Microbial recognition by Toll-like receptors

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · see citing works

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137 · see citing works

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129 · see citing works

Toll-like receptors: critical proteins linking innate and acquired immunity

Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777 · see citing works

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,027 · see citing works

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680 · see citing works

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605 · see citing works

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374 · see citing works

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,244 · see citing works

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680 · see citing works

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., & Akira, S. (2002) · Nature Immunology · doi:10.1038/ni758 · Cited by 2,517 · see citing works

Unresponsiveness of MyD88-deficient mice to endotoxin.

Kawai, T., Adachi, O., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80086-2 · Cited by 2,367 · see citing works

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

Ozinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L. A., & Aderem, A. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250476497 · Cited by 2,086 · see citing works

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

Kurt-Jones, E., Popova, L., Kwinn, L. A., Haynes, L., Jones, L. P., Tripp, R., Walsh, E., Freeman, M., Golenbock, D., Anderson, L., et al. (2000) · Nature Immunology · doi:10.1038/80833 · Cited by 1,842 · see citing works

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., & Kirschning, C. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17406 · Cited by 1,704 · see citing works

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G., Lin, R., & Hiscott, J. B. (2003) · Science · doi:10.1126/science.1081315 · Cited by 1,664 · see citing works

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

Ohashi, K., Burkart, V., Flohé, S. B., & Kolb, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.558 · Cited by 1,607 · see citing works

Novel Signal Transduction Pathway Utilized by Extracellular HSP70

Asea, A., Rehli, M., Kabingu, E., Boch, J. A., Baré, O., Auron, P. E., Stevenson, M. A., & Calderwood, S. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200497200 · Cited by 1,510 · see citing works

Innate immune sensing and its roots: the story of endotoxin

Beutler, B., & Rietschel, E. (2003) · Nature reviews. Immunology · doi:10.1038/nri1004 · Cited by 1,392 · see citing works

Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., & Simon, J. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20001858 · Cited by 1,378 · see citing works

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

Underhill, D. M., Ozinsky, A., Hajjar, A. M., Stevens, A. M., Wilson, C. B., Bassetti, M., & Aderem, A. A. (1999) · Nature · doi:10.1038/44605 · Cited by 1,369 · see citing works

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R. L., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.10 · Cited by 1,328 · see citing works

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling

Kobayashi, K. S., Hernandez, L. D., Galán, J. E., Janeway, C. A., Medzhitov, R. M., & Flavell, R. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00827-9 · Cited by 1,289 · see citing works

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

von Bernuth, H., Pïcard, C., Jin, Z., Sranujit, R. P., Xiao, H. Q., Ku, C., Chrabieh, M., Ben‐Mustapha, I., Ghandil, P., Çamcıoğlu, Y., et al. (2008) · Science · doi:10.1126/science.1158298 · Cited by 1,287 · see citing works

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Fitzgerald, K. A., Pålsson‐McDermott, E. M., Bowie, A., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E. K., Dunne, A., Gray, P., Harte, M. T., et al. (2001) · Nature · doi:10.1038/35092578 · Cited by 1,258 · see citing works

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint

Lomaga, M. A., Yeh, W., Sarosi, I., Duncan, G. S., Furlonger, C. L., Ho, A. P., Morony, S., Capparelli, C., Van, G. Y., Kaufman, S., et al. (1999) · Genes & Development · doi:10.1101/gad.13.8.1015 · Cited by 1,253 · see citing works

Discrimination of bacterial lipoproteins by Toll-like receptor 6

Takeuchi, O., Kawai, T., Mühlradt, P. F., Morr, M., Radolf, J. D., Zychlinsky, A., Takeda, K., & Akira, S. (2001) · International Immunology · doi:10.1093/intimm/13.7.933 · Cited by 1,233 · see citing works

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

Hoebe, K. H. N., Du, X., Georgel, P., Janssen, E. M., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., et al. (2003) · Nature · doi:10.1038/nature01889 · Cited by 1,232 · see citing works

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

Yamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.6668 · Cited by 1,227 · see citing works

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

Okamura, Y., Watari, M., Jerud, E. S., Young, D. W., Ishizaka, S. T., Rose, J., Chow, J. C., & Strauss, J. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100099200 · Cited by 1,217 · see citing works

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,208 · see citing works

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

Lund, J. M., Sato, A., Akira, S., Medzhitov, R. M., & Iwasaki, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030162 · Cited by 1,197 · see citing works

Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection1

Takeuchi, O., Hoshino, K., & Akira, S. (2000) · Journal of Immunology · doi:10.4049/jimmunol.165.10.5392 · Cited by 1,156 · see citing works

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

Kawai, T., Takeuchi, O., Fujita, T., Inoue, J., Mühlradt, P. F., Sato, S., Hoshino, K., & Akira, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.5887 · Cited by 1,095 · see citing works

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K., & Akira, S. (2003) · Nature Immunology · doi:10.1038/ni986 · Cited by 1,052 · see citing works

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., et al. (2002) · Nature · doi:10.1038/nature01182 · Cited by 995 · see citing works

TIRAP: an adapter molecule in the Toll signaling pathway

Horng, T., Barton, G. M., & Medzhitov, R. M. (2001) · Nature Immunology · doi:10.1038/ni0901-835 · Cited by 970 · see citing works

HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

Vabulas, R. M., Ahmad‐Nejad, P., Ghose, S., Kirschning, C. J., Issels, R. D., & Wagner, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111204200 · Cited by 949 · see citing works

Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4

Smiley, S. T., King, J. A., & Hancock, W. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2887 · Cited by 946 · see citing works

