Enhancement of the Skin-Protective Activities of Centella Asiatica L. Urban by a Nano-Encapsulation Process
Abstract
Aqueous extracts of Centella asiatica L. Urban were encapsulated by an edible biopolymer, gelatin, which has no effect on their cosmetic activities. The nanoparticles were w/o-type spherical liposomes that had an average diameter of 115.0nm. The encapsulation efficiency was estimated to be approximately 67%, which was relatively high for these aqueous extracts. The nanoparticles showed lower cytotoxicity (10%) in human skin fibroblast cells than the unencapsulated crude extract (15%) at 1.0mg/ml, this was possibly because a smaller amount of the extract was present in the nanoparticles. The nanoparticles efficiently reduced the expression of matrix metalloproteinase (MMP)-1 in UV-irradiated cells from 136.1% to 77.6% (UV-irradiated control) and inhibited hyaluronidase expression (>60%) at a concentration of 0.5mg/ml, which was higher than the levels produced by the unencapsulated crude extracts. The nanoparticles had a very high flux through mouse skin and also remained at relatively large concentrations in the derma when compared to the unencapsulated crude extracts. These results clearly indicate that the skin-protective activities of C. asiatica were significantly improved through the nano-encapsulation process. These findings also imply that a crude extract can be used and have the same efficacy as purified compounds, which should reduce the purification process and production costs.
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Delivery systems such as nanoencapsulation could be used to increase C. asiatica's wound healing properties, extending the areas that can be treated due to higher bioavailability and skin penetration.
“Delivery systems such as nanoencapsulation could be used to increase C. asiatica’s wound healing properties, extending the areas that can be treated due to its higher bioavailability [46] and penetration through the skin [54].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [46]
Cites
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Doll, R., & Peto, R. (1981) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/66.6.1192 · Cited by 3,927 · see citing works
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Peto, R. (1983) · Springer eBooks · doi:10.1007/978-1-4757-1117-2_30 · Cited by 3,504 · see citing works
Müller, R. H., Radtke, M., & Wissing, S. A. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00118-7 · Cited by 2,116 · see citing works
Structure and design of polymeric surfactant-based drug delivery systems
Torchilin, V. P. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00299-1 · Cited by 1,824 · see citing works
Yin Win, K., & Feng, S.-S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.07.050 · Cited by 1,452 · see citing works
Supercritical fluid extraction: Recent advances and applications
Herrero, M., Mendiola, J. A., Cifuentes, A., & Ibáñez, E. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.12.019 · Cited by 849 · see citing works
Electrospun poly(lactic acid-co-glycolic acid) scaffolds for skin tissue engineering
Kumbar, S. G., Nukavarapu, S. P., James, R., Nair, L. S., & Laurencin, C. T. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.06.028 · Cited by 568 · see citing works
Rujitanaroj, P.-O., Pimpha, N., & Supaphol, P. (2008) · Polymer · doi:10.1016/j.polymer.2008.08.021 · Cited by 527 · see citing works
Fish oil encapsulation with chitosan using ultrasonic atomizer
Klaypradit, W., & Huang, Y. (2007) · LWT · doi:10.1016/j.lwt.2007.06.014 · Cited by 272 · see citing works
Offord, E. A., Gautier, J.-C., Avanti, O., Scaletta, C., Runge, F., Krämer, K., & Applegate, L. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00831-6 · Cited by 254 · see citing works
Micro- and nanotechnologies for intelligent and responsive biomaterial-based medical systems
Caldorera‐Moore, M. E., & Peppas, N. A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.09.002 · Cited by 217 · see citing works
Tyrosine hydroxylation catalyzed by mammalian tyrosinase: An improved method of assay
Pomerantz, S. H. (1964) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(64)90359-6 · Cited by 183 · see citing works
Fang, J., Hwang, T., Huang, Y.-L., & Fang, C.-L. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.12.004 · Cited by 176 · see citing works
Influence of Asiatic Acid, Madecassic Acid, and Asiaticoside on Human Collagen I Synthesis
Bonte, F., Dumas, M., Chaudagne, C., & Meybeck, A. (1994) · Planta Medica · doi:10.1055/s-2006-959434 · Cited by 166 · see citing works
Liu, T., Chen, S., Liu, D., & Liou, S. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.05.025 · Cited by 163 · see citing works
Stability of Chitosan Nanoparticles for l -Ascorbic Acid during Heat Treatment in Aqueous Solution
Jang, K., & Lee, H. G. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073385e · Cited by 145 · see citing works
