Screening of plants used in the European traditional medicine to treat memory disorders for acetylcholinesterase inhibitory activity and anti amyloidogenic activity
Abstract
Ethnopharmacological relevance Plants used in the traditional medicine of Europe to treat memory dysfunction and/or to enhance memory were investigated for activity against the underlying mechanisms of Alzheimer's disease.Aim of the study To investigate 35 ethanolic extracts of plants, selected using an ethnopharmacological approach, for anti-amyloidogenic activity as well as an ability to inhibit the enzymatic activity of acetylcholinesterase.Materials and methods The anti-amyloidogenic activity of the extracts against amyloid beta was investigated by Thioflavin T fibrillation assays and the ability to inhibit the enzymatic activity of acetylcholinesterase was evaluated monitoring the hydrolysis of acetylthiocholine RESULTS: Under the experimental conditions investigated, extracts of two plants, Carum carvi and Olea sylvestris, inhibited amyloid beta fibrillation considerably, eight plant extracts inhibited amyloid beta fibrillation to some extent, 16 plant extracts had no effect on amyloid beta fibrillation and nine extracts accelerated fibrillation of amyloid beta. Furthermore, five plant extracts from Corydalis species inhibited the enzymatic activity of acetylcholinesterase considerably, one plant extract inhibited the enzymatic activity of acetylcholinesterase to some extent and 29 plant extract had no effect on the enzymatic activity of acetylcholinesterase.Conclusions An optimal extract in this study would possess acetylcholinesterase inhibitory activity as well as anti-amyloidogenic activity in order to address multiple facets of Alzheimer's disease, until the molecular origin of the disease is unraveled. Unfortunately no such extract was found.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Rosmarinus officinalis and Lavandula angustifolia contain rosmarinic acid, which is active against amyloid fibrillation.
“Both species contain rosmarinic acid that is active against amyloid fibrillation (Adsersen et al., 2006;Lobbens et al., 2017).”
From Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease (2022) · cites this paper as Lobbens et al., 2017
Rosmarinus officinalis extract inhibited Aβ fibrillation to some extent.
“R. officinalis extract inhibited Aβ fibrillation to some extent (Lobbens et al., 2017).”
From Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease (2022) · cites this paper as Lobbens et al., 2017
Cites
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221 · see citing works
Antioxidant Activity and Phenolic Compounds in Selected Herbs
Zheng, W., & Wang, S. Y. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010697n · Cited by 2,885 · see citing works
Petersen, M. (2002) · Phytochemistry · doi:10.1016/s0031-9422(02)00513-7 · Cited by 1,265 · see citing works
The case for rejecting the amyloid cascade hypothesis
Herrup, K. (2015) · Nature Neuroscience · doi:10.1038/nn.4017 · Cited by 768 · see citing works
Hudson, S. A., Ecroyd, H. W., Kee, T. W., & Carver, J. A. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07307.x · Cited by 614 · see citing works
Neuropathology, biochemistry, and biophysics of α‐synuclein aggregation
Uversky, V. N. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04764.x · Cited by 567 · see citing works
β-Phenylethylamines and the isoquinoline alkaloids
Bentley, K. W. (2006) · Natural Product Reports · doi:10.1039/b509523a · Cited by 564 · see citing works
Howes, M. R., Perry, N. S. L., & Houghton, P. J. (2003) · Phytotherapy Research · doi:10.1002/ptr.1280 · Cited by 418 · see citing works
Viola, H., Wasowski, C., de Stein, M. L., Wolfman, C., Silveira, R., Dajas, F., Medina, J., & Paladini, A. (1995) · Planta Medica · doi:10.1055/s-2006-958058 · Cited by 365 · see citing works
Plants traditionally used in age related brain disorders—A survey of ethnobotanical literature
Adams, M. A., Gmünder, F., & Hamburger, M. O. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.07.016 · Cited by 328 · see citing works
Neves, J. M., Matos, C. M., Moutinho, C. M. S. G., et al. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.04.041 · Cited by 322 · see citing works
Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants
Orhan, İ. E., Şener, B., Choudhary, M. I., & Khalid, A. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.11.016 · Cited by 302 · see citing works
Tunón, H., Olavsdotter, C., & Bohlin, L. (1995) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(95)01285-l · Cited by 266 · see citing works
Comparative study of rosmarinic acid content in some plants of Labiatae family
Hajimehdipoor, H., Saeidnia, S., Gohari, A., Hamedani, M. P., & Shekarchi, M. (2012) · Pharmacognosy Magazine · doi:10.4103/0973-1296.93316 · Cited by 251 · see citing works
Alkam, T., Nitta, A., Mizoguchi, H., Itoh, A., & Nabeshima, T. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.03.001 · Cited by 213 · see citing works
Adsersen, A., Gauguin, B., Gudiksen, L., & Jäger, A. K. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.09.032 · Cited by 205 · see citing works
ANTIOXBDANT PROPERTIES OF OREGANO (ORIGANUM VULGARE) LEAF EXTRACTS
Cervato, G., CARABELLI, M., GERVASIO, S., et al. (2000) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.2000.tb00715.x · Cited by 194 · see citing works
Hirohata, M., Hasegawa, K., Tsutsumi, S., Ohhashi, Y., Ookoshi, T., Ono, K., Yamada, M., & Naiki, H. (2007) · Biochemistry · doi:10.1021/bi061540x · Cited by 167 · see citing works
Medicinal Plants and Dementia Therapy: Herbal Hopes for Brain Aging?
