Global toll-like receptor 4 knockout results in decreased renal inflammation, fibrosis and podocytopathy

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374 · see citing works

Cellular and molecular mechanisms of renal fibrosis

Liu, Y. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.149 · Cited by 1,456 · see citing works

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

Navarro‐González, J. F., Fernández, C. M., de Fuentes, M. M., & García-Pérez, J. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.51 · Cited by 1,073 · see citing works

Inflammation and the pathogenesis of diabetic nephropathy

Wada, J., & Makino, H. (2012) · Clinical Science · doi:10.1042/cs20120198 · Cited by 776 · see citing works

Circulating TNF Receptors 1 and 2 Predict ESRD in Type 2 Diabetes

Niewczas, M. A., Gohda, T., SKUPIEN, J. K., Smiles, A. M., Walker, W. H., Rosetti, F., Culleré, X., Eckfeldt, J. H., Doria, A., Mayadas, T. N., et al. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011060627 · Cited by 486 · see citing works

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes

Dasu, M. R. K., Devaraj, S., Zhao, L., Hwang, D. H., & Jialal, I. (2008) · Diabetes · doi:10.2337/db08-0564 · Cited by 436 · see citing works

Proteinuria in diabetic kidney disease: a mechanistic viewpoint.

Jefferson, J., Shankland, S., & Pichler, R. (2008) · Kidney International · doi:10.1038/ki.2008.128 · Cited by 425 · see citing works

Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy

Lin, M. Y., Yiu, W. H., Wu, H., Chan, L. Y. Y., Leung, J. C. K., Au, W. S., Chan, K. W., Lai, K. N., & Tang, S. C. W. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010111210 · Cited by 386 · see citing works

Increased Toll-Like Receptor (TLR) 2 and TLR4 Expression in Monocytes from Patients with Type 1 Diabetes: Further Evidence of a Proinflammatory State

Devaraj, S., Dasu, M. R. K., Rockwood, J., Winter, W. E., Griffen, S. C., & Jialal, I. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2185 · Cited by 374 · see citing works

Inhibiting MicroRNA-192 Ameliorates Renal Fibrosis in Diabetic Nephropathy

Putta, S., Lanting, L. L., Sun, G., Lawson, G. W., Kato, M. V., & Natarajan, R. D. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011050485 · Cited by 369 · see citing works

Circulating TNF Receptors 1 and 2 Predict Stage 3 CKD in Type 1 Diabetes

Gohda, T., Niewczas, M. A., Ficociello, L., Walker, W. H., SKUPIEN, J. K., Rosetti, F., Culleré, X., Johnson, A. C., Crabtree, G. S., Smiles, A. M., et al. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011060628 · Cited by 357 · see citing works

Increased Monocytic Activity and Biomarkers of Inflammation in Patients With Type 1 Diabetes

Devaraj, S., Glaser, N. S., Griffen, S., Wang, J. F., Miguelino, E., & Jialal, I. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-1417 · Cited by 293 · see citing works

Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis

Kanasaki, K., Taduri, G., & Koya, D. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00007 · Cited by 226 · see citing works

Transforming growth factor β contributes to progressive diabetic nephropathy

Reeves, W. B., & Andreoli, T. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.7667 · Cited by 222 · see citing works

Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors

Dasu, M. R. K., & Jialal, I. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00490.2010 · Cited by 211 · see citing works

Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: Influence of inbred background, sex, and thymus

Leiter, E. H. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.2.630 · Cited by 186 · see citing works

Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes

Devaraj, S., Tobias, P. S., & Jialal, I. (2011) · Cytokine · doi:10.1016/j.cyto.2011.03.023 · Cited by 169 · see citing works

Transforming Growth Factor-β–Induced Cross Talk Between p53 and a MicroRNA in the Pathogenesis of Diabetic Nephropathy

Deshpande, S., Putta, S., Wang, M., Lai, J. Y., Bitzer, M., Nelson, R. G., Lanting, L. L., Kato, M. V., & Natarajan, R. D. (2013) · Diabetes · doi:10.2337/db13-0305 · Cited by 161 · see citing works

Diabetes is a proinflammatory state: a translational perspective

Devaraj, S., Dasu, M. R. K., & Jialal, I. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.44 · Cited by 150 · see citing works

Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy

Devaraj, S., Tobias, P. S., Kasinath, B. S., Ramsamooj, R., Afify, A. M., & Jialal, I. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.228924 · Cited by 141 · see citing works

Hyperglycemia induces Toll like receptor 4 expression and activity in mouse mesangial cells: relevance to diabetic nephropathy

Kaur, H., Chien, A., & Jialal, I. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00319.2012 · Cited by 115 · see citing works

Serum Lipopolysaccharide Activity Is Associated With the Progression of Kidney Disease in Finnish Patients With Type 1 Diabetes

Nymark, M., Pussinen, P. J., Tuomainen, A. M., Forsblom, C. M., Groop, P., Lehto, M. J., & on behalf of the FinnDiane Study Group (2009) · Diabetes Care · doi:10.2337/dc09-0467 · Cited by 111 · see citing works

Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications

Devaraj, S., Jialal, I., Yun, J.-M., & Bremer, A. A. (2010) · Metabolism · doi:10.1016/j.metabol.2010.01.005 · Cited by 103 · see citing works

The Role of Toll-Like Receptors in Diabetes-Induced Inflammation: Implications for Vascular Complications

Jialal, I., & Kaur, H. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0258-7 · Cited by 86 · see citing works

Role of Toll-like receptors in diabetic nephropathy

Mudaliar, H., Pollock, C. A., & Panchapakesan, U. (2014) · Clinical Science · doi:10.1042/cs20130267 · Cited by 72 · see citing works

Is the Risk and Nature of CVD the Same in Type 1 and Type 2 Diabetes?

Duca, L. M., Sippl, R., & Snell‐Bergeon, J. K. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0380-1 · Cited by 43 · see citing works

Inflammation in obesity, diabetes, and related disorders

Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066 · see citing works

Fibrosis: from mechanisms to medicines

Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works

Innate immunity in diabetic kidney disease

Tang, S. C. W., & Yiu, W. H. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0234-4 · Cited by 606 · see citing works

Innate immunity in diabetes and diabetic nephropathy

Wada, J., & Makino, H. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.175 · Cited by 432 · see citing works

Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets

Pichler, R. H., Afkarian, M., Dieter, B. P., & Tuttle, K. R. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00314.2016 · Cited by 302 · see citing works

Insights into the Mechanisms Involved in the Expression and Regulation of Extracellular Matrix Proteins in Diabetic Nephropathy

Hu, C., Sun, L., Xiao, L., Han, Y., Fu, X., Xiong, X., Xu, X., Liu, Y., Yang, S., Liu, F., et al. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666150625095407 · Cited by 197 · see citing works

Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy

Fernandes, R., Viana, S., Nunes, S., & Reis, F. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.032 · Cited by 172 · see citing works

Inflammation in diabetes complications: molecular mechanisms and therapeutic interventions

Zhao, L., Hu, H., Zhang, L., Liu, Z., Huang, Y., Liu, Q., Jin, L., Zhu, M., & Zhang, L. (2024) · MedComm · doi:10.1002/mco2.516 · Cited by 136 · see citing works

Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease

Liu, P., Zhang, Z., & Yao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.603416 · Cited by 110 · see citing works

Bletilla striata polysaccharide inhibits angiotensin II-induced ROS and inflammation via NOX4 and TLR2 pathways

Yue, L., Wang, W., Wang, Y., Du, T., Shen, W., Tang, H., Wang, Y., & Yin, H. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.05.002 · Cited by 107 · see citing works

HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases

Ren, W., Zhao, L., Sun, Y., Wang, X.-C., & Shi, X.-G. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00717-3 · Cited by 104 · see citing works

Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy

Garibotto, G., Carta, A., Picciotto, D., Viazzi, F. C., & Verzola, D. (2017) · Journal of Nephrology · doi:10.1007/s40620-017-0432-8 · Cited by 102 · see citing works

Intestinal microbiota and diabetic kidney diseases: the Role of microbiota and derived metabolites inmodulation of renal inflammation and disease progression

Mosterd, C. M., Kanbay, M., van den Born, B. H., van Raalte, D. H., & Rampanelli, E. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101484 · Cited by 94 · see citing works

Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy

Wang, X., Yao, B., Wang, Y., Fan, X., Wang, S., Niu, A., Yang, H., Fogo, A. B., Zhang, M., & Harris, R. C. (2016) · Diabetes · doi:10.2337/db16-0773 · Cited by 90 · see citing works

Sirtuin 1: A Target for Kidney Diseases

Kong, L., Wu, H., Zhou, W., Luo, M., Tan, Y., Miao, L., & Cai, L. (2015) · Molecular Medicine · doi:10.2119/molmed.2014.00211 · Cited by 82 · see citing works

Pattern recognition receptor‐mediated inflammation in diabetic vascular complications

Wang, X., Antony, V., Wang, Y., Wu, G., & Liang, G. (2020) · Medicinal Research Reviews · doi:10.1002/med.21711 · Cited by 73 · see citing works

Pyroptosis in development, inflammation and disease

Pan, Y., Cai, W., Huang, J., Cheng, A., Wang, M., Yin, Z., & Jia, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.991044 · Cited by 74 · see citing works

Nuciferine Alleviates Renal Injury by Inhibiting Inflammatory Responses in Fructose-Fed Rats

Wang, M., Zhao, X., Chen, T., Liu, Y.-L., Jiao, R., Zhang, J.-H., Ma, C., Liu, J., Pan, Y., & Kong, L. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b03031 · Cited by 73 · see citing works

All-trans retinoic acid ameliorates inflammatory response mediated by TLR4/NF-κB during initiation of diabetic nephropathy

Sierra-Mondragón, E., Molina‐Jijón, E., Namorado-Tónix, C., Rodríguez‐Muñoz, R., Pedraza‐Chaverrí, J., & Reyes, J. L. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.06.002 · Cited by 72 · see citing works

The Interplay of Renin‐Angiotensin System and Toll‐Like Receptor 4 in the Inflammation of Diabetic Nephropathy

Feng, Q., Liu, D., Lu, Y., & Liu, Z. (2020) · Journal of Immunology Research · doi:10.1155/2020/6193407 · Cited by 68 · see citing works

TAK-242, a Toll-Like Receptor 4 Antagonist, Protects against Aldosterone-Induced Cardiac and Renal Injury

Zhang, Y., Peng, W., Ao, X., Dai, H., Yuan, L., Huang, X., & Zhou, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142456 · Cited by 65 · see citing works

Kaempferol attenuates streptozotocin-induced diabetic nephropathy by downregulating TRAF6 expression: The role of TRAF6 in diabetic nephropathy

Luo, W., Chen, X., Lin, Y., Chen, X., Jia, W., Zhao, Y., Самородов, А. В., Zhang, Y., Hu, X., Zhuang, F., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113553 · Cited by 65 · see citing works

The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis

Choudhry, N., Li, K., Zhang, T., Wu, K., Song, Y., Farrar, C. A., Wang, N., Liu, C., Peng, Q., Wu, W., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.04.023 · Cited by 65 · see citing works

The Role of TLR4 on PGC‐1α‐Mediated Oxidative Stress in Tubular Cell in Diabetic Kidney Disease

Yuan, S., Liu, X., Zhu, X., Qu, Z. Y., Gong, Z., Li, J., Xiao, L., Yuan, Y., Liu, H., Sun, L., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6296802 · Cited by 63 · see citing works

P-Coumaric acid alleviates experimental diabetic nephropathy through modulation of Toll like receptor-4 in rats

Zabad, O. M., Samra, Y. A., & Eissa, L. A. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116965 · Cited by 60 · see citing works

Targeting inflammation for the treatment of Diabetic Kidney Disease: a five-compartment mechanistic model

Hofherr, A., Williams, J. H., Gan, L., Söderberg, M. P., Hansen, P., & Woollard, K. J. (2022) · BMC Nephrology · doi:10.1186/s12882-022-02794-8 · Cited by 60 · see citing works

Emerging Roles of Innate Immune Signaling and Toll-Like Receptors in Fibrosis and Systemic Sclerosis

Bhattacharyya, S., & Varga, J. (2015) · Current Rheumatology Reports · doi:10.1007/s11926-014-0474-z · Cited by 58 · see citing works

Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1

Miao, N., Xie, H., Xu, D., Yin, J., Wang, Y., Bao, W., Yin, F., Zhou, Z., Cheng, Q., Chen, P., et al. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0177-5 · Cited by 55 · see citing works

Knockdown of TLR4 attenuates high glucose-induced podocyte injury via the NALP3/ASC/Caspase-1 signaling pathway

Liu, Y., Xu, Z., Ma, F., Jia, Y., & Wang, G. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.134 · Cited by 53 · see citing works

The protective effect and mechanism of catalpol on high glucose-induced podocyte injury

Chen, Y., Liu, Q., Shan, Z., Zhao, Y., Li, M., Wang, B., Zheng, X., & Feng, W. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2656-8 · Cited by 50 · see citing works

High Mobility Group Box 1 (HMGB1): Molecular Signaling and Potential Therapeutic Strategies

Datta, S., Rahman, M. A., Koka, S., & Boini, K. M. (2024) · Cells · doi:10.3390/cells13231946 · Cited by 48 · see citing works

High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications

Wu, H., Chen, Z., Xie, J., Kang, L., Wang, L., & Xu, B. (2016) · Mediators of Inflammation · doi:10.1155/2016/3896147 · Cited by 46 · see citing works

Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway

Saurus, P., Kuusela, S., Lehtonen, E., Hyvönen, M. E., Ristola, M. A., Fogarty, C. L., Tienari, J., Lassenius, M. I., Forsblom, C. M., Lehto, M. J., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.125 · Cited by 47 · see citing works

The Inhibitory Effect of Rapamycin on Toll Like Receptor 4 and Interleukin 17 in the Early Stage of Rat Diabetic Nephropathy

Yu, R., Bo, H., Villani, V., Spencer, P. J., & Fu, P. (2016) · Kidney & Blood Pressure Research · doi:10.1159/000368547 · Cited by 48 · see citing works

A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways

Ka, S., Chao, L. K., Lin, J., Chen, S., Li, W., Lin, C.-N., Cheng, J.-C., Jheng, H.-L., Chen, A., & Hua, K. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.003 · Cited by 43 · see citing works

Association of polymorphisms in the MyD88, IRAK4 and TRAF6 genes and susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a southern Han Chinese population

Guo, C., Zhang, L., Nie, L., Zhang, N., Xiao, D., Ye, X., Ou, M., Liu, Y., Zhang, B., Wang, M., et al. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.04.003 · Cited by 41 · see citing works

The role of innate immunity in diabetic nephropathy and their therapeutic consequences

Yang, M., & Zhang, C. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.09.003 · Cited by 41 · see citing works

Pharmacological inhibition of MyD88 suppresses inflammation in tubular epithelial cells and prevents diabetic nephropathy in experimental mice

Zhang, Q., Xu, S., Qian, J., Yang, L., Chen, P., Wang, Y., Hu, X., Zhang, Y., Luo, W., & Liang, G. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00766-6 · Cited by 36 · see citing works

Blockade of myeloid differentiation 2 attenuates diabetic nephropathy by reducing activation of the renin‐angiotensin system in mouse kidneys

Wang, Y., Fang, Q., Jin, Y., Liu, Z., Zou, C., Yu, W., Li, W., Shan, X., Chen, R., Khan, Z. A., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14687 · Cited by 35 · see citing works

Natural compounds improve diabetic nephropathy by regulating the TLR4 signaling pathway

Wu, J., Li, K., Zhou, M., Gao, H., Wang, W., & Xiao, W. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.01.014 · Cited by 33 · see citing works

Liraglutide ameliorates inflammation and fibrosis by downregulating the TLR4/MyD88/NF-κB pathway in diabetic kidney disease

Huang, L., Lin, T., Shi, M., & Wu, P. (2024) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00083.2024 · Cited by 33 · see citing works

Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice

Pahwa, R., Balderas, M. A., Jialal, I., Chen, X., Luna, R. A., & Devaraj, S. (2017) · Journal of Diabetes Research · doi:10.1155/2017/6519785 · Cited by 33 · see citing works

