Cited by 231Blood transfusion and managementTrauma, Hemostasis, Coagulopathy, ResuscitationRespiratory Support and Mechanisms

The two-event model of transfusion-related acute lung injury

Silliman, Christopher C.·2006·Critical Care Medicine

Abstract

The objective of this review is to present the two-event model of transfusion-related acute lung injury (TRALI), a life-threatening complication of transfusions that has been the most common cause of transfusion-related death over the past 2 yrs in the United States. The two-event model of TRALI, which is identical to the pathogenesis of the acute respiratory distress syndrome (ARDS), is reviewed and contrasted to antibody-mediated TRALI. Laboratory studies, both in vitro and in vivo, are discussed as well as human studies of TRALI. Methods to avoid patient exposure to blood components that may cause TRALI are also discussed.

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Crossref · 10.1097/01.ccm.0000214292.62276.8e

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  • In acute lung injury, the intensity of neutrophil infiltrates correlates with impaired lung function and with high concentrations of neutrophil-derived proteolytic enzymes in bronchoalveolar lavage.

    “In acute lung injury, the intensity of neutrophil infiltrates correlates with impaired lung function and with high concentrations of neutrophil-derived proteolytic enzymes in bronchoalveolar lavage [12].”

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Authors
Silliman, C. C.
Affiliations
University of Colorado Anschutz (US)
Corresponding author
Silliman, Christopher C.
Venue
Critical Care Medicine
Published
2006-05
Volume
34
Issue
Suppl
Pages
S124-S131
ISSN
0090-3493 (ISSN-L)
OpenAlex
W1969460539
Cited by
231
References
106
Citations by year
2026: 6 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 14 · 2018: 9 · 2017: 11 · 2016: 10 · 2015: 8 · 2014: 15 · 2013: 15 · 2012: 20
FWCI
1.99
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL059355, HL 59355)
  • National Institute of General Medical Sciences (P50GM049222, 2P50 GM 49222)
Topics
  • Health Sciences › Medicine › Biochemistry › Blood transfusion and management
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords
transfusion-related acute lung injury, acute respiratory distress syndrome, transfusion reactions, pathogenesis, transfusion safety
MeSH terms
Animals, Antigen-Antibody Reactions, Histocompatibility Antigens Class II, Clinical Trials as Topic, Endothelium, Humans, Isoantibodies, Lung, Models, Biological, Neutrophils, Respiratory Distress Syndrome, Histocompatibility Antigens Class I, Transfusion Reaction

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