Enhanced asiaticoside skin permeation by Centella asiatica-loaded lipid nanoparticles: Effects of extract type and study of stratum corneum lipid dynamics
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SLNs, NLCs, nanoemulgels, and SLMs have been extensively utilized to encapsulate C. asiatica actives.
“Solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanoemulgels, and solid lipid microparticles (SLMs) have been extensively utilized to encapsulate C. asiatica actives.”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as da Rocha et al. 2019
NLCs containing asiaticoside penetrated the stratum corneum more effectively than free extracts, yielding a 50-60% increase in biological activity, especially in collagen stimulation and wound contraction.
“NLCs containing asiaticoside penetrated the stratum corneum more effectively than free extracts, yielding a 50–60% increase in biological activity – especially in collagen stimulation and wound contraction (da Rocha et al. 2019; Kim et al. 2021; Krzyżostan et al. 2024).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as da Rocha et al. 2019
Cites
Kwon, M. C., Choi, W. Y., Seo, Y. C., Kim, J. S., Yoon, C. S., Lim, H. W., Kim, H. S., Ahn, J. H., & Lee, H. Y. (2012) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2011.08.025 · Cited by 48 · see citing works
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A systematic review of the effect of Centella asiatica on wound healing
Arribas-López, E., Zand, N., Ojo, O., Snowden, M. J., & Kochhar, T. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063266 · Cited by 143 · see citing works
“When using nano lipid carriers (NLC), it has been shown that AS penetrated skin layers when applied topically [47].”
BackgroundCentella asiatica: Secondary metabolites, biological activities and biomass sources
Kunjumon, R., Johnson, A. J., & Baby, S. (2022) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100176 · Cited by 79 · see citing works
Bansal, K., Bhati, H., Vanshita, & Bajpai, M. (2024) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2024.100403 · Cited by 37 · see citing works
Handayani, R., Febriyanti, R. M., Muhaimin, M., & Chearunisaa, A. Y. (2025) · Pharmacia · doi:10.3897/pharmacia.72.e167217 · Cited by 5 · see citing works
Towards a predicted anti-aging molecular targets of asiaticoside based on bioinformatics analysis
Ayu Kencana, M. V. S. (2025) · International Journal of Medical Biochemistry · doi:10.14744/ijmb.2024.26122 · Cited by 2 · see citing works
“1a) is a major pentacyclic triterpene glycoside (saponin) with similar sugar chains (Glu-Glu-Rha) bonded to its carboxyl groups [10, 26, 27].”
- Authors
- da Rocha, P. B. R., Souza, B. D. S., Andrade, L. M., dos Anjos, J. L. V., Mendanha, S. A., Alonso, A., Marreto, R. N., & Taveira, S. F.
- Affiliations
- Universidade Federal de Goiás (BR)
- Corresponding author
- Taveira, Stephânia Fleury
- Venue
- Journal of Drug Delivery Science and Technology
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 50
- Pages
- 305-312
- ISSN
- 1773-2247 (ISSN-L)
- OpenAlex
- W2910936075
- Cited by
- 32
- References
- 1
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 4 · 2019: 1
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Drug Delivery Science and Technology (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação de Apoio à Pesquisa do Estado de Goiás (FAPEG)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- asiaticoside, Centella asiatica, nanostructured lipid carriers, lipid nanoparticles, skin permeation, dried plant extract, controlled release, epidermal penetration, systemic sclerosis, topical drug delivery
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