Perry, E. K., & Howes, M. R. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00202.x · Cited by 160 · see citing works
Tricco, A. C., Soobiah, C., Blondal, E., Veroniki, A. A., Khan, P. A., Vafaei, A., Ivory, J. D., Strifler, L., Ashoor, H. M., MacDonald, H. R., et al. (2015) · BMC Medicine · doi:10.1186/s12916-015-0371-y · Cited by 141 · see citing works
Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis
Iranshahy, M., Quinn, R. J., & Iranshahi, M. (2014) · RSC Advances · doi:10.1039/c3ra47944g · Cited by 136 · see citing works
Molecular Mechanisms Underlying the Flavonoid-Induced Inhibition of α-Synuclein Fibrillation
Meng, X., Munishkina, L. A., Fink, A. L., & Uversky, V. N. (2009) · Biochemistry · doi:10.1021/bi900506b · Cited by 130 · see citing works
Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation.
Liu, Y.-Q., Pukala, T., Musgrave, I., Williams, D. M., Dehle, F., & Carver, J. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.09.071 · Cited by 121 · see citing works
Orhan, İ. E., & Aslan, M. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.12.026 · Cited by 107 · see citing works
Lee, H. E., Kim, D. H., Park, S. J., Kim, J. M., Lee, Y. W., Jung, J. M., Lee, C. H., Hong, J. G., Liu, X., Cai, M., et al. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.08.015 · Cited by 102 · see citing works
Advances in Alzheimer’s Disease Drug Development
Rafii, M. S., & Aisen, P. S. S. (2015) · BMC Medicine · doi:10.1186/s12916-015-0297-4 · Cited by 95 · see citing works
New polyphenols active on β-amyloid aggregation
Rivière, C., Richard, T., Vitrac, X., Mérillon, J., Valls, J., & Monti, J. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.11.028 · Cited by 88 · see citing works
Mossa, A.-T. H., & Nawwar, G. A. M. (2011) · Human & Experimental Toxicology · doi:10.1177/0960327110391686 · Cited by 79 · see citing works
Leaf flavonoids as systematic characters in the genera Lavandula and Sabaudia
Upson, T. M., Grayer, R. J., Greenham, J. R., et al. (2000) · Biochemical Systematics and Ecology · doi:10.1016/s0305-1978(00)00013-2 · Cited by 77 · see citing works
Kumar, P., Singh, D. K., & Singh, D. K. (2008) · Phytotherapy Research · doi:10.1002/ptr.2578 · Cited by 76 · see citing works
Pedersen, J. T., Hureau, C., Hemmingsen, L., Heegaard, N. H. H., Østergaard, J., Vašák, M., & Faller, P. (2012) · Biochemistry · doi:10.1021/bi201774z · Cited by 70 · see citing works
Ursolic Acid of Origanum majorana L. Reduces Aâ-induced Oxidative Injury
Heo, H. J., Cho, H., Hong, B.-S., Kim, H. K., Heo, T., Kim, E.-K., Kim, S.-K., Kim, C., & Shin, D.-H. (2002) · Molecules and Cells · doi:10.1016/s1016-8478(23)14997-1 · Cited by 67 · see citing works
Cheng, H., Hsieh, M., Tsai, F., Wu, C., Chiu, C., Lee, M., Xu, H., Zhao, Z., & Peng, W. (2009) · Phytotherapy Research · doi:10.1002/ptr.2940 · Cited by 65 · see citing works
Fazili, N. A., & Naeem, A. (2014) · Biochimie · doi:10.1016/j.biochi.2014.11.011 · Cited by 64 · see citing works
Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury.