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

Suzuki, N., Suzuki, S., Duncan, G. S., Millar, D. G., Wada, T., Mirtsos, C., Takada, H., Wakeham, A. C., Itié, A., Li, S., et al. (2002) · Nature · doi:10.1038/nature736 · Cited by 858 · see citing works

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

Doyle, S. E., Vaidya, S. A., O’Connell, R. M., Dadgostar, H., Dempsey, P. W., Wu, T., Rao, G., Sun, R., Haberland, M. E., Modlin, R. L., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00390-4 · Cited by 845 · see citing works

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF‐3 and CBP/p300

Yoneyama, M., Suhara, W., Fukuhara, Y., Fukuda, M., Nishida, E., & Fujita, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.4.1087 · Cited by 841 · see citing works

Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

Pïcard, C., Puel, A., Bonnet, M., Ku, C., Bustamante, J. C., Yang, K., Soudais, C., Boisson‐Dupuis, S., Feinberg, J. M., Fieschi, C., et al. (2003) · Science · doi:10.1126/science.1081902 · Cited by 828 · see citing works

Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages

Underhill, D. M., Ozinsky, A., Smith, K. D., & Aderem, A. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14459 · Cited by 827 · see citing works

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

Horng, T., Barton, G. M., Flavell, R. A., & Medzhitov, R. M. (2002) · Nature · doi:10.1038/nature01180 · Cited by 809 · see citing works

Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells

Vabulas, R. M., Ahmad-Nejad, P., da Costa, C., Miethke, T., Kirschning, C. J., Häcker, H., & Wagner, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103217200 · Cited by 805 · see citing works

Human Toll-Like Receptors Mediate Cellular Activation by <i>Mycobacterium tuberculosis</i>

Means, T. K., Wang, S., Lien, E., Yoshimura, A., Golenbock, D. T., & Fenton, M. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3920 · Cited by 804 · see citing works

TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

Toshchakov, V. Y., Jones, B. W., Perera, P., Thomas, K., Cody, M. J., Zhang, S., Williams, B. R. G., Major, J. A., Hamilton, T. A., Fenton, M. J., et al. (2002) · Nature Immunology · doi:10.1038/ni774 · Cited by 803 · see citing works

IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

Li, S., Strelow, A., Fontana, E. J., & Wesche, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082100399 · Cited by 714 · see citing works

Receptor-Mediated Monitoring of Tissue Well-Being Via Detection of Soluble Heparan Sulfate by Toll-Like Receptor 4

Johnson, G. B., Brunn, G. J., Kodaira, Y., & Platt, J. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5233 · Cited by 648 · see citing works

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

Naito, A., Azuma, S., Tanaka, S., Miyazaki, T., Takaki, S., Takatsu, K., Nakao, K., Nakamura, K., Katsuki, M., Yamamoto, T. S., et al. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00265.x · Cited by 626 · see citing works

Limb and Skin Abnormalities in Mice Lacking IKKα

Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., & Akira, S. (1999) · Science · doi:10.1126/science.284.5412.313 · Cited by 609 · see citing works

NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase

Pomerantz, J. L., & Baltimore, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6694 · Cited by 595 · see citing works

Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite

Campos, M. A., de Almeida, I. C., Takeuchi, O., Akira, S., Valente, E. P., Procópio, D. O., Travassos, L. R., Smith, J. A., Golenbock, D. T., & Gazzinelli, R. T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.416 · Cited by 587 · see citing works

Cutting Edge: Preferentially the R -Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway

Takeuchi, O., Kaufmann, A. M., Grote, K., Kawai, T., Hoshino, K., Morr, M., Mühlradt, P. F., & Akira, S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.554 · Cited by 569 · see citing works

Cutting Edge: MyD88 Is Required for Resistance to Toxoplasma gondii Infection and Regulates Parasite-Induced IL-12 Production by Dendritic Cells1

Scanga, C., Aliberti, J., Jankovic, D., Tilloy, F., Bennouna, S., Denkers, E., Medzhitov, R., & Sher, A. (2002) · Journal of Immunology · doi:10.4049/jimmunol.168.12.5997 · Cited by 547 · see citing works

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

Rudolph, D., Yeh, W., Wakeham, A. C., Rudolph, B., Nallainathan, D., Potter, J., Elia, A., & Mak, T. W. (2000) · PubMed Central · Cited by 518 · see citing works

Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus

Haynes, L. M., Moore, D. D., Kurt‐Jones, E. A., Finberg, R. W., Anderson, L. J., & Tripp, R. A. (2001) · Journal of Virology · doi:10.1128/jvi.75.22.10730-10737.2001 · Cited by 496 · see citing works

Murine retroviruses activate B cells via interaction with toll-like receptor 4

Rassa, J., Meyers, J., Zhang, Y., Kudaravalli, R., & Ross, S. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.042355399 · Cited by 493 · see citing works

The Toll–IL-1 receptor adaptor family grows to five members

O'Neill, L. A. J., Fitzgerald, K. A., & Bowie, A. G. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00115-7 · Cited by 492 · see citing works

Severe liver degeneration and lack of <i>NF</i>-κ<i>B</i> activation in <i>NEMO/IKKγ</i>-deficient mice

Rudolph, D., Yeh, W.-C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia, A. J., & Mak, T. W. (2000) · Genes &amp; Development · doi:10.1101/gad.14.7.854 · Cited by 479 · see citing works

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling

Bowie, A., Kiss‐Toth, E., Symons, J. A., Smith, G. L., Dower, S., & O'Neill, L. A. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160027697 · Cited by 467 · see citing works

Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

Hajjar, A. M., O’Mahony, D. S., Ozinsky, A., Underhill, D. M., Aderem, A. A., Klebanoff, S. J., & Wilson, C. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.15 · Cited by 465 · see citing works

