The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
Liposome and immune system interplay: Challenges and potentials
Abstract
Liposome as a revolutionizing carrier, has exhibited favorable aspects in drug delivery. However, there are numerous challenges affecting its effectiveness. Hypersensitivity, accelerated blood clearance, opsonization, uptake by reticulo-endothelial system, and also immune suppression are known as the dominant manifestations of immune-related effects. They may cause failure to achieve the proof of regulatory approvals. In this review, liposome challenges in biologic environment have been discussed. Moreover, opsonization and liposome interactions with innate and acquired immune system have been investigated. Immune system elements including the corresponding receptors and cells were reviewed in this regard. By exploring immune related interactions of the liposome, it could be possible for the formulators to be aware of the immune related interactions of the administered liposomal formulation. On the other hand, immune targeted liposomes for immunotherapy and vaccination purposes could also be developed.
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“364 Their inherent ability to transport both hydrophobic and hydrophilic agents, 347 combined with their ease of synthesis, extensive surface area, and adaptability for targeted modi fi cations, positions them as a pivotal vehicle for drug delivery.”
BackgroundResearch progress in membrane fusion-based hybrid exosomes for drug delivery systems
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Metadata
- Authors
- Zahednezhad, F., Saadat, M., Valizadeh, H., Zakeri-Milani, P., & Baradaran, B.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 305
- Pages
- 194-209
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2946446720
- Cited by
- 267
- References
- 194
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zahednezhad, F., Saadat, M., Valizadeh, H., Zakeri-Milani, P., & Baradaran, B. (2019). Liposome and immune system interplay: Challenges and potentials. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2019.05.030
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