Cited by 67Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsNanoparticle-Based Drug Delivery

Micelles: promising ocular drug carriers for anterior and posterior segment diseases

Durgun, Meltem Ezgi, Güngör, Sevgi, Özsoy, Yıldız·2020·Journal of Ocular Pharmacology and Therapeutics

Abstract

Micelles have been studied in the targeting of drug substances to different tissues as a nano-sized delivery system for many years. Sustained drug release, ease of production, increased solubility, and bioavailability of drugs with low water solubility are the most important superiorites of micellar carriers. These advantages paved the way for the use of micelles as a drug delivery system in the ocular tissues. The unique anatomical structure of the eye as well as its natural barriers and physiology affect ocular bioavailability of the drugs negatively. Conventional dosage forms can only reach the anterior segment of the eye and are used for the treatment of diseases of this segment. In the treatment of posterior segment diseases, conventional dosage forms are administered sclerally, via an intravitreal injection, or systemically. However, ocular irritation, low patient compliance, and high side effects are also observed. Micellar ocular drug delivery systems have significant promise for the treatment of ocular diseases. The potential of micellar systems ocular drug delivery has been demonstrated by in vivo animal experiments and clinical studies, and they are continuing extensively. In this review, the recent research studies, in which the positive outcomes of micelles for ocular targeting of drugs for both anterior and posterior segment diseases as well as glaucoma has been demonstrated by in vitro , ex vivo , or in vivo studies, are highlighted.

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Crossref · 10.1089/jop.2019.0109

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Authors
Durgun, M. E., Güngör, S., & Özsoy, Y.
Affiliations
Istanbul University (TR)
Corresponding author
Durgun, Meltem Ezgi
Venue
Journal of Ocular Pharmacology and Therapeutics
Published
2020-07-01
Volume
36
Issue
6
Pages
323-341
ISSN
  • 1080-7683 (ISSN-L)
  • 1557-7732
OpenAlex
W3016967092
Cited by
67
References
123
Citations by year
2026: 8 · 2025: 9 · 2024: 14 · 2023: 15 · 2022: 12 · 2021: 6 · 2020: 2 · 2012: 1
FWCI
0.76
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Ocular Pharmacology and Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
micelles, ocular drug delivery, anterior segment diseases, posterior segment diseases, glaucoma, ocular bioavailability, nanocarriers, sustained drug release, drug solubility
MeSH terms
Anterior Eye Segment, Biological Availability, Delayed-Action Preparations, Drug Carriers, Eye Diseases, Humans, Micelles, Ophthalmic Solutions, Solubility, Surface Properties, Drug Delivery Systems, Posterior Eye Segment, Intravitreal Injections, Administration, Ophthalmic

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