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Cited by 187Immunotherapy and Immune ResponsesDermatology and Skin DiseasesT-cell and B-cell Immunology

Human skin dendritic cells in health and disease

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Haniffa, Muzlifah, Gunawan, Merry, Jardine, Laura·2015·Journal of Dermatological Science
DOI 10.1016/j.jdermsci.2014.08.012PMC PMC4728191
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Abstract

Dendritic cells (DCs) are specialized antigen presenting cells abundant in peripheral tissues such as skin where they function as immune sentinels. Skin DCs migrate to draining lymph node where they interact with naïve T cells to induce immune responses to microorganisms, vaccines, tumours and self-antigens. In this review, we present the key historical developments and recent advances in human skin DC research. We also integrate the current understanding on the origin and functional specializations of DC subsets in healthy skin with findings in inflammatory skin diseases focusing on psoriasis and atopic eczema. A comprehensive understanding of the dynamic changes in DC subsets in health and disease will form a strong foundation to facilitate the clinical translation of DC-based therapeutic and vaccination strategies.

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  • On day 115 of differentiation (≈16-week of embryonic development), the presence of CD207+ immune cells in the dermal region suggests two possibilities: migration of Langerhans cell precursors from the dermis, or presence of dermal dendritic cells, both of which express CD207+.

    “On day 115 of differentiation (≈16‐week of embryonic development), the presence of CD207+ immune cells in the dermal region suggests two possibilities: first, the migration of Langerhans cell precursors from the dermis[ 82 , 83 ]; and second, the presence of dermal dendritic cells,[ 82 , 83 ] both of which express CD207+.”

    From Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells (2025) · cites this paper as [83]

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Authors
Haniffa, M., Gunawan, M., & Jardine, L.
Affiliations
Newcastle University (GB)
Corresponding author
Haniffa, Muzlifah
ORCID
Venue
Journal of Dermatological Science
Publisher
Elsevier BV
Published
2015-02
Volume
77
Issue
2
Pages
85-92
ISSN
0923-1811 (ISSN-L)
DOI
10.1016/j.jdermsci.2014.08.012
PMC
PMC4728191
OpenAlex
W1986468304
Cited by
187
References
7
Citations by year
2026: 12 · 2025: 11 · 2024: 9 · 2023: 13 · 2022: 15 · 2021: 13 · 2020: 17 · 2019: 18 · 2018: 19 · 2017: 24 · 2016: 19 · 2015: 17
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Dermatological Science (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity) (cc-by-nc-nd)
Funders
  • Wellcome Trust (W T097941, WT088555)
  • British Skin Foundation
  • Newcastle University
  • AXA Research Fund
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
dermal dendritic cells, dendritic cell subsets, dendritic cell origin, antigen presentation, T cell activation, draining lymph nodes, psoriasis, atopic dermatitis, inflammatory skin diseases
MeSH terms
Antigens, Surface, Dermatitis, Atopic, Humans, Inflammation, Langerhans Cells, Psoriasis, Mononuclear Phagocyte System, Thrombomodulin, CD11 Antigens, Lipopolysaccharide Receptors

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