Self-citationApplication of targeted drug delivery system in Chinese medicine
Li, D.-C., Zhong, X., Zeng, Z., Jiang, J., Li, L., Zhao, M., Yang, X., Chen, J., Ben-shan, Z., Zhao, Q., et al. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.05.008 · Cited by 122 · see citing works
Gnanapragasam, A., Ebenezar, K. K., Sathish, V., Govindaraju, P., & Devaki, T. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.09.009 · Cited by 114 · see citing works
Microencapsulation of Radix salvia miltiorrhiza nanoparticles by spray-drying
Su, Y., Fu, Z., Zhang, J. Y., Wang, W. M., Wang, H., Wang, Y. C., & Zhang, Q. J. (2007) · Powder Technology · doi:10.1016/j.powtec.2007.08.014 · Cited by 107 · see citing works
Encapsulation of α-tocopherol in protein-based delivery particles
Somchue, W., Sermsri, W., Shiowatana, J., & Siripinyanond, A. (2009) · Food Research International · doi:10.1016/j.foodres.2009.04.021 · Cited by 105 · see citing works
Extraction of bioactive components from Centella asiatica using subcritical water
Kim, W.-J., Kim, J., Veriansyah, B., Kim, J. D., Lee, Y. W., Oh, S., & Tjandrawinata, R. R. (2008) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2008.11.007 · Cited by 104 · see citing works
Self-citationCharacterisation of antioxidative activities of various extracts of Centella asiatica (L) Urban
Hamid, A. A., Shah, Z. M., Muse, R., & Mohamed, S. (2002) · Food Chemistry · doi:10.1016/s0308-8146(01)00384-3 · Cited by 104 · see citing works
Jin, H., Xia, F., JIANG, C., Zhao, Y., & He, L. (2009) · Chinese Journal of Chemical Engineering · doi:10.1016/s1004-9541(08)60262-1 · Cited by 99 · see citing works
Anti-Rheumatoid Arthritic Effect of Madecassoside on Type II Collagen-Induced Arthritis in Mice
Liu, M., Dai, Y., Yao, X., Li, Y., Luo, Y., Xia, Y., & Gong, Z. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.06.011 · Cited by 87 · see citing works
Roso, M., Sundarrajan, S., Pliszka, D., Ramakrishna, S., & Modesti, M. (2008) · Nanotechnology · doi:10.1088/0957-4484/19/28/285707 · Cited by 82 · see citing works
Stability studies of new cosmetic formulations with vegetable extracts as functional agents
Anchisi, C., Maccioni, A. M., Sinico, C., & Valenti, D. (2001) · Il Farmaco · doi:10.1016/s0014-827x(01)01055-2 · Cited by 61 · see citing works
Kim, S., & Chung, J. H. (2008) · Phytomedicine · doi:10.1016/j.phymed.2007.11.004 · Cited by 56 · see citing works
The temporal alteration of GAD67/GAD65 ratio in the gerbil hippocampal complex following seizure
Kang, T., Kim, H. S., Seo, M.-O., Choi, S. Y., Kwon, O., Baek, N., Lee, H.-Y., & Won, M. H. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03056-6 · Cited by 45 · see citing works
Self-citationReverse-phase high performance liquid chromatography of asiaticoside in Centella asiatica
Verma, R. K., Bhartariya, K. G., Gupta, M. M., & Kumar, S. (1999) · Phytochemical Analysis · doi:10.1002/(sici)1099-1565(199907/08)10:4 · Cited by 43 · see citing works
Pollack, S. V. (1984) · Clinics in Dermatology · doi:10.1016/0738-081x(84)90022-1 · Cited by 41 · see citing works
Jeong, H., Han, J., Han, J., Kim, Y. H., Oh, S.-H., Kim, S.-S., Jeong, M.-H., Choi, G.-P., Park, U.-Y., & Lee, H.-Y. (2009) · Korean Journal of Medicinal Crop Science · Cited by 25 · see citing works
Self-citationPark, S., & Yoo, H. S. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.08.039 · Cited by 20 · see citing works
Yang, X., Lee, H.-Y., You, S. G., & Kim, J. (2009) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2009.07.001 · Cited by 18 · see citing works
Self-citationL-DOPA oxidation products prevent H2O2-induced oxidative damage to cellular DNA
Shi, Y., Benzie, I. F. F., & Buswell, J. A. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02172-0 · Cited by 15 · see citing works
Delivery by shock waves of active principle embedded in gelatin-based capsules
Goldenstedt, C., Birer, A., Cathignol, D., Chesnais, S., Elbahri, Z., Massard, C., Taverdet, J. L., & Lafon, C. (2007) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2007.10.005 · Cited by 11 · see citing works
Stability Study of the Active Constituents in theCentella asiaticaExtract Formulations
Inamdar, P. K., Yeole, R. D., Srivastava, M. M., & SOUZA, N. J. D. (1996) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049609058563 · Cited by 8 · see citing works
Cole, S. K., Story, M. J., Attwood, D., LAUDAŃSKI, T., Robertson, J., & Barnwell, S. G. (1992) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(92)90318-v · Cited by 7 · see citing works
Cui, X., Bai, J., Xiang-ge, H., & Zhang, Y. (2005) · PubMed · Cited by 6 · see citing works
Savini, G., Dunsmore, J. D., & Robertson, I. (1996) · Veterinary Parasitology · doi:10.1016/0304-4017(95)00929-9 · Cited by 6 · see citing works
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3 of the 42 references couldn’t be matched to a known paper.