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

Matsumoto, M., Kikkawa, S., Kohase, M., Miyake, K., & Seya, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00380-7 · Cited by 451 · see citing works

The CD14 Ligands Lipoarabinomannan and Lipopolysaccharide Differ in Their Requirement for Toll-Like Receptors

Means, T. K., Lien, E., Yoshimura, A., Wang, S., Golenbock, D. T., & Fenton, M. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6748 · Cited by 431 · see citing works

Endotoxin Contamination in Recombinant Human Heat Shock Protein 70 (Hsp70) Preparation Is Responsible for the Induction of Tumor Necrosis Factor α Release by Murine Macrophages

Gao, B., & Tsan, M.-F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208742200 · Cited by 396 · see citing works

JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection

Chu, W., Ostertag, D. G., Li, Z.-W., Chang, L., Chen, Y., Hu, Y., Williams, B. R. G., Perrault, J., & Karin, M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80146-6 · Cited by 389 · see citing works

The Poxvirus Protein A52R Targets Toll-like Receptor Signaling Complexes to Suppress Host Defense

Harte, M. T., Haga, I. R., Maloney, G., Gray, P., Reading, P. C., Bartlett, N. W., Smith, G. L., Bowie, A., & O'Neill, L. A. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021652 · Cited by 370 · see citing works

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases

Shimada, T., Kawai, T., Takeda, K., Matsumoto, M., Inoue, J., Tatsumi, Y., Kanamaru, A., & Akira, S. (1999) · International Immunology · doi:10.1093/intimm/11.8.1357 · Cited by 369 · see citing works

GENETIC CONTROL OF RESPONSES TO BACTERIAL LIPOPOLYSACCHARIDES IN MICE

Watson, J. D., & Riblet, R. J. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.140.5.1147 · Cited by 353 · see citing works

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1

Weaver, B. K., Kumar, K. P., & Reich, N. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1359 · Cited by 351 · see citing works

The Roles of Toll-Like Receptor 9, MyD88, and DNA-Dependent Protein Kinase Catalytic Subunit in the Effects of Two Distinct CpG DNAs on Dendritic Cell Subsets

Hemmi, H., Kaisho, T., Takeda, K., & Akira, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3059 · Cited by 338 · see citing works

IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex

Peters, R., Liao, S.-M., & Maniatis, T. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80445-1 · Cited by 335 · see citing works

Cutting Edge: Immune Stimulation by Neisserial Porins Is Toll-Like Receptor 2 and MyD88 Dependent

Massari, P., Henneke, P., Ho, Y., Latz, E., Golenbock, D. T., & Wetzler, L. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1533 · Cited by 292 · see citing works

Induction of Cross-Tolerance by Lipopolysaccharide and Highly Purified Lipoteichoic Acid Via Different Toll-Like Receptors Independent of Paracrine Mediators

Lehner, M. D., Morath, S., Michelsen, K. S., Schumann, R. R., & Härtung, T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.5161 · Cited by 284 · see citing works

Differential involvement of IFN- in Toll-like receptor-stimulated dendritic cell activation

Hoshino, K., Kaisho, T., Iwabe, T., Takeuchi, O., & Akira, S. (2002) · International Immunology · doi:10.1093/intimm/dxf089 · Cited by 282 · see citing works

Impaired Cytokine Signaling in Mice Lacking the IL-1 Receptor-Associated Kinase

Thomas, J. A., Allen, J. L., Tsen, M. F., Dubnicoff, T., Danao, J., Liao, X. C., Cao, Z., & Wasserman, S. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.978 · Cited by 280 · see citing works

IL-1 Receptor-Associated Kinase Modulates Host Responsiveness to Endotoxin

Swantek, J. L., Tsen, M. F., Cobb, M. H., & Thomas, J. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4301 · Cited by 279 · see citing works

Essential role of IRF-3 in lipopolysaccharide-induced interferon-β gene expression and endotoxin shock

Sakaguchi, S., Negishi, H., Asagiri, M., Nakajima, C., Mizutani, T., Takaoka, A., Honda, K., & Taniguchi, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01049-0 · Cited by 264 · see citing works

Cutting Edge: Administration of Anti-CD40 Ligand and Donor Bone Marrow Leads to Hemopoietic Chimerism and Donor-Specific Tolerance Without Cytoreductive Conditioning

Durham, M. M., Bingaman, A. W., Adams, A. B., Ha, J., Waitze, S. R., Pearson, T. C., & Larsen, C. P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.1 · Cited by 248 · see citing works

Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation

Opitz, B., Schröder, N. W. J., Spreitzer, I., Michelsen, K. S., Kirschning, C. J., Hallatschek, W., Zähringer, U., Härtung, T., Göbel, U. B., & Schumann, R. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010481200 · Cited by 228 · see citing works

Activation of Macrophages by Linear (1→3)-β-d-Glucans

Kataoka, K., Muta, T., Yamazaki, S., & Takeshige, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206756200 · Cited by 219 · see citing works

Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production

Kanakaraj, P., Schafer, P., Cavender, D., Wu, Y., Ngo, K., Grealish, P., Wadsworth, S., Peterson, P. A., Siekierka, J., Harris, C. A., et al. (1998) · Journal of Experimental Medicine · doi:10.1084/jem.187.12.2073 · Cited by 219 · see citing works

Defective Interleukin (IL)-18–mediated Natural Killer and T Helper Cell Type 1 Responses in IL-1 Receptor–associated Kinase (IRAK)-deficient Mice