Cyclin-dependent kinase 2 protects podocytes from apoptosis

Saurus, P., Kuusela, S., Dumont, V., Lehtonen, E., Fogarty, C. L., Lassenius, M. I., Forsblom, C. M., Lehto, M. J., Saleem, M. A., Groop, P., et al. (2016) · Scientific Reports · doi:10.1038/srep21664 · Cited by 31 · see citing works

Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy

Ito, S., Nakashima, H., Ishikiriyama, T., Nakashima, M., Yamagata, A., Imakiire, T., Kinoshita, M., Seki, S., Kumagai, H., & Oshima, N. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00191.2021 · Cited by 28 · see citing works

Epigenetics and endoplasmic reticulum in podocytopathy during diabetic nephropathy progression

Wang, X., Zhao, J., Li, Y., Rao, J., & Xu, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1090989 · Cited by 29 · see citing works

Deletion of the forminDiaph1protects from structural and functional abnormalities in the murine diabetic kidney

Manigrasso, M. B., Friedman, R. A., Ramasamy, R., D’Agati, V. D., & Schmidt, A. M. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00075.2018 · Cited by 26 · see citing works

The mechanisms underlying Chinese medicines to treat inflammation in diabetic kidney disease

Deng, L., Shi, C., Li, R., Zhang, Y., Wang, X., Cai, G., Hong, Q., & Chen, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118424 · Cited by 25 · see citing works

A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation

Ishibashi, R., Takemoto, M., Akimoto, Y., Ishikawa, T., He, P., Maezawa, Y., Sakamoto, K., Tsurutani, Y., Ide, S., Ide, K., et al. (2016) · Scientific Reports · doi:10.1038/srep25955 · Cited by 24 · see citing works

MiR‐885‐3p is down‐regulated in peripheral blood mononuclear cells from T1D patients and regulates the inflammatory response via targeting TLR4/NF‐κB signaling

Zhang, X. D., Gu, H., Wang, L., Huang, F., & Cai, J. (2019) · The Journal of Gene Medicine · doi:10.1002/jgm.3145 · Cited by 23 · see citing works

Bergenin ameliorates diabetic nephropathy in C57BL/6 J mice by TLR4/MyD88/NF-κB signalling pathway regulation

Quan, Y., Su, P., Shangguan, C., Hao, H., Yue, L., & Chen, C. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116633 · Cited by 23 · see citing works

The role of Toll-like receptor 4 in high-glucose-induced inflammatory and fibrosis markers in human peritoneal mesothelial cells

Choi, S.-Y., Ryu, H., Choi, J., Cho, J., Kim, C., Kim, Y.-L., & Park, S.-H. (2016) · International Urology and Nephrology · doi:10.1007/s11255-016-1430-9 · Cited by 23 · see citing works

Advances in understanding the innate immune‐associated diabetic kidney disease

Wan, S., Wan, S., Jiao, X., Cao, H., Gu, Y., Yan, L., Zheng, Y., Niu, P., & Shao, F. (2021) · The FASEB Journal · doi:10.1096/fj.202002334r · Cited by 22 · see citing works

Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy

Kajiwara, K., Sawa, Y., Fujita, T., & Tamaoki, S. (2021) · BMC Nephrology · doi:10.1186/s12882-020-02203-y · Cited by 21 · see citing works

Role of Gut Microbiota, Immune Imbalance, and Allostatic Load in the Occurrence and Development of Diabetic Kidney Disease

Han, Y. Z., Zheng, H., Du, B. X., Zhang, Y., Zhu, X. Y., Li, J., Wang, Y., & Liu, W. J. (2023) · Journal of Diabetes Research · doi:10.1155/2023/8871677 · Cited by 20 · see citing works

Toll-like receptor 4 knockout protects against diabetic-induced imbalance of bone metabolism via autophagic suppression

Zhang, Y., Shen, X., Cheng, L., Chen, R., Zhao, F., Zhong, S., Lan, C., & Yan, S. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.10.025 · Cited by 20 · see citing works

Fibrinogen links podocyte injury with Toll‐like receptor 4 and is associated with disease activity in FSGS patients

