Micelles: promising ocular drug carriers for anterior and posterior segment diseases
Abstract
Micelles have been studied in the targeting of drug substances to different tissues as a nano-sized delivery system for many years. Sustained drug release, ease of production, increased solubility, and bioavailability of drugs with low water solubility are the most important superiorites of micellar carriers. These advantages paved the way for the use of micelles as a drug delivery system in the ocular tissues. The unique anatomical structure of the eye as well as its natural barriers and physiology affect ocular bioavailability of the drugs negatively. Conventional dosage forms can only reach the anterior segment of the eye and are used for the treatment of diseases of this segment. In the treatment of posterior segment diseases, conventional dosage forms are administered sclerally, via an intravitreal injection, or systemically. However, ocular irritation, low patient compliance, and high side effects are also observed. Micellar ocular drug delivery systems have significant promise for the treatment of ocular diseases. The potential of micellar systems ocular drug delivery has been demonstrated by in vivo animal experiments and clinical studies, and they are continuing extensively. In this review, the recent research studies, in which the positive outcomes of micelles for ocular targeting of drugs for both anterior and posterior segment diseases as well as glaucoma has been demonstrated by in vitro , ex vivo , or in vivo studies, are highlighted.
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Alterations in polymer block structures will impact all properties of micelles such as CMC, encapsulation efficiency and degradation rate.
“Alterations in polymer block structures will also impact all properties of micelles such as CMC, encapsulation efficiency and degradation rate [214].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [214]
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- Authors
- Durgun, M. E., Güngör, S., & Özsoy, Y.
- Affiliations
- Istanbul University (TR)
- Corresponding author
- Durgun, Meltem Ezgi
- Venue
- Journal of Ocular Pharmacology and Therapeutics
- Publisher
- SAGE Publications
- Published
- 2020-07-01
- Volume
- 36
- Issue
- 6
- Pages
- 323-341
- ISSN
- 1080-7683 (ISSN-L)
- 1557-7732
- OpenAlex
- W3016967092
- Cited by
- 67
- References
- 123
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 14 · 2023: 15 · 2022: 12 · 2021: 6 · 2020: 2 · 2012: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ocular Pharmacology and Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- micelles, ocular drug delivery, anterior segment diseases, posterior segment diseases, glaucoma, ocular bioavailability, nanocarriers, sustained drug release, drug solubility
- MeSH terms
- Anterior Eye Segment, Biological Availability, Delayed-Action Preparations, Drug Carriers, Eye Diseases, Humans, Micelles, Ophthalmic Solutions, Solubility, Surface Properties, Drug Delivery Systems, Posterior Eye Segment, Intravitreal Injections, Administration, Ophthalmic
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