Cited by 882Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsAdvancements in Transdermal Drug Delivery

On the use of the Weibull function for the discernment of drug release mechanisms

Papadopoulou, Vasiliki, Kosmidis, Kosmas, Vlachou, Marilena, Macheras, Panos·2006·International Journal of Pharmaceutics

Abstract

Previous findings from our group based on Monte Carlo simulations indicated that Fickian drug release from Euclidian or fractal matrices can be described with the Weibull function. In this study, the entire drug release kinetics of various published data and experimental data from commercial or prepared controlled release formulations of diltiazem and diclofenac are analyzed using the Weibull function. The exponent of time b of the Weibull function is linearly related to the exponent n of the power law derived from the analysis of the first 60% of the release curves. The value of the exponent b is an indicator of the mechanism of transport of a drug through the polymer matrix. Estimates for b< or =0.75 indicate Fickian diffusion in either fractal or Euclidian spaces while a combined mechanism (Fickian diffusion and Case II transport) is associated with b values in the range 0.75<b<1. For values of b higher than 1, the drug transport follows a complex release mechanism.

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Crossref · 10.1016/j.ijpharm.2005.10.044

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Authors
Papadopoulou, V., Kosmidis, K., Vlachou, M., & Macheras, P.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • Aristotle University of Thessaloniki (GR)
Corresponding author
Macheras, Panos
Venue
International Journal of Pharmaceutics
Publisher
Elsevier BV
Published
2006-02
Volume
309
Issue
1-2
Pages
44-50
ISSN
0378-5173 (ISSN-L)
OpenAlex
W2017137997
Cited by
882
References
38
Citations by year
2026: 98 · 2025: 79 · 2024: 72 · 2023: 65 · 2022: 87 · 2021: 78 · 2020: 72 · 2019: 54 · 2018: 36 · 2017: 41 · 2016: 25 · 2015: 28 · 2014: 26 · 2013: 34 · 2012: 16
FWCI
6.38
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Pharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords
Weibull function, drug release kinetics, release mechanism, Fickian diffusion, Case II transport, diltiazem, diclofenac, controlled-release formulation, flow index
MeSH terms
Delayed-Action Preparations, Diclofenac, Diffusion, Diltiazem, Kinetics, Methylcellulose, Models, Chemical, Polymers, Solubility, Tablets, Hypromellose Derivatives

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