Kanakaraj, P., Ngo, K., Wu, Y., Angulo, A., Ghazal, P., Harris, C. A., Siekierka, J., Peterson, P. A., & Fung-Leung, W. (1999) · Journal of Experimental Medicine · doi:10.1084/jem.189.7.1129 · Cited by 196 · see citing works

TIRP, a Novel Toll/Interleukin-1 receptor (TIR) Domain-containing Adapter Protein Involved in TIR Signaling

Bin, L., Xu, L., & Shu, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303451200 · Cited by 115 · see citing works

NF‐κB activation through IKK‐i‐dependent I‐TRAF/TANK phosphorylation

Nomura, Kawai, T., Nakanishi, K., & Akira, S. (2000) · Genes to Cells · doi:10.1046/j.1365-2443.2000.00315.x · Cited by 102 · see citing works

Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes

Ropert, C., Ferreira, L. R. P., Campos, M. A., Procópio, D. O., Travassos, L. R., Ferguson, M. A. J., Reis, L. F. L., Teixeira, M. M., de Almeida, I. C., & Gazzinelli, R. T. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01609-x · Cited by 77 · see citing works

Leishmania major activates IL-1α expression in macrophages through a MyD88-dependent pathway

Hawn, T. R., Ozinsky, A., Underhill, D. M., C, F. S. B. A., Akira, S., & Aderem, A. A. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01596-4 · Cited by 76 · see citing works

Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.

Yoshimura, A., Lien, E., Ingalls, R., Tuomanen, E., Dziarski, R., & Golenbock, D. (1999) · Journal of Immunology · doi:10.4049/jimmunol.163.1.1 · Cited by 2 · see citing works

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works

Gut microbiome and health: mechanistic insights

de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut · doi:10.1136/gutjnl-2021-326789 · Cited by 2,388 · see citing works

YERSINIA OUTER PROTEINS: Role in Modulation of Host Cell Signaling Responses and Pathogenesis

Viboud, G. I., & Bliska, J. B. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121320 · Cited by 600 · see citing works

Genomic Insights into Syntrophy: The Paradigm for Anaerobic Metabolic Cooperation

Sieber, J. R., McInerney, M. J., & Gunsalus, R. P. (2010) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102844 · Cited by 524 · see citing works

The microbiome: a key regulator of stress and neuroinflammation

Rea, K., Dinan, T. G., & Cryan, J. F. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.03.001 · Cited by 508 · see citing works

Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum: CELL SIGNALING RECEPTORS, GPI STRUCTURAL REQUIREMENT, AND REGULATION OF GPI ACTIVITY

Krishnegowda, G., Hajjar, A., Zhu, J., Douglass, E., Uematsu, S., Akira, S., Woods, A., & Gowda, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413541200 · Cited by 36 · see citing works

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

Minter, M. R., Taylor, J. M., & Crack, P. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13411 · Cited by 451 · see citing works

RAGE regulation and signaling in inflammation and beyond

Kierdorf, K., & Fritz, G. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012519 · Cited by 434 · see citing works

Signaling pathways in obesity: mechanisms and therapeutic interventions

Wen, X., Zhang, B., Wu, B., Xiao, H., Li, Z., Li, R., Xu, X., & Li, T. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01149-x · Cited by 456 · see citing works

Neutrophil apoptosis and the resolution of infection

Kennedy, A. D., & DeLeo, F. R. (2008) · Immunologic Research · doi:10.1007/s12026-008-8049-6 · Cited by 399 · see citing works

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

Varnum, M. M., & Ikezu, T. (2012) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0181-2 · Cited by 393 · see citing works

Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes

Nagy, I., Pivarcsi, A., Kis, K., Koreck, A., Bodai, L., McDowell, A., Seltmann, H., Patrick, S., Zouboulis, C. C., & Kemény, L. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.04.001 · Cited by 375 · see citing works

Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons

Gregorio, J., Meller, S., Conrad, C., Di Nardo, A., Homey, B., Lauerma, A., Arai, N., Gallo, R. L., DiGiovanni, J., & Gilliet, M. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20101102 · Cited by 367 · see citing works

The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway

Chen, C., Kao, C., & Liu, C.-M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092729 · Cited by 341 · see citing works

Distinct Strains of Propionibacterium acnes Induce Selective Human β-Defensin-2 and Interleukin-8 Expression in Human Keratinocytes Through Toll-Like Receptors

Nagy, I., Pivarcsi, A., Koreck, A., Széll, M., Urbán, E. Z., & Kemény, L. V. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23705.x · Cited by 336 · see citing works

Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors

Jo, E., Yang, C., Choi, C. H., & Harding, C. V. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00914.x · Cited by 331 · see citing works

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20

Turer, E. E., Tavares, R. M., Mortier, E., Hitotsumatsu, O., Advincula, R., Lee, B. L., Shifrin, N. T., Malynn, B. A., & Ma, A. I. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071108 · Cited by 270 · see citing works

Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: Underlying mechanisms

Teeling, J. L., & Perry, V. H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.031 · Cited by 251 · see citing works

Trigeminal Nociceptors Express TLR-4 and CD14: a Mechanism for Pain due to Infection

Wadachi, R., & Hargreaves, K. (2006) · Journal of Dental Research · doi:10.1177/154405910608500108 · Cited by 240 · see citing works

Antitumor Activity of the TLR-5 Ligand Flagellin in Mouse Models of Cancer

Sfondrini, L., Rossini, A., Besusso, D., Merlo, A. C., Tagliabue, E., Ménard, S., & Balsari, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6624 · Cited by 194 · see citing works

Long-term activation of TLR3 by Poly(I:C) induces inflammation and impairs lung function in mice

