Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice

Choi, Won Hee; Son, Hyo Jeong; Jang, Young Jin; Ahn, Jiyun; Jung, Chang Hwa; Ha, Tae Youl

doi:10.1002/mnfr.201700218

Cited by 81Muscle Physiology and DisordersFlavonoids in Medical ResearchAdipose Tissue and Metabolism

Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice

Choi, Won Hee, Son, Hyo Jeong, Jang, Young Jin, Ahn, Jiyun, Jung, Chang Hwa, Ha, Tae Youl·2017·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.201700218

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Abstract

SCOPE: It was investigated whether apigenin (AP) protected against skeletal muscle atrophy induced by obesity. METHODS AND RESULTS: Mice were fed a high-fat diet (HFD) for 9 weeks to induce obesity, and then were assigned to two groups; the HFD group received a high-fat diet, and the HFD+AP group received a 0.1% AP-containing HFD. After additional feeding of the experimental diet for 8 weeks, mice in the HFD group were highly obese compared with the mice in the standard diet fed mice group. The mice in the AP-treated group showed less fat pad accumulation and less inflammatory cytokines without body weight reduction. The weight of skeletal muscle in the AP group tended to increase as compared with that of the HFD group. Furthermore, AP reduced the expression of atrophic genes, including MuRF1 and Atrogin-1, but increased the exercise capacity. The mitochondrial function and mitochondrial biogenesis were enhanced by AP. In cultured C2C12 cells, AP also suppressed palmitic acid-induced muscle atrophy and mitochondrial dysfunction. In addition, AP activated AMP-activated protein kinase (AMPK) in the C2C12 and the muscle of HFD-induced obese mice. CONCLUSION: The results suggested that AP ameliorated the obesity-induced skeletal muscle atrophy by attenuating mitochondrial dysfunction.

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In C2C12 myotubes, apigenin suppresses muscle atrophy and mitochondrial dysfunction induced by palmitic acid.
“The group also reported that in C2C12 myotubes, apigenin suppresses muscle atrophy and mitochondrial dysfunction induced by palmitic acid [110].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [110]
The positive effect of apigenin is related to upregulation of mitochondrial content and downregulation of gene expression of MuRF1 and MAFbx in skeletal muscle of C57BL/6 mice.
“The positive effect of apigenin is related to the upregulation of mitochondrial content and downregulation of gene expression of MuRF1 and MAFbx in skeletal muscle of C57BL/6 mice [110].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [110]
Dietary supplementation of apigenin ameliorates obesity-induced skeletal muscle atrophy and increases exercise capacity.
“Choi et al. reported that dietary supplementation of apigenin ameliorates the obesity-induced skeletal muscle atrophy and increases the exercise capacity.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [110]

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Authors: Choi, W. H., Son, H. J., Jang, Y. J., Ahn, J., Jung, C. H., & Ha, T. Y.
Affiliations: Korea Food Research Institute (KR)
Corresponding author: Ha, Tae Youl
ORCID: Choi, Won Hee
Jang, Young Jin
Ahn, Jiyun
Jung, Chang Hwa
Ha, Tae Youl
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2017-11-02
Volume: 61
Issue: 12
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.201700218
OpenAlex: W2761348958
Cited by: 81
References: 41
Citations by year: 2026: 6 · 2025: 11 · 2024: 6 · 2023: 13 · 2022: 12 · 2021: 16 · 2020: 9 · 2019: 4 · 2018: 4
FWCI: 1.90
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
Funders: Korea Food Research Institute (E0160500)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: apigenin, skeletal muscle atrophy, obesity, mitochondrial dysfunction, mitochondrial biogenesis, AMPK, high-fat diet, MuRF1, atrogin-1, muscle protein degradation, exercise capacity, palmitic acid, C2C12 myocytes, dietary flavonoids
MeSH terms: Animals, Cell Line, Male, Mice, Inbred C57BL, Mice, Obese, Mitochondria, Muscle, Muscular Atrophy, Obesity, Muscle, Skeletal, Palmitic Acid, Apigenin, AMP-Activated Protein Kinases, Diet, High-Fat

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Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice

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