Health-related quality of life in women and men with type 2 diabetes: a comparison across treatment groups

Schunk, M.; Reitmeir, P.; Schipf, S.; Völzke, H.; Meisinger, C.; Ladwig, K.-H.; Kluttig, A.; Greiser, K.H.; Berger, K.; Müller, G.; Ellert, U.; Neuhauser, H.; Tamayo, T.; Rathmann, W.; Holle, R.

doi:10.1016/j.jdiacomp.2014.11.010

Cited by 31Diabetes Treatment and ManagementHealth Systems, Economic Evaluations, Quality of LifeDiabetes Management and Education

Health-related quality of life in women and men with type 2 diabetes: a comparison across treatment groups

Schunk, M., Reitmeir, P., Schipf, S., Völzke, H., Meisinger, C., Ladwig, K.-H., Kluttig, A., Greiser, K.H. +7 more·2015·Journal of Diabetes and its Complications

DOI 10.1016/j.jdiacomp.2014.11.010

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Abstract

Aim This study compares health-related quality of life (HRQL) in patients with type 2 diabetes (T2DM) across treatment groups and explores gender differences.Methods Four regional surveys (KORA, CARLA, SHIP, DHS) and a national survey (GNHIES98) were pooled at individual level. HRQL was assessed with the SF-12/-36v1. Linear regression models were used to assess the effect of T2DM by treatment type (no medication; oral; oral/insulin combination; insulin) on the physical (PCS-12) and mental summary score (MCS-12) and the SF-6D, controlling for age, sex, study and covariates. We also performed an explanatory analysis of single items.Results PCS-12 scores and treatment type were associated (P-value 0.006), with lowest values for insulin treatment (-4.44 vs. oral; -4.41 vs. combination). MCS-12 scores were associated with treatment type and gender (P-value <0.012), with lower scores for women undergoing oral (-4.25 vs. men) and combination treatment (-6.99 vs. men). Similar results were observed for SF-6D utilities and single items, related to mental health, social functioning, vitality and role limitation (emotional). Comorbidities were predictors of lower PCS-12 and SF-6D scores.Conclusions T2DM treatment impacts differently on physical and mental HRQL and on women and men. Further studies of gender-specific perceptions of T2DM treatment regimens are needed.

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There was evidence that a clinically important difference may be plausible for a number of secondary outcomes, including total cholesterol and LDL cholesterol at 12 months and quality of life at 12 months indicated by the SF-12 mental component score.
“As well as the encouraging data for HbA1c and systolic blood pressure, there was evidence that a clinically important difference may be plausible for a number of secondary outcomes, including total cholesterol and LDL cholesterol at 12 months57 and quality of life at 12 months, indicated by the SF-12 mental component score.58”
From Mobile Health Biometrics to Enhance Exercise and Physical Activity Adherence in Type 2 Diabetes (MOTIVATE-T2D): a decentralised feasibility randomised controlled trial delivered across the UK and Canada (2025) · cites this paper as [58]

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Health‐related quality of life in subjects with and without Type 2 diabetes: pooled analysis of five population‐based surveys in Germany
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The difference of Quality of Life (QOL) between hospitalized male and female patients with Type 2 Diabetes Mellitus in a selected hospital in Sri Lanka
Rathnayake, R. M. U. K., & Cuihuan, H. (2019) · Proceedings of Annual Scientific Sessions of Faculty of Medical Sciences

Authors: Schunk, M., Reitmeir, P., Schipf, S., Völzke, H., Meisinger, C., Ladwig, K.-H., Kluttig, A., Greiser, K. H., Berger, K., Müller, G., Ellert, U., Neuhauser, H., Tamayo, T., Rathmann, W., & Holle, R.
Affiliations: Helmholtz Munich (DE)
Universität Greifswald (DE)
Martin Luther University Halle-Wittenberg (DE)
German Cancer Research Center (DE)
University of Münster (DE)
Robert Koch Institute (DE)
Deutsches Diabetes-Zentrum e.V. (DE)
ORCID: Schunk, M.
Reitmeir, P.
Schipf, S.
Völzke, H.
Meisinger, C.
Kluttig, A.
Greiser, K.H.
Berger, K.
Neuhauser, H.
Rathmann, W.
Holle, R.
Venue: Journal of Diabetes and its Complications
Publisher: Elsevier BV
Published: 2015-03
Volume: 29
Issue: 2
Pages: 203-211
ISSN: 0891-6632 (ISSN-L)
1056-8727
DOI: 10.1016/j.jdiacomp.2014.11.010
OpenAlex: W2022428376
Cited by: 31
References: 51
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 1
FWCI: 2.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Diabetes and its Complications (publishedVersion)
PubMed (publishedVersion)
Site cant be reached (submittedVersion)
OPUS (Augsburg University) (submittedVersion)
Funders: Bundesministerium für Bildung und Forschung
Helmholtz Zentrum München
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords: type 2 diabetes, health-related quality of life, gender differences, diabetes treatment, insulin therapy, oral antidiabetic drugs, combination therapy, physical function, mental health, SF-12, SF-6D, comorbidities, role limitations
MeSH terms: Aged, Combined Modality Therapy, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diet, Diabetic, Drug Therapy, Combination, Female, Germany, Health Surveys, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Psychiatric Status Rating Scales, Quality of Life, Sex Characteristics, Stress, Physiological, Stress, Psychological, Comorbidity, Prevalence, Linear Models

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Health-related quality of life in women and men with type 2 diabetes: a comparison across treatment groups

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