The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A New “Silver-Bullet” to treat caries in children – Nano Silver Fluoride: A randomised clinical trial
Open accessAbstract
BACKGROUND: Untreated dental caries in children remains a public health challenge in poor communities. OBJECTIVES: This prospective controlled clinical trial investigated the effectiveness of a new anti-caries agent, Nano Silver Fluoride (NSF), applied once a year to arrest caries in children. METHODS: One hundred thirty decayed primary teeth were randomly divided into two groups: NSF as the experimental agent and water as the control group. Teeth were clinically diagnosed and treated by one masked examiner and followed up at seven days and five and 12 months by another calibrated examiner who was blinded to the type of treatment. The criteria of the ICDAS II were followed to determine the activity of lesion and the diagnosis of caries. The Pearson's chi-square test was used to compare the groups during different follow-up exams. RESULTS: At seven days, 81% of teeth in the NSF group exhibited arrested caries, whereas in controls, no teeth had arrested decay (p<0.001) [PF, prevented fraction=81%]. After five months, the NSF group had 72.7% with arrested decay, and the control group had 27.4% (p<0.001) [PF=62.5%]. At 12 months, 66.7% of the lesions treated with NSF were still arrested, while the control group had 34.7% remaining arrested (p=0.003) [PF=50%]. The number need to treat (NNT) at five months was two, and at 12 months, the number was three. CLINICAL SIGNIFICANCE: The NSF formulation is effective to arrest active dentine caries and not stain teeth. CONCLUSIONS: NSF was demonstrated to be effective in arresting caries in children in poor communities.
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Cites
Fluoride varnishes for preventing dental caries in children and adolescents
Marinho, V. C., Worthington, H. V., Walsh, T., & Clarkson, J. E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002279.pub2 · Cited by 1,022
Cited by
Naha, P. C., Liu, Y., Hwang, G., Huang, Y., Gubara, S., Jonnakuti, V., Simon-Soro, A., Kim, D., Gao, L., Koo, H., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b08702 · Cited by 367
Mechanisms of silver diamine fluoride on arresting caries: a literature review
Zhao, I. S., Gao, S. S., Hiraishi, N., Burrow, M. F., Duangthip, D., Mei, M. L., Lo, E. C.-M., & Chu, C.-H. (2018) · International Dental Journal · doi:10.1111/idj.12320 · Cited by 365
Evidence-based dentistry update on silver diamine fluoride
Crystal, Y. O., & Niederman, R. (2019) · Dental Clinics of North America · doi:10.1016/j.cden.2018.08.011 · Cited by 253
Silver diamine fluoride for managing carious lesions: an umbrella review
Seifo, N., Cassie, H., Radford, J. R., & Innes, N. P. T. (2019) · BMC Oral Health · doi:10.1186/s12903-019-0830-5 · Cited by 217
Chibinski, A. C., Wambier, L. M., Feltrin, J., Loguercio, A. D., Wambier, D. S., & Reis, A. (2017) · Caries Research · doi:10.1159/000478668 · Cited by 216
Metadata
- Authors
- dos Santos, V. E., Filho, A. V., Ribeiro Targino, A. G., Pelagio Flores, M. A., Galembeck, A., Caldas, A. F., & Rosenblatt, A.
- Venue
- Journal of Dentistry
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 42
- Issue
- 8
- Pages
- 945-951
- ISSN
- 0300-5712 (ISSN-L)
- OpenAlex
- W2010898747
- Cited by
- 229
- References
- 1
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: A New “Silver-Bullet” to treat caries in children – Nano Silver Fluoride: A randomised clinical trial. https://app.cochat.ai/papers/10.1016/j.jdent.2014.05.017
- The paper
- dos Santos, V. E., Filho, A. V., Ribeiro Targino, A. G., Pelagio Flores, M. A., Galembeck, A., Caldas, A. F., & Rosenblatt, A. (2014). A New “Silver-Bullet” to treat caries in children – Nano Silver Fluoride: A randomised clinical trial. Journal of Dentistry. https://doi.org/10.1016/j.jdent.2014.05.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
