The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Mechanisms of nanotoxicity: Generation of reactive oxygen species
Open accessAbstract
Nanotechnology is a rapidly developing field in the 21(st) century, and the commercial use of nanomaterials for novel applications is increasing exponentially. To date, the scientific basis for the cytotoxicity and genotoxicity of most manufactured nanomaterials are not understood. The mechanisms underlying the toxicity of nanomaterials have recently been studied intensively. An important mechanism of nanotoxicity is the generation of reactive oxygen species (ROS). Overproduction of ROS can induce oxidative stress, resulting in cells failing to maintain normal physiological redox-regulated functions. This in turn leads to DNA damage, unregulated cell signaling, change in cell motility, cytotoxicity, apoptosis, and cancer initiation. There are critical determinants that can affect the generation of ROS. These critical determinants, discussed briefly here, include: size, shape, particle surface, surface positive charges, surface-containing groups, particle dissolution, metal ion release from nanometals and nanometal oxides, UV light activation, aggregation, mode of interaction with cells, inflammation, and pH of the medium.
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Cites
Free radicals, metals and antioxidants in oxidative stress-induced cancer
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The effect of particle design on cellular internalization pathways
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Oxidative DNA damage and disease: induction, repair and significance
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“The damage in cell function and development includes oxidative modification of proteins to generate protein radicals [45], initiation of lipid peroxidation [46e48], DNA-strand breaks, modification to nucleic acids [49], modulation of gene expression through activation of redox-sensitive transcription factors [50,51],…”
BackgroundTanaka, M., Yamamoto, Y., Misawa, E., Nabeshima, K., Saito, M., Yamauchi, K., Abe, F., & Furukawa, F. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000454718 · Cited by 1,092
Fenton Chemistry: An Introduction
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Self-citation
Cited by
Schirinzi, G. F., Pérez-Pomeda, I., Sanchís, J., Rossini, C., Farré, M., & Barceló, D. (2017) · Environmental Research · doi:10.1016/j.envres.2017.08.043 · Cited by 902
Potential toxicity of polystyrene microplastic particles
Hwang, J., Choi, D., Han, S., Jung, S. Y., Choi, J., & Hong, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-64464-9 · Cited by 699
An assessment of the toxicity of polypropylene microplastics in human derived cells
Hwang, J., Choi, D., Han, S., Choi, J., & Hong, J. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.05.071 · Cited by 668
Toxicology of silica nanoparticles: an update
Murugadoss, S., Lison, D., Godderis, L., Van Den Brule, S., Mast, J., Brassinne, F., Sebaihi, N., & Hoet, P. H. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-1993-y · Cited by 518
Hersh, A. M., Alomari, S., & Tyler, B. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084153 · Cited by 478
Metadata
- Authors
- Fu, P. P., Xia, Q., Hwang, H.-M., Ray, P. C., & Yu, H.
- Venue
- Journal of Food and Drug Analysis
- Published
- 2014-03
- Volume
- 22
- Issue
- 1
- Pages
- 64-75
- ISSN
- 1021-9498 (ISSN-L)
- OpenAlex
- W2116384075
- Cited by
- 1,398
- References
- 6
- FWCI
- 27.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fu, P. P., Xia, Q., Hwang, H.-M., Ray, P. C., & Yu, H. (2014). Mechanisms of nanotoxicity: Generation of reactive oxygen species. Journal of Food and Drug Analysis. https://doi.org/10.1016/j.jfda.2014.01.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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