The DOI matches its Crossref record.
Liver enzyme abnormalities in taking traditional herbal medicine in Korea: A retrospective large sample cohort study of musculoskeletal disorder patients
Abstract
Ethnopharmacological relevance The objective of this study is to report the incidence of liver injury from herbal medicine in musculoskeletal disease patients as large-scale studies are scarce. Considering that herbal medicine is frequently used in patients irrespective of liver function in Korea, we investigated the prevalence of liver injury by liver function test results in musculoskeletal disease patients. Materials and methods Of 32675 inpatients taking herbal medicine at 7 locations of a Korean medicine hospital between 2005 and 2013, we screened for liver injury in 6894 patients with liver function tests (LFTs) at admission and discharge. LFTs included t-bilirubin, AST, ALT, and ALP. Liver injury at discharge was assessed by LFT result classifications at admission (liver injury, liver function abnormality, and normal liver function). In analyses for risk factors of liver injury at discharge, we adjusted for age, sex, length of stay, conventional medicine intake, HBs antigen/antibody, and liver function at admission. Results A total 354 patients (prevalence 5.1%) had liver injury at admission, and 217 (3.1%) at discharge. Of the 354 patients with liver injury at admission, only 9 showed a clinically significant increase after herbal medicine intake, and 225 returned to within normal range or showed significant liver function recovery. Out of 4769 patients with normal liver function at admission, 27 (0.6%) had liver injury at discharge. In multivariate analyses for risk…
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“using the RUCAM algorithm but leaving individual causality grading unreported for unknown reason(s),51,54”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [51]
In the citing paper
“forgetting quotation of the used RUCAM publication,51,54”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [51]
In the citing paper
“These included, for instance, the use of a RUCAM version modified by the authors for unknown reason(s) without own method re-validation,40,44,51,53”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [51]
In the citing paper
“With 0.6%, identical data of HILI prevalence were achieved;51,54,73”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [51]
In the citing paper
“A low HILI prevalence was found in a large retrospective single center study from Korea, in which 27/4769 patients (0.6%) with musculoskeletal disorders received TCMs, as reported by Lee et al.,51 with confirmed results through secondary evaluation by the same group.73”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [51]
In the citing paper
“Disregarding thresholds impedes clear differentiation between liver injury and LT abnormality.51”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [51]
In the citing paper
“HILI is seemingly not a problem in Korea,51,54,73 similar to Germany, considering the low TCM-related HILI incidence data.77”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [51]
In the citing paper
“The low prevalence data were achieved by both groups using HILI cases with ALT thresholds of at least 3×ULN, which included many cases with unspecific LT increases.51,54,73”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [51]
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Research works printed but not linked: 20
- Abboud, 2007, Drug-induced liver injury, Drug Saf.: Int. J. Med. Toxicol. Drug Exp., 30, 277, 10.2165/00002018-200730040-00001 · DOI
- Al-Khafaji, 2000, Monitoring of liver enzymes in patients on Chinese medicine, J. Chin. Med., 62, 6
- Chalasani, 2008, Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States, Gastroenterology, 135, 1924, 10.1053/j.gastro.2008.09.011 · DOI · Paper page
- Eisenberg, 1998, Trends in alternative medicine use in the United States, 1990–1997: results of a follow-up national survey, J. Am. Med. Assoc., 280, 1569, 10.1001/jama.280.18.1569 · DOI
- Eisenberg, 1993, Unconventional medicine in the United States. Prevalence, costs, and patterns of use, N. Engl. J. Med., 328, 246, 10.1056/NEJM199301283280406 · DOI · Paper page
- Holt, 2006, Mechanisms of drug-induced liver injury, AAPS J., 8, E48, 10.1208/aapsj080106 · DOI
- Jeong, 2012, A prospective study on the safety of herbal medicines, used alone or with conventional medicines, J. Ethnopharmacol., 143, 884, 10.1016/j.jep.2012.08.016 · DOI
- Ju, 2012, The clinical features of drug-induced liver injury observed through liver biopsy: focus on relevancy to autoimmune hepatitis, Clin. Mol. Hepatol., 18, 213, 10.3350/cmh.2012.18.2.213 · DOI
- Licata, 2013, Herbal hepatotoxicity: a hidden epidemic, Intern. Emerg. Med., 8, 13, 10.1007/s11739-012-0777-x · DOI
- Lucena, 2009, Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex, Hepatology, 49, 2001, 10.1002/hep.22895 · DOI · Paper page
- Melchart, 1999, Monitoring of liver enzymes in patients treated with traditional Chinese drugs, Complement. Ther. Med., 7, 208, 10.1016/S0965-2299(99)80003-X · DOI
- Mitsuma, 2002, Adverse reactions encountered during treatment with Japanese oriental (Kampo) medicines, Korean J. Orient. Intern. Med., 2, 9
- Sheehan, 1992, Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis, Lancet, 340, 13, 10.1016/0140-6736(92)92424-E · DOI
- Singh, 2012, Herbs-are they safe enough? an overview, Crit. Rev. Food Sci. Nutr., 52, 876, 10.1080/10408398.2010.512426 · DOI
- Tajiri, 2013, Liver physiology and liver diseases in the elderly, World J. Gastroenterol., 19, 8459, 10.3748/wjg.v19.i46.8459 · DOI
- Tovar, 2009, Herbal toxicity, Disease-a-Month, 55, 592, 10.1016/j.disamonth.2009.05.001 · DOI
- Wai, 2007, Drug-induced liver injury at an Asian center: a prospective study, Liver Int.: Off. J. Int. Assoc. Study Liver, 27, 465, 10.1111/j.1478-3231.2007.01461.x · DOI
- Wang, 2009, Drug-induced liver disease: an 8-year study of patients from one gastroenterological department, J. Dig. Dis., 10, 195, 10.1111/j.1751-2980.2009.00385.x · DOI
- Wolsko, 2003, Patterns and perceptions of care for treatment of back and neck pain: results of a national survey, Spine, 28, 292, 10.1097/01.BRS.0000042225.88095.7C · DOI
- Ye, 2010, The bright future of Chinese herbal medicine: only after a twisty road, Contemp. Clin. Trials, 31, 508, 10.1016/j.cct.2010.07.007 · DOI
Cited by
Sorted by citations
Teschke, R., Zhu, Y., & Jing, J. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00009 · Cited by 41
Metadata
- Authors
- Lee, J., Shin, J.-S., Kim, M.-R., Byun, J.-H., Lee, S.-Y., Shin, Y.-S., Kim, H., Byung Park, K., Shin, B.-C., Lee, M. S., & Ha, I.-H.
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 169
- Pages
- 407-412
- ISSN
- 0378-8741
- Cited by
- 25
- References
- 0
- Language
- en
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