing works
Liposomes as nanomedical devices
Bozzuto, G., & Molinari, A. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s68861 · Cited by 2,305 · see citing works
Progress and challenges towards targeted delivery of cancer therapeutics
Rosenblum, D., Joshi, N., Tao, W., Karp, J. M., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-03705-y · Cited by 2,220 · see citing works
Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221 · see citing works
Liposomal Formulations in Clinical Use: An Updated Review
Bulbake, U., Doppalapudi, S., Kommineni, N., & Khan, W. (2017) · Pharmaceutics · doi:10.3390/pharmaceutics9020012 · Cited by 2,174 · see citing works
Controlled drug delivery vehicles for cancer treatment and their performance
Senapati, S., Mahanta, A. K., Kumar, S., & Maiti, P. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-017-0004-3 · Cited by 2,167 · see citing works
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164 · see citing works
Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
WICKI, A. N., Witzigmann, D., Balasubramanian, V., & Huwyler, J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.030 · Cited by 1,912 · see citing works
The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906 · see citing works
Ulbrich, K., Holá, K., Šubr, V., Bakandritsos, A., Tuček, J., & Zbořil, R. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00589 · Cited by 1,741 · see citing works
Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies
Mitragotri, S., Burke, P. A., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4363 · Cited by 1,702 · see citing works
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
Torchilin, V. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4333 · Cited by 1,674 · see citing works
New developments in liposomal drug delivery
Pattni, B. S., Chupin, V. V., & Torchilin, V. P. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00046 · Cited by 1,600 · see citing works
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
Din, F. U., Aman, W., Ullah, I., Qureshi, O. S., Mustapha, O., Shafique, S., & Zeb, A. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s146315 · Cited by 1,597 · see citing works
Liposomes: Structure, composition, types, and clinical applications
Nsairat, H., Khater, D., Sayed, U., Odeh, F., Al Bawab, A., & Alshaer, W. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09394 · Cited by 1,561 · see citing works
The evolution of commercial drug delivery technologies
Vargason, A. M., Anselmo, A. C., & Mitragotri, S. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00698-w · Cited by 1,361 · see citing works
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350 · see citing works
Liu, P., Chen, G., & Zhang, J. (2022) · Molecules · doi:10.3390/molecules27041372 · Cited by 1,334 · see citing works
Anselmo, A. C., & Mitragotri, S. (2016) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10003 · Cited by 1,321 · see citing works
Danhier, F. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.015 · Cited by 1,288 · see citing works
The Role of Ligands in the Chemical Synthesis and Applications of Inorganic Nanoparticles
Heuer‐Jungemann, A., Feliu, N., Bakaimi, I., Al‐Hamaly, M. A., Alkilany, A. M., Chakraborty, I., Masood, A., Casula, M. F., Κωστοπούλου, Α., Oh, E., et al. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00733 · Cited by 1,287 · see citing works
van der Meel, R., Sulheim, E., Shi, Y., Kiessling, F. M., Mulder, W. J. M., & Lammers, T. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0567-y · Cited by 1,251 · see citing works
Challenges and strategies in anti-cancer nanomedicine development: An industry perspective
Hare, J. I., Lammers, T., Ashford, M. B., Puri, S., Storm, G., & Barry, S. T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.025 · Cited by 1,246 · see citing works
Extracellular vesicles as drug delivery systems: Why and how?