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A review on the extraction methods use in medicinal plants, principle, strength and limitation
(2015) · Medicinal & Aromatic Plants · doi:10.4172/2167-0412.1000196 · Cited by 1,325 · see citing works
Hoang, H. T., Moon, J.-Y., & Lee, Y.-C. (2021) · Cosmetics · doi:10.3390/cosmetics8040106 · Cited by 329 · see citing works
Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials
Tzanova, M. T., Atanasov, V., Yaneva, Z. L., Ivanova, D., & Dinev, T. (2020) · Processes · doi:10.3390/pr8101222 · Cited by 206 · see citing works
A systematic review of the effect of Centella asiatica on wound healing
Arribas-López, E., Zand, N., Ojo, O., Snowden, M. J., & Kochhar, T. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063266 · Cited by 143 · see citing works
“asiatica’s wound healing properties, extending the areas that can be treated due to its higher bioavailability [46] and penetration through the skin [54].”
BackgroundZorzi, G. K., Carvalho, E. L. S., von Poser, G. L., & Teixeira, H. F. (2015) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2015.07.015 · Cited by 99 · see citing works
Centella asiatica: Secondary metabolites, biological activities and biomass sources
Kunjumon, R., Johnson, A. J., & Baby, S. (2022) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100176 · Cited by 79 · see citing works
Nema, N. K., Maity, N., Sarkar, B. K., & Mukherjee, P. K. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2013.782505 · Cited by 58 · see citing works
Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review
Kumar, M., Kumar, D., Mahmood, S., Singh, V., Chopra, S., Hilles, A. R., & Bhatia, A. (2024) · RSC Pharmaceutics · doi:10.1039/d3pm00024a · Cited by 56 · see citing works
Leung, K. C., Seneviratne, C. J., Li, X., Leung, P. C., Lau, C. B., Wong, C.-H., Pang, K., Wong, C. K., Wat, E., & Jin, L. (2016) · Nanomaterials · doi:10.3390/nano6040061 · Cited by 52 · see citing works
Eissa, M., Hashim, Y. Z. H.-Y., Nasir, M. H. M., Nor, Y. A., Salleh, H. M., Isa, M., Azziz, S. S. S. A., Warif, N. M. A., Ramadan, E. S., & Badawi, N. M. (2021) · Drug Delivery · doi:10.1080/10717544.2021.2012307 · Cited by 47 · see citing works
Istrati, D., Lacatusu, I., Bordei, N., Badea, G., Oprea, O., Ștefan, L. M., Stan, R., Badea, N. M., & Meghea, A. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.03.087 · Cited by 43 · see citing works
Review: The Bioavailability Activity of Centella asiatica
Yasurin, P., Sriariyanun, M., & Phusantisampan, T. (2015) · King Mongkut’s University of Technology North Bangkok International Journal of Applied Science and Technology · doi:10.14416/j.ijast.2015.11.001 · Cited by 37 · see citing works
Ambwani, S., Tandon, R., Ambwani, T. K., & Malik, Y. S. (2018) · Journal of Experimental Biology and Agricultural Sciences · doi:10.18006/2018.6(1).87.107 · Cited by 39 · see citing works
Rebia, R. A., Sadon, N. S. B., & Tanaka, T. (2019) · Nanomaterials · doi:10.3390/nano9121665 · Cited by 35 · see citing works
Prospects on Nano-Based Platforms for Antimicrobial Photodynamic Therapy Against Oral Biofilms
Balhaddad, A. A., García, I. M., Ibrahim, M. S., Rolim, J. P. M. L., Gomes, E. A. B., Martinho, F. C., Collares, F. M., Xu, H. H. K., & Melo, M. A. S. (2020) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2020.4815 · Cited by 33 · see citing works
da Rocha, P. B. R., Souza, B. D. S., Andrade, L. M., dos Anjos, J. L. V., Mendanha, S. A., Alonso, A., Marreto, R. N., & Taveira, S. F. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.01.016 · Cited by 32 · see citing works
