The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model
Open accessAbstract
The effects of pear vinegar (PV), which was specially brewed for enhanced galacturonic acid content, on the DSS-induced ulcerative colitis (UC) mouse model were evaluated. PV improved clinical symptoms, colon inflammation, and histological tissue injury in the DSS-induced acute UC mouse model. Moreover, PV suppressed inflammation due to acute UC by suppressing the myeloperoxidase (MPO)-mediated activation of inflammatory cells such as leukocytes and decreasing the serum concentration of IL-6. Our results demonstrated the protective action of PV in the DSS-induced acute UC mouse model. On the other hand, commercial apple vinegar did not show a protective effect in the DSS-induced acute UC mouse model. Our findings indicate that PV may act as a new functional food for inflammatory bowel disease patients.
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In the citing paper
“Research experiments have proven that pear vinegar has an interesting ability in reducing serum IL-6 and IL-1ß concentrations [109].”
From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [109]
In the citing paper
“Previously, it proved that the pear vinegar ameliorates histological disorganization induced by dextran sodium sulfate (DSS) in an experimental animal model.”
From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [109]
Citations
Cites
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Fruit, Vegetables, Dietary Fiber, and Risk of Colorectal Cancer
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Il-6 signaling in inflammatory bowel disease: Pathophysiological role and clinical relevance
Mudter, J., & Neurath, M. F. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20148 · Cited by 440
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Myeloperoxidase: A Useful Biomarker for Cardiovascular Disease Risk Stratification?
Schindhelm, R. K., van der Zwan, L., Teerlink, T., & Scheffer, P. G. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.126029 · Cited by 234
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d-Galacturonic acid catabolism in microorganisms and its biotechnological relevance
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Cited by
Sorted by citations
A review of pears (Pyrus spp.), ancient functional food for modern times
Hong, S., Lansky, E. S., Kang, S.-S., & Yang, M. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03392-1 · Cited by 89
Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality
Ousaaid, D., Mechchate, H., Laaroussi, H., Hano, C., Bakour, M., El Ghouizi, A., Conte, R., Lyoussi, B., & El Arabi, I. (2021) · Molecules · doi:10.3390/molecules27010222 · Cited by 81
Bordbar, M. M., Tashkhourian, J., & Hemmateenejad, B. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.11.010 · Cited by 63
Zhao, L., Du, X., Tian, J., Kang, X., Li, Y., Dai, W., Li, D., Zhang, S., & Li, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.644387 · Cited by 56
Park, J. E., Kim, J. Y., Kim, J., Kim, Y. J., Kim, M. J., Kwon, S. W., & Kwon, O. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.03.028 · Cited by 47
Metadata
- Authors
- Wakuda, T., Azuma, K., Saimoto, H., Ifuku, S., Morimoto, M., Arifuku, I., Asaka, M., Tsuka, T., Imagawa, T., Okamoto, Y., Osaki, T., & Minami, S.
- Affiliations
- Tottori University (JP)
- Tottori Institute of Industrial Technology (JP)
- Corresponding author
- Osaki, Tomohiro
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 5
- Issue
- 1
- Pages
- 516-523
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W2095258336
- Cited by
- 23
- References
- 22
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 3 · 2017: 1 · 2015: 2 · 2014: 5 · 2013: 3
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- galacturonic acid, ulcerative colitis, DSS-induced colitis, myeloperoxidase, interleukin-6, colonic inflammation, functional foods, inflammatory bowel disease, apple cider vinegar
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- CoChat. (2026). Citation check: Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model. https://app.cochat.ai/papers/10.1016/j.jff.2012.10.010
- The paper
- Wakuda, T., Azuma, K., Saimoto, H., Ifuku, S., Morimoto, M., Arifuku, I., Asaka, M., Tsuka, T., Imagawa, T., Okamoto, Y., Osaki, T., & Minami, S. (2013). Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model. Journal of Functional Foods. https://doi.org/10.1016/j.jff.2012.10.010