Wang, H., Zheng, C., Xu, X., Zhao, Y., Lu, Y., & Liu, Z. (2017) · Nephrology · doi:10.1111/nep.13046 · Cited by 18 · see citing works

The long noncoding RNA Meg3 mediates TLR4-induced inflammation in experimental obstructive nephropathy

Yiu, W. H., Lok, S. W. Y., Xue, R., Chen, J., Lai, K. N., Lan, H. Y., & Tang, S. C. W. (2023) · Clinical Science · doi:10.1042/cs20220537 · Cited by 17 · see citing works

The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors

Kajiwara, K., Takata, S., To, T. T., Takara, K., Hatakeyama, Y., Tamaoki, S., Darveau, R. P., Ishikawa, H. T., & Sawa, Y. (2017) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-017-0271-8 · Cited by 16 · see citing works

A non‐polar fraction of Saponaria officinalis L. acted as a TLR4/MD2 complex antagonist and inhibited TLR4/MyD88 signaling in vitro and in vivo

Yu, G., Lim, D., Karunarathne, W. A. H. M., Kim, G., Kim, H., Kim, J., & Park, W. (2022) · The FASEB Journal · doi:10.1096/fj.202200018rr · Cited by 16 · see citing works

Association of Lipopolysaccharide-Toll-Like Receptor 4 Signaling and Microalbuminuria in Patients with Type 2 Diabetes Mellitus

Zhang, L., Zhang, Y., Liu, J., Li, Y., & Quan, J. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s377776 · Cited by 12 · see citing works

Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice

Wang, M., Zhang, Q., Lou, S., Jin, L., Wu, G., Wu, W., Tang, Q., Wang, Y., Long, X., Huang, P. C., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115660 · Cited by 11 · see citing works

Increased fibrosis and angiogenesis in subcutaneous gluteal adipose tissue in nascent metabolic syndrome

Jialal, I., ADAMS-HUET, B. A., Major, A. M., & Devaraj, S. (2017) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.12.004 · Cited by 11 · see citing works

Treatment with lecinoxoids attenuates focal and segmental glomerulosclerosis development in nephrectomized rats

Yacov, N., Feldman, B., Volkov, A., Ishai, E., Breitbart, E., & Mendel, I. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13114 · Cited by 9 · see citing works

Overexpression of SGLT2 in the kidney of a P. gingivalis LPS-induced diabetic nephropathy mouse model

Kajiwara, K., & Sawa, Y. (2021) · BMC Nephrology · doi:10.1186/s12882-021-02506-8 · Cited by 8 · see citing works

Commensal microbiome dysbiosis elicits interleukin-8 signaling to drive fibrotic skin disease

Zhang, W., Peng, Q., Huang, X., Huang, Q., Zhang, Z., Li, F., Zheng, N., Shi, B., Fan, Z., Maj, T., et al. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae273 · Cited by 8 · see citing works

Toll-like Receptors as Potential Therapeutic Targets in Kidney Diseases

Ren, Q., Cheng, L., Yi, J., Ma, L., Pan, J., Gou, S., & Fu, P. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867325666190603110907 · Cited by 6 · see citing works

Protective role for C3aR in experimental chronic pyelonephritis

Zhao, S., Wu, K., Min, X., Wang, C., Cao, B., Ma, N., Yang, X., Zhu, Z., Fu, R., Zhou, W., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202201007r · Cited by 6 · see citing works

TLR4 deletion reduces small fiber sensory abnormalities and nerve degeneration in diabetic male mice

Crowards, S., Ryals, J. M., Heslop, L. L., Hauser, W., Totta-Griese, G., Madden, T., & Wright, D. E. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.10.052 · Cited by 5 · see citing works

The evolving role of toll-like receptors in diabetic vascular complications

Jialal, I., & Pahwa, R. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.04.002 · Cited by 5 · see citing works

Telbivudine antagonizes TLR4 to inhibit the epithelial-to-mesenchymal transition in human proximal tubular epithelial cells in vitro

Chen, J., Li, D., & Luo, E. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105683 · Cited by 4 · see citing works

Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells

Seki, A., Kajiwara, K., Teramachi, J., Egusa, M., Miyawaki, T., & Sawa, Y. (2025) · BMC Nephrology · doi:10.1186/s12882-025-03965-z · Cited by 3 · see citing works