Rachpirom, M., Pichayakorn, W., & Puttarak, P. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17807 · Cited by 26 · see citing works
Lens, M. B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062484 · Cited by 25 · see citing works
Sondari, D., & Tursiloadi, S. (2018) · AIP conference proceedings · doi:10.1063/1.5082515 · Cited by 25 · see citing works
Green Extraction: Enhanced Extraction Yield of Asiatic Acid from Centella asiatica (L.) Nanopowders
Borhan, M. Z., Ahmad, R., RUSOP, M., & Abdullah, S. (2013) · Journal of Applied Chemistry · doi:10.1155/2013/460168 · Cited by 25 · see citing works
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Mahendra, C. K., Ser, H., Pusparajah, P., Htar, T. T., Chuah, L., Yap, W. H., Tang, Y.-Q., Zengin, G., Tang, S. Y., Lee, W.-L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052884 · Cited by 15 · see citing works
Overview of Nanocosmetics with Emphasis on those Incorporating Natural Extracts
Maghraby, Y. R., Ibrahim, A. H., El-Shabasy, R. M., & Azzazy, H. M. E.-S. (2024) · ACS Omega · doi:10.1021/acsomega.4c00062 · Cited by 14 · see citing works
Herbals and green synthesized nanoparticles in dentistry
Subbiah, U., Elango, S., & Jayesh, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815886-9.00025-5 · Cited by 14 · see citing works
Abbas, S., Latif, M. S., Shafie, N. S., Ghazali, M. I., Abidin, N. A. Z., Mustafa, M. K., & Kormin, F. B. (2021) · Food Research · doi:10.26656/fr.2017.5(2).355 · Cited by 12 · see citing works
Ebau, F., Scano, A., Manca, M. L., Manconi, M., Cabras, V., Pilloni, M., & Ennas, G. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37462 · Cited by 12 · see citing works
Nanoscale Delivery Systems: Actual and Potential Applications in the Natural Products Industry
Antal, D., Ardelean, F., Rodica, C. A., Ollivier, É., & Maria-Corina, S. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170220155540 · Cited by 12 · see citing works
da Rocha, P., Souza, B. D. S., Andrade, L. M., Marreto, R. N., Lima, E. M., & Taveira, S. F. (2017) · Planta Medica · doi:10.1055/s-0043-113325 · Cited by 10 · see citing works
Synergistic effects of plant extracts and nanoparticles for therapy
Ghosh, S., Sarkar, B., Ranadheera, C. S., & Thongmee, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15457-7.00003-4 · Cited by 8 · see citing works
Polymeric colloidal nanocarriers entrapped with Centella asiatica extract
Perez, A. G. M., Machado, J. M., Manhani, K. C., Léo, P., Noriega, P., & Zanin, M. H. A. (2020) · SN Applied Sciences · doi:10.1007/s42452-020-03681-3 · Cited by 7 · see citing works
Bigels as novel systems for the delivery active compounds from Centella asiatica
Kulawik‐Pióro, A., Osak, E., Mendrycka, M., & Trześniewska-Ofiara, Z. (2023) · Soft Materials · doi:10.1080/1539445x.2023.2243922 · Cited by 7 · see citing works
Plant extracts: Antioxidant and antimicrobial properties and their effect of nanoencapsulation
Parham, S., Parham, S.-S., & Nur, H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99527-6.00019-7 · Cited by 6 · see citing works
New-generation nanotechnology for development of cosmetics using plant extracts
Araújo, A. R. T. S., Rodrigues, M., Mascarenhas‐Melo, F., Peixoto, D., Guerra, C., Cabral, C., Veiga, F., & Paiva‐Santos, A. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822967-5.00002-3 · Cited by 6 · see citing works
Nanoparticulate Delivery Systems for Phytoconstituents
Sarwa, K. K., Patel, D., Uraon, D., Jangde, M. S., Suryawanshi, V. K., & Saraf, S. (2022) · doi:10.1002/9781119811794.ch6 · Cited by 6 · see citing works
