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An assessment of the toxicity of polypropylene microplastics in human derived cells
Abstract
Environmental pollution caused by plastic waste is a growing global problem. Discarded plastic products and debris (microplastic particles) in the oceans detrimentally affect marine ecosystems and may impact human. Humans are exposed to plastic debris via the consumption of seafood and drinking water, contact with food packaging, or inhalation of particles. The accumulation of microplastic particles in humans has potential health risks such as cytotoxicity, hypersensitivity, unwanted immune response, and acute response like hemolysis. We investigated the cellular responses of secondary polypropylene microplastics (PP particles) of approximately ~20 μm and 25-200 μm in different condition and size to normal cells, immune cells, blood cells, and murine immune cells by cytokine analysis, ROS assay, polarization assay and proliferation assay. We found that PP particles showed low cytotoxicity effect in size and concentration manner, however, a high concentration, small sized, DMSO method of PP particles stimulated the immune system and enhanced potential hypersensitivity to PP particles via an increase in the levels of cytokines and histamines in PBMCs, Raw 264.7 and HMC-1 cells.
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Cites
NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Microplastics in the marine environment
Andrady, A. L. (2011) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2011.05.030 · Cited by 8,105
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Hidalgo-Ruz, V., Gutow, L., Thompson, R. C., & Thiel, M. (2012) · Environmental Science & Technology · doi:10.1021/es2031505 · Cited by 5,440
Accumulation of microplastic on shorelines woldwide: Sources and sinks
Browne, M. A., Crump, P., Niven, S. J., Teuten, E., Tonkin, A., Galloway, T., & Thompson, R. (2011) · Environmental Science & Technology · doi:10.1021/es201811s · Cited by 4,548
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176
The pollution of the marine environment by plastic debris: a review.
Derraik, J. G. B. (2002) · Marine Pollution Bulletin · doi:10.1016/s0025-326x(02)00220-5 · Cited by 4,042
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
Horton, A. A., Walton, A., Spurgeon, D. J., Lahive, E., & Svendsen, C. (2017) · Science of The Total Environment · doi:10.1016/j.scitotenv.2017.01.190 · Cited by 3,756
Research works printed but not linked: 17
- Buonocore, 2010, vol. 15, 186
- Clayman, 1981, Polypropylene, Ophthalmology, 88, 959, 10.1016/S0161-6420(81)80012-7 · doi:10.1016/s0161-6420(81)80012-7
- Collins, 1991, Variation of polypropylene microtacticity by catalyst selection, Organometallics, 10, 2061, 10.1021/om00052a064 · doi:10.1021/om00052a064
- Fukunaga, 1987, Decrease of molecular weight of polystyrene by ball-milling, Chem. Lett., 16, 1503, 10.1246/cl.1987.1503 · doi:10.1246/cl.1987.1503
- Karbalaei, 2018, Occurrence, sources, human health impacts and mitigation of microplastic pollution, Environ. Sci. Pollut. Res., 1
- Kirby, 1991, The effects of surgical isolation and application of polypropylene spiral prostheses on tracheal blood flow, Vet. Surg., 20, 49, 10.1111/j.1532-950X.1991.tb00305.x · doi:10.1111/j.1532-950x.1991.tb00305.x
- Martakis, 1994, Gamma-sterilization effects and influence of the molecular weight distribution on the postirradiation resistance of polypropylene for medical devices, J. Appl. Polym. Sci., 51, 313, 10.1002/app.1994.070510214 · doi:10.1002/app.1994.070510214
- Mays, 2018, Evidence-Based Validation of Hemolysis Index Thresholds by Use of Retrospective Clinical Data, J. Appl. Lab. Med., 3, 109, 10.1373/jalm.2017.024992 · doi:10.1373/jalm.2017.024992
- Mazzaglia, 2018, Supramolecular adducts of anionic porphyrins and a biocompatible polyamine: effect of photodamage-on human red blood cells, J. Nanosci. Nanotechnol., 18, 7269, 10.1166/jnn.2018.15747 · doi:10.1166/jnn.2018.15747
- Mohanty, 2002, Novel hybrid coupling agent as an adhesion promoter in natural fiber reinforced powder polypropylene composites, J. Mater. Sci. Lett., 21, 1885, 10.1023/A:1021577632600 · doi:10.1023/a:1021577632600
- Naito, 1994, The need for standardizing the index of hemolysis, Artif. Organs, 18, 7, 10.1111/j.1525-1594.1994.tb03292.x · doi:10.1111/j.1525-1594.1994.tb03292.x
- Pankhania, 1994, Hollow fibre bioreactor for wastewater treatment using bubbleless membrane aeration, Water Res., 28, 2233, 10.1016/0043-1354(94)90037-X · doi:10.1016/0043-1354(94)90037-x
- Quest, 1984, Two-year inhalation toxicity study of propylene in F344/N rats and B6C3F1 mice, Toxicol. Appl. Pharmacol., 76, 288, 10.1016/0041-008X(84)90010-3 · doi:10.1016/0041-008x(84)90010-3
- Schayer, 1956, The metabolism of histamine in various species, Br. J. Pharmacol. Chemother., 11, 472, 10.1111/j.1476-5381.1956.tb00020.x · doi:10.1111/j.1476-5381.1956.tb00020.x
- Shao, 2014, An efficient mono-component polymeric intumescent flame retardant for polypropylene: preparation and application, ACS Appl. Mater. Interfaces, 6, 7363, 10.1021/am500789q · doi:10.1021/am500789q
- Song, 2003, Effectiveness of polypropylene film as a barrier to migration from recycled paperboard packaging to fatty and high-moisture food, Food Addit. Contam., 20, 875, 10.1080/02652030310001597592 · doi:10.1080/02652030310001597592
- Wang, 2012, Polypropylene/layered double hydroxide nanocomposites, J. Mater. Chem., 22, 19113, 10.1039/c2jm33493c · doi:10.1039/c2jm33493c
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Environmental exposure to microplastics: An overview on possible human health effects
Prata, J. C., da Costa, J. P., Lopes, I., Duarte, A. C., & Rocha-Santos, T. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134455 · Cited by 2,690
Potential toxicity of polystyrene microplastic particles
Hwang, J., Choi, D., Han, S., Jung, S. Y., Choi, J., & Hong, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-64464-9 · Cited by 699
Self-citationLifetime Accumulation of Microplastic in Children and Adults
Mohamed Nor, N. H., Kooi, M., Diepens, N. J., & Koelmans, A. A. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c07384 · Cited by 652
Micro- and nanoplastic induced cellular toxicity in mammals: A review
Banerjee, A., & Shelver, W. L. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142518 · Cited by 492
Wu, P., Lin, S., Cao, G., Wu, J., Jin, H., Wang, C., Wong, M. H., Yang, Z., & Cai, Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129361 · Cited by 428
Metadata
- Authors
- Hwang, J., Choi, D., Han, S., Choi, J., & Hong, J.
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 684
- Pages
- 657-669
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W2946017099
- Cited by
- 668
- References
- 91
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- Funders
- National Research Foundation of Korea
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