Cinnamon Modulates Toll-Like Receptors: a New Therapeutic Approach for Diabetes

Niknejad, A., Razavi, S. M., Hosseini, Y., Arab, Z. N., Abdolghaffari, A. H., & Momtaz, S. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00460-0 · Cited by 2 · see citing works

MicroRNA-630: A promising avenue for alleviating inflammation in diabetic kidney disease

Donate‐Correa, J., González-Luis, A., Díaz‐Vera, J., & Hernandez-Fernaud, J. R. (2024) · World Journal of Diabetes · doi:10.4239/wjd.v15.i7.1398 · Cited by 2 · see citing works

Extract from Polygala fallax Hemsl. Protects Kidneys in db/db Mice by Inhibiting the TLR4/MyD88/NF- κ B Signaling PathwayPreprint

Bao, Y., Wang, Z., Xu, Q., Wang, L., Wen, Y., Deng, P., & Xu, Q. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.08.552432

Commensal microbiome dysbiosis elicits IL-8 signaling to drive fibrotic skin diseasePreprint

Zhang, W., Peng, Q., Huang, X., Huang, Q., Zhang, Z., Li, F., Zheng, N., Shi, B., Fan, Z., Maj, T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.19.558395

Label-free quantitative proteomics analysis of bovine mammary glands induced with Escherichia coli

Zhou, L., Luoreng, Z., & Wang, X. (2025) · American Journal of Veterinary Research · doi:10.2460/ajvr.24.12.0403

Recent advances in bioinspired polymeric nanofiber for the treatment of inflammatory diseases

Sahu, G., Maurya, M., Pandey, H., & Mishra, S. B. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27745-0.00011-9

The novel MyD88 inhibitor A5S ameliorates inflammation-driven diabetic cardiorenal complications

Liu, Y., Zhang, J., Liang, Z., Zheng, J., Liu, G., Zhuang, L., Chen, P., Tang, Q., Liang, G., Ying, H., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178603

Molecular Insights into the Immunogenetic Pathways of Diabetic Kidney Disease

Yu, C., Xiong, C., Xie, K., Chen, Z., Liu, E., Wang, L., & Gao, J. (2026) · The Nephron journals/Nephron journals · doi:10.1159/000551516

REGγ Links Inflammation to Fibrosis in Post–Necrotizing Enterocolitis Intestinal Strictures by Activating Transforming Growth Factor-β/Smad3 Signaling

Zhu, X., Li, Y., (302636), H. W., He, L., Wang, C., Jia, R., Yang, M., Wang, X., Aziz, F., Zhang, B., et al. (2026) · American Journal Of Pathology · doi:10.1016/j.ajpath.2026.05.003

Neuroprotective effect of karanjin from Pongamia pinnata, in streptozotocin induced diabetic neuropathy in rats via modulation of the TLR4-MyD88 pathway.

Wu, C., Chen, S., Xian, G., & Wang, Y. (2026) · Investigación Clínica · doi:10.54817/ic.v67n3a05

Funding: This w...

Ma, J., Chadban, S. J., Zhao, C. Y., Chen, X., Kwan, T., Panchapakesan, U., Pollock, C. A., & Wu, H. (2014)

TLR4 Activation Promotes Podocyte Injury and Interstitial Fibrosis in Diabetic Nephropathy

Ma, J., Chadban, S. J., Zhao, C. Y., Chen, X., Kwan, T., Panchapakesan, U., Pollock, C. A., & Wu, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097985 · Cited by 158 · see citing works

Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes

Devaraj, S., Tobias, P. S., & Jialal, I. (2011) · Cytokine · doi:10.1016/j.cyto.2011.03.023 · Cited by 169 · see citing works

Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy

Devaraj, S., Tobias, P. S., Kasinath, B. S., Ramsamooj, R., Afify, A. M., & Jialal, I. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.228924 · Cited by 141 · see citing works

Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation

Li, Z., Tan, D., Lin, J., Zhang, T., Liu, B., Zhao, B., Liang, D., Li, L., Wei, X., Lv, Z., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.013 · Cited by 12 · see citing works