Stowell, N. C., Seideman, J. H., Raymond, H. A., Smalley, K. A., Lamb, R. J., Egenolf, D., Bugelski, P. J., Murray, L. A., Marsters, P. A., Bunting, R. A., et al. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-43 · Cited by 185 · see citing works

MicroRNAs as Molecular Switches in Macrophage Activation

Curtale, G., Rubino, M., & Locati, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00799 · Cited by 182 · see citing works

Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish

van der Vaart, M., Spaink, H. P., & Meijer, A. H. (2012) · Advances in Hematology · doi:10.1155/2012/159807 · Cited by 172 · see citing works

Essential Role for Caspase-8 in Toll-like Receptors and NFκB Signaling

Lemmers, B., Salmena, L., Bidère, N., Su, H., Matysiak-Zablocki, E., Murakami, K., Ohashi, P. S., Jurisicova, A., Lenardo, M., Hakem, R., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606721200 · Cited by 163 · see citing works

The expression and roles of Toll-like receptors in the biology of the human neutrophil

Parker, L. C., Whyte, M. K. B., Dower, S., & Sabroe, I. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1104636 · Cited by 175 · see citing works

Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway

Hoarau, C., Lagaraine, C., Martin, L., Velge-Roussel, F., & Lebranchu, Y. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.10.043 · Cited by 171 · see citing works

Activation of Toll-Like Receptor (TLR)2, TLR4, and TLR9 in the Mammalian Cornea Induces MyD88-Dependent Corneal Inflammation

Johnson, A. C., Heinzel, F. P., Diaconu, E., Sun, Y., Hise, A. G., Golenbock, D. T., Lass, J. H., & Pearlman, E. M. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1077 · Cited by 167 · see citing works

Immunohistochemical localization of Toll‐like receptors 1–10 in periodontitis

Beklen, A., Hukkanen, M., Rautemaa‐Richardson, R., & Konttinen, Y. T. (2008) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2008.00448.x · Cited by 165 · see citing works

Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols of Plasmodium falciparum

Zhu, J., Gowda, K., & Gowda, D. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413539200 · Cited by 164 · see citing works

Epstein-Barr Virus Induces MCP-1 Secretion by Human Monocytes via TLR2

Gaudreault, É., Fiola, S., Olivier, M., & Gosselin, J. (2007) · Journal of Virology · doi:10.1128/jvi.00403-07 · Cited by 163 · see citing works

1. Overview of the human immune response

Chaplin, D. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.09.034 · Cited by 158 · see citing works

Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin

Sugita, K., Kabashima, K., Atarashi, K., Shimauchi, T., Kobayashi, M., & TOKURA, Y. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03258.x · Cited by 152 · see citing works

TLR SIGNALING PATHWAY IN PATIENTS WITH SEPSIS

Salomão, R., Martins, P. S., Brunialti, M. K. C., Fernandes, M. D. L., Martos, L., Mendes, M. E., Gomes, N. E., & Rigato, O. (2008) · Shock · doi:10.1097/shk.0b013e318181af2a · Cited by 143 · see citing works

Gut Microbiota: A Perspective for Psychiatrists

Rea, K., Dinan, T. G., & Cryan, J. F. (2019) · Neuropsychobiology · doi:10.1159/000504495 · Cited by 142 · see citing works

TLR9 Is Required for the Gut-Associated Lymphoid Tissue Response following Oral Infection of Toxoplasma gondii

Minns, L. A., Menard, L. C., Foureau, D., Darche, S., Ronet, C., Mielcarz, D. W., Buzoni–Gatel, D., & Kasper, L. H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7589 · Cited by 140 · see citing works

Anti-inflammatory effects of resveratrol occur via inhibition of lipopolysaccharide-induced NF-κB activation in Caco-2 and SW480 human colon cancer cells

Panaro, M. A., Carofiglio, V. E., Acquafredda, A., Cavallo, P., & Cianciulli, A. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511007227 · Cited by 139 · see citing works

MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans

Biondo, C., Midiri, A., Messina, L., Tomasello, F. F., Garufi, G., Catania, M. R., Bombaci, M., Beninati, C., Teti, G., & Mancuso, G. (2005) · European Journal of Immunology · doi:10.1002/eji.200425799 · Cited by 139 · see citing works

Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells

Kanazawa, N. (2007) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2006.09.001 · Cited by 134 · see citing works

Functional analysis of a zebrafishmyd88mutant identifies key transcriptional components of the innate immune system

van der Vaart, M., van Soest, J. J., Spaink, H. P., & Meijer, A. H. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010843 · Cited by 134 · see citing works

Nontypeable Haemophilus influenzae Initiates Formation of Neutrophil Extracellular Traps

Juneau, R. A., Pang, B., Weimer, K. E. D., Armbruster, C. E., & Swords, W. E. (2010) · Infection and Immunity · doi:10.1128/iai.00660-10 · Cited by 134 · see citing works

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

Cecil, J. D., O’brien-simpson, N. M., Lenzo, J. C., Holden, J. A., Chen, Y.-Y., Singleton, W., Gause, K. T., Yan, Y., Caruso, F., & Reynolds, E. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151967 · Cited by 126 · see citing works

Toll-like Receptors in Tumor Immunotherapy

Paulos, C. M., Kaiser, A., Wrzesinski, C., Hinrichs, C. S., Cassard, L., Boni, A., Muranski, P. J., Sanchez-Perez, L. A., Palmer, D. C., Yu, Z., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1378 · Cited by 124 · see citing works

Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation

Paciello, I., Silipo, A., Fazio, L. L., Curcurù, L., Zumsteg, A. B., Noël, G., Ciancarella, V., Sturiale, L., Molinaro, A., & Bernardini, M. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303641110 · Cited by 120 · see citing works

