The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Predicting drug release kinetics from nanocarriers inside dialysis bags
Abstract
Dialysis methods are frequently used to determine the in vitro drug release kinetics of nanoparticle drug delivery systems. However, the need for the released drug to diffuse through the dialysis membrane delays its appearance in the sampling compartment. Thus, the apparent drug release data outside the dialysis bag typically does not match the desired release kinetics inside the bag adjacent to the nanocarriers. To address this issue, here we describe a simple approach to determine the actual drug release kinetics from nano drug carriers inside the dialysis bag from the experimental data measured from the sampling compartment. First, a calibration experiment is carried out to determine the diffusion barrier properties of the dialysis membranes. The apparent drug release profile of the nanocarrier is then determined using the dialysis method, and a mathematical model is applied to determine the actual drug release kinetics from the experimental data. The model was tested on DOXIL® (doxorubicin liposomes), and an excellent agreement was found between the predicted and measured drug concentration inside the dialysis membranes. By taking the barrier effects of dialysis membranes into consideration, our model independent of drug carrier not only enables the proper interpretation of the data from dialysis studies but also helps to evaluate the dialysis methodology applied to in vitro drug release assays.
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“Thus, results of drug release from nanocarriers should always be compared with those coming from a reference solution of the drug alone [121], to determine the diffusion barrier properties of the dialysis membrane.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [121]
Citations
Cites
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Development of a Flow-Through USP-4 Apparatus Drug Release Assay to Evaluate Doxorubicin Liposomes
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Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135
Analytical characterization of liposomes and other lipid nanoparticles for drug delivery
Fan, Y., Marioli, M., & Zhang, K. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113642 · Cited by 427
Weng, J., Tong, H. H. Y., & Chow, S. F. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080732 · Cited by 304
Ortiz, A. C., Yáñez, O., Salas‐Huenuleo, E., & Morales, J. O. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040531 · Cited by 135
Giordani, S., Marassi, V., Zattoni, A., Roda, B., & Reschiglian, P. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115751 · Cited by 132
Metadata
- Authors
- Yu, M., Yuan, W., Li, D., Schwendeman, A., & Schwendeman, S. P.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Schwendeman, Anna
- Schwendeman, Steven P.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 315
- Pages
- 23-30
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2981215046
- Cited by
- 232
- References
- 17
- Citations by year
- 2026: 48 · 2025: 49 · 2024: 40 · 2023: 33 · 2022: 33 · 2021: 19 · 2020: 9 · 2019: 1
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- United States-Israel Binational Science Foundation
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- drug release kinetics, dialysis, nanocarriers, mathematical modeling of drug release, liposomal doxorubicin, pegylated liposomal doxorubicin, nanoparticle drug delivery
- MeSH terms
- Dialysis, Diffusion, Doxorubicin, Drug Carriers, Membranes, Artificial, Models, Theoretical, Polyethylene Glycols, Drug Delivery Systems, Nanoparticles, Drug Liberation
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