Heo, H. J., Cho, H., Hong, B.-S., et al. (2002) · PubMed · Cited by 60 · see citing works
1H, 13C MAS NMR and DFT GIAO study of quercetin and its complex with Al(III) in solid state
Ahmedova, A., Paradowska, K., & Wawer, I. (2012) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2012.02.007 · Cited by 55 · see citing works
Ladiwala, A. R. A., Mora‐Pale, M., Lin, J. C., Bale, S. S., Fishman, Z. S., Dordick, J. S., & Tessier, P. M. (2011) · ChemBioChem · doi:10.1002/cbic.201100123 · Cited by 54 · see citing works
Characterization of the raw essential oil eugenol extracted from Syzygium aromaticum L.
dos Santos, A. L., Chierice, G. O., Alexander, K. S., et al. (2009) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-009-0030-7 · Cited by 42 · see citing works
In vitroOligomerization and Fibrillogenesis of Amyloid-beta Peptides
Benseny‐Cases, N., Klementieva, O., & Cladera, J. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-5416-4_3 · Cited by 38 · see citing works
Makowska‐Wąs, J., Galanty, A., Gdula‐Argasińska, J., Tyszka‐Czochara, M., Szewczyk, A., Nunes, R., Carvalho, I. S., Michalik, M., & Paśko, P. (2016) · Chemistry & Biodiversity · doi:10.1002/cbdv.201600331 · Cited by 37 · see citing works
Grădinariu, V., Cioancă, O., Hriţcu, L., et al. (2014) · Phytochemistry Reviews · doi:10.1007/s11101-014-9389-6 · Cited by 35 · see citing works
Mizukami, H., & Ellis, B. (1991) · Plant Cell Reports · doi:10.1007/bf00193150 · Cited by 33 · see citing works
β-Phenylethylamines and the isoquinoline alkaloids
Bentley, K. W., Bentley, K. W., & Bentley, K. W. (1999) · Natural Product Reports · doi:10.1039/a708927i · Cited by 31 · see citing works
Atawodi, S. E.-O., Atawodi, J. C., Pfundstein, B., et al. (2011) · Electronic journal of environmental, agricultural and food chemistry · Cited by 27 · see citing works
Probing and Trapping a Sensitive Conformation: Amyloid-β Fibrils, Oligomers, and Dimers
Fawver, J. N., Duong, K. T., Wise-Scira, O., Chapa, R. P., Schall, H. E., Coskuner‐Weber, O., Zhu, X., Colom, L. V., & Murray, I. V. J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120880 · Cited by 24 · see citing works
Lobbens, E. S. B., Breydo, L., Skamris, T., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2016.06.009 · Cited by 24 · see citing works
Self-citationEUGENOL: A POTENTIAL PHYTOCHEMICAL WITH MULTIFACETED THERAPEUTIC ACTIVITIES
Garg, A., & Sanjay, S. (2010) · Cited by 20 · see citing works
Breydo, L., Morgan, D., & Uversky, V. N. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9148-8 · Cited by 16 · see citing works
Sheibani, V., Afarinesh, M. R., Hajializadeh, Z., Abbasnejad, M., Haghpanah, T., Arabnezhad, R., & Sepehri, G. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.22038/ijbms.2011.4984 · Cited by 15 · see citing works
Lobbens, E. S. B., Foderà, V., Nyberg, N. T., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149148 · Cited by 10 · see citing works
Self-citationZhang, Y., Yang, H., Fang, F., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124736 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease
Fernandes, F., Barroso, M. F., De Simone, A., Emriková, E., Dias-Teixeira, M., Pereira, J. P., Chlebek, J., Fernandes, V. C., Rodrigues, F., Andrisano, V., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115107 · Cited by 45 · see citing works
- Authors
- Lobbens, E. S. B., Vissing, K. J., Jorgensen, L., van de Weert, M., & Jäger, A. K.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Jäger, Anna K.
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 200
- Pages
- 66-73
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2587826324
- Cited by
- 20
- References
- 51
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Universitetet i Oslo
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, memory disorders, acetylcholinesterase inhibition, anti-amyloidogenic activity, amyloid-beta fibrillation, traditional medicinal plants, caraway, Corydalis, plant extracts, ethnopharmacology
- MeSH terms
- Acetylcholinesterase, Cholinesterase Inhibitors, Europe, Humans, Medicine, Traditional, Memory Disorders, Plant Extracts, Plants, Medicinal, Amyloid beta-Peptides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review