Cited by 20Medicinal Plants and NeuroprotectionCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments

Screening of plants used in the European traditional medicine to treat memory disorders for acetylcholinesterase inhibitory activity and anti amyloidogenic activity

Lobbens, Eva S.B., Vissing, Karina J., Jorgensen, Lene, van de Weert, Marco, Jäger, Anna K.·2017·Journal of Ethnopharmacology

Abstract

Ethnopharmacological relevance Plants used in the traditional medicine of Europe to treat memory dysfunction and/or to enhance memory were investigated for activity against the underlying mechanisms of Alzheimer's disease.Aim of the study To investigate 35 ethanolic extracts of plants, selected using an ethnopharmacological approach, for anti-amyloidogenic activity as well as an ability to inhibit the enzymatic activity of acetylcholinesterase.Materials and methods The anti-amyloidogenic activity of the extracts against amyloid beta was investigated by Thioflavin T fibrillation assays and the ability to inhibit the enzymatic activity of acetylcholinesterase was evaluated monitoring the hydrolysis of acetylthiocholine RESULTS: Under the experimental conditions investigated, extracts of two plants, Carum carvi and Olea sylvestris, inhibited amyloid beta fibrillation considerably, eight plant extracts inhibited amyloid beta fibrillation to some extent, 16 plant extracts had no effect on amyloid beta fibrillation and nine extracts accelerated fibrillation of amyloid beta. Furthermore, five plant extracts from Corydalis species inhibited the enzymatic activity of acetylcholinesterase considerably, one plant extract inhibited the enzymatic activity of acetylcholinesterase to some extent and 29 plant extract had no effect on the enzymatic activity of acetylcholinesterase.Conclusions An optimal extract in this study would possess acetylcholinesterase inhibitory activity as well as anti-amyloidogenic activity in order to address multiple facets of Alzheimer's disease, until the molecular origin of the disease is unraveled. Unfortunately no such extract was found.

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Crossref · 10.1016/j.jep.2017.02.020

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Authors
Lobbens, E. S. B., Vissing, K. J., Jorgensen, L., van de Weert, M., & Jäger, A. K.
Affiliations
University of Copenhagen (DK)
Corresponding author
Jäger, Anna K.
Venue
Journal of Ethnopharmacology
Publisher
Elsevier BV
Published
2017-03
Volume
200
Pages
66-73
ISSN
0378-8741 (ISSN-L)
OpenAlex
W2587826324
Cited by
20
References
51
Citations by year
2025: 4 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 1
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Ethnopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
Universitetet i Oslo
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, memory disorders, acetylcholinesterase inhibition, anti-amyloidogenic activity, amyloid-beta fibrillation, traditional medicinal plants, caraway, Corydalis, plant extracts, ethnopharmacology
MeSH terms
Acetylcholinesterase, Cholinesterase Inhibitors, Europe, Humans, Medicine, Traditional, Memory Disorders, Plant Extracts, Plants, Medicinal, Amyloid beta-Peptides

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