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Cited by 24Neutrophil, Myeloperoxidase and Oxidative MechanismsInflammation biomarkers and pathwaysSepsis Diagnosis and Treatment

The systemic inflammatory response syndrome induces functional changes and relative hyporesponsiveness in neutrophils

Fung, Yoke Lin, Fraser, John F., Wood, Peter, Minchinton, Robyn M., Silliman, MD,, Christopher C.·2008·Journal of Critical Care
DOI 10.1016/j.jcrc.2007.09.004
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Abstract

Purpose To study the effects of systemic inflammatory response syndrome (SIRS) on polymorhonuclear neutrophil (PMN) function and phenotype by comparing neutrophils from critically ill patients with SIRS against those from healthy blood donors.Material and methods Intensive care unit patients (n = 110) who met at least one SIRS criterion were recruited to the study. One hundred healthy blood donors were recruited as normal controls.Results Polymorphonuclear cells from critically ill patients with SIRS were more resistant to activation than PMNs from healthy donors, but when stimulated had an exaggerated microbicidal response. Buffer-treated PMNs from patients with SIRS had significantly higher CD43 surface expression that may inhibit heterotypic cellular contact or ligand stimulation of membrane receptors, had significantly lower expression of IgG receptor CD16, demonstrated resistance to shedding of L-selectin when primed by platelet-activating factor which could be pro-inflammatory, and had reduced respiratory burst when primed by platelet-activating factor than activated by formyl-Met-Leu-Phe.Conclusion The phenotypic and functional changes observed in neutrophils in the critically ill indicate that they require a higher level of stimulus to become activated. This may represent an auto-protective mechanism where the neutrophils in the already inflamed host may, by this mechanism, avoid excessive inflammation reducing the risk of further host cell injury and death.

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Crossref · 10.1016/j.jcrc.2007.09.004

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  • The kinetics of delivery of neutrophils to tissues may be a more relevant determinant and marker of susceptibility to infection, and/or ongoing inflammation, than circulating white blood cell counts.

    “The kinetics of delivery of neutrophils to tissues may be a more relevant determinant and marker of susceptibility to infection, and/or ongoing inflammation, than circulating white blood cell counts [11].”

    From Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass (2014) · cites this paper as [11]

  • Examination of autopsy specimens from patients with multiple organ failure revealed localization of neutrophils in renal blood vessel aggregates and large-scale infiltration of lung tissues.

    “Examination of autopsy specimens from patients with multiple organ failure (MOF) revealed localization of neutrophils in both renal blood vessel aggregates and large-scale infiltration of the lung tissues [11].”

    From Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass (2014) · cites this paper as [11]

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Authors
Fung, Y. L., Fraser, J. F., Wood, P., Minchinton, R. M., & Silliman, M.
Affiliations
Australian Red Cross Lifeblood (AU)
Corresponding author
Fung, Yoke Lin
ORCID
Venue
Journal of Critical Care
Publisher
Elsevier BV
Published
2008-12
Volume
23
Issue
4
Pages
542-549
ISSN
0883-9441 (ISSN-L)
DOI
10.1016/j.jcrc.2007.09.004
OpenAlex
W2165578482
Cited by
24
References
31
Citations by year
2020: 1 · 2019: 2 · 2018: 3 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 3
FWCI
0.97
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Critical Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Keywords
systemic inflammatory response syndrome, neutrophils, neutrophil activation, CD43, CD16, L-selectin shedding, platelet-activating factor, respiratory burst, microbicidal activity, neutrophil phenotype, critically ill patients
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Humans, Intensive Care Units, Middle Aged, Neutrophils, Superoxides, Antigens, CD, Respiratory Burst, Systemic Inflammatory Response Syndrome, Young Adult

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