Elsharkasy, O. M., Nordin, J. Z., Hagey, D. W., de Jong, O. G., Schiffelers, R. M., Andaloussi, S. E., & Vader, P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.004 · Cited by 1,217 · see citing works
The role of lipid components in lipid nanoparticles for vaccines and gene therapy
Gregersen, C. H., Kulkarni, J. A., Witzigmann, D., Lind, M. L., Petersson, K., & Simonsen, J. B. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114416 · Cited by 1,215 · see citing works
Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
de Almeida, M. S., Sušnik, E., Drašler, B., Taladriz‐Blanco, P., Petri‐Fink, A., & Rothen‐Rutishauser, B. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01127d · Cited by 1,108 · see citing works
Therapeutic Nanoparticles and Their Targeted Delivery Applications
Yetisgin, A. A., Çetinel, S., Zuvin, M., Koşar, A., & Kutlu, Ö. (2020) · Molecules · doi:10.3390/molecules25092193 · Cited by 1,103 · see citing works
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
The Smart Drug Delivery System and Its Clinical Potential
Liu, D., Yang, F., Xiong, F., & Gu, N. (2016) · Theranostics · doi:10.7150/thno.14858 · Cited by 1,066 · see citing works
Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization
Sun, Q., Zhou, Z., Qiu, N., & Shen, Y. (2017) · Advanced Materials · doi:10.1002/adma.201606628 · Cited by 1,063 · see citing works
Therapeutic efficacy of nanoparticles and routes of administration
Chenthamara, D., Sadhasivam, S., Ramakrishnan, S. G., Krishnaswamy, S., Essa, M. M., Lin, F., & Qoronfleh, M. W. (2019) · Biomaterials Research · doi:10.1186/s40824-019-0166-x · Cited by 1,073 · see citing works
Targeting drugs to tumours using cell membrane-coated nanoparticles
Fang, R. H., Gao, W., & Zhang, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00699-x · Cited by 980 · see citing works
Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances
Narayan, R., Nayak, U. Y., Raichur, A. M., & Garg, S. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030118 · Cited by 949 · see citing works
Bovine milk-derived exosomes for drug delivery
Munagala, R., Aqil, F., Jeyabalan, J., & Gupta, R. C. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.020 · Cited by 936 · see citing works
Yusuf, A., Almotairy, A. R. Z., Henidi, H. A., Alshehri, O. Y., & Aldughaim, M. S. (2023) · Polymers · doi:10.3390/polym15071596 · Cited by 978 · see citing works
Liposome composition in drug delivery design, synthesis, characterization, and clinical application
Large, D. E., Abdelmessih, R. G., Fink, E. A., & Auguste, D. T. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113851 · Cited by 886 · see citing works
Lombardo, D., Kiselev, M. A., & Caccamo, M. T. (2019) · Journal of Nanomaterials · doi:10.1155/2019/3702518 · Cited by 864 · see citing works
Advances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 869 · see citing works
Naksuriya, O., Okonogi, S., Schiffelers, R. M., & Hennink, W. E. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.090 · Cited by 844 · see citing works
Nichols, J. W., & Bae, Y. H. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.057 · Cited by 834 · see citing works
Innovative approaches for cancer treatment: current perspectives and new challenges
Pucci, C., Martinelli, C., & Ciofani, G. (2019) · ecancermedicalscience · doi:10.3332/ecancer.2019.961 · Cited by 832 · see citing works
Recent progress in drug delivery
Li, C., Wang, J., Wang, Y., Gao, H., Wei, G., Huang, Y., Yu, H., Gan, Y., Wang, Y., Mei, L., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.08.003 · Cited by 818 · see citing works
Clinical Translation of Nanomedicine
Min, Y., Caster, J. M., Eblan, M. J., & Wang, A. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00116 · Cited by 795 · see citing works
Fang, J., Islam, W., & Maeda, H. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.005 · Cited by 757 · see citing works
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come
Yingchoncharoen, P., Kalinowski, D. S., & Richardson, D. R. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012070 · Cited by 744 · see citing works
Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems
Yoo, J., Park, C., Yi, G., Lee, D., & Koo, H. (2019) · Cancers · doi:10.3390/cancers11050640 · Cited by 730 · see citing works
Controlled drug delivery systems: Past forward and future back
Park, K. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.054 · Cited by 721 · see citing works
Mehta, M., Bui, T. A., Yang, X., Aksoy, Y. A., Goldys, E. M., & Deng, W. (2023) · ACS Materials Au · doi:10.1021/acsmaterialsau.3c00032 · Cited by 740 · see citing works
