The two-event model of transfusion-related acute lung injury
Abstract
The objective of this review is to present the two-event model of transfusion-related acute lung injury (TRALI), a life-threatening complication of transfusions that has been the most common cause of transfusion-related death over the past 2 yrs in the United States. The two-event model of TRALI, which is identical to the pathogenesis of the acute respiratory distress syndrome (ARDS), is reviewed and contrasted to antibody-mediated TRALI. Laboratory studies, both in vitro and in vivo, are discussed as well as human studies of TRALI. Methods to avoid patient exposure to blood components that may cause TRALI are also discussed.
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In acute lung injury, the intensity of neutrophil infiltrates correlates with impaired lung function and with high concentrations of neutrophil-derived proteolytic enzymes in bronchoalveolar lavage.
“In acute lung injury, the intensity of neutrophil infiltrates correlates with impaired lung function and with high concentrations of neutrophil-derived proteolytic enzymes in bronchoalveolar lavage [12].”
From Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass (2014) · cites this paper as [12]
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Fung, Y. L., Fraser, J. F., Wood, P., Minchinton, R. M., & Silliman, M. (2008) · Journal of Critical Care · doi:10.1016/j.jcrc.2007.09.004 · Cited by 24 · see citing works
Wilcox, M. E., Charbonney, E., d’Empaire, P. P., Duggal, A., Pinto, R., Javid, A., Dos Santos, C., Rubenfeld, G. D., Sutherland, S., Liles, W. C., et al. (2014) · Journal of Inflammation · doi:10.1186/s12950-014-0032-5 · Cited by 17 · see citing works
“In acute lung injury, the intensity of neutrophil infiltrates correlates with impaired lung function and with high concentrations of neutrophil-derived proteolytic enzymes in bronchoalveolar lavage [12].”
Background
- Authors
- Silliman, C. C.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Silliman, Christopher C.
- Venue
- Critical Care Medicine
- Published
- 2006-05
- Volume
- 34
- Issue
- Suppl
- Pages
- S124-S131
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W1969460539
- Cited by
- 231
- References
- 106
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 14 · 2018: 9 · 2017: 11 · 2016: 10 · 2015: 8 · 2014: 15 · 2013: 15 · 2012: 20
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL059355, HL 59355)
- National Institute of General Medical Sciences (P50GM049222, 2P50 GM 49222)
- Topics
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- transfusion-related acute lung injury, acute respiratory distress syndrome, transfusion reactions, pathogenesis, transfusion safety
- MeSH terms
- Animals, Antigen-Antibody Reactions, Histocompatibility Antigens Class II, Clinical Trials as Topic, Endothelium, Humans, Isoantibodies, Lung, Models, Biological, Neutrophils, Respiratory Distress Syndrome, Histocompatibility Antigens Class I, Transfusion Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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