Ryu, D. H., Cho, J. Y., Hamayun, M., Lee, S. H., Ho, H.-T., Jung, J. H., & Kim, H. (2025) · Chemical and Biological Technologies in Agriculture · doi:10.1186/s40538-025-00745-7 · Cited by 5 · see citing works
Self-citationUygur, E., Karatay, K. B., Derviş, E., Evren, V., Kılçar, A. Y., Güldü, Ö. K., Sezgın, C., Çinleti, B. A., Tekin, V., & Müftüler, F. Z. B. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04103-w · Cited by 5 · see citing works
Nanocosmetics: Production, Characterization, and Performance Improvement
Santos, J. S. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.93600 · Cited by 5 · see citing works
Martinez-Rivas, C., Álvarez-Román, R., Rivas-Morales, C., Elaı̈ssari, A., Fessi, H., & Galindo-Rodríguez, S. A. (2017) · Journal of Analytical Methods in Chemistry · doi:10.1155/2017/9086467 · Cited by 4 · see citing works
Lee, H., Baek, J.-H., Im, D., Heo, J.-W., & Kim, T. (2025) · Frontiers in Plant Science · doi:10.3389/fpls.2025.1646310 · Cited by 3 · see citing works
Self-citationEom, S., Kim, E. R., Jung, H., 이중후, Song, C., Yoo, J. W., Baek, H. S., Lee, J., Jung, D., Kwak, M. K., et al. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c25201 · Cited by 3 · see citing works
Wickramasinghe, A. S. D., Attanayake, A. P., & Kalansuriya, P. (2024) · Journal of Microencapsulation · doi:10.1080/02652048.2024.2313230 · Cited by 3 · see citing works
Abbas, G. M., Haikal, A., Shaaban, A. E., & Zayed, A. (2026) · Springer eBooks · doi:10.1007/978-981-95-8064-4_7 · Cited by 1 · see citing works
Identification of Centella Asiatica Extract in a Cosmetic Cream
López, P. G., Catalano, A. V., Cufre, I. M., Tarcaya, V. P., Cogoi, L., & Broussalis, A. M. (2015) · International Journal of Phytocosmetics and Natural Ingredients · doi:10.15171/ijpni.2015.16 · Cited by 1 · see citing works
Yin, D., YuWei, W. A. N. G., YuHan, Y. A. N. G., Li, K., & Zhou, X. (2023) · Scientia Sinica Vitae · doi:10.1360/ssv-2022-0269 · Cited by 1 · see citing works
Development of Natural Cosmeceuticals: Harnessing Asia's Biodiversity
Aziz, A. A., Hamid, M. A., Noor, N. M., Yaakob, H., Hasham, R., & Sarmidi, M. R. (2014) · doi:10.1002/9781118460566.ch30
Recent developments of nanostructures for anticancer natural compounds delivery
Gunnaseelam, G., & Rahman, T. (2023) · The Pharma Innovation · doi:10.22271/tpi.2023.v12.i12aj.25092
Beneficial effect of Centella asiatica: Synthesis of the last 2 decades
Takahashi, C. M., Cáceda, H. A. V., & Poemape, J. (2025) · Revista Colombiana de Ciencias Químico Farmacéuticas · doi:10.15446/rcciquifa.v54n3.114481
- Authors
- Kwon, M. C., Choi, W. Y., Seo, Y. C., Kim, J. S., Yoon, C. S., Lim, H. W., Kim, H. S., Ahn, J. H., & Lee, H. Y.
- Affiliations
- Kangwon National University (KR)
- Corresponding author
- Lee, Hyeon Yong
- Venue
- Journal of Biotechnology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 157
- Issue
- 1
- Pages
- 100-106
- ISSN
- 0168-1656 (ISSN-L)
- OpenAlex
- W2081206066
- Cited by
- 48
- References
- 42
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 2
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A103017)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Centella asiatica, nanoencapsulation, liposomes, aqueous plant extract, cytotoxicity, dermal fibroblasts, MMP-1, hyaluronidase, UV-induced skin damage, topical delivery, cosmetic ingredients
- MeSH terms
- Analysis of Variance, Animals, Biopolymers, Cell Line, Cell Survival, Chickens, Cosmetics, Female, Fibroblasts, Gelatin, Humans, Hyaluronoglucosaminidase, Mice, Hairless, Particle Size, Plant Extracts, Skin, Protective Agents, Matrix Metalloproteinase 1, Centella, Mice, Nanocapsules
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