Dioscorea Nipponica Extracts Enhance Recovery from Skeletal Muscle Atrophy by Suppressing NF-κB Expression
Open accessAbstract
Saponin derived from natural extracts can alleviate muscle atrophy. Dioscorea nipponica Makino (DNM) is commonly used in herbal medicine and contains various steroidal saponins, although its efficacy and mechanisms of action for treating muscle atrophy remain unknown. Here, differentiated myoblast cells treated with DNM showed increased MyoD and MyoG expression and effectively promoted muscle formation. DNM effectively inhibited muscle atrophy induced by tumor necrosis factor alpha (TNFα) monotherapy, and combination treatment with protodioscin and protogracillin (among the tested DNM constituents) showed a synergistic effect on differentiated myoblast cells. DNM and this combination repressed TNFα-induced increased MuRF1 and Atrogin1/MAFbx expression by inhibiting nuclear factor-kappa B (NF-κB) expression. DNM also effectively promoted the recovery of muscle formation in injured mice. Therefore, DNM and its multi-constituents can potentially be used as therapeutic agents for muscle-related diseases and represent prospective food supplements.
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In an in vitro model of C2C12 cells, Dioscorea nipponica extracts inhibits TNF-α-induced atrophy and promotes myoblast differentiation.
“In vitro model of C2C12 cells, Dioscorea nipponica extracts inhibits TNF-α-induced atrophy and promotes myoblast differentiation [129].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [129]
Dioscorea nipponica extracts protect against injury-induced muscle atrophy by suppressing NF-κB expression in C57BL/6 mice.
“Dioscorea nipponica extracts is abundant in polysaccharides and protects against injury-induced muscle atrophy by suppressing NF-κB expression in C57BL/6 mice.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [129]
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Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works
- Authors
- Park, K.-S., Kim, H. J., Hwang, J. T., & Ko, B. S.
- Affiliations
- Korea Institute of Oriental Medicine (KR)
- Corresponding author
- Ko, Byoung Seob
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 73
- Pages
- 104109
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W3040975943
- Cited by
- 8
- References
- 35
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 2 · 2021: 2
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Council of Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Keywords
- Dioscorea nipponica, muscle atrophy, NF-κB, steroidal saponins, protodioscin, TNF-α, MuRF1, myogenesis, MyoD, myogenin, muscle regeneration, synergistic effect, dietary supplements
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