The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery
Cheng, X., & Lee, R. J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.01.022 · Cited by 703 · see citing works
Supramolecular self-assemblies as functional nanomaterials
Busseron, E., Ruff, Y., Moulin, É., & Giuseppone, N. (2013) · Nanoscale · doi:10.1039/c3nr02176a · Cited by 699 · see citing works
Kozma, G. T., Shimizu, T., Ishida, T., & Szebeni, J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.024 · Cited by 696 · see citing works
Cancer nanomedicine: from targeted delivery to combination therapy
Xu, X., Ho, W., Zhang, X., Bertrand, N., & Farokhzad, O. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.01.001 · Cited by 693 · see citing works
Dilliard, S. A., & Siegwart, D. J. (2023) · Nature Reviews Materials · doi:10.1038/s41578-022-00529-7 · Cited by 707 · see citing works
Current hurdles to the translation of nanomedicines from bench to the clinic
Đorđević, S., Gonzalez, M. M., Conejos‐Sánchez, I., Carreira, B., Pozzi, S., Acúrcio, R. C., Satchi‐Fainaro, R., Florindo, H. F., & Vicent, M. J. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01024-2 · Cited by 715 · see citing works
Zhou, J., Yu, G., & Huang, F. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00898d · Cited by 678 · see citing works
The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment
Yang, M., Li, J., Gu, P., & Fan, X. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.12.010 · Cited by 680 · see citing works
Form Follows Function: Nanoparticle Shape and Its Implications for Nanomedicine
Kinnear, C., Moore, T. L., Rodríguez‐Lorenzo, L., Rothen‐Rutishauser, B., & Petri‐Fink, A. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00194 · Cited by 673 · see citing works
Adapting liposomes for oral drug delivery
He, H., Lu, Y., Qi, J., Zhu, Q., Chen, Z., & Wu, W. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.06.005 · Cited by 663 · see citing works
Current Trends in The Use of Liposomes for Tumor Targeting
Deshpande, P. P., Biswas, S., & Torchilin, V. P. (2013) · Nanomedicine · doi:10.2217/nnm.13.118 · Cited by 663 · see citing works
Transport and interactions of nanoparticles in the kidneys
Du, B., Yu, M., & Zheng, J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0038-3 · Cited by 651 · see citing works
Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine
Simón‐Yarza, T., Mielcarek, A., Couvreur, P., & Serre, C. (2018) · Advanced Materials · doi:10.1002/adma.201707365 · Cited by 653 · see citing works
Xu, M., Qi, Y., Liu, G. H., Song, Y., Jiang, X., & Du, B. (2023) · ACS Nano · doi:10.1021/acsnano.3c05853 · Cited by 647 · see citing works
The role of micelle size in tumor accumulation, penetration, and treatment
Wang, J., Mao, W., Lock, L. L., Tang, J., Sui, M., Sun, W., Cui, H., Xu, D., & Shen, Y. (2015) · ACS Nano · doi:10.1021/acsnano.5b02017 · Cited by 635 · see citing works
Lipids and Lipid Derivatives for RNA Delivery
Zhang, Y., Sun, C., Wang, C., Jankovic, K. E., & Dong, Y. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00244 · Cited by 638 · see citing works
Recent Advances in Tumor Targeting via EPR Effect for Cancer Treatment
Subhan, M. A., Yalamarty, S. S. K., Filipczak, N., Parveen, F., & Torchilin, V. P. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11060571 · Cited by 623 · see citing works
Managing diabetes with nanomedicine: challenges and opportunities
Omid Veiseh, A., Tang, B. C., Whitehead, K. A., Anderson, D. G., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4477 · Cited by 618 · see citing works
Meng, W., He, C., Hao, Y., Wang, L., Li, L., & Zhu, G. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1748758 · Cited by 618 · see citing works
Nanocarriers for cancer-targeted drug delivery
Kumari, P., Ghosh, B., & Biswas, S. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1051049 · Cited by 612 · see citing works
Emran, T. B., Shahriar, A., Mahmud, A. R., Rahman, T., Abir, M. H., Siddiquee, M. F. R., Ahmed, H., Rahman, N., Nainu, F., Wahyudin, E., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.891652 · Cited by 606 · see citing works
Liposomal Drug Delivery Systems and Anticancer Drugs
Olusanya, T. O. B., Haj-Ahmad, R., Ibegbu, M. D., Smith, J. R., & Elkordy, A. (2018) · Molecules · doi:10.3390/molecules23040907 · Cited by 605 · see citing works
Crystal Engineering of Pharmaceutical Cocrystals in the Discovery and Development of Improved Drugs
Bolla, G., Sarma, B., & Nangia, A. K. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00987 · Cited by 603 · see citing works
Recent advancements in liposome technology
Filipczak, N., Pan, J., Yalamarty, S. S. K., & Torchilin, V. P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.022 · Cited by 604 · see citing works
