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Cited by 290

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Phenotypic characterization of idiosyncratic drug‐induced liver injury: The influence of age and sex†

Lucena, M. Isabel, Andrade, Raúl J., Kaplowitz, Neil, García‐Cortes, Miren, Fernández, M. Carmen, Romero‐Gomez, Manuel, Bruguera, Miguel, Hallal, Hacibe, Robles‐Diaz, Mercedes, Rodriguez‐González, Jose F., Navarro, Jose Maria, Salmeron, Javier, Martinez‐Odriozola, Pedro, Pérez‐Alvarez, Ramón, Borraz, Yolanda, Hidalgo, Ramón·2009·Hepatology
DOI 10.1002/hep.22895
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Abstract

Increased age and female sex are suggested risk factors for drug-induced hepatotoxicity (DILI). We studied the influence of these variables on the propensity to develop DILI, as well as its clinical expression and outcome. All cases of DILI submitted to the Spanish Registry between April 1994 and August 2007 were analyzed. Six hundred three DILI cases (310 men; mean age, 54 years) showed a similar sex distribution, reaching two peaks in the 40- to 49-year-old and 60- to 69-year-old age groups. No cases were recorded in the 20- to 29-year-old group. Patients aged > or =60 years accounted for 46% of the cases, with a male predominance (158 males, 118 females; P= 0.009), as opposed to younger patients. Older age was independently associated with cholestatic type of injury (odds ratio for an age interval for 1 year: 1.024 [95% confidence interval: 1.010-1.038]; male/female ratio, 1:2; P = 0.001) and younger age with hepatocellular damage (odds ratio: 0.983 [95% confidence interval: 0.972-0.994]; female/male ratio, 1:2; P = 0.002). In the mixed group, no age effect was evident. Outcome with fulminant liver failure/liver transplantation was more frequently encountered in women (P < 0.01). conclusion: Neither older age nor female sex are predisposing factors to overall DILI. However, older age is a determinant for cholestatic damage with a male predominance, whereas younger age is associated with cytolytic damage and a female overrepresentation. Women distinctly exhibit the worst ou…

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  • Females have been reported to have increased, unchanged, or even decreased incidence of DILI.

    “females have been reported to have increased, 8,26,27,31 unchanged, 9,30 or even decreased 12,21 incidence of DILI (Table 4).”

    From Incidence and Etiology of Drug-Induced Liver Injury in Mainland China (2019) · cites this paper as [31]

Citations

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Research works printed but not linked: 31