Interferons (IFNs) are key cytokines in both innate and adaptive antiviral immune responses—and viruses counteract IFN action

Bonjardim, C. A. (2005) · Microbes and Infection · doi:10.1016/j.micinf.2005.02.001 · Cited by 118 · see citing works

Transcriptional Activation of Alpha/Beta Interferon Genes: Interference by Nonsegmented Negative-Strand RNA Viruses

Conzelmann, K. (2005) · Journal of Virology · doi:10.1128/jvi.79.9.5241-5248.2005 · Cited by 117 · see citing works

Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides

Martin‐Armas, M., Simón-Santamaría, J., Pettersen, I., Moens, U. L., Smedsrød, B. H., & Sveinbjørnsson, B. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.09.020 · Cited by 108 · see citing works

HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation

Heron, S., & Elahi, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00241 · Cited by 104 · see citing works

Toll-Like Receptor-2 Mediates Diet and/or Pathogen Associated Atherosclerosis: Proteomic Findings

Madan, M., & Amar, S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003204 · Cited by 95 · see citing works

Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399Ile are hypo-responsive to Porphyromonas gingivalis

Kinane, D. F., Shiba, H., Stathopoulou, P. G., Zhao, H., Lappin, D. F., Singh, A. V., Eskan, M. A., Beckers, S., Waigel, S. J., Alpert, B., et al. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364282 · Cited by 96 · see citing works

Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling

Shinohara, H., Inoue, A., Toyama‐Sorimachi, N., Nagai, Y., Yasuda, T., Suzuki, H., Horai, R., Iwakura, Y., Yamamoto, T. S., Karasuyama, H., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041817 · Cited by 92 · see citing works

Toll-like receptor 4 activates NF-κB and MAP kinase pathways to regulate expression of proinflammatory COX-2 in renal medullary collecting duct cells

Küper, C., Beck, F.-X., & Neuhofer, W. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00590.2010 · Cited by 92 · see citing works

The Radioprotective 105/MD-1 Complex Links TLR2 and TLR4/MD-2 in Antibody Response to Microbial Membranes

Nagai, Y., Kobayashi, T., Motoi, Y., Ishiguro, K., Akashi, S., Saitoh, S.-I., Kusumoto, Y., Kaisho, T., Akira, S., Matsumoto, M., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7043 · Cited by 92 · see citing works

Positive modulators of the α7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer's disease

Echeverrı́a, V., Iarkov, A., & Aliev, G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.002 · Cited by 91 · see citing works

[The role of Toll-like receptors (TLR) in innate and adaptive immune responses and their function in immune response regulation].

Majewska, M., & Szczepanik, M. (2006) · PubMed · Cited by 91 · see citing works

Evaluation of β-(1→3, 1→6)-glucans and High-M alginate used as immunostimulatory dietary supplement during first feeding and weaning of Atlantic cod (Gadus morhua L.)

Skjermo, J., Størseth, T. R., Hansen, K., Handå, A., & Øie, G. (2006) · Aquaculture · doi:10.1016/j.aquaculture.2006.07.035 · Cited by 90 · see citing works

The microbiota-gut-brain axis: Focus on the fundamental communication pathways

Bistoletti, M., Bosi, A., Banfi, D., Giaroni, C., & Baj, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.012 · Cited by 88 · see citing works

Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis

Martins, P. S., Brunialti, M. K. C., Martos, L., Machado, F. R., de Assunção, M. S. C., Blecher, S., & Salomão, R. (2008) · Critical Care · doi:10.1186/cc6801 · Cited by 88 · see citing works

Role of MyD88 and TLR9 in the Innate Immune Response Elicited by Serotype 5 Adenoviral Vectors

Yamaguchi, T., Kawabata, K., Koizumi, N., Sakurai, F., Kaneda‐Nakashima, K., Sakurai, H., Sasaki, T., Okada, N., Yamanishi, K., & Mizuguchi, H. (2007) · Human Gene Therapy · doi:10.1089/hum.2007.016 · Cited by 87 · see citing works

Distinct toll-like receptor expression in monocytes and T cells in chronic HCV infection

Dolganiuc, A. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i8.1198 · Cited by 85 · see citing works

The Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer

Oseni, S. O., Naar, C., Pavlović, M. D., Asghar, W., Hartmann, J. X., Fields, G. B., Esiobu, N., & Kumi-Diaka, J. K. (2023) · Cancers · doi:10.3390/cancers15123110 · Cited by 94 · see citing works

Expression and functionality of Toll‐like receptor 3 in the megakaryocytic lineage

D’Atri, L. P., Etulain, J., Rivadeneyra, L., Lapponi, M. J., Centurion, M., Cheng, K., Yin, H. H., & Schattner, M. A. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12842 · Cited by 80 · see citing works

Replacement of fishmeal by spirulina Arthrospira platensis affects growth, immune related-gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection

Cao, S., Zhang, P., Zou, T., Fei, S., Han, D. H., Jin, J., Liu, H., Yang, Y., Zhu, X., & Xie, S. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.05.022 · Cited by 82 · see citing works

Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells

Latvala, S., Pietilä, T. E., Veckman, V., Kekkonen, R. A., Tynkkynen, S., Korpela, R., & Julkunen, I. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5570 · Cited by 79 · see citing works

Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs

Hasan, U. A., Caux, C., Perrot, I., Doffin, A., Ménétrier‐Caux, C., Trinchieri, G., Tommasino, M., & Vlach, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700664104 · Cited by 78 · see citing works