Hyaluronic acid for anticancer drug and nucleic acid delivery
Dosio, F., Arpicco, S., Stella, B., & Fattal, E. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.011 · Cited by 596 · see citing works
Nanopharmaceuticals (part 1): products on the market
Weissig, V., Pettinger, T. K., & Murdock, N. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s46900 · Cited by 591 · see citing works
Nanooncology: The future of cancer diagnosis and therapy
Thakor, A. S., & Gambhir, S. S. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21199 · Cited by 591 · see citing works
Stimuli‐responsive liposomes for drug delivery
Lee, Y. R., & Thompson, D. H. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1450 · Cited by 586 · see citing works
Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery
Ge, X., Wei, M., He, S., & Yuan, W. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020055 · Cited by 579 · see citing works
Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors
Gagliardi, A., Giuliano, E., Eeda, V., Fresta, M., Bulotta, S., Awasthi, V., & Cosco, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.601626 · Cited by 592 · see citing works
Chen, B., Cheng, T., & Roffler, S. R. (2021) · ACS Nano · doi:10.1021/acsnano.1c05922 · Cited by 573 · see citing works
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Xu, L., Wang, X., Liu, Y., Yang, G., Falconer, R. J., & Zhao, C. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100109 · Cited by 568 · see citing works
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Vangijzegem, T., Stanicki, D., & Laurent, S. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1554647 · Cited by 553 · see citing works
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Blum, A. P., Kammeyer, J. K., Rush, A. M., Callmann, C. E., Hahn, M. E., & Gianneschi, N. C. (2014) · Journal of the American Chemical Society · doi:10.1021/ja510147n · Cited by 544 · see citing works
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Venditto, V. J., & Szoka, F. C. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.038 · Cited by 538 · see citing works
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Wolfram, J., Zhu, M., Yang, Y. P., Shen, J., Gentile, E., Paolino, D., Fresta, M., Nie, G., Chen, C., Shen, H., et al. (2015) · Current Drug Targets · doi:10.2174/1389450115666140804124808 · Cited by 535 · see citing works
Eloy, J. O., de Souza, M. C., Petrilli, R., Barcellos, J. P. A., Lee, R. J., & Marchetti, J. M. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.09.029 · Cited by 535 · see citing works
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Thi, T. T. H., Suys, E. J. A., Lee, J. S., Nguyen, D. H., Park, K. D., & Truong, N. P. (2021) · Vaccines · doi:10.3390/vaccines9040359 · Cited by 538 · see citing works
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Sayed, M. M. E., Lila, A. S. A., Shimizu, T., Alaaeldin, E., Hussein, A. K., Sarhan, H. A., Szebeni, J., & Ishida, T. (2019) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2019.1627174 · Cited by 536 · see citing works
Dawidczyk, C. M., Kim, C., Park, J. H., Russell, L. M., Lee, K. H., Pomper, M. G., & Searson, P. C. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.036 · Cited by 526 · see citing works
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Anselmo, A. C., & Mitragotri, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.053 · Cited by 523 · see citing works
- Authors
- Barenholz, Y. (.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Barenholz, Yechezkel (Chezy)
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 160
- Issue
- 2
- Pages
- 117-134
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W1989230986
- Cited by
- 4,792
- References
- 140
- Citations by year
- 2026: 415 · 2025: 541 · 2024: 462 · 2023: 405 · 2022: 444 · 2021: 441 · 2020: 436 · 2019: 303 · 2018: 324 · 2017: 284 · 2016: 243 · 2015: 188 · 2014: 174 · 2013: 106 · 2012: 23
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- pegylated liposomal doxorubicin, PEGylated liposomes, nanotherapeutics, doxorubicin, enhanced permeability and retention effect, passive tumor targeting, liposome circulation time, remote loading, phosphatidylcholine, cholesterol, drug release, generic drug availability
- MeSH terms
- Antibiotics, Antineoplastic, Chemistry, Pharmaceutical, Delayed-Action Preparations, Doxorubicin, Drug Carriers, Drug Compounding, Humans, Liposomes, Solubility, United States, United States Food and Drug Administration, Drug Design, Drug Approval, Nanoparticles
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