  1. Senior, 2007, Drug hepatotoxicity from a regulatory perspective, Clin Liver Dis, 11, 507, 10.1016/j.cld.2007.06.002 · DOI
  2. Carey, 2008, Inpatient admissions for drug‐induced liver injury: results from a single center, Dig Dis Sci, 53, 1977, 10.1007/s10620-008-0250-x · DOI
  3. Abboud, 2007, Drug‐induced liver injury, Drug Saf, 30, 277, 10.2165/00002018-200730040-00001 · DOI
  4. Andrade, 2004, HLA class II genotype influences the type of liver injury in drug‐induced idiosyncratic liver disease, HEPATOLOGY, 39, 1603, 10.1002/hep.20215 · DOI
  5. Hoofnagle, 2004, Drug‐induced liver injury network (DILIN), HEPATOLOGY, 40, 773, 10.1002/hep.20445 · DOI
  6. Molokhia, 2006, EUDRAGENE: European collaboration to establish a case‐control DNA collection for studying the genetic basis of adverse drug reactions, Pharmacogenomics, 7, 633, 10.2217/14622416.7.4.633 · DOI
  7. Björnsoon, 2005, Outcome and prognostic markers in severe drug‐induced liver disease, HEPATOLOGY, 42, 481, 10.1002/hep.20800 · DOI · Paper page
  8. Andrade, 2005, Drug‐induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10‐year period, Gastroenterology, 129, 512, 10.1016/j.gastro.2005.05.006 · DOI
  9. Watkins, 2006, Drug‐induced liver injury: summary of a single topic clinical research conference, HEPATOLOGY, 43, 618, 10.1002/hep.21095 · DOI
  10. Sgro, 2002, Incidence of drug‐induced hepatic injuries: a French population‐based study, HEPATOLOGY, 36, 451, 10.1053/jhep.2002.34857 · DOI
  11. Fris, 1992, Drug‐induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987, J Intern Med, 232, 133, 10.1111/j.1365-2796.1992.tb00562.x · DOI
  12. De Valle, 2006, Drug‐induced liver injury in a Swedish University hospital out‐patient hepatology clinic, Aliment Pharmacol Ther, 24, 1187, 10.1111/j.1365-2036.2006.03117.x · DOI
  13. Ibáñez, 2002, The Grup d'Estudi Multicentric d'Hepatotoxicitat Aguda de Barcelona (GEMHAB). Prospective surveillance of acute serious liver disease unrelated to infectious, obstructive, or metabolic diseases: epidemiological and clinical features, and exposure to drugs, J Hepatol, 37, 592, 10.1016/S0168-8278(02)00231-3 · DOI
  14. Russo, 2004, Liver transplantation for acute liver failure from drug induced liver injury in the United States, Liver Transpl, 10, 1018, 10.1002/lt.20204 · DOI · Paper page
  15. Danan, 1993, Causality assessment of adverse reactions to drugs I. A novel method based on the conclusions of international consensus meetings: application to drug‐induced liver injuries, J Clin Epidemiol, 46, 1323, 10.1016/0895-4356(93)90101-6 · DOI · Paper page
  16. Gronhangen, 1978, Predisposing factors in hepatitis induced by isoniazid, rifampin treatment of tuberculosis, Am Rev Respir Dis, 118, 161
  17. Lucena, 2006, Determinants of the clinical expression of amoxicillin‐clavulanate hepatotoxicity: a prospective series from Spain, HEPATOLOGY, 44, 850, 10.1002/hep.21324 · DOI
  18. Gual, 1999, Does the concept of a standard drink apply to viticultural societies?, Alcohol Alcohol, 34, 153, 10.1093/alcalc/34.2.153 · DOI
  19. Bénichou, 1990, Criteria of drug‐induced liver disorder. Report of an international consensus meeting, J Hepatol, 11, 272, 10.1016/0168-8278(90)90124-A · DOI · Paper page
  20. Lucena, 1992, Análisis de las pautas de dosificación de medicamentos en pacientes geriátricos, Med Clin, 98, 329
  21. Roe, 2002, Gender‐ and age‐related prescription drug use patterns, Ann Pharmacother, 36, 30, 10.1345/aph.1A113 · DOI · Paper page
  22. Fernandez‐Liz, 2007, Identifying how age and gender influence prescription drug use in a primary health care invorement in Catalonia, Spain, Br J Clin Pharmacol, 65, 407, 10.1111/j.1365-2125.2007.03029.x · DOI
  23. Garcia Rodriguez, 1996, Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid, Arch Intern Med, 156, 1327, 10.1001/archinte.1996.00440110099013 · DOI
  24. Larrey, 1992, Hepatitis associated with amoxycillin‐clavulanic acid combination report of 15 cases, Gut, 33, 368, 10.1136/gut.33.3.368 · DOI
  25. Kaiser, 2005, Gender in the pharmacy: does it matter?, Science, 308, 1572, 10.1126/science.308.5728.1572 · DOI
  26. Schwartz, 2003, The influence of sex on pharmacokinetics, Clin Pharmacokinet, 42, 107, 10.2165/00003088-200342020-00001 · DOI
  27. Pillans, 1996, Drug associated hepatic reactions in New Zealand: 21 years experience, N Z Med J, 109, 315
  28. Chalasani, 2008, Causes, clinical features, and outcomes from a prospective study of drug‐induced liver injury in the United States, Gastroenterolology, 135, 1924, 10.1053/j.gastro.2008.09.011 · DOI
  29. Lucena, 2008, Glutathione‐S‐transferase M1 and T1 null genotypes as susceptibility factor for idiosyncratic drug‐induced liver injury, HEPATOLOGY, 48, 588, 10.1002/hep.22370 · DOI
  30. Lammert, 2008, Relationship between daily dose of oral medications and idiosyncratic drug‐induced liver injury: search for signals, HEPATOLOGY, 47, 2003, 10.1002/hep.22272 · DOI
  31. Almdal, 1991, Incidence of parenchymal liver diseases in Denmark, 1981 to 1985: analysis of hospitalization registry data, HEPATOLOGY, 13, 650, 10.1002/hep.1840130407 · DOI

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Metadata

Authors
Lucena, M. I., Andrade, R. J., Kaplowitz, N., García‐Cortes, M., Fernández, M. C., Romero‐Gomez, M., Bruguera, M., Hallal, H., Robles‐Diaz, M., Rodriguez‐González, J. F., Navarro, J. M., Salmeron, J., Martinez‐Odriozola, P., Pérez‐Alvarez, R., Borraz, Y., & Hidalgo, R.
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-06
Volume
49
Issue
6
Pages
2001-2009
ISSN
0270-9139
DOI
10.1002/hep.22895
Cited by
290
References
1
Language
en
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2283 d)

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