Co-delivery of latanoprost and timolol from micelles-laden contact lenses for the treatment of glaucoma
Abstract
Glaucoma is a group of irreversible ocular diseases which result in damage to the optic nerve and vision loss. The objective of the present work was to develop micelles-laden contact lenses (CLs-M) that could achieve the sustained release of timolol and latanoprost simultaneously for the treatment of glaucoma. CLs-M were obtained by free radical polymerization of HEMA monomer with timolol and latanoprost loaded mPEG-PLA micelles. The prepared CLs-M had a minimal impact on critical CLs properties, and could release timolol and latanoprost in simulated tear fluid for 144 h and 120 h individually, which is promising for extended drugs release applications. The in vivo PK study on rabbit eyes showed sustained timolol and latanoprost release for up to 120 h and 96 h in tear fluid, respectively. There was significant improvement of the mean residence time (79.6-fold and 122.2-fold) and bioavailability (2.2-fold and 7.3-fold) for both timolol and latanoprost delivered by CLs-M compared with eye drops. An in vivo PD study in a rabbit model with high IOP showed sustained reduction in the IOP for over 168 h. The relative pharmacological availability (PA) of CLs-M was 9.8 times as high as the eye drops. The protein adsorption, ocular irritation study and histological examination study indicated the safety of CLs-M. Therefore, this work has demonstrated the promising potential of micelles-laden CLs to co-deliver timolol and latanoprost for an extended period of time to treat glaucoma.
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Researchers have crafted CLs-M capable of sustaining the release of timolol and latanoprost concurrently for glaucoma therapy.
“Researchers have crafted CLs-M capable of sustaining the release of timolol and latanoprost concurrently for glaucoma therapy.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [117]
In vivo pharmacokinetic studies in rabbit eyes demonstrated the sustained release of timolol and latanoprost lasted for up to 120 h and 96 h in tear fluid, respectively.
“In vivo pharmacokinetic studies in rabbit eyes demonstrated the sustained release of timolol and latanoprost lasted for up to 120 h and 96 h in tear fluid, respectively.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [117]
There was marked enhancement of the mean residence time and bioavailability for both timolol and latanoprost delivered via CLs-M as opposed to eye drops.
“There was marked enhancement of the mean residence time and bioavailability for both timolol and latanoprost delivered via CLs-M as opposed to eye drops [117] (Fig. 5d).”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [117]
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“There was marked enhancement of the mean residence time and bioavailability for both timolol and latanoprost delivered via CLs-M as opposed to eye drops [117] (Fig.”
Self-citation
- Authors
- Xu, J., Ge, Y., Bu, R., Zhang, A., Feng, S., Wang, J., Gou, J., Yin, T., He, H., Zhang, Y., & Tang, X.
- Affiliations
- Shenyang Pharmaceutical University (CN)
- Corresponding author
- Zhang, Yu
- ORCID
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 305
- Pages
- 18-28
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2945320519
- Cited by
- 126
- References
- 34
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 26 · 2023: 28 · 2022: 15 · 2021: 14 · 2020: 15
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Liaoning Province Natural Science (20180551031)
- Liaoning Province Doctoral Start-up Fund Program
- Shenyang Pharmaceutical University (GGJJ2018102)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- glaucoma, latanoprost, timolol, co-delivery, sustained drug release, ocular drug delivery, intraocular pressure, pharmacokinetics, pharmacodynamics, ocular bioavailability, protein adsorption, eye irritation
- MeSH terms
- Latanoprost, Animals, Antihypertensive Agents, Contact Lenses, Drug Carriers, Drug Combinations, Glaucoma, Intraocular Pressure, Male, Micelles, Polyethylene Glycols, Polyglutamic Acid, Rabbits, Timolol, Drug Delivery Systems
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