Evidence-based dentistry update on silver diamine fluoride
Open accessAbstract
This article reviews current evidence on the effectiveness of silver diamine fluoride (SDF) as a caries arresting and preventive agent. It provides clinical recommendations around SDF's appropriate use as part of a comprehensive caries management program. Systematic reviews confirm that SDF is effective for caries arrest on cavitated lesions in primary teeth and root caries in the elderly. It may also prevent new lesions. Application is easy, noninvasive, affordable, and safe. Although it stains the lesions dark as it arrests them, it provides clinicians with an additional tool for caries management when esthetics are not a primary concern.
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Silver diamine fluoride has been shown to arrest caries progression in primary teeth by up to 80%, making it valuable for underserved populations and children with dental anxiety or special healthcare needs.
“For instance, SDF a non-invasive, cost-effective topical agent has been shown to arrest caries progression in primary teeth by up to 80%, making it particularly valuable for underserved populations and children with dental anxiety or special healthcare needs [7,8].”
From Minimally Invasive Techniques for Managing Dental Caries in Children: Efficacy, Applications, and Future Directions (2025) · cites this paper as [7]
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Parental perceptions and acceptance of silver diamine fluoride staining in Italy
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Silver diamine fluoride alters microbial communities in subsurface dentin
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The use of silver diamine fluoride in a children's hospital: Critical analysis and action protocol
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A 12-Month Randomized Clinical Trial of 38% SDF vs. Restorative Treatment
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Bond Strength and Microleakage of a Novel Glass Ionomer Cement Containing Silver Diamine Fluoride
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Nanosilver fluoride as a caries arresting agent: A narrative review
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Pharmacokinetics of 38 Percent Silver Diamine Fluoride in Children.
Ellenikiotis, H., Chen, K., Soleimani‐Meigooni, D. N., Rothen, M. L., Thompson, B., Lin, Y. S., & Milgrom, P. (2022) · PubMed · Cited by 9 · see citing works
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The Use of Silver Diamine Fluoride in Pediatric Dentistry
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Clinical use of silver diamine fluoride in older adults: A scoping review
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Case Report: Dental Findings Can Aid in Early Diagnosis of APECED Syndrome
Brenchley, L., Ferré, E. M. N., Schmitt, M. M., Gardner, P. J., Lionakis, M. S., & Moutsopoulos, N. M. (2021) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2021.670624 · Cited by 6 · see citing works
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Top 100 cited articles on Silver diamine fluoride-A bibliometric analysis
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“For instance, SDF a non-invasive, cost-effective topical agent has been shown to arrest caries progression in primary teeth by up to 80%, making it particularly valuable for underserved populations and children with dental anxiety or special healthcare needs [7,8].”
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Abbas, B., Aamer, S., Anwar, F. S., Farhan, F., Wajahat, M., & Khurshid, Z. (2021) · European Journal of General Dentistry · doi:10.1055/s-0041-1739510 · Cited by 4 · see citing works
- Authors
- Crystal, Y. O., & Niederman, R.
- Affiliations
- New York University (US)
- Corresponding author
- Crystal, Yasmi O.
- Venue
- Dental Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 63
- Issue
- 1
- Pages
- 45-68
- ISSN
- 0011-8532 (ISSN-L)
- PMC
- PMC6500430
- OpenAlex
- W2901262305
- Cited by
- 253
- References
- 64
- Citations by year
- 2026: 28 · 2025: 38 · 2024: 38 · 2023: 47 · 2022: 46 · 2021: 35 · 2020: 17 · 2019: 4
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Dental Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01MD011526)
- Patient-Centered Outcomes Research Institute (PCS-1609-36824)
- Topics
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
- Health Sciences › Dentistry › Oral Surgery › Endodontics and Root Canal Treatments
- Keywords
- silver diamine fluoride, caries arrest, dental caries prevention, primary teeth, root caries, cavitated lesions, caries management, dental caries
- MeSH terms
- Aged, Quaternary Ammonium Compounds, Anti-Bacterial Agents, Cariostatic Agents, Child, Dental Caries, Fluorides, Topical, Humans, Pediatric Dentistry, Tooth Remineralization, Tooth, Deciduous, Patient Satisfaction, Root Caries, Silver Compounds, Evidence-Based Dentistry
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