High Basal Levels of Functional Toll-Like Receptor 3 (TLR3) and Noncanonical Wnt5a Are Expressed in Papillary Thyroid Cancer and Are Coordinately Decreased by Phenylmethimazole Together with Cell Proliferation and Migration

McCall, K. D., Harii, N., Lewis, C. J., Malgor, R., Kim, W. B., Saji, M., Kohn, A. D., Moon, R. T., & Kohn, L. D. (2007) · Endocrinology · doi:10.1210/en.2007-0459 · Cited by 76 · see citing works

2. Update on primary immunodeficiency diseases

Bonilla, F. A., & Geha, R. S. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.09.051 · Cited by 75 · see citing works

Macrophage-Elicited Osteoclastogenesis in Response to Bacterial Stimulation Requires Toll-Like Receptor 2-Dependent Tumor Necrosis Factor-Alpha Production

Ukai, T., Yumoto, H., Gibson, F., & Genco, C. (2007) · Infection and Immunity · doi:10.1128/iai.01241-07 · Cited by 77 · see citing works

Recognition of fungal RNA by TLR 7 has a nonredundant role in host defense against experimental candidiasis

Biondo, C., Malara, A., Costa, A., Signorino, G., Cardile, F., Midiri, A., Galbo, R., Papasergi, S., Domina, M., Pugliese, M., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242532 · Cited by 69 · see citing works

Effect of toll‐like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma

Mohamed, F. E. Z. A., Al-Jehani, R. M., Minogue, S., Andreola, F., Winstanley, A. M., Damink, S. W. M. O., Habtesion, A., Malagó, M., Davies, N. A., Luong, T. V., et al. (2014) · Liver International · doi:10.1111/liv.12626 · Cited by 70 · see citing works

Involvement of Toll-Like Receptors 2 and 4 in the Innate Immune Response to Treponema denticola and Its Outer Sheath Components

Nussbaum, G., Ben-Adi, S., Genzler, T., Sela, M., & Rosen, G. (2009) · Infection and Immunity · doi:10.1128/iai.00488-09 · Cited by 70 · see citing works

Cross Talk between MyD88 and Focal Adhesion Kinase Pathways

Zeisel, M. B., Druet, V. A., Sibilia, J., Klein, J.-P., Quesniaux, V. F. J., & Wachsmann, D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7393 · Cited by 69 · see citing works

Unraveling the Complexities of Toll-like Receptors: From Molecular Mechanisms to Clinical Applications

Chen, Y.-H., Wu, K., & Wu, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25095037 · Cited by 73 · see citing works

Up-regulated cathepsin C induces macrophage M1 polarization through FAK-triggered p38 MAPK/NF-κB pathway

Alam, S., Liu, Q., Liu, S., Liu, Y., Zhang, Y., Yang, X., Liu, G., Fan, K., & Ma, J. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.06.017 · Cited by 67 · see citing works

Measles virus–dendritic cell interaction via SLAM inhibits innate immunity: Selective signaling through TLR4 but not other TLRs mediates suppression of IL-12 synthesis

Hahm, B., Cho, J.-H., & Oldstone, M. B. A. (2006) · Virology · doi:10.1016/j.virol.2006.10.004 · Cited by 65 · see citing works

Lipopeptides for Vaccine Development

Hamley, I. W. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00258 · Cited by 63 · see citing works

Clinical and Pathological Implications of Concurrent Autoimmune Thyroid Disorders and Papillary Thyroid Cancer

Cunha, L. L., Ferreira, R. C. U., Marcello, M. A., Vassallo, J., & Ward, L. S. (2011) · Journal of Thyroid Research · doi:10.4061/2011/387062 · Cited by 62 · see citing works

NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy

Grondona, P., Bucher, P., Schulze‐Osthoff, K., Hailfinger, S., & Schmitt, A. (2018) · Biomedicines · doi:10.3390/biomedicines6020038 · Cited by 62 · see citing works

TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells

Theiner, G., Rößner, S., Dalpke, A. H., Bode, K. A., Berger, T. G., Gessner, A., & Lutz, M. B. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.02.021 · Cited by 61 · see citing works

The Role of the Gastrointestinal Microbiota in Visceral Pain

Rea, K., O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_115 · Cited by 60 · see citing works

Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy

Fakhri, S., Moradi, S. Z., Yarmohammadi, A., Narimani, F., Wallace, C. E., & Bishayee, A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.834072 · Cited by 59 · see citing works

Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice

Yao, H., Chen, L., Xu, C., Wang, J., Chen, J., Xie, Q.-M., Wu, X., & Yan, X. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.03.020 · Cited by 58 · see citing works

Effects of Propionibacterium acnes on various mRNA expression levels in normal human epidermal keratinocytes in vitro

Akaza, N., Akamatsu, H., KISHI, M., Mizutani, H., Ishii, I., Nakata, S., & Matsunaga, K. (2009) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2009.00626.x · Cited by 57 · see citing works

Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream

Torres, A., Storey, L., Anders, M., Miller, R. L., Bulbulian, B. J., Jin, J., Raghavan, S., Lee, J. S., Slade, H. B., & Birmachu, W. (2007) · Journal of Translational Medicine · doi:10.1186/1479-5876-5-7 · Cited by 55 · see citing works

Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists

Nguyen-Pham, T.-N., Lim, M.-S., Nguyen, T.-A. T., Lee, Y.-K., Jin, C.-J., Lee, H. J., Hong, C. Y., Ahn, J., Yang, D., Kim, Y., et al. (2011) · Cellular and Molecular Immunology · doi:10.1038/cmi.2011.7 · Cited by 54 · see citing works

Flavonoids Affect Host-Microbiota Crosstalk through TLR Modulation

Pérez-Cano, F. J., Massot‐Cladera, M., Rodríguez-Lagunas, M. J., & Castell, M. (2014) · Antioxidants · doi:10.3390/antiox3040649 · Cited by 54 · see citing works

Toll‐like Receptor 2‐Mediated Gene Expression in Epithelial Cells During Helicobacter pylori Infection

Ding, S., Torok, A. M., Smith, M. F., & Goldberg, J. B. (2005) · Helicobacter · doi:10.1111/j.1523-5378.2005.00311.x · Cited by 54 · see citing works

Bis (3-bromo-4,5-dihydroxybenzyl) ether, a novel bromophenol from the marine red alga Polysiphonia morrowii that suppresses LPS-induced inflammatory response by inhibiting ROS-mediated ERK signaling pathway in RAW 264.7 macrophages

Choi, Y. K., Ye, B., Kim, E.-A., Kim, J., Kim, M.-S., Lee, W., Ahn, G., Kang, N., Jung, W., & Heo, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.121 · Cited by 54 · see citing works

MyD88 is necessary for neutrophil recruitment in hypersensitivity pneumonitis

Nance, S. C., Yi, A., Re, F., & Fitzpatrick, E. A. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0607391 · Cited by 53 · see citing works

MicroRNA-21 regulate the cell apoptosis and cell proliferation of polycystic ovary syndrome (PCOS) granulosa cells through target toll like receptor TLR8

Yu, Y., Li, G., He, X., Lin, Y., Chen, Z., Lin, X.-H., & Xu, H. (2021) · Bioengineered · doi:10.1080/21655979.2021.1969193 · Cited by 52 · see citing works

Surface TLR2 and TLR4 Expression on Mature Rat Mast Cells Can Be Affected by Some Bacterial Components and Proinflammatory Cytokines

Pietrzak, A., Wierzbicki, M., Wiktorska, M., & Brzezińska‐Błaszczyk, E. (2011) · Mediators of Inflammation · doi:10.1155/2011/427473 · Cited by 52 · see citing works

Dendritic Cells andLeishmaniaInfection: Adding Layers of Complexity to a Complex Disease

Feijó, D. F., Tibúrcio, R., Ampuero, M. R., Brodskyn, C., & Tavares, N. M. (2016) · Journal of Immunology Research · doi:10.1155/2016/3967436 · Cited by 51 · see citing works

Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human β-defensin 2 production

Décanis, N., Savignac, K., & Rouabhia, M. (2009) · Cytokine · doi:10.1016/j.cyto.2008.11.011 · Cited by 51 · see citing works

Trans‐cinnamic aldehyde inhibits Aggregatibacter actinomycetemcomitans‐induced inflammation in THP‐1–derived macrophages via autophagy activation

Chung, J., Kim, S., Lee, H. A., Park, M. H., Kim, S., Song, Y., & Na, H. S. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0727 · Cited by 49 · see citing works

The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes

Hansen, F. C., Kalle, M., van der Plas, M. J. A., Strömdahl, A., Malmsten, M., Mörgelin, M., & Schmidtchen, A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403009 · Cited by 49 · see citing works

Annexin-A1 Regulates TLR-Mediated IFN-β Production through an Interaction with TANK-Binding Kinase 1

Bist, P., Shu, S., Lee, H., Arora, S., Nair, S., Lim, J. Y., Dayalan, J., Gasser, S., Biswas, S. K., Fairhurst, A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301504 · Cited by 48 · see citing works

Role of Macrophage Apoptosis in the Pathogenesis of Yersinia

Zhang, Y., & Bliska, J. B. (2005) · Springer eBooks · doi:10.1007/3-540-27320-4_7 · Cited by 48 · see citing works

CD14 , TLR4 and TRAM Show Different Trafficking Dynamics During LPS Stimulation

Klein, D. C. G., Skjesol, A., Kers‐Rebel, E. D., Sherstova, T., Sporsheim, B., Egeberg, K. W., Stokke, B. T., Espevik, T., & Husebye, H. (2015) · Traffic · doi:10.1111/tra.12274 · Cited by 47 · see citing works

The Link between Gut Dysbiosis Caused by a High-Fat Diet and Hearing Loss

Kociszewska, D., Chan, J., Thorne, P. R., & Vlajkovic, S. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413177 · Cited by 47 · see citing works

Modulation of connexin expression and gap junction communication in astrocytes by the gram‐positive bacterium S. aureus

Esen, N., Shuffield, D., Syed, M., & Kielian, T. (2006) · Glia · doi:10.1002/glia.20438 · Cited by 47 · see citing works

Diallyl trisulfide exerts anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 macrophages by suppressing the Toll-like receptor 4/nuclear factor-κB pathway

Lee, H. H., Han, M. H., Hwang, H. J., Kim, G., Moon, S., Hyun, J. W., Kim, W., & Choi, Y. H. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.2036 · Cited by 46 · see citing works

Evolution and integration of innate immune recognition systems: the Toll-like receptors

Takeda, K. (2005) · Journal of Endotoxin Research · doi:10.1177/09680519050110011101 · Cited by 105 · see citing works

Toll-like Receptors and their Adaptors in Innate Immunity

Takeda, K. (2005) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1568014053005336 · Cited by 9 · see citing works

TLR signaling pathways

Takeda, K., & Akira, S. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2003.10.003 · Cited by 2,461 · see citing works

Seminars in Immunology 16 (2004) 3–9 TLR signaling pathways

Takeda, K., & Akira, S. (2015)

Pathogen Associated Molecular Pattern Recognition in Innate Immunity

Akira, S. (2003) · Inflammation and Regeneration · doi:10.2492/jsir.23.211 · Cited by 3 · see citing works